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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of regulated secretory pathway
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Accession:GO:1903307 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: up regulation of regulated secretory pathway;   upregulation of regulated secretory pathway
 narrow_synonym: activation of regulated secretory pathway



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positive regulation of regulated secretory pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab15 RAB15, member RAS oncogene family involved_in ISO UniProtKB:P51159 (PMID:22899725) RGD PMID:22899725 NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942
JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO UniProtKB:P59190 (PMID:22899725) RGD PMID:22899725 NCBI chr 8:73,782,730...73,836,630
Ensembl chr 8:73,782,694...73,847,829
JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO
IEA
(PMID:22899725)
GO_REF:0000107
RGD
Ensembl
PMID:22899725 GO_REF:0000107 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Rab3d RAB3D, member RAS oncogene family involved_in ISO (PMID:22899725) RGD PMID:22899725 NCBI chr 8:20,438,622...20,449,269
Ensembl chr 8:20,439,294...20,449,185
JBrowse link
G Unc13d unc-13 homolog D involved_in ISO UniProtKB:P51159 (PMID:22899725) RGD PMID:22899725 NCBI chr10:101,296,755...101,311,513
Ensembl chr10:101,296,776...101,311,687
JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:20586096)
UniProt
RGD
PMID:20586096 GO_REF:0000024 NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647
JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO
ISS
(PMID:19004505), (PMID:19246320)
GO_REF:0000024
RGD
UniProt
PMID:19004505 PMID:19246320 GO_REF:0000024 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513
JBrowse link
positive regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arf1 ADP-ribosylation factor 1 IDA RGD PMID:10657240 RGD:9684853 NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in IMP
IBA
GO_REF:0000033 GO_Central
RGD
PMID:17172292 GO_REF:0000033, RGD:2316206 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Cadps calcium dependent secretion activator IMP RGD PMID:9289490 RGD:1299539 NCBI chr15:12,289,803...12,742,786
Ensembl chr15:12,290,262...12,742,779
JBrowse link
G Cdk5 cyclin-dependent kinase 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:15123626)
Ensembl
RGD
PMID:15123626 GO_REF:0000107 NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
JBrowse link
G Cdk5r2 cyclin-dependent kinase 5 regulatory subunit 2 acts_upstream_of_or_within ISO (PMID:15123626) RGD PMID:15123626 NCBI chr 9:76,416,251...76,417,719
Ensembl chr 9:76,416,062...76,418,344
JBrowse link
G Doc2a double C2 domain alpha involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:181,457,415...181,462,528
Ensembl chr 1:181,458,390...181,462,030
JBrowse link
G Doc2b double C2 domain beta involved_in IDA
IBA
PMID:18596155
GO_REF:0000033
GO_Central PMID:18596155 GO_REF:0000033, RGD:8554556 NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
JBrowse link
G Doc2g double C2-like domains, gamma involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:201,295,377...201,299,867
Ensembl chr 1:201,296,342...201,299,865
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 involved_in IDA PMID:18167541
PMID:17301173
PMID:20484665
UniProt PMID:18167541 PMID:17301173 PMID:20484665 RGD:10047360, RGD:10047384, RGD:10047179 NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
JBrowse link
G Rph3a rabphilin 3A involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592
JBrowse link
G Rph3al rabphilin 3A-like (without C2 domains) involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:60,689,943...60,833,354
Ensembl chr10:60,690,031...60,801,883
JBrowse link
G Scamp5 secretory carrier membrane protein 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19234194)
UniProt
Ensembl
RGD
PMID:19234194 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:57,845,831...57,884,516
Ensembl chr 8:57,846,659...57,872,027
JBrowse link
G Stx1a syntaxin 1A involved_in IDA PMID:17301173
PMID:20484665
PMID:18167541
UniProt PMID:17301173 PMID:20484665 PMID:18167541 RGD:10047384, RGD:10047179, RGD:10047360 NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930
JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within ISO (PMID:15123626) RGD PMID:15123626 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Syt1 synaptotagmin 1 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
G Syt10 synaptotagmin 10 involved_in ISS
ISO
GO_REF:0000024
(PMID:21496647)
UniProt
RGD
PMID:21496647 GO_REF:0000024 NCBI chr 7:120,857,698...120,920,863
Ensembl chr 7:120,862,972...120,920,863
JBrowse link
G Syt7 synaptotagmin 7 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 1:207,031,359...207,093,787
Ensembl chr 1:207,031,592...207,089,026
JBrowse link
G Syt9 synaptotagmin 9 IDA RGD PMID:21551071 RGD:7205660 NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007
JBrowse link
positive regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt1 synaptotagmin 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:11242035)
UniProt
RGD
PMID:11242035 GO_REF:0000024 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803
JBrowse link
positive regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in ISO (PMID:18468511) RGD PMID:18468511 NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332
JBrowse link
positive regulation of eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:11714832) RGD PMID:11714832 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Stx4 syntaxin 4 involved_in ISO (PMID:16677249) RGD PMID:16677249 NCBI chr 1:182,451,108...182,459,701
Ensembl chr 1:182,451,117...182,459,979
JBrowse link
positive regulation of histamine secretion by mast cell term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nppa natriuretic peptide A involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:23624557) RGD PMID:23624557 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Snx4 sorting nexin 4 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174
JBrowse link
G Vamp7 vesicle-associated membrane protein 7 involved_in ISO (PMID:18253931) RGD PMID:18253931 NCBI chr12:16,728,486...16,764,261
Ensembl chr12:16,728,524...16,764,097
JBrowse link
G Vamp8 vesicle-associated membrane protein 8 involved_in IEA
ISO
GO_REF:0000107
(PMID:18253931)
Ensembl
RGD
PMID:18253931 GO_REF:0000107 NCBI chr 4:104,442,383...104,452,884
Ensembl chr 4:104,442,393...104,452,897
JBrowse link
positive regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:11454903)
GO_REF:0000107
RGD
Ensembl
PMID:11454903 GO_REF:0000107 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Adora3 adenosine A3 receptor acts_upstream_of_or_within ISO MGI:2155986 (PMID:12817016) RGD PMID:12817016 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:18209484 RGD:5130941 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Fcer1a Fc epsilon receptor Ia acts_upstream_of_or_within ISO (PMID:9000133) RGD PMID:9000133 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Fcer1g Fc epsilon receptor Ig acts_upstream_of_or_within ISO MGI:2384004 (PMID:14764707) RGD PMID:14764707 NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISS
ISO
GO_REF:0000024
(PMID:21746961)
UniProt
RGD
PMID:21746961 GO_REF:0000024 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Gab2 GRB2-associated binding protein 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:11449275)
UniProt
RGD
PMID:11449275 GO_REF:0000024 NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031
JBrowse link
G Gata1 GATA binding protein 1 IMP RGD PMID:22390417 RGD:9587812 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gata2 GATA binding protein 2 IMP RGD PMID:22390417 RGD:9587812 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Il13 interleukin 13 acts_upstream_of_or_within ISO MGI:1931804|MGI:96556 (PMID:15944273) RGD PMID:15944273 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il4 interleukin 4 acts_upstream_of_or_within ISO MGI:1857195|MGI:96541 (PMID:15944273) RGD PMID:15944273 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:1861951 (PMID:15944273) RGD PMID:15944273 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IMP RGD PMID:16177098 RGD:1578516 NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310
JBrowse link
G Nppc natriuretic peptide C involved_in IDA PMID:9663691 UniProt PMID:9663691 RGD:13461752 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Pld2 phospholipase D2 IMP RGD PMID:16861349 RGD:2299903 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Sphk2 sphingosine kinase 2 involved_in ISO (PMID:17346996) RGD PMID:17346996 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Stxbp1 syntaxin binding protein 1 IMP RGD PMID:23487749 RGD:12904029 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
