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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation


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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in IMP (PMID:26260791) UniProt PMID:26260791 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572 		JBrowse link
G APOE apolipoprotein E involved_in IDA (PMID:28164773) UniProt PMID:28164773 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion involved_in IGI (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr15:30,360,566...30,393,900
Ensembl chr15:30,360,566...30,393,849 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in IGI (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in IGI (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chr20:1,368,978...1,393,054
Ensembl chr20:1,368,977...1,393,164 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IMP (PMID:24577224) Alzheimers_University_of_Toronto PMID:24577224 NCBI chr11:85,957,175...86,069,860
Ensembl chr11:85,957,175...86,069,882 		JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (MGI:5795815|PMID:23070049) ParkinsonsUK-UCL PMID:23070049 MGI:5795815 NCBI chr19:17,601,336...17,688,354
Ensembl chr19:17,601,336...17,688,365 		JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLOT2 flotillin 2 involved_in IMP (PMID:24612608) UniProt PMID:24612608 NCBI chr17:28,879,339...28,897,733
Ensembl chr17:28,879,335...28,897,733 		JBrowse link
G MIR107 microRNA 107 involved_in IC (PMID:18234899) ARUK-UCL PMID:18234899 NCBI chr10:89,592,747...89,592,827
Ensembl chr10:89,592,747...89,592,827 		JBrowse link
G MIR15B microRNA 15b acts_upstream_of IDA (PMID:29961672) ARUK-UCL PMID:29961672 NCBI chr 3:160,404,588...160,404,685
Ensembl chr 3:160,404,588...160,404,685 		JBrowse link
G MIR29A microRNA 29a acts_upstream_of IDA (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 7:130,876,747...130,876,810
Ensembl chr 7:130,876,747...130,876,810 		JBrowse link
G MIR29B1 microRNA 29b-1 acts_upstream_of IDA (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539 		JBrowse link
G MIR29B2 microRNA 29b-2 acts_upstream_of IDA (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 1:207,802,443...207,802,523
Ensembl chr 1:207,802,443...207,802,523 		JBrowse link
G PRNP prion protein (Kanno blood group) involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IMP (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806 PMID:27853422 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IDA
IMP
IEA		 (PMID:16407538)
(PMID:17855360), (PMID:21989385)		 Alzheimers_University_of_Toronto
Ensembl		 PMID:16407538 PMID:17855360 PMID:21989385 GO_REF:0000107 NCBI chr11:121,452,314...121,633,763
Ensembl chr11:121,452,314...121,633,763 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572 		JBrowse link
G APOE apolipoprotein E involved_in IDA (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G BIN1 bridging integrator 1 involved_in IEA
IMP		 (PMID:27179792) Ensembl
ARUK-UCL		 PMID:27179792 GO_REF:0000107 NCBI chr 2:127,048,023...127,107,154
Ensembl chr 2:127,048,027...127,107,288 		JBrowse link
G CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion involved_in IGI (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr15:30,360,566...30,393,900
Ensembl chr15:30,360,566...30,393,849 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in IGI (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CLU clusterin involved_in IDA (PMID:12047389), (PMID:17412999) Alzheimers_University_of_Toronto PMID:12047389 PMID:17412999 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IDA (PMID:17553422) UniProt PMID:17553422 NCBI chr17:75,236,599...75,262,363
Ensembl chr17:75,236,599...75,262,363 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr17:41,717,739...41,734,646
Ensembl chr17:41,717,742...41,734,644 		JBrowse link
G IGF1 insulin like growth factor 1 involved_in IGI (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G MIR153-1 microRNA 153-1 involved_in IDA (PMID:22733824) ARUK-UCL PMID:22733824 NCBI chr 2:219,294,111...219,294,200
Ensembl chr 2:219,294,111...219,294,200 		JBrowse link
G MIR153-2 microRNA 153-2 involved_in IDA (PMID:22733824) ARUK-UCL PMID:22733824 NCBI chr 7:157,574,336...157,574,422
Ensembl chr 7:157,574,336...157,574,422 		JBrowse link
G MIR15B microRNA 15b acts_upstream_of IDA (PMID:29961672) ARUK-UCL PMID:29961672 NCBI chr 3:160,404,588...160,404,685
Ensembl chr 3:160,404,588...160,404,685 		JBrowse link
G MIR186 microRNA 186 acts_upstream_of IDA (PMID:25100943) ARUK-UCL PMID:25100943 NCBI chr 1:71,067,631...71,067,716
Ensembl chr 1:71,067,631...71,067,716 		JBrowse link
G MIR24-1 microRNA 24-1 acts_upstream_of IDA (PMID:25100943) ARUK-UCL PMID:25100943 NCBI chr 9:95,086,021...95,086,088
Ensembl chr 9:95,086,021...95,086,088 		JBrowse link
G MIR24-2 microRNA 24-2 acts_upstream_of IDA (PMID:25100943) ARUK-UCL PMID:25100943 NCBI chr19:13,836,287...13,836,359
