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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of amyloid precursor protein catabolic process
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Accession:GO:1902991 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid precursor protein catabolic process.
Comment:An example of this is human FKBP1A/12 (UniProt symbol P62942) in PMID:24499793 (inferred from direct assay).
Synonyms:exact_synonym: regulation of APP catabolic process;   regulation of APP catabolism;   regulation of amyloid precursor protein breakdown;   regulation of amyloid precursor protein catabolism;   regulation of amyloid precursor protein degradation


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regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G FKBP1A FKBP prolyl isomerase 1A involved_in ISO (PMID:24499793) ParkinsonsUK-UCL PMID:24499793 NCBI chr20:1,519,330...1,548,473 JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G UNC13A unc-13 homolog A involved_in ISO (PMID:23070049) ParkinsonsUK-UCL PMID:23070049 NCBI chr19:17,088,654...17,175,559
Ensembl chr19:18,068,006...18,150,642 		JBrowse link
negative regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLOT2 flotillin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:27,876,424...27,894,836
Ensembl chr17:28,385,191...28,405,585 		JBrowse link
G PRNP prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:4,713,616...4,728,847
Ensembl chr20:4,523,155...4,523,916 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:14,192,293...14,352,357
Ensembl chr18:17,833,047...17,990,086 		JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:116,297,014...116,477,399
Ensembl chr11:120,222,491...120,402,432 		JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (PMID:18429932)
(PMID:23467355), (PMID:27030769) 		Alzheimers_University_of_Toronto PMID:18429932 PMID:23467355 PMID:27030769 NCBI chr19:62,811...77,897
Ensembl chr19:1,018,095...1,042,104 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G BIN1 bridging integrator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:33,168,767...33,228,075
Ensembl chr2B:127,716,550...127,775,378 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:69,185,045...69,208,766
Ensembl chr17:74,737,164...74,762,039 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr17:15,578,658...15,596,313
Ensembl chr17:15,797,949...15,810,299 		JBrowse link
G IGF1 insulin like growth factor 1 involved_in ISO (PMID:27277332) ARUK-UCL PMID:27277332 NCBI chr12:99,986,887...100,066,773
Ensembl chr12:103,385,911...103,462,177 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (PMID:20708605) ARUK-UCL PMID:20708605 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:39,663,986...40,208,770
Ensembl chr 9:84,021,837...84,372,678 		JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:16554819)
(PMID:25576397) 		UniProt PMID:16554819 PMID:25576397 NCBI chr19:9,389,829...9,404,099
Ensembl chr19:10,053,254...10,066,853 		JBrowse link
G PRNP prion protein (Kanno blood group) involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:4,713,616...4,728,847
Ensembl chr20:4,523,155...4,523,916 		JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:14,192,293...14,352,357
Ensembl chr18:17,833,047...17,990,086 		JBrowse link
G RTN1 reticulon 1 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chr14:40,198,279...40,472,255 JBrowse link
G RTN2 reticulon 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:42,434,085...42,446,862
Ensembl chr19:51,030,708...51,043,404 		JBrowse link
G RTN3 reticulon 3 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chr11:59,039,313...59,117,572
Ensembl chr11:62,391,284...62,468,595 		JBrowse link
G RTN4 reticulon 4 involved_in ISO (PMID:15286784) UniProt PMID:15286784 NCBI chr2A:55,129,272...55,207,031 JBrowse link
G SORL1 sortilin related receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:116,297,014...116,477,399
Ensembl chr11:120,222,491...120,402,432 		JBrowse link
G SPON1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:14,063,166...14,368,180
Ensembl chr11:13,776,671...14,057,741 		JBrowse link
negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIN1 bridging integrator 1 involved_in ISO (PMID:27179792) ARUK-UCL PMID:27179792 NCBI chr2B:33,168,767...33,228,075
Ensembl chr2B:127,716,550...127,775,378 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 acts_upstream_of_or_within ISO (PMID:16641999) MGI PMID:16641999 NCBI chr14:55,683,121...55,728,365
Ensembl chr14:74,526,733...74,572,000 		JBrowse link
positive regulation of amyloid precursor protein catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776 		JBrowse link
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,828,363...31,831,981
Ensembl chr 6:32,708,251...32,711,641 		JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:22406537) ARUK-UCL PMID:22406537 NCBI chr21:12,324,455...12,608,594
