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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of regulated secretory pathway
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Accession:GO:1903306 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: down regulation of regulated secretory pathway;   downregulation of regulated secretory pathway
 narrow_synonym: inhibition of regulated secretory pathway


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negative regulation of regulated secretory pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Septin5 septin 5 IMP RGD PMID:10321247 RGD:1302866 NCBI chr11:95,877,946...95,883,738
Ensembl chr11:95,873,864...95,883,737 		JBrowse link
negative regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A involved_in IMP PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871 		JBrowse link
G Cbarp CACN subunit beta associated regulatory protein involved_in ISO
IEA
IBA 		(PMID:24751537)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:24751537 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,566,637...9,575,204
Ensembl chr 7:10,217,328...10,225,854 		JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:11533141 RGD:13508598 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622 		JBrowse link
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO
IEA 		MGI:2684314 (PMID:19251639)
GO_REF:0000107 		RGD
Ensembl		 PMID:19251639 GO_REF:0000107 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:29,676,171...29,721,613 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 acts_upstream_of_or_within ISO
IEA 		(PMID:2357966)
GO_REF:0000107 		RGD
Ensembl		 PMID:2357966 GO_REF:0000107 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha involved_in IC PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 2:227,839,058...228,113,560
Ensembl chr 2:227,839,062...228,113,554 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family acts_upstream_of_or_within ISO MGI:97852 (PMID:23616533) RGD PMID:23616533 NCBI chr 7:55,308,922...55,342,217
Ensembl chr 7:55,308,922...55,342,217 		JBrowse link
G Rest RE1-silencing transcription factor involved_in IMP PMID:21536750 UniProt PMID:21536750 RGD:8554180 NCBI chr14:31,213,415...31,233,451
Ensembl chr14:31,213,415...31,248,662 		JBrowse link
G Stxbp3 syntaxin binding protein 3 involved_in ISO
IEA 		(PMID:12649283)
GO_REF:0000107 		RGD
Ensembl		 PMID:12649283 GO_REF:0000107 NCBI chr 2:199,130,725...199,173,823
Ensembl chr 2:199,130,725...199,173,823 		JBrowse link
G Syt4 synaptotagmin 4 IDA RGD PMID:21551071 RGD:7205660 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815 		JBrowse link
G Trim9 tripartite motif-containing 9 IMP
IDA 		RGD PMID:11524423 PMID:11524423 RGD:631246, RGD:631246 NCBI chr 6:88,756,824...88,856,588
Ensembl chr 6:94,493,268...94,592,551 		JBrowse link
negative regulation of calcium ion-dependent exocytosis of neurotransmitter term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk5 cyclin-dependent kinase 5 acts_upstream_of_or_within IMP PMID:23699505 ARUK-UCL PMID:23699505 RGD:13792535 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777 		JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 involved_in ISO
ISS 		(PMID:18424730)
GO_REF:0000024 		RGD
UniProt		 PMID:18424730 GO_REF:0000024 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798 		JBrowse link
G Nckap1l NCK associated protein 1 like involved_in ISO (PMID:32647003) RGD PMID:32647003 NCBI chr 7:136,455,900...136,501,384
Ensembl chr 7:136,455,897...136,501,384 		JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 involved_in IMP PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815 		JBrowse link
G Trim9 tripartite motif-containing 9 IDA RGD PMID:11524423 RGD:631246 NCBI chr 6:88,756,824...88,856,588
Ensembl chr 6:94,493,268...94,592,551 		JBrowse link
negative regulation of eosinophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 involved_in ISS
ISO 		GO_REF:0000024
(PMID:14662900) 		BHF-UCL
RGD		 PMID:14662900 GO_REF:0000024 NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:132,611,410...132,620,059 		JBrowse link
negative regulation of mast cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in
acts_upstream_of_or_within 		ISO (PMID:16339535)
(PMID:12874256) 		RGD PMID:12874256 PMID:16339535 NCBI chr10:100,428,826...100,441,693
Ensembl chr10:100,428,826...100,442,958 		JBrowse link
