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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of proteolysis involved in protein catabolic process
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Accession:GO:1903052 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of proteolysis involved in protein catabolic process.
Comment:overexpression of cathepsin C propeptide significantly increased the degradation of intestinal alkaline phosphatase (IAP)
Synonyms:exact_synonym: positive regulation of peptidolysis involved in cellular protein catabolic process;   positive regulation of peptidolysis involved in cellular protein catabolism;   positive regulation of proteolysis involved in cellular protein catabolic process;   up regulation of peptidolysis involved in cellular protein catabolic process;   up regulation of peptidolysis involved in cellular protein catabolism;   up regulation of proteolysis involved in cellular protein catabolic process;   upregulation of peptidolysis involved in cellular protein catabolic process;   upregulation of peptidolysis involved in cellular protein catabolism;   upregulation of proteolysis involved in cellular protein catabolic process
 narrow_synonym: activation of peptidolysis involved in cellular protein catabolic process;   activation of peptidolysis involved in cellular protein catabolism;   activation of proteolysis involved in cellular protein catabolic process
 related_synonym: activation of peptidolysis during cellular protein catabolic process;   activation of peptidolysis during cellular protein catabolism;   activation of proteolysis during cellular protein catabolic process;   activation of proteolysis during cellular protein catabolism;   positive regulation of peptidolysis during cellular protein catabolic process;   positive regulation of peptidolysis during cellular protein catabolism;   positive regulation of proteolysis during cellular protein catabolic process;   positive regulation of proteolysis during cellular protein catabolism;   up regulation of peptidolysis during cellular protein catabolic process;   up regulation of peptidolysis during cellular protein catabolism;   up regulation of proteolysis during cellular protein catabolic process;   up regulation of proteolysis during cellular protein catabolism;   upregulation of peptidolysis during cellular protein catabolic process;   upregulation of peptidolysis during cellular protein catabolism;   upregulation of proteolysis during cellular protein catabolic process;   upregulation of proteolysis during cellular protein catabolism


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positive regulation of proteolysis involved in protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:24005319) RGD PMID:24005319 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668 		JBrowse link
G Ctsc cathepsin C involved_in IDA PMID:18307834 ParkinsonsUK-UCL PMID:18307834 RGD:8661625 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:36543799) RGD PMID:36543799 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Gba1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (MGI:5141165|PMID:21700325) RGD PMID:21700325 MGI:5141165 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:5444793|PMID:22949502) RGD PMID:22949502 MGI:5444793 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Rgn regucalcin IDA RGD PMID:1513338 RGD:9590188 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
IEA		 (PMID:36543799)
GO_REF:0000107		 RGD
Ensembl		 PMID:36543799 GO_REF:0000107 NCBI chr 5:38,962,721...38,995,134
Ensembl chr 5:38,962,171...38,995,199 		JBrowse link
positive regulation of anaphase-promoting complex-dependent catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc20 cell division cycle 20 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512 		JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952 		JBrowse link
positive regulation of ERAD pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atxn3 ataxin 3 involved_in ISO (PMID:17000876) RGD PMID:17000876 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISO
IEA		 (PMID:24424410)
GO_REF:0000107		 RGD
Ensembl		 PMID:24424410 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO UniProtKB:Q9BUN8 (PMID:18555783) RGD PMID:18555783 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Cav1 caveolin 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:24089527)		 Ensembl
RGD		 PMID:24089527 GO_REF:0000107 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:18307982), (PMID:22045699) RGD PMID:18307982 PMID:22045699 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Rnf185 ring finger protein 185 involved_in ISO
IEA
