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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation


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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chr17:33,910,047...33,935,212 JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:19,835,934...19,947,239
Ensembl chr 9:19,835,938...20,123,566 		JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (PMID:23070049) ParkinsonsUK-UCL PMID:23070049 NCBI chr 2:60,057,926...60,130,015 JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLOT2 flotillin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:45,102,205...45,120,503
Ensembl chr12:45,101,531...45,120,455 		JBrowse link
G MIR15B microRNA mir-15b acts_upstream_of ISO (PMID:29961672) ARUK-UCL PMID:29961672 NCBI chr13:100,083,172...100,083,269
Ensembl chr13:100,083,172...100,083,269 		JBrowse link
G MIR29A microRNA mir-29a acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr18:18,040,032...18,040,117
Ensembl chr18:18,040,032...18,040,118 		JBrowse link
G MIR29B-1 microRNA mir-29b-1 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr18:18,039,629...18,039,709
Ensembl chr18:18,039,629...18,039,709 		JBrowse link
G MIR29B-2 microRNA mir-29b-2 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 9:135,019,079...135,019,162
Ensembl chr 9:135,019,075...135,019,164 		JBrowse link
G PRNP prion protein involved_in ISO (PMID:17573534) ARUK-UCL PMID:17573534 NCBI chr17:13,694,195...13,705,126
Ensembl chr17:13,694,190...13,705,124 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:106,163,899...106,314,998
Ensembl chr 6:106,163,989...106,314,944 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,435,350...48,653,670
Ensembl chr 9:48,435,345...48,653,655 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:18429932)
(PMID:23467355), (PMID:27030769) 		Alzheimers_University_of_Toronto PMID:18429932 PMID:23467355 PMID:27030769 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G BIN1 bridging integrator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:25,328,679...25,379,675
Ensembl chr15:25,328,674...25,383,652 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764 		JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:6,051,854...6,072,424
Ensembl chr12:6,055,696...6,074,478 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr12:20,938,463...20,950,053
Ensembl chr12:20,939,554...20,950,051 		JBrowse link
G IGF1 insulin like growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033 		JBrowse link
G MIR103-1 microRNA mir-103-1 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr16:55,329,442...55,329,523
Ensembl chr16:55,329,442...55,329,523 		JBrowse link
G MIR103-2 microRNA mir-103-2 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr17:31,808,837...31,808,916
Ensembl chr17:31,808,836...31,808,920 		JBrowse link
G MIR15A microRNA mir-15a acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr11:17,757,463...17,757,541
Ensembl chr11:17,757,460...17,757,554 		JBrowse link
G MIR15B microRNA mir-15b acts_upstream_of ISO (PMID:29961672) ARUK-UCL PMID:29961672 NCBI chr13:100,083,172...100,083,269
Ensembl chr13:100,083,172...100,083,269 		JBrowse link
G MIR16-1 microRNA mir-16-1 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr13:100,083,329...100,083,405
Ensembl chr13:100,083,329...100,083,405 		JBrowse link
G MIR16-2 microRNA mir-16-2 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr11:17,757,606...17,757,684
Ensembl chr11:17,757,601...17,757,687 		JBrowse link
G MIR186 microRNA mir-186 acts_upstream_of ISO (PMID:25100943) ARUK-UCL PMID:25100943 NCBI chr 6:141,943,328...141,943,409
Ensembl chr 6:141,943,328...141,943,409 		JBrowse link
G MIR29A microRNA mir-29a acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr18:18,040,032...18,040,117
Ensembl chr18:18,040,032...18,040,118 		JBrowse link
G MIR29B-1 microRNA mir-29b-1 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr18:18,039,629...18,039,709
Ensembl chr18:18,039,629...18,039,709 		JBrowse link
G MIR29B-2 microRNA mir-29b-2 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 9:135,019,079...135,019,162
Ensembl chr 9:135,019,075...135,019,164 		JBrowse link
G MIR29C microRNA mir-29c acts_upstream_of ISO (PMID:25973041) ARUK-UCL PMID:25973041 NCBI chr 9:135,019,638...135,019,725
Ensembl chr 9:135,019,638...135,019,725 		JBrowse link
G MIR339-2 microRNA mir-339-2 acts_upstream_of ISO (PMID:24352696) ARUK-UCL PMID:24352696 NCBI chr 1:164,025,972...164,026,057
Ensembl chr 1:164,025,972...164,026,057 		JBrowse link
G MIR361 microRNA mir-361 involved_in ISO (PMID:31601077) ARUK-UCL PMID:31601077 NCBI chr  X:68,924,500...68,924,579
Ensembl chr  X:68,924,500...68,924,579 		JBrowse link
G MIR455 microRNA mir-455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) ARUK-UCL PMID:25100943 PMID:31181293 NCBI chr 1:254,824,200...254,824,279
Ensembl chr 1:254,824,196...254,824,291 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882 		JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:68,715,898...68,729,471
Ensembl chr 2:68,715,880...68,729,870 		JBrowse link
G PRNP prion protein involved_in ISO (PMID:17573534) ARUK-UCL PMID:17573534 NCBI chr17:13,694,195...13,705,126
Ensembl chr17:13,694,190...13,705,124 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:106,163,899...106,314,998
Ensembl chr 6:106,163,989...106,314,944 		JBrowse link
G RTN1 reticulon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:188,704,260...188,925,855
Ensembl chr 1:188,704,260...188,926,054 		JBrowse link
G RTN2 reticulon 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,855,844...51,864,753
Ensembl chr 6:51,854,998...51,875,169 		JBrowse link