G Cd84 CD84 molecule involved_in ISO
IEA 		(PMID:22068234)
GO_REF:0000107 		RGD
Ensembl		 PMID:22068234 GO_REF:0000107 NCBI chr13:86,859,979...86,899,984
Ensembl chr13:86,859,990...86,894,318 		JBrowse link
G Foxf1 forkhead box F1 acts_upstream_of_or_within ISO
IEA 		MGI:2179135 (PMID:18421012)
GO_REF:0000107 		RGD
Ensembl		 PMID:18421012 GO_REF:0000107 NCBI chr19:66,062,635...66,066,427
Ensembl chr19:66,062,369...66,066,428 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 acts_upstream_of_or_within ISO MGI:2653910 (PMID:15944273) RGD PMID:15944273 NCBI chr  X:115,814,620...115,886,080
Ensembl chr  X:115,814,622...115,841,455 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:24465902) RGD PMID:24465902 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:64,405,044...64,428,070 		JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO
IEA 		MGI:3051384 (PMID:15235600)
GO_REF:0000107 		RGD
Ensembl		 PMID:15235600 GO_REF:0000107 NCBI chr12:32,096,338...32,139,949
Ensembl chr12:32,096,338...32,139,040 		JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 involved_in ISO (PMID:23408620) RGD PMID:23408620 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:64,405,044...64,428,070 		JBrowse link
G RT1-CE5 RT1 class I, locus CE5 involved_in ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:3,407,880...3,484,130 JBrowse link
negative regulation of neutrophil degranulation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abr ABR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO MGI:88141 (PMID:19703997) RGD PMID:19703997 NCBI chr10:61,760,743...61,959,526
Ensembl chr10:61,760,743...61,959,467 		JBrowse link
G Bcr BCR activator of RhoGEF and GTPase acts_upstream_of_or_within ISO MGI:107771 (PMID:19703997) RGD PMID:19703997 NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,468,732...13,596,333 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO
IEA 		(PMID:30911105)
GO_REF:0000107 		RGD
Ensembl		 PMID:30911105 GO_REF:0000107 NCBI chr 3:97,529,509...97,548,204
Ensembl chr 3:97,527,572...97,549,540 		JBrowse link
negative regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (PMID:23616533) RGD PMID:23616533 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G ENSRNOG00000063623 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G ENSRNOG00000066432 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in IMP PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:152,284,857...152,322,686
Ensembl chr  X:152,284,841...152,322,675 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
MGI:894315 (PMID:23616533)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:23616533 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:195,896,971...195,974,808 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:97852 (PMID:23616533) 		GO_Central
RGD		 PMID:23616533 GO_REF:0000033 NCBI chr 7:55,308,922...55,342,217
Ensembl chr 7:55,308,922...55,342,217 		JBrowse link
G Syt4 synaptotagmin 4 involved_in ISO
IEA 		(PMID:19448629)
GO_REF:0000107 		RGD
Ensembl		 PMID:19448629 GO_REF:0000107 NCBI chr18:23,311,454...23,320,863
Ensembl chr18:23,312,859...23,320,815 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20668
    negative regulation of biological process 5980
      negative regulation of cellular process 5729
        negative regulation of secretion by cell 216
          negative regulation of exocytosis 41
            negative regulation of regulated secretory pathway 32
              negative regulation of calcium ion-dependent exocytosis + 12
              negative regulation of leukocyte degranulation + 14
              negative regulation of synaptic vesicle exocytosis + 8
Path 2
Term Annotations click to browse term
  biological_process 20668
    localization 5832
      establishment of localization 5111
        transport 4854
          secretion 1249
            secretion by cell 1051
              exocytosis 415
                regulated exocytosis 281
                  regulation of regulated secretory pathway 172
                    negative regulation of regulated secretory pathway 32
                      negative regulation of calcium ion-dependent exocytosis + 12
                      negative regulation of leukocyte degranulation + 14
                      negative regulation of synaptic vesicle exocytosis + 8
paths to the root