ISS		 (PMID:27485036)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:27485036 GO_REF:0000024 GO_REF:0000107 NCBI chr14:78,292,517...78,329,832
Ensembl chr14:78,292,516...78,329,864 		JBrowse link
G Rnft1 ring finger protein, transmembrane 1 involved_in ISO
IBA		 (PMID:27485036)
GO_REF:0000033		 RGD
GO_Central		 PMID:27485036 GO_REF:0000033 NCBI chr10:71,310,052...71,322,507
Ensembl chr10:71,310,104...71,323,778 		JBrowse link
G Rnft2 ring finger protein, transmembrane 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:38,329,217...38,387,303
Ensembl chr12:38,329,269...38,387,290 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in IEA
ISO		 GO_REF:0000107
(PMID:23246001)		 Ensembl
RGD		 PMID:23246001 GO_REF:0000107 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (PMID:26265139) RGD PMID:26265139 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Tmem259 transmembrane protein 259 involved_in ISO
IBA		 (MGI:5648655|PMID:25977983)
GO_REF:0000033		 RGD
GO_Central		 PMID:25977983 GO_REF:0000033 MGI:5648655 NCBI chr 7:9,724,196...9,730,932
Ensembl chr 7:9,722,485...9,730,932 		JBrowse link
G Tmem67 transmembrane protein 67 IMP RGD PMID:19815549 RGD:8554391 NCBI chr 5:25,536,458...25,589,378
Ensembl chr 5:25,536,458...25,589,334 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 involved_in ISO (PMID:29932915) RGD PMID:29932915 NCBI chr 6:88,960,691...88,971,744
Ensembl chr 6:88,960,695...88,971,301 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:18307982)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:18307982 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18307982) RGD PMID:18307982 NCBI chr  X:17,853,086...17,856,505
Ensembl chr  X:17,853,114...17,856,505 		JBrowse link
G Usp13 ubiquitin specific peptidase 13 involved_in ISO (PMID:24424410) RGD PMID:24424410 NCBI chr 2:115,576,912...115,689,153
Ensembl chr 2:115,577,091...115,686,222 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:19911006) RGD PMID:19911006 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
positive regulation of proteasomal protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag2 BAG cochaperone 2 involved_in ISO UniProtKB:P10636 (MGI:6148635|PMID:19228967) RGD PMID:19228967 MGI:6148635 NCBI chr 9:35,970,033...35,980,677
Ensembl chr 9:35,970,033...35,980,721 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO
IEA
ISS		 (PMID:20080667)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:20080667 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:23675531) RGD PMID:23675531 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Ecscr endothelial cell surface expressed chemotaxis and apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IBA		 (PMID:19416853)
GO_REF:0000033		 RGD
GO_Central		 PMID:19416853 GO_REF:0000033 NCBI chr18:27,309,711...27,319,106
Ensembl chr18:27,309,718...27,319,032 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO (PMID:23858059)
(MGI:5543313|PMID:23858059)		 RGD PMID:23858059 MGI:5543313 NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5770038|PMID:24709664)		 UniProt
RGD		 PMID:24709664 GO_REF:0000024 MGI:5770038 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Kcne2 potassium voltage-gated channel subfamily E regulatory subunit 2 involved_in ISO (PMID:22180649) RGD PMID:22180649 NCBI chr11:31,517,176...31,530,026
Ensembl chr11:31,295,614...31,530,043 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISS
ISO		 GO_REF:0000024
(PMID:16300740)		 UniProt
RGD		 PMID:16300740 GO_REF:0000024 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Oaz1 ornithine decarboxylase antizyme 1 IDA RGD PMID:12359729 RGD:7245486 NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310 		JBrowse link
G Osbpl7 oxysterol binding protein-like 7 involved_in ISO (PMID:21669198) RGD PMID:21669198 NCBI chr10:82,035,995...82,053,566
Ensembl chr10:82,036,042...82,053,557 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO UniProtKB:Q9WVS6 (PMID:23858059) RGD PMID:23858059 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185 		JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358 		JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055 		JBrowse link
G Rnf40 ring finger protein 40 IDA RGD PMID:12121982 RGD:633892 NCBI chr 1:182,202,475...182,217,899
Ensembl chr 1:182,202,600...182,217,241 		JBrowse link
G Tmtc3 transmembrane O-mannosyltransferase targeting cadherins 3 involved_in ISO (PMID:21603654) RGD PMID:21603654 NCBI chr 7:35,264,886...35,310,010
Ensembl chr 7:35,264,892...35,310,385 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6150565|PMID:29518356) RGD PMID:29518356 MGI:6150565 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
positive regulation of proteasomal ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:23512198)
