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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of regulated secretory pathway
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Accession:GO:1903307 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: up regulation of regulated secretory pathway;   upregulation of regulated secretory pathway
 narrow_synonym: activation of regulated secretory pathway


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positive regulation of regulated secretory pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab15 RAB15, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004955466:4,958,414...4,981,464
Ensembl chrNW_004955466:4,958,414...4,981,464
JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004955409:588,725...621,874
Ensembl chrNW_004955409:588,254...621,874
JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004955524:3,220,108...3,224,376
Ensembl chrNW_004955524:3,221,366...3,224,376
JBrowse link
G Rab3d RAB3D, member RAS oncogene family involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004955495:2,254,336...2,259,211
Ensembl chrNW_004955495:2,251,818...2,259,233
JBrowse link
G Unc13d unc-13 homolog D involved_in ISO (PMID:22899725) UniProt PMID:22899725 NCBI chrNW_004955506:6,407,073...6,423,406
Ensembl chrNW_004955506:6,407,723...6,423,406
JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in ISO (MGI:4834982|PMID:20586096) UniProt PMID:20586096 MGI:4834982 NCBI chrNW_004955532:2,107,019...2,112,356
Ensembl chrNW_004955532:2,106,565...2,108,892
JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO (PMID:19246320)
(PMID:19004505)
UniProt PMID:19004505 PMID:19246320 NCBI chrNW_004955456:15,013,472...15,020,809 JBrowse link
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP ribosylation factor 1 ISO RGD PMID:10657240 RGD:9684853 NCBI chrNW_004955581:319,942...335,112
Ensembl chrNW_004955581:319,942...335,112
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G ISO RGD PMID:17172292 RGD:2316206 NCBI chrNW_004955451:11,136,885...11,194,321
Ensembl chrNW_004955451:11,137,214...11,194,036
JBrowse link
G Cadps calcium dependent secretion activator ISO RGD PMID:9289490 RGD:1299539 NCBI chrNW_004955517:2,965,471...3,420,183 JBrowse link
G Cdk5 cyclin dependent kinase 5 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) MGI PMID:15123626 MGI:3709145 NCBI chrNW_004955491:5,491,744...5,497,280
Ensembl chrNW_004955491:5,491,744...5,497,280
JBrowse link
G Cdk5r2 cyclin dependent kinase 5 regulatory subunit 2 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) MGI PMID:15123626 MGI:3709145 NCBI chrNW_004955453:14,471,625...14,474,082
Ensembl chrNW_004955453:14,472,757...14,473,896
JBrowse link
G Doc2b double C2 domain beta involved_in ISO PMID:18596155 UniProt PMID:18596155 RGD:8554556 NCBI chrNW_004955481:1,839,894...1,859,733
Ensembl chrNW_004955481:1,842,815...1,860,374
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in ISO PMID:17301173
PMID:20484665
PMID:18167541
UniProt PMID:17301173 PMID:18167541 PMID:20484665 RGD:10047179 RGD:10047360 RGD:10047384 NCBI chrNW_004955445:8,680,979...8,779,662
Ensembl chrNW_004955445:8,680,965...8,774,110
JBrowse link
G Scamp5 secretory carrier membrane protein 5 involved_in ISO (PMID:19234194) UniProt PMID:19234194 NCBI chrNW_004955450:2,986,522...3,009,655
Ensembl chrNW_004955450:2,986,468...3,009,774
JBrowse link
G Stx1a syntaxin 1A involved_in ISO PMID:17301173
PMID:18167541
PMID:20484665
UniProt PMID:17301173 PMID:18167541 PMID:20484665 RGD:10047179 RGD:10047360 RGD:10047384 NCBI chrNW_004955456:14,030,233...14,046,456
Ensembl chrNW_004955456:14,030,226...14,046,456
JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within ISO (MGI:3709145|PMID:15123626) MGI PMID:15123626 MGI:3709145 NCBI chrNW_004955419:963,829...1,000,759
Ensembl chrNW_004955419:963,829...1,000,759
JBrowse link
G Syt1 synaptotagmin 1 ISO RGD PMID:21551071 RGD:7205660 NCBI chrNW_004955405:17,840,012...18,372,156
Ensembl chrNW_004955405:17,839,884...18,372,566
JBrowse link