G RTN3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chr 2:8,291,750...8,354,920 JBrowse link
G RTN4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:86,180,022...86,252,126
Ensembl chr 3:86,180,022...86,252,126 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:48,435,350...48,653,670
Ensembl chr 9:48,435,345...48,653,655 		JBrowse link
G SPON1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:44,967,982...45,299,677
Ensembl chr 2:44,967,986...45,299,677 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIN1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chr15:25,328,679...25,379,675
Ensembl chr15:25,328,674...25,383,652 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) MGI PMID:16641999 NCBI chr 7:98,327,402...98,362,652
Ensembl chr 7:98,327,408...98,362,606 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of IEA Ensembl GO_REF:0000107
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,435,094...189,716,056 		JBrowse link
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,666,457...94,673,442
Ensembl chr 4:94,666,460...94,674,071 		JBrowse link
G EFNA3 ephrin A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,709,941...94,719,350
Ensembl chr 4:94,710,647...94,719,248 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:123,350,867...123,501,872
Ensembl chr15:123,352,816...123,503,126 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:19,835,934...19,947,239
Ensembl chr 9:19,835,938...20,123,566 		JBrowse link
G RANBP9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr 7:9,976,094...10,057,757
Ensembl chr 7:9,976,096...10,057,669 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:125,353,063...125,493,368
Ensembl chr 3:125,352,920...125,493,362 		JBrowse link
G SPON1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:44,967,982...45,299,677
Ensembl chr 2:44,967,986...45,299,677 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in 		IEA
ISO 		PMID:22086926 Ensembl
ARUK-UCL		 PMID:22086926 GO_REF:0000107 RGD:14697726
G ABCG1 ATP binding cassette subfamily G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:205,561,897...205,628,428
Ensembl chr13:205,561,951...205,628,425 		JBrowse link
G APOE apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G CASP3 caspase 3 involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764 		JBrowse link
G CSNK1E casein kinase 1 epsilon ISO RGD PMID:17360493 RGD:10395238 NCBI chr 5:9,594,461...9,620,483
Ensembl chr 5:9,594,934...9,620,476 		JBrowse link
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,666,457...94,673,442
Ensembl chr 4:94,666,460...94,674,071 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:123,350,867...123,501,872
Ensembl chr15:123,352,816...123,503,126 		JBrowse link
G GSAP gamma-secretase activating protein involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:102,694,846...102,785,208
Ensembl chr 9:102,694,861...102,787,536 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:49,690,319...49,700,735
Ensembl chr 6:49,690,370...49,701,189 		JBrowse link
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chr 1:27,037,151...27,061,095
Ensembl chr 1:27,037,165...27,061,093 		JBrowse link
G LRRTM3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:70,172,460...70,352,073
Ensembl chr14:70,172,746...70,180,777 		JBrowse link
G MIR206 microRNA mir-206 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chr 7:45,976,293...45,976,372
Ensembl chr 7:45,976,293...45,976,372 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:19,835,934...19,947,239
Ensembl chr 9:19,835,938...20,123,566 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:125,353,063...125,493,368
Ensembl chr 3:125,352,920...125,493,362 		JBrowse link
G SLC2A13 solute carrier family 2 member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:71,294,999...71,673,853
Ensembl chr 5:71,295,008...71,673,785 		JBrowse link
G SP1 Sp1 transcription factor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 5:18,588,763...18,633,177
Ensembl chr 5:18,588,758...18,630,089 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:201,008,506...201,159,946
Ensembl chr13:201,009,480...201,159,948 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr 9:19,835,934...19,947,239
Ensembl chr 9:19,835,938...20,123,566 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:98,327,402...98,362,652
Ensembl chr 7:98,327,408...98,362,606 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18945
    regulation of biological process 12626
      regulation of cellular process 12285
        regulation of metabolic process 6322
          regulation of macromolecule metabolic process 5801
            regulation of protein metabolic process 1858
              regulation of amyloid precursor protein catabolic process 60
                negative regulation of amyloid precursor protein catabolic process + 34
                positive regulation of amyloid precursor protein catabolic process + 27
                regulation of amyloid-beta formation + 52
Path 2
Term Annotations click to browse term
  biological_process 18945
    biological regulation 13007
      regulation of biological process 12626
        regulation of cellular process 12285
          regulation of metabolic process 6322
            regulation of primary metabolic process 5168
              regulation of protein metabolic process 1858
                regulation of amyloid precursor protein catabolic process 60
                  negative regulation of amyloid precursor protein catabolic process + 34
                  positive regulation of amyloid precursor protein catabolic process + 27
                  regulation of amyloid-beta formation + 52
paths to the root