Ensembl chr19:13,836,287...13,836,359 		JBrowse link
G MIR298 microRNA 298 acts_upstream_of IDA (PMID:31942037) ARUK-UCL PMID:31942037 NCBI chr20:58,818,226...58,818,313
Ensembl chr20:58,818,226...58,818,313 		JBrowse link
G MIR29A microRNA 29a acts_upstream_of IDA (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 7:130,876,747...130,876,810
Ensembl chr 7:130,876,747...130,876,810 		JBrowse link
G MIR29B1 microRNA 29b-1 acts_upstream_of IDA (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 7:130,877,459...130,877,539
Ensembl chr 7:130,877,459...130,877,539 		JBrowse link
G MIR29B2 microRNA 29b-2 acts_upstream_of IDA (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 1:207,802,443...207,802,523
Ensembl chr 1:207,802,443...207,802,523 		JBrowse link
G MIR29C microRNA 29c acts_upstream_of IC
IDA		 (PMID:21565331)
(PMID:25973041)		 ARUK-UCL PMID:21565331 PMID:25973041 NCBI chr 1:207,801,852...207,801,939
Ensembl chr 1:207,801,852...207,801,939 		JBrowse link
G MIR339 microRNA 339 acts_upstream_of IDA (PMID:24352696) ARUK-UCL PMID:24352696 NCBI chr 7:1,022,933...1,023,026
Ensembl chr 7:1,022,933...1,023,026 		JBrowse link
G MIR361 microRNA 361 involved_in IDA (PMID:31601077) ARUK-UCL PMID:31601077 NCBI chr  X:85,903,636...85,903,707
Ensembl chr  X:85,903,636...85,903,707 		JBrowse link
G MIR455 microRNA 455 acts_upstream_of IDA (PMID:25100943), (PMID:31181293) ARUK-UCL PMID:25100943 PMID:31181293 NCBI chr 9:114,209,434...114,209,529
Ensembl chr 9:114,209,434...114,209,529 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within IGI (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chr 9:84,668,522...85,027,054
Ensembl chr 9:84,668,375...85,095,751 		JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISS
IMP		 (PMID:25576397) UniProt PMID:25576397 GO_REF:0000024 NCBI chr19:9,835,318...9,849,689
Ensembl chr19:9,835,257...9,849,689 		JBrowse link
G PRNP prion protein (Kanno blood group) involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IMP (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806 PMID:27853422 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813 		JBrowse link
G RTN1 reticulon 1 involved_in IDA (PMID:15286784) UniProt PMID:15286784 NCBI chr14:59,595,976...59,870,776
Ensembl chr14:59,595,976...59,870,776 		JBrowse link
G RTN2 reticulon 2 involved_in IDA (PMID:15286784) UniProt PMID:15286784 NCBI chr19:45,485,294...45,497,047
Ensembl chr19:45,485,294...45,497,055 		JBrowse link
G RTN3 reticulon 3 involved_in IDA (PMID:15286784) UniProt PMID:15286784 NCBI chr11:63,681,450...63,759,891
Ensembl chr11:63,681,446...63,759,891 		JBrowse link
G RTN4 reticulon 4 involved_in IDA (PMID:15286784) UniProt PMID:15286784 NCBI chr 2:54,972,189...55,137,831
Ensembl chr 2:54,972,187...55,112,621 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IDA
IMP
IEA		 (PMID:16407538), (PMID:22621900)
(PMID:17855360), (PMID:21989385), (PMID:24001769), (PMID:24523320)		 Alzheimers_University_of_Toronto
Ensembl		 PMID:16407538 PMID:17855360 PMID:21989385 PMID:22621900 PMID:24001769 More... GO_REF:0000107 NCBI chr11:121,452,314...121,633,763
Ensembl chr11:121,452,314...121,633,763 		JBrowse link
G SPON1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16227578) Ensembl
MGI		 PMID:16227578 GO_REF:0000107 NCBI chr11:13,962,723...14,268,133
Ensembl chr11:13,962,723...14,268,133 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of IMP
IGI		 (PMID:22086926)
(PMID:20704561)		 ARUK-UCL PMID:20704561 PMID:22086926 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915 		JBrowse link
G APP amyloid beta precursor protein involved_in IGI (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA
ISS		 Ensembl
Alzheimers_University_of_Toronto		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:85,957,175...86,069,860
Ensembl chr11:85,957,175...86,069,882 		JBrowse link
G RANBP9 RAN binding protein 9 acts_upstream_of ISS ARUK-UCL GO_REF:0000024 NCBI chr 6:13,621,498...13,711,835
Ensembl chr 6:13,621,498...13,711,835 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IMP (PMID:24305806) ARUK-UCL PMID:24305806 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330 		JBrowse link
G SPON1 spondin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16227578) Ensembl
MGI		 PMID:16227578 GO_REF:0000107 NCBI chr11:13,962,723...14,268,133
Ensembl chr11:13,962,723...14,268,133 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 involved_in
acts_upstream_of		 ISS
IMP		 (PMID:22086926) ARUK-UCL PMID:22086926 NCBI chr 9:137,007,234...137,028,922
Ensembl chr 9:137,007,234...137,028,915 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in IDA (PMID:17293612) ARUK-UCL PMID:17293612 NCBI chr21:42,199,689...42,297,244
Ensembl chr21:42,199,689...42,297,244 		JBrowse link
G APOE apolipoprotein E involved_in IDA (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G CASP3 caspase 3 involved_in IDA