(PMID:15937334)
GO_REF:0000107		 RGD
Ensembl		 PMID:15937334 PMID:23512198 GO_REF:0000107 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg7 autophagy related 7 acts_upstream_of_or_within ISO MGI:2446434|MGI:3587769|MGI:3691571 (PMID:23152632) RGD PMID:23152632 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Aurka aurora kinase A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17060449)		 Ensembl
RGD		 PMID:17060449 GO_REF:0000107 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390 		JBrowse link
G Axin1 axin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
(PMID:16601693)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:16601693 GO_REF:0000033 GO_REF:0000107 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Axin2 axin 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bag2 BAG cochaperone 2 NOT|involved_in ISO UniProtKB:P10636 (MGI:6148635|PMID:19228967) RGD PMID:19228967 MGI:6148635 NCBI chr 9:35,970,033...35,980,677
Ensembl chr 9:35,970,033...35,980,721 		JBrowse link
G Bbs7 Bardet-Biedl syndrome 7 acts_upstream_of_or_within ISO UniProtKB:Q99496 (PMID:22302990) RGD PMID:22302990 NCBI chr 2:119,434,760...119,474,665
Ensembl chr 2:119,434,760...119,474,396 		JBrowse link
G Cbfa2t3 CBFA2/RUNX1 partner transcriptional co-repressor 3 involved_in ISO (PMID:25974097) RGD PMID:25974097 NCBI chr19:50,679,897...50,750,028
Ensembl chr19:50,680,729...50,749,610 		JBrowse link
G Chfr checkpoint with forkhead and ring finger domains acts_upstream_of_or_within ISO (PMID:22285184) RGD PMID:22285184 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014 		JBrowse link
G Clu clusterin involved_in ISO
IBA
IEA
ISS		 (PMID:20068069)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:20068069 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cop1 COP1, E3 ubiquitin ligase involved_in ISO (PMID:19805145) RGD PMID:19805145 NCBI chr13:71,467,164...71,561,826
Ensembl chr13:71,429,961...71,538,890 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 involved_in ISO
IEA		 (PMID:11955436), (PMID:19364825)
GO_REF:0000107		 RGD
Ensembl		 PMID:11955436 PMID:19364825 GO_REF:0000107 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271 		JBrowse link
G Csnk1d casein kinase 1, delta involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:3849793|PMID:19414593)		 UniProt
GO_Central
RGD		 PMID:19414593 GO_REF:0000024 GO_REF:0000033 MGI:3849793 NCBI chr10:106,221,992...106,256,620
Ensembl chr10:106,221,992...106,256,614 		JBrowse link
G Csnk1e casein kinase 1, epsilon involved_in ISO
IBA		 (MGI:3849793|PMID:19414593)
GO_REF:0000033		 RGD
GO_Central		 PMID:19414593 GO_REF:0000033 MGI:3849793 NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794 		JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:12805222)		 Ensembl
RGD		 PMID:12805222 GO_REF:0000107 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Dda1 DET1 and DDB1 associated 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,156,310...18,163,938
Ensembl chr16:18,156,386...18,163,937 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:23675531) RGD PMID:23675531 NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680 		JBrowse link
G Det1 DET1 partner of COP1 E3 ubiquitin ligase involved_in ISO
IBA		 UniProtKB:Q8NHY2 (PMID:14739464)
GO_REF:0000033		 RGD
GO_Central		 PMID:14739464 GO_REF:0000033 NCBI chr 1:132,749,736...132,765,963
Ensembl chr 1:132,749,756...132,765,923 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 involved_in ISO
IBA		 (PMID:15936278)
GO_REF:0000033		 RGD
GO_Central		 PMID:15936278 GO_REF:0000033 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 involved_in ISO (PMID:20177058) RGD PMID:20177058 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Fbxo22 F-box protein 22 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:19319192)		 GO_Central
RGD		 PMID:19319192 GO_REF:0000033 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148 		JBrowse link
G Fbxw8 F-box and WD repeat domain containing 8 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6148490|PMID:29153991)		 Ensembl
RGD		 PMID:29153991 GO_REF:0000107 MGI:6148490 NCBI chr12:38,426,466...38,517,076
Ensembl chr12:38,426,444...38,516,424 		JBrowse link
G Gabarap GABA type A receptor-associated protein involved_in ISS
ISO		 GO_REF:0000024
(PMID:25684205)		 UniProt
RGD		 PMID:25684205 GO_REF:0000024 NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765 		JBrowse link
G Gba1 glucosylceramidase beta 1 acts_upstream_of_or_within ISO (MGI:5501380|PMID:23707074) RGD PMID:23707074 MGI:5501380 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:2387010 (PMID:17189825) RGD PMID:17189825 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO
IBA
IEA		 (PMID:25897075)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:25897075 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:1924375|MGI:3039600 (PMID:22660580)
GO_REF:0000033
(PMID:19364825), (PMID:22660580), (PMID:25897075)		 Ensembl
RGD
GO_Central		 PMID:19364825 PMID:22660580 PMID:25897075 GO_REF:0000033 GO_REF:0000107 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hamp hepcidin antimicrobial peptide involved_in ISO
IEA		 (PMID:37277838)
GO_REF:0000107		 RGD
Ensembl		 PMID:37277838 GO_REF:0000107 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO
IBA		 (PMID:24613385)
GO_REF:0000033		 RGD
GO_Central		 PMID:24613385 GO_REF:0000033 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO
IBA		 (PMID:24613385)
GO_REF:0000033		 RGD
GO_Central		 PMID:24613385 GO_REF:0000033 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspbp1 HSPA (Hsp70) binding protein 1 involved_in ISO (PMID:16831871) RGD PMID:16831871 NCBI chr 1:69,165,394...69,189,062
Ensembl chr 1:69,165,572...69,244,593 		JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1861437|MGI:3039600 (PMID:22660580)		 Ensembl
RGD		 PMID:22660580 GO_REF:0000107 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Klhl40 kelch-like family member 40 involved_in ISO (MGI:5700633|PMID:25940086) RGD PMID:25940086 MGI:5700633 NCBI chr 8:121,441,285...121,446,801
Ensembl chr 8:121,441,287...121,446,800 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (MGI:4454597|PMID:20457918) RGD PMID:20457918 MGI:4454597 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in ISO (MGI:6148490|PMID:29153991) RGD PMID:29153991 MGI:6148490 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 involved_in IEA
ISO		 GO_REF:0000107
(MGI:6148490|PMID:29153991)		 Ensembl
RGD		 PMID:29153991 GO_REF:0000107 MGI:6148490 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:11278372) RGD PMID:11278372 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Nkd2 NKD inhibitor of WNT signaling pathway 2 involved_in ISO (PMID:20177058) RGD PMID:20177058 NCBI chr 1:29,442,898...29,470,839
Ensembl chr 1:29,441,328...29,470,821 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:25818168), (PMID:27323397)
(MGI:5897550|PMID:21804542)		 RGD PMID:21804542 PMID:25818168 PMID:27323397 MGI:5897550 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
G Nub1 negative regulator of ubiquitin-like proteins 1 involved_in ISO (PMID:16707496) RGD PMID:16707496 NCBI chr 4:10,442,917...10,473,689
Ensembl chr 4:10,442,917...10,473,694 		JBrowse link
G Pabir1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 involved_in ISO
ISS		 (PMID:27588481)
GO_REF:0000024		 RGD
UniProt		 PMID:27588481 GO_REF:0000024 NCBI chr 1:222,114,988...222,116,294
Ensembl chr 1:222,112,591...222,116,396 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 involved_in ISO (MGI:5487503|PMID:22406621) RGD PMID:22406621 MGI:5487503 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:63,338,150...63,438,905 		JBrowse link
G Plk1 polo-like kinase 1 involved_in ISO
ISS
IEA		 (PMID:19473992)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:19473992 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400 		JBrowse link
G Plk2 polo-like kinase 2 IMP RGD PMID:18723513 RGD:7241135 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947 		JBrowse link
G Prickle1 prickle planar cell polarity protein 1 involved_in ISO
IEA		 (PMID:17030191)
GO_REF:0000107		 RGD
Ensembl		 PMID:17030191 GO_REF:0000107 NCBI chr 7:124,639,142...124,735,027
Ensembl chr 7:124,639,142...124,658,113 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Psen1 presenilin 1 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 involved_in ISO
IEA
ISS		 (PMID:16023600)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:16023600 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:104,656,809...104,665,122
Ensembl chr  X:104,656,812...104,665,097 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19785988)		 UniProt
RGD		 PMID:19785988 GO_REF:0000024 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein involved_in ISO (PMID:26296656) RGD PMID:26296656 NCBI chr19:23,313,563...23,320,702
Ensembl chr19:23,314,797...23,320,695 		JBrowse link
G Rbx1 ring-box 1 involved_in ISO UniProtKB:Q7L5Y6 (PMID:14739464) RGD PMID:14739464 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 involved_in ISO (PMID:19483087) RGD PMID:19483087 NCBI chr14:16,113,263...16,129,017
Ensembl chr14:16,113,224...16,129,167 		JBrowse link
G Rnf180 ring finger protein 180 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:18363970), (PMID:23926250)		 GO_Central
RGD		 PMID:18363970 PMID:23926250 GO_REF:0000033 NCBI chr 2:36,330,285...36,511,168
