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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation

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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:26260791) UniProt PMID:26260791 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:28164773) UniProt PMID:28164773 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chrNW_004955596:580,106...606,210
Ensembl chrNW_004955596:580,106...603,255 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:24577224) Alzheimers_University_of_Toronto PMID:24577224 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208 		JBrowse link
G Unc13a unc-13 homolog A involved_in ISO (PMID:23070049) ParkinsonsUK-UCL PMID:23070049 NCBI chrNW_004955524:725,353...769,745 JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 involved_in ISO (PMID:24612608) UniProt PMID:24612608 NCBI chrNW_004955481:4,276,847...4,298,523
Ensembl chrNW_004955481:4,276,860...4,298,523 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in ISO (PMID:17573534) ARUK-UCL PMID:17573534 NCBI chrNW_004955415:15,442,313...15,454,644
Ensembl chrNW_004955415:15,442,313...15,454,644 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806 PMID:27853422 NCBI chrNW_004955402:9,752,101...9,864,317
Ensembl chrNW_004955402:9,750,730...9,864,317 		JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538)
(PMID:18362153)
(PMID:17855360), (PMID:21989385) 		Alzheimers_University_of_Toronto PMID:16407538 PMID:17855360 PMID:18362153 PMID:21989385 NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:18429932)
(PMID:23467355), (PMID:27030769) 		Alzheimers_University_of_Toronto PMID:18429932 PMID:23467355 PMID:27030769 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chrNW_004955459:3,376,149...3,423,157
Ensembl chrNW_004955459:3,399,611...3,422,621 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700 		JBrowse link
G Clu clusterin involved_in ISO (PMID:12047389), (PMID:17412999) Alzheimers_University_of_Toronto PMID:12047389 PMID:17412999 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) UniProt PMID:17553422 NCBI chrNW_004955553:2,103,694...2,124,748
Ensembl chrNW_004955553:2,108,379...2,124,748 		JBrowse link
G Igf1 insulin like growth factor 1 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chrNW_004955405:37,505,830...37,582,152
Ensembl chrNW_004955405:37,512,201...37,582,152 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within ISO (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chrNW_004955432:2,284,283...2,629,631
Ensembl chrNW_004955432:2,288,898...2,630,878 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(PMID:16554819) 		UniProt PMID:16554819 PMID:25576397 NCBI chrNW_004955495:1,250,557...1,261,617
Ensembl chrNW_004955495:1,250,453...1,266,235 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in ISO (PMID:17573534) ARUK-UCL PMID:17573534 NCBI chrNW_004955415:15,442,313...15,454,644
Ensembl chrNW_004955415:15,442,313...15,454,644 		JBrowse link
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:24305806), (PMID:27853422) ARUK-UCL PMID:24305806 PMID:27853422 NCBI chrNW_004955402:9,752,101...9,864,317
Ensembl chrNW_004955402:9,750,730...9,864,317 		JBrowse link
G Rtn1 reticulon 1 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004955466:13,290,419...13,454,387 JBrowse link
G Rtn2 reticulon 2 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004955574:1,543...11,476
Ensembl chrNW_004955574:1,071...21,117 		JBrowse link
G Rtn3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004955422:21,289,652...21,358,865 JBrowse link
G Rtn4 reticulon 4 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chrNW_004955424:28,061,346...28,125,838 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:17855360), (PMID:21989385), (PMID:24001769), (PMID:24523320)
(PMID:16174740), (PMID:16407538), (PMID:22621900)
(PMID:18362153), (PMID:19036982) 		Alzheimers_University_of_Toronto
UniProt		 PMID:16174740 PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 More... NCBI chrNW_004955412:22,421,984...22,576,179
Ensembl chrNW_004955412:22,421,984...22,576,179 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within ISO (PMID:16227578) MGI PMID:16227578 NCBI chrNW_004955414:29,180,246...29,475,547
Ensembl chrNW_004955414:29,179,928...29,475,547 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bin1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chrNW_004955459:3,376,149...3,423,157
Ensembl chrNW_004955459:3,399,611...3,422,621 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) MGI PMID:16641999 NCBI chrNW_004955523:393,632...438,114
Ensembl chrNW_004955523:393,706...436,583 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of ISO (PMID:22086926)
(PMID:20704561) 		ARUK-UCL PMID:20704561 PMID:22086926 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
G Ager advanced glycosylation end-product specific receptor involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004955437:645,482...648,607
Ensembl chrNW_004955437:645,897...648,479 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268 		JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,610,929...1,617,217
Ensembl chrNW_004955545:1,610,929...1,617,460 		JBrowse link
G Efna3 ephrin A3 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,570,351...1,578,610
Ensembl chrNW_004955545:1,570,339...1,577,639 		JBrowse link
G Epha4 EPH receptor A4 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955453:12,099,800...12,240,199
Ensembl chrNW_004955453:12,099,757...12,240,199 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955454:15,025,967...15,111,142
