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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation

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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:26260791) UniProt PMID:26260791 NCBI chrNW_004624828:7,572,821...7,592,428
Ensembl chrNW_004624828:7,573,130...7,591,038 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) UniProt PMID:28164773 NCBI chrNW_004624907:1,752,322...1,755,308 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004624768:908,907...1,024,953
Ensembl chrNW_004624768:909,099...1,024,902 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chrNW_004624741:2,669,909...2,692,959
Ensembl chrNW_004624741:2,666,636...2,692,938 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:24577224) Alzheimers_University_of_Toronto PMID:24577224 NCBI chrNW_004624845:3,875,601...3,990,347
Ensembl chrNW_004624845:3,891,061...3,990,342 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (PMID:23070049) ParkinsonsUK-UCL PMID:23070049 NCBI chrNW_004624908:418,248...464,203 JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO (PMID:24612608) UniProt PMID:24612608 NCBI chrNW_004624786:1,449,001...1,465,208
Ensembl chrNW_004624786:1,450,234...1,465,102 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624741:5,785,139...5,802,162
Ensembl chrNW_004624741:5,785,158...5,802,162 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806 PMID:27853422 NCBI chrNW_004624770:10,592,304...10,731,640 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538)
(PMID:18362153)
(PMID:17855360), (PMID:21989385) 		Alzheimers_University_of_Toronto PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 NCBI chrNW_004624880:3,579,783...3,749,958
Ensembl chrNW_004624880:3,583,838...3,749,930 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:18429932)
(PMID:23467355), (PMID:27030769) 		Alzheimers_University_of_Toronto PMID:18429932 PMID:23467355 PMID:27030769 NCBI chrNW_004624828:7,572,821...7,592,428
Ensembl chrNW_004624828:7,573,130...7,591,038 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004624907:1,752,322...1,755,308 JBrowse link
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chrNW_004624732:13,543,975...13,592,942
Ensembl chrNW_004624732:13,544,507...13,592,795 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004624768:908,907...1,024,953
Ensembl chrNW_004624768:909,099...1,024,902 		JBrowse link
G Clu clusterin involved_in ISO (PMID:12047389), (PMID:17412999) Alzheimers_University_of_Toronto PMID:12047389 PMID:17412999 NCBI chrNW_004624758:22,431,331...22,444,185
Ensembl chrNW_004624758:22,426,918...22,444,357 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) UniProt PMID:17553422 NCBI chrNW_004624801:5,057,611...5,073,276
Ensembl chrNW_004624801:5,059,126...5,073,157 		JBrowse link
G Igf1 insulin like growth factor 1 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chrNW_004624750:5,881,065...5,954,799
Ensembl chrNW_004624750:5,881,091...5,952,300 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within ISO (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chrNW_004624809:8,274,736...8,622,287
Ensembl chrNW_004624809:8,276,951...8,616,765 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(PMID:16554819) 		UniProt PMID:16554819 PMID:25576397 NCBI chrNW_004624828:2,121,262...2,131,645
Ensembl chrNW_004624828:2,121,329...2,131,645 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624741:5,785,139...5,802,162
Ensembl chrNW_004624741:5,785,158...5,802,162 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806 PMID:27853422 NCBI chrNW_004624770:10,592,304...10,731,640 JBrowse link
G Rtn1 reticulon 1 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004624734:41,274,072...41,529,134
Ensembl chrNW_004624734:41,274,546...41,530,090 		JBrowse link
G Rtn2 reticulon 2 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004624907:2,345,223...2,350,844
Ensembl chrNW_004624907:2,344,134...2,352,199 		JBrowse link
G Rtn3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004624767:22,498,849...22,558,990
Ensembl chrNW_004624767:22,500,763...22,558,804 		JBrowse link
G Rtn4 reticulon 4 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004624833:6,514,409...6,584,061 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:17855360), (PMID:21989385), (PMID:24001769), (PMID:24523320)
(PMID:16174740), (PMID:16407538), (PMID:22621900)
(PMID:18362153), (PMID:19036982) 		Alzheimers_University_of_Toronto
UniProt		 PMID:16174740 PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 More... NCBI chrNW_004624880:3,579,783...3,749,958
Ensembl chrNW_004624880:3,583,838...3,749,930 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624766:5,890,266...6,173,154
Ensembl chrNW_004624766:5,890,255...6,172,174 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chrNW_004624732:13,543,975...13,592,942
Ensembl chrNW_004624732:13,544,507...13,592,795 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) MGI PMID:16641999 NCBI chrNW_004624734:26,514,594...26,551,361
Ensembl chrNW_004624734:26,514,594...26,549,374 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:22086926)
(PMID:20704561) 		ARUK-UCL PMID:20704561 PMID:22086926 NCBI chrNW_004624760:880,216...898,753
Ensembl chrNW_004624760:880,148...898,751 		JBrowse link
G Ager advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624754:24,138,086...24,140,900 JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004624745:13,904,912...14,159,374
