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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation


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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:57,668,371...57,684,111
Ensembl chr20:57,667,706...57,677,342 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr 3:36,852,082...37,164,930
Ensembl chr 3:36,852,543...36,978,399 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chr24:19,618,581...19,643,685
Ensembl chr24:19,618,558...19,643,046 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616 		JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (PMID:23070049) ParkinsonsUK-UCL PMID:23070049 NCBI chr20:45,179,275...45,237,544
Ensembl chr20:45,188,750...45,238,115 		JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLOT2 flotillin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:43,050,929...43,066,886
Ensembl chr 9:43,052,114...43,071,742 		JBrowse link
G MIR15B microRNA mir-15b acts_upstream_of ISO (PMID:29961672) ARUK-UCL PMID:29961672 NCBI chr34:26,460,663...26,460,722
Ensembl chr34:26,460,645...26,460,741 		JBrowse link
G MIR29A microRNA mir-29a acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr14:6,184,844...6,184,903
Ensembl chr14:6,184,830...6,184,916 		JBrowse link
G MIR29B-1 microRNA mir-29b-1 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr14:6,184,457...6,184,521
Ensembl chr14:6,184,446...6,184,531 		JBrowse link
G MIR29B-2 microRNA mir-29b-2 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 7:6,651,878...6,651,943
Ensembl chr 7:6,651,866...6,651,955 		JBrowse link
G PRNP prion protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:16,845,224...16,862,319
Ensembl chr24:16,846,207...16,859,815 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:66,862,614...67,001,538
Ensembl chr 7:66,862,608...67,142,853 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:12,493,750...12,650,530
Ensembl chr 5:12,431,377...12,650,784 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:18429932)
(PMID:23467355), (PMID:27030769) 		Alzheimers_University_of_Toronto PMID:18429932 PMID:23467355 PMID:27030769 NCBI chr20:57,668,371...57,684,111
Ensembl chr20:57,667,706...57,677,342 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G BIN1 bridging integrator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:23,503,934...23,534,407
Ensembl chr19:23,375,363...23,534,303 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr 3:36,852,082...37,164,930
Ensembl chr 3:36,852,543...36,978,399 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:5,235,377...5,250,982
Ensembl chr 9:5,235,025...5,249,361 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr 9:21,065,770...21,074,462
Ensembl chr 9:21,065,846...21,072,991 		JBrowse link
G IGF1 insulin like growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:41,203,320...41,275,964
Ensembl chr15:41,202,518...41,275,794 		JBrowse link
G MIR103-1 microRNA mir-103-1 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr 4:43,182,876...43,182,937
Ensembl chr 4:43,182,871...43,182,942 		JBrowse link
G MIR103-2 microRNA mir-103-2 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr24:17,468,354...17,468,430
Ensembl chr24:17,468,355...17,468,434 		JBrowse link
G MIR153 microRNA mir-153 involved_in ISO (PMID:22733824) ARUK-UCL PMID:22733824 NCBI chr16:19,932,378...19,932,457
Ensembl chr16:19,932,378...19,932,457 		JBrowse link
G MIR15A microRNA mir-15a acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr22:1,846,880...1,846,938
Ensembl chr22:1,846,866...1,846,960 		JBrowse link
G MIR15B microRNA mir-15b acts_upstream_of ISO (PMID:29961672) ARUK-UCL PMID:29961672 NCBI chr34:26,460,663...26,460,722
Ensembl chr34:26,460,645...26,460,741 		JBrowse link
G MIR16-1 microRNA mir-16-1 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr22:1,847,020...1,847,084
Ensembl chr22:1,847,007...1,847,093 		JBrowse link
G MIR16-2 microRNA mir-16-2 acts_upstream_of ISO (PMID:27343180) ARUK-UCL PMID:27343180 NCBI chr34:26,460,807...26,460,871
Ensembl chr34:26,460,807...26,460,871 		JBrowse link
G MIR186 microRNA mir-186 acts_upstream_of ISO (PMID:25100943) ARUK-UCL PMID:25100943 NCBI chr 6:74,881,615...74,881,675
Ensembl chr 6:74,881,601...74,881,686 		JBrowse link
G MIR24-1 microRNA mir-24-1 acts_upstream_of ISO (PMID:25100943) ARUK-UCL PMID:25100943 NCBI chr 1:71,677,608...71,677,669
Ensembl chr 1:71,677,608...71,677,669 		JBrowse link
G MIR24-2 microRNA mir-24-2 acts_upstream_of ISO (PMID:25100943) ARUK-UCL PMID:25100943 NCBI chr20:48,620,684...48,620,745
Ensembl chr20:48,620,674...48,620,745 		JBrowse link
G MIR29A microRNA mir-29a acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr14:6,184,844...6,184,903
Ensembl chr14:6,184,830...6,184,916 		JBrowse link
G MIR29B-1 microRNA mir-29b-1 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr14:6,184,457...6,184,521
Ensembl chr14:6,184,446...6,184,531 		JBrowse link
G MIR29B-2 microRNA mir-29b-2 acts_upstream_of ISO (PMID:18434550) ARUK-UCL PMID:18434550 NCBI chr 7:6,651,878...6,651,943
Ensembl chr 7:6,651,866...6,651,955 		JBrowse link
G MIR29C-2 microRNA mir-29c-2 acts_upstream_of ISO (PMID:25973041) ARUK-UCL PMID:25973041 NCBI chr 7:6,651,339...6,651,396 JBrowse link
G MIR339-1 microRNA mir-339-1 acts_upstream_of ISO (PMID:24352696) ARUK-UCL PMID:24352696 NCBI chr 6:15,853,520...15,853,577
Ensembl chr 6:15,853,520...15,853,577 		JBrowse link
G MIR361 microRNA mir-361 involved_in ISO (PMID:31601077) ARUK-UCL PMID:31601077 NCBI chr  X:66,698,698...66,698,760
Ensembl chr  X:66,698,698...66,698,760 		JBrowse link
G MIR455 microRNA mir-455 acts_upstream_of ISO (PMID:25100943), (PMID:31181293) ARUK-UCL PMID:25100943 PMID:31181293 NCBI chr11:68,461,911...68,461,968
Ensembl chr11:68,461,896...68,461,983 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:74,447,927...74,777,910
Ensembl chr 1:74,449,060...74,777,032 		JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:51,156,887...51,168,131
Ensembl chr20:51,157,121...51,168,136 		JBrowse link
G PRNP prion protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:16,845,224...16,862,319