G Syt10 synaptotagmin 10 involved_in ISO (MGI:5751674|PMID:21496647) UniProt PMID:21496647 MGI:5751674 NCBI chrNW_004955505:2,392,086...2,449,528
Ensembl chrNW_004955505:2,403,055...2,449,528
JBrowse link
G Syt7 synaptotagmin 7 ISO RGD PMID:21551071 RGD:7205660 NCBI chrNW_004955511:6,051,392...6,093,651
Ensembl chrNW_004955511:6,051,386...6,093,651
JBrowse link
G Syt9 synaptotagmin 9 ISO RGD PMID:21551071 RGD:7205660 NCBI chrNW_004955414:23,061,163...23,221,986
Ensembl chrNW_004955414:23,061,163...23,221,962
JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 involved_in ISO (MGI:2179533|PMID:11242035) UniProt PMID:11242035 MGI:2179533 NCBI chrNW_004955405:17,840,012...18,372,156
Ensembl chrNW_004955405:17,839,884...18,372,566
JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (MGI:3795609|PMID:18468511) ParkinsonsUK-UCL PMID:18468511 MGI:3795609 NCBI chrNW_004955402:29,195,124...29,204,816
Ensembl chrNW_004955402:29,193,455...29,204,975
JBrowse link
positive regulation of eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:11714832) UniProt PMID:11714832 NCBI chrNW_004955425:24,050,901...24,054,039 JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chrNW_004955486:2,061,196...2,062,805
Ensembl chrNW_004955486:2,060,735...2,063,003
JBrowse link
G Pla2g3 phospholipase A2 group III involved_in ISO (PMID:23624557)
(MGI:5492190|PMID:23624557)
UniProt PMID:23624557 MGI:5492190 NCBI chrNW_004955455:5,314,520...5,320,151
Ensembl chrNW_004955455:5,315,450...5,320,053
JBrowse link
G Snx4 sorting nexin 4 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004955427:24,520,125...24,579,589
Ensembl chrNW_004955427:24,520,125...24,579,589
JBrowse link
G Vamp7 vesicle associated membrane protein 7 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004955594:20,496...72,648
Ensembl chrNW_004955594:18,727...72,654
JBrowse link
G Vamp8 vesicle associated membrane protein 8 involved_in ISO (PMID:18253931) UniProt PMID:18253931 NCBI chrNW_004955424:1,922,830...1,926,844
Ensembl chrNW_004955424:1,923,092...1,926,728
JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2b receptor acts_upstream_of_or_within ISO (MGI:3776334|PMID:11454903) MGI PMID:11454903 MGI:3776334 NCBI chrNW_004955467:1,342,271...1,363,149
Ensembl chrNW_004955467:1,342,271...1,363,138
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:18209484 RGD:5130941 NCBI chrNW_004955478:10,380,185...10,390,838
Ensembl chrNW_004955478:10,379,287...10,404,825
JBrowse link
G Fcer1a Fc fragment of IgE receptor Ia acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) MGI PMID:9000133 MGI:85068 NCBI chrNW_004955468:11,094,792...11,101,191
Ensembl chrNW_004955468:11,094,788...11,101,173
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig acts_upstream_of_or_within ISO (MGI:3029067|PMID:14764707) MGI PMID:14764707 MGI:3029067 NCBI chrNW_004955468:12,971,931...12,975,206
Ensembl chrNW_004955468:12,971,931...12,975,206
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO (MGI:5294498|PMID:21746961) UniProt PMID:21746961 MGI:5294498 NCBI chrNW_004955452:6,840,274...6,863,460
Ensembl chrNW_004955452:6,841,802...6,863,542
JBrowse link
G Gab2 GRB2 associated binding protein 2 involved_in ISO (MGI:2137187|PMID:11449275) UniProt PMID:11449275 MGI:2137187 NCBI chrNW_004955414:13,640,713...13,754,401
Ensembl chrNW_004955414:13,679,588...13,751,079
JBrowse link
G Gata1 GATA binding protein 1 ISO RGD PMID:22390417 RGD:9587812 NCBI chrNW_004955543:334,581...342,042
Ensembl chrNW_004955543:334,061...342,061
JBrowse link
G Gata2 GATA binding protein 2 ISO RGD PMID:22390417 RGD:9587812 NCBI chrNW_004955429:15,326,551...15,334,774
Ensembl chrNW_004955429:15,327,113...15,336,460
JBrowse link
G Il13 interleukin 13 acts_upstream_of_or_within ISO (MGI:3589858|PMID:15944273) MGI PMID:15944273 MGI:3589858 NCBI chrNW_004955408:4,046,406...4,049,795 JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO (MGI:3589858|PMID:15944273) MGI PMID:15944273 MGI:3589858 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3589858|PMID:15944273) MGI PMID:15944273 MGI:3589858 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 ISO RGD PMID:16177098 RGD:1578516 NCBI chrNW_004955511:4,377,894...4,400,797