IEA		 (PMID:17553422) UniProt
Ensembl		 PMID:17553422 GO_REF:0000107 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr15:30,360,566...30,393,900
Ensembl chr15:30,360,566...30,393,849 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr15:32,030,483...32,173,018
Ensembl chr15:31,923,438...32,173,018 		JBrowse link
G CLU clusterin involved_in IEA
ISS		 Ensembl
Alzheimers_University_of_Toronto		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700 		JBrowse link
G CSNK1E casein kinase 1 epsilon involved_in ISO
IEA		 RGD
Ensembl		 PMID:17360493 GO_REF:0000107 RGD:10395238 NCBI chr22:38,290,691...38,318,084
Ensembl chr22:38,290,691...38,318,084 		JBrowse link
G EFNA1 ephrin A1 involved_in IDA (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IGI (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chr 2:221,418,027...221,574,202
Ensembl chr 2:221,418,027...221,574,202 		JBrowse link
G GSAP gamma-secretase activating protein involved_in IDA
IBA
IEA		 (PMID:20811458) UniProt
GO_Central
Ensembl		 PMID:20811458 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:77,310,751...77,416,630
Ensembl chr 7:77,310,751...77,416,349 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IMP
IGI		 (PMID:12761548) ARUK-UCL PMID:12761548 NCBI chr19:42,230,190...42,242,602
Ensembl chr19:42,226,225...42,242,625 		JBrowse link
G IFNG interferon gamma involved_in ISS
IGI		 (PMID:19808651) ARUK-UCL PMID:19808651 GO_REF:0000024 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 6:137,197,484...137,219,385
Ensembl chr 6:137,197,483...137,219,449 		JBrowse link
G LRRTM3 leucine rich repeat transmembrane neuronal 3 involved_in
acts_upstream_of_or_within		 IEA
IMP		 (PMID:17098871) Ensembl
MGI		 PMID:17098871 GO_REF:0000107 NCBI chr10:66,926,036...67,101,551
Ensembl chr10:66,926,036...67,101,551 		JBrowse link
G MIR206 microRNA 206 involved_in IDA (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chr 6:52,144,349...52,144,434
Ensembl chr 6:52,144,349...52,144,434 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IMP (PMID:24577224) Alzheimers_University_of_Toronto PMID:24577224 NCBI chr11:85,957,175...86,069,860
Ensembl chr11:85,957,175...86,069,882 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit acts_upstream_of
involved_in		 ISS
IEA		 (PMID:21329555) ARUK-UCL
Ensembl		 PMID:21329555 GO_REF:0000107 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IMP (PMID:24305806) ARUK-UCL PMID:24305806 NCBI chr 2:11,179,759...11,345,437
Ensembl chr 2:11,179,759...11,348,330 		JBrowse link
G SLC2A13 solute carrier family 2 member 13 involved_in IGI (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chr12:39,755,025...40,106,081
Ensembl chr12:39,755,025...40,106,089 		JBrowse link
G SP1 Sp1 transcription factor acts_upstream_of IMP (PMID:14701757) ARUK-UCL PMID:14701757 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G TNF tumor necrosis factor involved_in IEA
ISS		 Ensembl
ARUK-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:38,290,691...38,398,915
Ensembl chr22:38,291,918...38,398,522 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PICALM phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISS (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr11:85,957,175...86,069,860
Ensembl chr11:85,957,175...86,069,882 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 involved_in IMP (PMID:16641999) UniProt PMID:16641999 NCBI chr14:75,131,469...75,176,612
Ensembl chr14:75,131,469...75,176,612 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      regulation of metabolic process 7352
        regulation of macromolecule metabolic process 6764
          regulation of protein metabolic process 2004
            regulation of amyloid precursor protein catabolic process 59
              negative regulation of amyloid precursor protein catabolic process + 35
              positive regulation of amyloid precursor protein catabolic process + 26
              regulation of amyloid-beta formation + 53
              regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 0
              regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        macromolecule metabolic process 10246
          protein metabolic process 4391
            amyloid precursor protein metabolic process 102
              amyloid precursor protein catabolic process 73
                regulation of amyloid precursor protein catabolic process 59
                  negative regulation of amyloid precursor protein catabolic process + 35
                  positive regulation of amyloid precursor protein catabolic process + 26
                  regulation of amyloid-beta formation + 53
                  regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 0
                  regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process + 0
paths to the root