Ensembl chr24:16,846,207...16,859,815 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:66,862,614...67,001,538
Ensembl chr 7:66,862,608...67,142,853 		JBrowse link
G RTN1 reticulon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:34,810,127...35,029,201
Ensembl chr 8:34,810,342...35,033,330 		JBrowse link
G RTN2 reticulon 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,976,820...110,080,252
Ensembl chr 1:109,976,930...110,048,532
Ensembl chr 1:109,976,930...110,048,532 		JBrowse link
G RTN3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chr18:53,239,893...53,298,020
Ensembl chr18:53,239,914...53,297,984 		JBrowse link
G RTN4 reticulon 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:55,884,452...55,954,476
Ensembl chr10:55,885,125...55,936,574 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:12,493,750...12,650,530
Ensembl chr 5:12,431,377...12,650,784 		JBrowse link
G SPON1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:36,778,435...37,030,042
Ensembl chr21:36,778,458...37,028,636 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIN1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chr19:23,503,934...23,534,407
Ensembl chr19:23,375,363...23,534,303 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) MGI PMID:16641999 NCBI chr 8:48,221,372...48,257,242 JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:20704561)
(PMID:22086926) 		ARUK-UCL PMID:20704561 PMID:22086926 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337 		JBrowse link
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,373,197...42,381,161
Ensembl chr 7:42,373,639...42,378,946 		JBrowse link
G EFNA3 ephrin A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,409,215...42,417,701
Ensembl chr 7:42,410,119...42,417,599 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:27,670,143...27,809,642
Ensembl chr37:27,677,566...27,809,646 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:7,367,617...7,448,862
Ensembl chr29:7,332,684...7,448,507 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616 		JBrowse link
G RANBP9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr35:13,063,689...13,157,228
Ensembl chr35:13,064,286...13,157,202 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,931,786...8,012,484
Ensembl chr17:7,934,739...8,178,707 		JBrowse link
G SPON1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr21:36,778,435...37,030,042
Ensembl chr21:36,778,458...37,028,636 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in 		ISO (PMID:22086926) ARUK-UCL PMID:22086926 RGD:14697726 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:36,574,406...36,627,598
Ensembl chr31:36,553,380...36,620,043 		JBrowse link
G APOE apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440 		JBrowse link
G CASP3 caspase 3 involved_in IEA
ISS 		Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:36,852,082...37,164,930
Ensembl chr 3:36,852,543...36,978,399 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G CSNK1E casein kinase 1 epsilon ISO RGD PMID:17360493 RGD:10395238 NCBI chr10:26,386,646...26,412,429
Ensembl chr10:26,393,033...26,411,624 		JBrowse link
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,373,197...42,381,161
Ensembl chr 7:42,373,639...42,378,946 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:27,670,143...27,809,642
Ensembl chr37:27,677,566...27,809,646 		JBrowse link
G GSAP gamma-secretase activating protein involved_in IEA
IBA 		Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr18:17,406,903...17,479,429
Ensembl chr18:17,407,532...17,484,688 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:112,129,116...112,138,714
Ensembl chr 1:112,103,825...112,138,559 		JBrowse link
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chr 1:29,646,776...29,669,669
Ensembl chr 1:29,647,552...29,669,578 		JBrowse link
G LRRTM3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:18,320,720...18,485,863
Ensembl chr 4:18,321,084...18,481,131 		JBrowse link
G MIR206 microRNA mir-206 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chr12:19,805,523...19,805,582
Ensembl chr12:19,805,523...19,805,582 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,931,786...8,012,484
Ensembl chr17:7,934,739...8,178,707 		JBrowse link
G SLC2A13 solute carrier family 2 member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:13,535,997...13,898,154
Ensembl chr27:13,536,054...13,905,483 		JBrowse link
G SP1 Sp1 transcription factor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr31:32,564,970...32,655,232
Ensembl chr31:32,511,502...32,652,572 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr21:13,437,819...13,540,167
Ensembl chr21:13,437,925...13,539,616 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,221,372...48,257,242 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22130
    regulation of biological process 12177
      regulation of cellular process 11828
        regulation of metabolic process 6528
          regulation of macromolecule metabolic process 5999
            regulation of protein metabolic process 1926
              regulation of amyloid precursor protein catabolic process 63
                negative regulation of amyloid precursor protein catabolic process + 37
                positive regulation of amyloid precursor protein catabolic process + 27
                regulation of amyloid-beta formation + 55
Path 2
Term Annotations click to browse term
  biological_process 22130
    biological regulation 12559
      regulation of biological process 12177
        regulation of cellular process 11828
          regulation of metabolic process 6528
            regulation of primary metabolic process 5326
              regulation of protein metabolic process 1926
                regulation of amyloid precursor protein catabolic process 63
                  negative regulation of amyloid precursor protein catabolic process + 37
                  positive regulation of amyloid precursor protein catabolic process + 27
                  regulation of amyloid-beta formation + 55
paths to the root