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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of regulated secretory pathway
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Accession:GO:1903307 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: up regulation of regulated secretory pathway;   upregulation of regulated secretory pathway
 narrow_synonym: activation of regulated secretory pathway



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positive regulation of regulated secretory pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RAB15 RAB15, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:89,015,041...89,039,482
Ensembl chr 7:89,015,042...89,039,484
JBrowse link
G RAB27A RAB27A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:116,532,816...116,606,477
Ensembl chr 1:116,533,024...116,605,199
JBrowse link
G RAB3A RAB3A, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:59,603,090...59,609,773
Ensembl chr 2:59,603,117...59,609,767
JBrowse link
G RAB3D RAB3D, member RAS oncogene family involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:70,023,470...70,035,679
Ensembl chr 2:70,026,181...70,035,653
JBrowse link
G UNC13D unc-13 homolog D involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:5,573,428...5,598,914
Ensembl chr12:5,573,667...5,589,088
JBrowse link
induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA GOC GO_REF:0000108 NCBI chr10:44,321,954...44,887,410
Ensembl chr10:44,421,666...44,885,424
JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 involved_in IEA GOC GO_REF:0000108 NCBI chr15:402,801...455,691
Ensembl chr15:186,315...459,856
JBrowse link
G CNR1 cannabinoid receptor 1 involved_in IEA GOC GO_REF:0000108 NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,466,027...56,492,602
JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HYAL3 hyaluronidase 3 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr13:32,790,843...32,796,995
Ensembl chr13:32,789,421...32,796,563
JBrowse link
G ZP3 zona pellucida glycoprotein 3 involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941
JBrowse link
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARF1 ADP ribosylation factor 1 ISO RGD PMID:10657240 RGD:9684853 NCBI chr 2:51,219,597...51,237,640
Ensembl chr 2:51,219,667...51,237,639
JBrowse link
G CACNA1B calcium voltage-gated channel subunit alpha1 B involved_in IBA (PMID:21873635) GO_Central PMID:21873635
G CACNA1F calcium voltage-gated channel subunit alpha1 F involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:43,250,449...43,284,458
Ensembl chr  X:43,246,786...43,283,990
JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:17172292 PMID:21873635 RGD:2316206 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,054
JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:8,593,014...8,702,734
Ensembl chr 5:8,595,142...8,712,393
JBrowse link
G CADPS calcium dependent secretion activator ISO RGD PMID:9289490 RGD:1299539 NCBI chr13:43,979,694...44,482,985 JBrowse link
G CDK5 cyclin dependent kinase 5 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) MGI PMID:15123626 MGI:3709145 NCBI chr18:6,166,914...6,171,157 JBrowse link
G CDK5R2 cyclin dependent kinase 5 regulatory subunit 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709145|PMID:15123626) Ensembl
MGI
PMID:15123626 GO_REF:0000107 MGI:3709145 NCBI chr15:120,985,069...120,990,864
Ensembl chr15:120,985,245...120,991,318
JBrowse link
G DOC2B double C2 domain beta involved_in ISO PMID:18596155 UniProt PMID:18596155 RGD:8554556 NCBI chr12:47,529,383...47,558,236
Ensembl chr12:47,529,566...47,562,373
JBrowse link
G KCNB1 potassium voltage-gated channel subfamily B member 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr17:51,032,163...51,152,566
Ensembl chr17:51,039,956...51,144,696
JBrowse link
G SCAMP5 secretory carrier membrane protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:58,550,190...58,577,894
Ensembl chr 7:58,550,197...58,608,056
JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709145|PMID:15123626) Ensembl
MGI
PMID:15123626 GO_REF:0000107 MGI:3709145 NCBI chr 1:268,116,124...268,205,805
Ensembl chr 1:268,116,118...268,213,921
JBrowse link
