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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of regulated secretory pathway
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Accession:GO:1903306 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of regulated secretory pathway.
Comment:An example of this is protein domain-specific expression of Synaptotagmin 1 in rat (P21707) in PMID:12526776 inferred from mutant phenotype.
Synonyms:exact_synonym: down regulation of regulated secretory pathway;   downregulation of regulated secretory pathway
 narrow_synonym: inhibition of regulated secretory pathway


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negative regulation of calcium ion-dependent exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A IMP PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Cbarp CACN subunit beta associated regulatory protein ISO
IBA
(MGI:MGI:5607190|PMID:24751537)
PMID:21873635
RGD PMID:24751537, PMID:21873635 MGI:MGI:5607190, RGD:13792537 NCBI chr 7:12,433,422...12,441,048
Ensembl chr 7:12,433,933...12,441,048
JBrowse link
G Gnai2 G protein subunit alpha i2 IMP RGD PMID:11533141 RGD:13508598 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Notch1 notch receptor 1 ISO MGI:MGI:2684314 (MGI:MGI:3841508|PMID:19251639) RGD PMID:19251639 MGI:MGI:3841508 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Pou5f1 POU class 5 homeobox 1 ISO (MGI:MGI:59016|PMID:2357966) RGD PMID:2357966 MGI:MGI:59016 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha IC PMID:19965390 BHF-UCL PMID:19965390 RGD:2316628 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family ISO MGI:MGI:97852 (MGI:MGI:5490391|PMID:23616533) RGD PMID:23616533 MGI:MGI:5490391 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990
JBrowse link
G Rest RE1-silencing transcription factor IMP PMID:21536750 UniProt PMID:21536750 RGD:8554180 NCBI chr14:33,131,985...33,152,019
Ensembl chr14:33,134,511...33,164,141
JBrowse link
G Stxbp3 syntaxin binding protein 3 ISO (PMID:12649283) RGD PMID:12649283 NCBI chr 2:211,595,763...211,638,756
Ensembl chr 2:211,595,659...211,638,788
JBrowse link
G Syt4 synaptotagmin 4 IDA RGD PMID:21551071 RGD:7205660 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link
G Trim9 tripartite motif-containing 9 IMP RGD PMID:11524423 RGD:631246 NCBI chr 6:92,660,026...92,760,036
Ensembl chr 6:92,660,505...92,760,018
JBrowse link
negative regulation of cytotoxic T cell degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ceacam1 CEA cell adhesion molecule 1 ISO
ISS
(PMID:18424730)
GO_REF:0000024
RGD
UniProt
PMID:18424730 GO_REF:0000024 NCBI chr 1:82,327,955...82,344,345
Ensembl chr 1:82,327,955...82,344,345
JBrowse link
negative regulation of dense core granule exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Syt4 synaptotagmin 4 IMP PMID:20303854 ParkinsonsUK-UCL PMID:20303854 RGD:11541109 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link
negative regulation of eosinophil degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr2 C-C motif chemokine receptor 2 ISO
ISS
(MGI:MGI:3699670|PMID:14662900)
GO_REF:0000024
RGD
BHF-UCL
PMID:14662900 GO_REF:0000024, MGI:MGI:3699670
negative regulation of mast cell degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule ISO (MGI:MGI:3721168|PMID:12874256)
(PMID:16339535)
RGD PMID:12874256, PMID:16339535 MGI:MGI:3721168 NCBI chr10:103,437,978...103,451,170
Ensembl chr10:103,438,303...103,450,947
JBrowse link
G Cd84 CD84 molecule ISO (PMID:22068234) RGD PMID:22068234 NCBI chr13:90,241,369...90,283,625
Ensembl chr13:90,244,681...90,277,865
JBrowse link
G Foxf1 forkhead box F1 ISO MGI:MGI:2179135 (MGI:MGI:4367570|PMID:18421012) RGD PMID:18421012 MGI:MGI:4367570 NCBI chr19:53,012,306...53,016,100
Ensembl chr19:53,012,332...53,016,086
JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:17234154 RGD:1601626 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO
IEA
MGI:MGI:2653910 (MGI:MGI:3589858|PMID:15944273)
GO_REF:0000107
RGD
Ensembl
PMID:15944273 GO_REF:0000107, MGI:MGI:3589858 NCBI chr  X:118,443,955...118,514,716
Ensembl chr  X:118,443,823...118,513,061
JBrowse link
G Lgals9 galectin 9 ISO (PMID:24465902) RGD PMID:24465902 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G Rabgef1 RAB guanine nucleotide exchange factor 1 ISO MGI:MGI:3051384 (MGI:MGI:3050742|PMID:15235600) RGD PMID:15235600 MGI:MGI:3050742 NCBI chr12:29,960,132...30,004,727
Ensembl chr12:29,961,120...29,988,959
JBrowse link
negative regulation of natural killer cell degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lgals9 galectin 9 ISO (MGI:MGI:5491117|PMID:23408620) RGD PMID:23408620 MGI:MGI:5491117 NCBI chr10:64,737,022...64,760,195
Ensembl chr10:64,737,022...64,760,201
JBrowse link
G RT1-CE5 RT1 class I, locus CE5 ISO (PMID:24018270) RGD PMID:24018270 NCBI chr20:4,892,702...4,896,993
Ensembl chr20:4,892,702...4,896,991
JBrowse link
negative regulation of neutrophil degranulation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abr ABR activator of RhoGEF and GTPase ISO
IEA
MGI:MGI:88141 (MGI:MGI:4366690|PMID:19703997)
GO_REF:0000107
RGD
Ensembl
PMID:19703997 GO_REF:0000107, MGI:MGI:4366690 NCBI chr10:64,565,121...64,657,079
Ensembl chr10:64,567,268...64,657,089
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase ISO MGI:MGI:107771 (MGI:MGI:4366690|PMID:19703997) RGD PMID:19703997 MGI:MGI:4366690 NCBI chr20:14,421,250...14,546,406
Ensembl chr20:14,421,141...14,545,772
JBrowse link
negative regulation of synaptic vesicle exocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO (MGI:MGI:5490391|PMID:23616533) RGD PMID:23616533 MGI:MGI:5490391 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Fmr1 FMRP translational regulator 1 IMP PMID:24709664 UniProt PMID:24709664 RGD:11059581 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO
IBA
MGI:MGI:894315 (MGI:MGI:5490391|PMID:23616533)
PMID:21873635
RGD PMID:23616533, PMID:21873635 MGI:MGI:5490391, RGD:13792537 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rap1b RAP1B, member of RAS oncogene family ISO
IBA
MGI:MGI:97852 (MGI:MGI:5490391|PMID:23616533)
PMID:21873635
RGD PMID:23616533, PMID:21873635 MGI:MGI:5490391, RGD:13792537 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990
JBrowse link
G Syt4 synaptotagmin 4 ISO (MGI:MGI:4457852|PMID:19448629) RGD PMID:19448629 MGI:MGI:4457852 NCBI chr18:24,172,580...24,181,989
Ensembl chr18:24,172,587...24,182,012
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    negative regulation of biological process 5698
      negative regulation of cellular process 5146
        negative regulation of secretion by cell 203
          negative regulation of exocytosis 34
            negative regulation of regulated secretory pathway 26
              negative regulation of calcium ion-dependent exocytosis + 11
              negative regulation of leukocyte degranulation + 12
              negative regulation of synaptic vesicle exocytosis + 5
Path 2
Term Annotations click to browse term
  biological_process 20015
    localization 6487
      establishment of localization 4918
        transport 4774
          secretion 1217
            secretion by cell 1020
              exocytosis 414
                regulated exocytosis 279
                  regulation of regulated secretory pathway 201
                    negative regulation of regulated secretory pathway 26
                      negative regulation of calcium ion-dependent exocytosis + 11
                      negative regulation of leukocyte degranulation + 12
                      negative regulation of synaptic vesicle exocytosis + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.