Ensembl chr 2:36,330,292...36,512,614 		JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:28,735,522...28,901,261
Ensembl chr16:28,735,440...28,901,644 		JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 involved_in IMP
IBA
ISO		 PMID:22128169
GO_REF:0000033
(PMID:22128169)		 GO_Central
RGD		 PMID:22128169 PMID:22128169 GO_REF:0000033, RGD:13673844 NCBI chr18:34,045,715...34,148,342
Ensembl chr18:34,046,879...34,146,856 		JBrowse link
G Sh3rf3 SH3 domain containing ring finger 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:26,765,278...27,099,261
Ensembl chr20:26,765,015...27,099,257 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:20203304) RGD PMID:20203304 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt2 sirtuin 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:24681946)
GO_REF:0000107
(MGI:5574427|PMID:24681946)		 UniProt
RGD
Ensembl		 PMID:24681946 GO_REF:0000024 GO_REF:0000107 MGI:5574427 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:27457971) RGD PMID:27457971 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (PMID:15590694) RGD PMID:15590694 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (PMID:11146632) RGD PMID:11146632 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 involved_in ISO (PMID:18408734) RGD PMID:18408734 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 involved_in ISO (PMID:18408734) RGD PMID:18408734 NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513 		JBrowse link
G Taf1 TATA-box binding protein associated factor 1 involved_in ISO (PMID:15053879) RGD PMID:15053879 NCBI chr  X:66,640,915...66,716,543
Ensembl chr  X:66,640,982...66,716,543 		JBrowse link
G Tf transferrin involved_in ISO (PMID:37277838) RGD PMID:37277838 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO
IBA		 (MGI:4457446|PMID:20410507)
GO_REF:0000033		 RGD
GO_Central		 PMID:20410507 GO_REF:0000033 MGI:4457446 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731 		JBrowse link
G Trib2 tribbles pseudokinase 2 involved_in ISO (MGI:4457446|PMID:20410507) RGD PMID:20410507 MGI:4457446 NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370 		JBrowse link
G Trib3 tribbles pseudokinase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 IMP RGD PMID:12750002 RGD:1299567 NCBI chr11:85,304,528...85,338,430
Ensembl chr11:85,304,526...85,336,369 		JBrowse link
G Usp5 ubiquitin specific peptidase 5 involved_in ISO (PMID:19098288) RGD PMID:19098288 NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711 		JBrowse link
G Vcp valosin-containing protein involved_in ISO (PMID:9452483) RGD PMID:9452483 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
G Zer1 zyg-11 related, cell cycle regulator involved_in ISO (PMID:31273098) RGD PMID:31273098 NCBI chr 3:13,369,688...13,397,524
Ensembl chr 3:13,369,688...13,397,420 		JBrowse link
G Zfand2a zinc finger AN1-type containing 2A acts_upstream_of_or_within ISO MGI:3664591 (PMID:16973439) RGD PMID:16973439 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677 		JBrowse link
G Zyg11b zyg-11 family member B, cell cycle regulator involved_in ISO (PMID:31273098) RGD PMID:31273098 NCBI chr 5:122,985,548...123,042,735
Ensembl chr 5:122,992,147...123,042,736 		JBrowse link
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20889502)		 UniProt
RGD		 PMID:20889502 GO_REF:0000024 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
positive regulation of ubiquitin-dependent protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agbl4 AGBL carboxypeptidase 4 acts_upstream_of_or_within ISO MGI:5788002 (PMID:29593216) RGD PMID:29593216 NCBI chr 5:125,254,963...126,534,367
Ensembl chr 5:125,254,956...126,534,367 		JBrowse link
G Agtpbp1 ATP/GTP binding carboxypeptidase 1 acts_upstream_of_or_within ISO MGI:1857523 (PMID:29593216) RGD PMID:29593216 NCBI chr17:5,120,540...5,238,874
Ensembl chr17:5,120,609...5,238,869 		JBrowse link
G Atxn3 ataxin 3 involved_in ISO (PMID:17000876) RGD PMID:17000876 NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902 		JBrowse link
G Axin1 axin 1 involved_in
acts_upstream_of_or_within		 IDA
ISO		 PMID:10228155
(PMID:16601693)		 RGD PMID:16601693 PMID:10228155 RGD:8553327 NCBI chr10:15,163,477...15,215,615
Ensembl chr10:15,163,684...15,215,615 		JBrowse link
G Bcap31 B-cell receptor-associated protein 31 involved_in ISO (PMID:18555783) RGD PMID:18555783 NCBI chr  X:151,397,567...151,429,666
Ensembl chr  X:151,397,576...151,428,506 		JBrowse link
G Ccdc22 coiled-coil domain containing 22 involved_in ISO
IBA		 (PMID:23563313)
GO_REF:0000033		 RGD
GO_Central		 PMID:23563313 GO_REF:0000033 NCBI chr  X:14,898,296...14,910,244
Ensembl chr  X:14,898,296...14,910,244 		JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 NOT|involved_in ISS