G SYT1 synaptotagmin 1 ISO RGD PMID:21551071 RGD:7205660 NCBI chr 5:101,871,313...102,394,310
Ensembl chr 5:101,871,312...102,020,847
JBrowse link
G SYT10 synaptotagmin 10 involved_in ISO (MGI:5751674|PMID:21496647) UniProt PMID:21496647 MGI:5751674 NCBI chr 5:40,869,418...40,940,851
Ensembl chr 5:40,872,283...40,934,326
JBrowse link
G SYT7 synaptotagmin 7 ISO RGD PMID:21551071 RGD:7205660 NCBI chr 2:9,947,962...10,012,713
Ensembl chr 2:9,947,925...10,012,521
JBrowse link
G SYT9 synaptotagmin 9 ISO RGD PMID:21551071 RGD:7205660 NCBI chr 9:2,191,757...2,395,157
Ensembl chr 9:2,191,751...2,394,103
JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT1 synaptotagmin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:101,871,313...102,394,310
Ensembl chr 5:101,871,312...102,020,847
JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SYT4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chr 6:127,382,248...127,392,258
Ensembl chr 6:127,382,260...127,392,167
JBrowse link
positive regulation of eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858
JBrowse link
G STX4 syntaxin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,422,266...17,431,377
Ensembl chr 3:17,416,842...17,431,053
JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,919,495...71,932,254
JBrowse link
G PLA2G3 phospholipase A2 group III involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:47,923,005...47,928,762
Ensembl chr14:47,923,787...47,928,810
JBrowse link
G SNX4 sorting nexin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:134,824,028...134,903,765
Ensembl chr13:134,824,043...134,905,359
JBrowse link
G VAMP7 vesicle associated membrane protein 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:125,863,266...125,917,232
Ensembl chr  X:125,863,291...125,917,227
JBrowse link
G VAMP8 vesicle associated membrane protein 8 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chr 3:59,187,900...59,193,165 JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of_or_within ISO (MGI:3776334|PMID:11454903) MGI PMID:11454903 MGI:3776334 NCBI chr12:59,431,834...59,449,701
Ensembl chr12:59,393,220...59,449,692
JBrowse link
G ADORA3 adenosine A3 receptor acts_upstream_of_or_within ISO (MGI:2664591|PMID:12817016) MGI PMID:12817016 MGI:2664591 NCBI chr 4:108,854,300...108,857,769
Ensembl chr 4:108,814,405...108,873,927
JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO RGD PMID:18209484 RGD:5130941 NCBI chr12:17,251,361...17,306,308
Ensembl chr12:17,252,018...17,306,319
JBrowse link
G FCER1A Fc epsilon receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) MGI PMID:9000133 MGI:85068 NCBI chr 4:91,118,867...91,125,448
Ensembl chr 4:91,118,879...91,125,437
JBrowse link
G FCER1G Fc epsilon receptor Ig acts_upstream_of_or_within ISO (MGI:3029067|PMID:14764707) MGI PMID:14764707 MGI:3029067 NCBI chr 4:89,242,467...89,246,344
Ensembl chr 4:89,242,459...89,247,065
JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:84,809,534...84,830,401
Ensembl chr 6:84,809,542...84,830,361
JBrowse link
G GAB2 GRB2 associated binding protein 2 involved_in ISO (MGI:2137187|PMID:11449275) UniProt PMID:11449275 MGI:2137187 NCBI chr 9:12,663,658...12,851,423
Ensembl chr 9:12,656,882...12,851,402
JBrowse link
G GATA1 GATA binding protein 1 ISO RGD PMID:22390417 RGD:9587812 NCBI chr  X:42,898,431...42,905,939
Ensembl chr  X:42,898,442...42,905,976
JBrowse link
G GATA2 GATA binding protein 2 ISO RGD PMID:22390417 RGD:9587812 NCBI chr13:71,981,139...71,997,626
Ensembl chr13:71,984,063...71,997,622
JBrowse link
G IL13 interleukin 13 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3589858|PMID:15944273) Ensembl
MGI
PMID:15944273 GO_REF:0000107 MGI:3589858 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3589858|PMID:15944273)
GO_Central
MGI
PMID:15944273 PMID:21873635 MGI:3589858 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3589858|PMID:15944273) MGI PMID:15944273 MGI:3589858 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544
JBrowse link
G MS4A2 membrane spanning 4-domains A2 ISO RGD PMID:16177098 RGD:1578516 NCBI chr 2:11,400,415...11,420,314
Ensembl chr 2:11,400,420...11,420,299
JBrowse link
G NPPC natriuretic peptide C involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr15:132,504,669...132,509,688