Ensembl chrNW_004624745:13,902,577...14,159,372 		JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004624885:2,382,712...2,388,805
Ensembl chrNW_004624885:2,383,045...2,389,107 		JBrowse link
G Efna3 ephrin A3 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004624885:2,420,610...2,428,048
Ensembl chrNW_004624885:2,421,467...2,428,011 		JBrowse link
G Epha4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624823:3,555,273...3,697,794
Ensembl chrNW_004624823:3,555,288...3,698,990 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624886:4,029,318...4,168,797
Ensembl chrNW_004624886:4,027,178...4,168,902 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:22539346) Alzheimers_University_of_Toronto PMID:22539346 NCBI chrNW_004624845:3,875,601...3,990,347
Ensembl chrNW_004624845:3,891,061...3,990,342 		JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chrNW_004624756:12,589,115...12,672,323
Ensembl chrNW_004624756:12,589,125...12,671,462 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806) ARUK-UCL PMID:24305806 NCBI chrNW_004624865:4,461,200...4,591,309
Ensembl chrNW_004624865:4,461,215...4,588,836 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004624766:5,890,266...6,173,154
Ensembl chrNW_004624766:5,890,255...6,172,174 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 involved_in
acts_upstream_of 		ISO PMID:22086926
(PMID:22086926) 		ARUK-UCL PMID:22086926 RGD:14697726 NCBI chrNW_004624760:880,216...898,753
Ensembl chrNW_004624760:880,148...898,751 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) ARUK-UCL PMID:17293612 NCBI chrNW_004624745:28,137,140...28,188,670
Ensembl chrNW_004624745:28,104,744...28,188,704 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004624907:1,752,322...1,755,308 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624768:908,907...1,024,953
Ensembl chrNW_004624768:909,099...1,024,902 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624758:22,431,331...22,444,185
Ensembl chrNW_004624758:22,426,918...22,444,357 		JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004624885:2,382,712...2,388,805
Ensembl chrNW_004624885:2,383,045...2,389,107 		JBrowse link
G Epha4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624823:3,555,273...3,697,794
Ensembl chrNW_004624823:3,555,288...3,698,990 		JBrowse link
G Gsap gamma-secretase activating protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624739:26,582,689...26,657,097 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (PMID:12761548) ARUK-UCL PMID:12761548 NCBI chrNW_004624907:511,919...522,106
Ensembl chrNW_004624907:511,889...522,168 		JBrowse link
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004624886:618,372...640,954
Ensembl chrNW_004624886:618,289...642,928 		JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO (PMID:17098871) MGI PMID:17098871 NCBI chrNW_004624754:1,348,448...1,499,649
Ensembl chrNW_004624754:1,348,129...1,496,259 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:24577224)
(PMID:22539346), (PMID:24577224) 		Alzheimers_University_of_Toronto PMID:22539346 PMID:24577224 NCBI chrNW_004624845:3,875,601...3,990,347
Ensembl chrNW_004624845:3,891,061...3,990,342 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:20,732,813...20,742,016
Ensembl chrNW_004624767:20,732,938...20,741,272 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806) ARUK-UCL PMID:24305806 NCBI chrNW_004624865:4,461,200...4,591,309
Ensembl chrNW_004624865:4,461,215...4,588,836 		JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chrNW_004624778:396,414...728,278
Ensembl chrNW_004624778:396,503...726,262 		JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO (PMID:14701757) ARUK-UCL PMID:14701757 NCBI chrNW_004624904:1,475,664...1,507,588 JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in ISO (PMID:25556849) ARUK-UCL PMID:25556849 NCBI chrNW_004624745:26,180,858...26,316,848
Ensembl chrNW_004624745:26,180,864...26,315,234 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004624845:3,875,601...3,990,347
Ensembl chrNW_004624845:3,891,061...3,990,342 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,514,594...26,551,361
Ensembl chrNW_004624734:26,514,594...26,549,374 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17647
    regulation of biological process 11484
      regulation of cellular process 11155
        regulation of metabolic process 5929
          regulation of macromolecule metabolic process 5409
            regulation of protein metabolic process 1708
              regulation of amyloid precursor protein catabolic process 42
                negative regulation of amyloid precursor protein catabolic process + 19
                positive regulation of amyloid precursor protein catabolic process + 24
                regulation of amyloid-beta formation + 34
Path 2
Term Annotations click to browse term
  biological_process 17647
    biological regulation 11839
      regulation of biological process 11484
        regulation of cellular process 11155
          regulation of metabolic process 5929
            regulation of primary metabolic process 4964
              regulation of protein metabolic process 1708
                regulation of amyloid precursor protein catabolic process 42
                  negative regulation of amyloid precursor protein catabolic process + 19
                  positive regulation of amyloid precursor protein catabolic process + 24
                  regulation of amyloid-beta formation + 34
paths to the root