G Stxbp2 syntaxin binding protein 2 IMP RGD PMID:23487749 RGD:12904029 NCBI chr12:1,689,364...1,701,145
Ensembl chr12:1,689,410...1,700,458
JBrowse link
G Syk spleen associated tyrosine kinase acts_upstream_of_or_within
involved_in
IMP
ISO
IEA
MGI:2384078 (PMID:9000133)
GO_REF:0000107
RGD
Ensembl
PMID:9000133 PMID:16861349 GO_REF:0000107, RGD:2299903 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
JBrowse link
positive regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1g1 adaptor related protein complex 1 subunit gamma 1 involved_in ISO (PMID:23632890) RGD PMID:23632890 NCBI chr19:37,744,633...37,831,134
Ensembl chr19:37,744,633...37,829,167
JBrowse link
G Cd160 CD160 molecule involved_in ISO (PMID:19109136) RGD PMID:19109136 NCBI chr 2:184,340,820...184,383,421
Ensembl chr 2:184,340,599...184,375,834
JBrowse link
G Klrc2 killer cell lectin like receptor C2 involved_in ISO (PMID:21825173) RGD PMID:21825173 NCBI chr 4:163,122,700...163,133,843
Ensembl chr 4:163,122,704...163,133,843
JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in ISO
IEA
(PMID:23632890)
GO_REF:0000107
RGD
Ensembl
PMID:23632890 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:27455421) RGD PMID:27455421 NCBI chr20:3,403,418...3,479,476 JBrowse link
positive regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in ISO
IBA
UniProtKB:P05107|UniProtKB:P11215 (PMID:21193407)
GO_REF:0000033
RGD
GO_Central
PMID:21193407 GO_REF:0000033 NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621
JBrowse link
G Cd177l2 CD177 molecule like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:80,323,188...80,328,311
Ensembl chr 1:80,323,863...80,328,311
JBrowse link
G Itgam integrin subunit alpha M involved_in ISO UniProtKB:P05107|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb2 integrin subunit beta 2 involved_in ISO UniProtKB:P11215|UniProtKB:Q8N6Q3 (PMID:21193407) RGD PMID:21193407 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Lypd10 Ly6/PLAUR domain containing 10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:80,273,019...80,278,238
Ensembl chr 1:80,273,019...80,278,219
JBrowse link
G Ptafr platelet-activating factor receptor IMP RGD PMID:2829894 RGD:10041060 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251
JBrowse link
positive regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 involved_in IMP PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Dnm1l dynamin 1-like involved_in IMP PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Nlgn1 neuroligin 1 involved_in IMP
ISO
IEA
PMID:19628693
(PMID:19628693)
GO_REF:0000107
RGD
Ensembl
PMID:19628693 PMID:19628693 GO_REF:0000107, RGD:8554760 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
JBrowse link
G Slc4a8 solute carrier family 4 member 8 acts_upstream_of_or_within ISO (PMID:21593314) RGD PMID:21593314 NCBI chr 7:131,861,284...131,939,295
Ensembl chr 7:131,864,102...131,931,051
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20052
    positive regulation of biological process 6738
      positive regulation of cellular process 6397
        positive regulation of secretion by cell 399
          positive regulation of exocytosis 105
            positive regulation of regulated secretory pathway 68
              positive regulation of calcium ion-dependent exocytosis + 23
              positive regulation of leukocyte degranulation + 37
              positive regulation of synaptic vesicle exocytosis + 5
Path 2
Term Annotations click to browse term
  biological_process 20052
    localization 5696
      establishment of localization 4997
        transport 4691
          secretion 1211
            secretion by cell 1016
              exocytosis 408
                regulated exocytosis 279
                  regulation of regulated secretory pathway 168
                    positive regulation of regulated secretory pathway 68
                      positive regulation of calcium ion-dependent exocytosis + 23
                      positive regulation of leukocyte degranulation + 37
                      positive regulation of synaptic vesicle exocytosis + 5
paths to the root