Ensembl chr15:132,506,474...132,509,673
JBrowse link
G PLD2 phospholipase D2 ISO RGD PMID:16861349 RGD:2299903 NCBI chr12:52,073,913...52,087,804
Ensembl chr12:52,073,896...52,087,809
JBrowse link
G SPHK2 sphingosine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:53,982,911...53,986,779
Ensembl chr 6:53,979,012...53,986,770
JBrowse link
G STXBP1 syntaxin binding protein 1 ISO RGD PMID:23487749 RGD:12904029 NCBI chr 1:268,116,124...268,205,805
Ensembl chr 1:268,116,118...268,213,921
JBrowse link
G STXBP2 syntaxin binding protein 2 ISO RGD PMID:23487749 RGD:12904029 NCBI chr 2:71,504,575...71,513,446
Ensembl chr 2:71,504,569...71,513,422
JBrowse link
G SYK spleen associated tyrosine kinase involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(MGI:85068|PMID:9000133)
(PMID:21873635)
Ensembl
MGI
RGD
GO_Central
PMID:9000133 PMID:16861349 PMID:21873635 GO_REF:0000107 MGI:85068 RGD:2299903 NCBI chr14:2,103,706...2,160,886
Ensembl chr14:2,056,712...2,161,172
JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1G1 adaptor related protein complex 1 subunit gamma 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:14,719,949...14,809,821
Ensembl chr 6:14,719,954...14,809,744
JBrowse link
G CD160 CD160 molecule involved_in ISO (PMID:19109136) UniProt PMID:19109136 NCBI chr 4:99,579,891...99,585,808 JBrowse link
G LAMP1 lysosomal associated membrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,600,818...78,617,587
Ensembl chr11:78,600,713...78,617,615
JBrowse link
G SLA-7 MHC class I antigen 7 involved_in ISO (PMID:27455421) UniProt PMID:27455421 NCBI chr 7:23,634,731...23,638,722 JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD177 CD177 molecule involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:50,246,165...50,255,935
Ensembl chr 6:50,246,537...50,255,713
JBrowse link
G ITGAM integrin subunit alpha M involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,216,719...17,272,134
Ensembl chr 3:17,136,161...17,273,657
JBrowse link
G ITGAX integrin subunit alpha X involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,178,725...17,201,388 JBrowse link
G ITGB2 integrin subunit beta 2 involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,954...207,544,108
JBrowse link
G PTAFR platelet activating factor receptor ISO RGD PMID:2829894 RGD:10041060 NCBI chr 6:85,235,390...85,272,360
Ensembl chr 6:85,235,390...85,272,333
JBrowse link
positive regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2L1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359
JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr 5:41,571,054...41,636,058 JBrowse link
G NLGN1 neuroligin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:111,851,007...112,727,202
Ensembl chr13:112,036,053...112,725,618
JBrowse link
G SLC4A8 solute carrier family 4 member 8 acts_upstream_of_or_within ISO (MGI:5013899|PMID:21593314) ARUK-UCL PMID:21593314 MGI:5013899 NCBI chr 5:16,842,667...16,921,669
Ensembl chr 5:16,842,710...16,977,611
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16675
    positive regulation of biological process 6295
      positive regulation of cellular process 5816
        positive regulation of secretion by cell 368
          positive regulation of exocytosis 102
            positive regulation of regulated secretory pathway 65
              positive regulation of calcium ion-dependent exocytosis + 19
              positive regulation of leukocyte degranulation + 35
              positive regulation of synaptic vesicle exocytosis + 8
Path 2
Term Annotations click to browse term
  biological_process 16675
    localization 6012
      establishment of localization 4473
        transport 4313
          secretion 1085
            secretion by cell 916
              exocytosis 394
                regulated exocytosis 278
                  regulation of regulated secretory pathway 187
                    positive regulation of regulated secretory pathway 65
                      positive regulation of calcium ion-dependent exocytosis + 19
                      positive regulation of leukocyte degranulation + 35
                      positive regulation of synaptic vesicle exocytosis + 8
paths to the root