Ensembl chrNW_004955454:15,035,979...15,111,142 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:22539346) Alzheimers_University_of_Toronto PMID:22539346 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208 		JBrowse link
G Ranbp9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chrNW_004955465:1,042,649...1,122,824
Ensembl chrNW_004955465:1,042,649...1,122,824 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806) ARUK-UCL PMID:24305806 NCBI chrNW_004955487:5,856,190...5,972,408
Ensembl chrNW_004955487:5,859,204...5,972,401 		JBrowse link
G Spon1 spondin 1 acts_upstream_of_or_within ISO (PMID:16227578) MGI PMID:16227578 NCBI chrNW_004955414:29,180,246...29,475,547
Ensembl chrNW_004955414:29,179,928...29,475,547 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in 		ISO (PMID:22086926) ARUK-UCL PMID:22086926 RGD:14697726 NCBI chrNW_004955513:5,035,879...5,051,140
Ensembl chrNW_004955513:5,033,771...5,051,200 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) ARUK-UCL PMID:17293612 NCBI chrNW_004955407:39,410,262...39,459,383
Ensembl chrNW_004955407:39,410,262...39,459,383 		JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888 		JBrowse link
G Casp3 caspase 3 involved_in ISO PMID:17553422
(PMID:17553422) 		UniProt PMID:17553422 RGD:13825190 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO (PMID:20164328) ARUK-UCL PMID:20164328 NCBI chrNW_004955416:30,687,518...30,798,700
Ensembl chrNW_004955416:30,687,478...30,798,700 		JBrowse link
G Clu clusterin involved_in ISO (PMID:12145324) Alzheimers_University_of_Toronto PMID:12145324 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
G Csnk1e casein kinase 1 epsilon ISO RGD PMID:17360493 RGD:10395238 NCBI chrNW_004955413:24,560,889...24,591,669
Ensembl chrNW_004955413:24,560,900...24,591,669 		JBrowse link
G Efna1 ephrin A1 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955545:1,610,929...1,617,217
Ensembl chrNW_004955545:1,610,929...1,617,460 		JBrowse link
G Epha4 EPH receptor A4 involved_in ISO (PMID:24217950) ARUK-UCL PMID:24217950 NCBI chrNW_004955453:12,099,800...12,240,199
Ensembl chrNW_004955453:12,099,757...12,240,199 		JBrowse link
G Gsap gamma-secretase activating protein involved_in ISO (PMID:20811458) UniProt PMID:20811458 NCBI chrNW_004955410:7,740,548...7,810,563 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (PMID:12761548) ARUK-UCL PMID:12761548 NCBI chrNW_004955555:668,641...676,351
Ensembl chrNW_004955555:667,973...676,351 		JBrowse link
G Ifng interferon gamma involved_in ISO (PMID:19808651)
(PMID:17255335) 		ARUK-UCL PMID:17255335 PMID:19808651 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004955436:22,183,318...22,199,013 JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within ISO (PMID:17098871) MGI PMID:17098871 NCBI chrNW_004955425:19,480,944...19,657,178
Ensembl chrNW_004955425:19,480,907...19,654,804 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO (PMID:24577224)
(PMID:22539346), (PMID:24577224) 		Alzheimers_University_of_Toronto PMID:22539346 PMID:24577224 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit acts_upstream_of ISO (PMID:21329555) ARUK-UCL PMID:21329555 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516 		JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (PMID:24305806) ARUK-UCL PMID:24305806 NCBI chrNW_004955487:5,856,190...5,972,408
Ensembl chrNW_004955487:5,859,204...5,972,401 		JBrowse link
G Slc2a13 solute carrier family 2 member 13 involved_in ISO (PMID:26094765) ARUK-UCL PMID:26094765 NCBI chrNW_004955505:395,380...664,272
Ensembl chrNW_004955505:396,744...662,738 		JBrowse link
G Sp1 Sp1 transcription factor acts_upstream_of ISO (PMID:14701757) ARUK-UCL PMID:14701757 NCBI chrNW_004955458:644,435...677,360
Ensembl chrNW_004955458:644,378...677,441 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO (PMID:17255335) ARUK-UCL PMID:17255335 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A involved_in ISO (PMID:25556849) ARUK-UCL PMID:25556849 NCBI chrNW_004955407:36,456,628...36,588,940
Ensembl chrNW_004955407:36,453,098...36,589,382 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chrNW_004955414:6,871,220...6,970,569
Ensembl chrNW_004955414:6,871,520...6,969,208 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 involved_in ISO (PMID:16641999) UniProt PMID:16641999 NCBI chrNW_004955523:393,632...438,114
Ensembl chrNW_004955523:393,706...436,583 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12628
    regulation of biological process 8796
      regulation of cellular process 8508
        regulation of metabolic process 5007
          regulation of macromolecule metabolic process 4520
            regulation of protein metabolic process 1653
              regulation of amyloid precursor protein catabolic process 44
                negative regulation of amyloid precursor protein catabolic process + 19
                positive regulation of amyloid precursor protein catabolic process + 26
                regulation of amyloid-beta formation + 36
Path 2
Term Annotations click to browse term
  biological_process 12628
    biological regulation 9097
      regulation of biological process 8796
        regulation of cellular process 8508
          regulation of metabolic process 5007
            regulation of primary metabolic process 4143
              regulation of protein metabolic process 1653
                regulation of amyloid precursor protein catabolic process 44
                  negative regulation of amyloid precursor protein catabolic process + 19
                  positive regulation of amyloid precursor protein catabolic process + 26
                  regulation of amyloid-beta formation + 36
paths to the root