ISO		 GO_REF:0000024
(PMID:16173922)		 UniProt
RGD		 PMID:16173922 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590 		JBrowse link
G Clu clusterin involved_in ISS
ISO		 GO_REF:0000024
(PMID:20068069)		 UniProt
RGD		 PMID:20068069 GO_REF:0000024 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Disc1 DISC1 scaffold protein acts_upstream_of_or_within ISO (PMID:20880836) RGD PMID:20880836 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778 		JBrowse link
G Egf epidermal growth factor involved_in ISO (MGI:4887523|PMID:20208556) RGD PMID:20208556 MGI:4887523 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fbxo22 F-box protein 22 acts_upstream_of_or_within ISO (PMID:19319192) RGD PMID:19319192 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO
ISS		 (PMID:20208556), (PMID:27238018)
(MGI:6282935|PMID:27238018)
GO_REF:0000024		 RGD
UniProt		 PMID:20208556 PMID:27238018 GO_REF:0000024 MGI:6282935 NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (PMID:22045699) RGD PMID:22045699 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G L3mbtl3 L3MBTL histone methyl-lysine binding protein 3 involved_in ISO (PMID:29691401) RGD PMID:29691401 NCBI chr 1:18,988,763...19,089,247
Ensembl chr 1:18,990,618...19,089,263 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870), (MGI:6478861|PMID:24638062) RGD PMID:18619870 PMID:24638062 MGI:3803048 MGI:6478861 NCBI chr 5:143,087,759...143,109,807
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:21241890) RGD PMID:21241890 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5306293|PMID:18206965)		 UniProt
RGD		 PMID:18206965 GO_REF:0000024 MGI:5306293 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO		 GO_REF:0000024
(MGI:4453113|PMID:19880522)		 UniProt
RGD		 PMID:19880522 GO_REF:0000024 MGI:4453113 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rnf139 ring finger protein 139 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr 7:90,439,726...90,450,911
Ensembl chr 7:90,436,621...90,488,009 		JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in IEA
ISO		 GO_REF:0000107
(PMID:23246001)		 Ensembl
RGD		 PMID:23246001 GO_REF:0000107 NCBI chr 7:8,653,681...8,670,460
Ensembl chr 7:8,653,778...8,670,458 		JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 involved_in ISO (PMID:21454619) RGD PMID:21454619 NCBI chr12:9,635,009...9,726,520
Ensembl chr12:9,635,025...9,726,519 		JBrowse link
G Sumo3 small ubiquitin-like modifier 3 acts_upstream_of_or_within ISO (PMID:18644859) RGD PMID:18644859 NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877
Ensembl chr20:11,007,148...11,020,877 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 involved_in ISO
IEA		 (PMID:18762808)
GO_REF:0000107		 RGD
Ensembl		 PMID:18762808 GO_REF:0000107 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080 		JBrowse link
G Traf7 TNF receptor associated factor 7 involved_in ISO (PMID:21518757) RGD PMID:21518757 NCBI chr10:13,533,570...13,552,290
Ensembl chr10:13,533,570...13,552,203 		JBrowse link
G Trim67 tripartite motif-containing 67 acts_upstream_of_or_within ISO (PMID:22337885) RGD PMID:22337885 NCBI chr19:52,763,991...52,805,906
Ensembl chr19:52,764,387...52,800,422 		JBrowse link
G Vcp valosin-containing protein IMP RGD PMID:16103111 RGD:1599730 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      macromolecule metabolic process 10146
        protein metabolic process 5693
          proteolysis 1814
            positive regulation of proteolysis 346
              positive regulation of proteolysis involved in protein catabolic process 132
                positive regulation of proteasomal protein catabolic process + 111
                positive regulation of proteolysis associated with antigen processing and presentation 0
                positive regulation of ubiquitin-dependent protein catabolic process + 100
Path 2
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13553
      regulation of biological process 13127
        regulation of metabolic process 6817
          regulation of primary metabolic process 5708
            regulation of protein metabolic process 2281
              positive regulation of protein metabolic process 1253
                positive regulation of proteolysis 346
                  positive regulation of proteolysis involved in protein catabolic process 132
                    positive regulation of proteasomal protein catabolic process + 111
                    positive regulation of proteolysis associated with antigen processing and presentation 0
                    positive regulation of ubiquitin-dependent protein catabolic process + 100
paths to the root