Ensembl chrNW_004955511:4,380,502...4,400,852
JBrowse link
G Nppc natriuretic peptide C involved_in ISO PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chrNW_004955453:3,884,580...3,888,494
Ensembl chrNW_004955453:3,884,560...3,888,850
JBrowse link
G Pld2 phospholipase D2 ISO RGD PMID:16861349 RGD:2299903 NCBI chrNW_004955467:10,239,177...10,250,516
Ensembl chrNW_004955467:10,239,177...10,250,890
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (MGI:3703830|PMID:17346996) UniProt PMID:17346996 MGI:3703830 NCBI chrNW_004955559:1,921,479...1,929,450
Ensembl chrNW_004955559:1,917,301...1,928,493
JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO RGD PMID:23487749 RGD:12904029 NCBI chrNW_004955419:963,829...1,000,759
Ensembl chrNW_004955419:963,829...1,000,759
JBrowse link
G Stxbp2 syntaxin binding protein 2 ISO RGD PMID:23487749 RGD:12904029 NCBI chrNW_004955563:1,617,621...1,624,441
Ensembl chrNW_004955563:1,617,621...1,624,441
JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within ISO (MGI:85068|PMID:9000133) RGD
MGI
PMID:9000133 PMID:16861349 MGI:85068 RGD:2299903 NCBI chrNW_004955515:1,328,793...1,400,206
Ensembl chrNW_004955515:1,328,630...1,380,581
JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004955484:4,430,461...4,511,368
Ensembl chrNW_004955484:4,430,461...4,510,497
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) UniProt PMID:19109136 NCBI chrNW_004955568:365,700...372,149 JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:23632890) UniProt PMID:23632890 NCBI chrNW_004955404:557,090...573,532
Ensembl chrNW_004955404:557,862...573,379
JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004955555:1,106,722...1,120,756 JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004955493:8,116,886...8,160,806
Ensembl chrNW_004955493:8,116,834...8,260,759
JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO (PMID:21193407) UniProt PMID:21193407 NCBI chrNW_004955407:41,779,849...41,805,637
Ensembl chrNW_004955407:41,777,777...41,800,201
JBrowse link
G Ptafr platelet activating factor receptor ISO RGD PMID:2829894 RGD:10041060 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
JBrowse link
positive regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174
JBrowse link
G Dnm1l dynamin 1 like involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chrNW_004955505:3,025,742...3,081,491
Ensembl chrNW_004955505:3,023,018...3,081,680
JBrowse link
G Nlgn1 neuroligin 1 involved_in ISO PMID:19628693
(MGI:4355770|PMID:19628693)
BHF-UCL PMID:19628693 MGI:4355770 RGD:8554760 NCBI chrNW_004955420:3,360,745...4,171,587
Ensembl chrNW_004955420:3,549,021...4,167,493
JBrowse link
G Slc4a8 solute carrier family 4 member 8 acts_upstream_of_or_within ISO (MGI:5013899|PMID:21593314) ARUK-UCL PMID:21593314 MGI:5013899 NCBI chrNW_004955547:1,896,597...1,975,285
Ensembl chrNW_004955547:1,896,862...1,969,975
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12099
    positive regulation of biological process 5556
      positive regulation of cellular process 5145
        positive regulation of secretion by cell 347
          positive regulation of exocytosis 91
            positive regulation of regulated secretory pathway 56
              positive regulation of calcium ion-dependent exocytosis + 17
              positive regulation of leukocyte degranulation + 31
              positive regulation of synaptic vesicle exocytosis + 5
Path 2
Term Annotations click to browse term
  biological_process 12099
    localization 4894
      establishment of localization 3491
        transport 3333
          secretion 966
            secretion by cell 817
              exocytosis 321
                regulated exocytosis 248
                  regulation of regulated secretory pathway 166
                    positive regulation of regulated secretory pathway 56
                      positive regulation of calcium ion-dependent exocytosis + 17
                      positive regulation of leukocyte degranulation + 31
                      positive regulation of synaptic vesicle exocytosis + 5
paths to the root