Ensembl chr21:25,684,355...25,995,072 		JBrowse link
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,475,128...130,482,531
Ensembl chr 1:134,083,855...134,091,228 		JBrowse link
G EFNA3 ephrin A3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,426,910...130,435,628
Ensembl chr 1:134,036,490...134,045,213 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:108,664,475...108,818,802
Ensembl chr2B:227,248,958...227,402,790 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:52,318,497...52,455,741
Ensembl chr 8:49,755,708...49,825,287 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G RANBP9 RAN binding protein 9 acts_upstream_of ISO PMID:24592211 ARUK-UCL PMID:24592211 RGD:38501074 NCBI chr 6:13,466,063...13,556,303
Ensembl chr 6:13,837,308...13,926,693 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:11,167,353...11,331,339
Ensembl chr2A:11,318,370...11,478,986 		JBrowse link
G SPON1 spondin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:14,063,166...14,368,180
Ensembl chr11:13,776,671...14,057,741 		JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in 		IEA
ISO 		PMID:22086926 Ensembl
ARUK-UCL		 PMID:22086926 GO_REF:0000107 RGD:14697726 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (PMID:17293612) ARUK-UCL PMID:17293612 NCBI chr21:28,534,697...28,619,590
Ensembl chr21:41,839,115...41,933,050 		JBrowse link
G APOE apolipoprotein E involved_in ISO (PMID:24154541), (PMID:24259049) Alzheimers_University_of_Toronto PMID:24154541 PMID:24259049 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490 		JBrowse link
G CASP3 caspase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:26,867,973...26,884,838
Ensembl chr 8:24,070,053...24,083,523 		JBrowse link
G CSNK1E casein kinase 1 epsilon ISO RGD PMID:17360493 RGD:10395238 NCBI chr22:19,202,599...19,229,344
Ensembl chr22:37,027,094...37,072,942 		JBrowse link
G EFNA1 ephrin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,475,128...130,482,531
Ensembl chr 1:134,083,855...134,091,228 		JBrowse link
G EPHA4 EPH receptor A4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:108,664,475...108,818,802
Ensembl chr2B:227,248,958...227,402,790 		JBrowse link
G GSAP gamma-secretase activating protein involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:69,231,374...69,340,215
Ensembl chr 7:83,043,730...83,146,026 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:39,118,330...39,130,768
Ensembl chr19:47,710,197...47,726,948 		JBrowse link
G IFNG interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IFNGR1 interferon gamma receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:134,958,270...134,980,560
Ensembl chr 6:139,045,821...139,068,053 		JBrowse link
G LOC100977072 neuronal acetylcholine receptor subunit alpha-7 involved_in ISO (PMID:20164328) ARUK-UCL PMID:20164328 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194 		JBrowse link
G LRRTM3 leucine rich repeat transmembrane neuronal 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:63,407,003...63,594,210
Ensembl chr10:65,722,425...65,893,608 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr11:61,012,839...61,022,225
Ensembl chr11:64,347,859...64,356,868 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:11,167,353...11,331,339
Ensembl chr2A:11,318,370...11,478,986 		JBrowse link
G SLC2A13 solute carrier family 2 member 13 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:48,609,170...48,948,828
Ensembl chr12:49,469,306...49,803,110 		JBrowse link
G SP1 Sp1 transcription factor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr12:35,338,492...35,374,462
Ensembl chr12:36,127,681...36,158,356 		JBrowse link
G TNF tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:23,729,204...23,878,820
Ensembl chr21:37,137,253...37,231,987 		JBrowse link
G PICALM phosphatidylinositol binding clathrin assembly protein NOT|involved_in ISO (PMID:26005850) ARUK-UCL PMID:26005850 NCBI chr11:81,011,324...81,122,352
Ensembl chr11:84,619,241...84,730,684 		JBrowse link
G TMED10 transmembrane p24 trafficking protein 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:55,683,121...55,728,365
Ensembl chr14:74,526,733...74,572,000 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    regulation of biological process 11474
      regulation of cellular process 11118
        regulation of metabolic process 6552
          regulation of macromolecule metabolic process 6012
            regulation of protein metabolic process 1796
              regulation of amyloid precursor protein catabolic process 45
                negative regulation of amyloid precursor protein catabolic process + 20
                positive regulation of amyloid precursor protein catabolic process + 26
                regulation of amyloid-beta formation + 37
Path 2
Term Annotations click to browse term
  biological_process 19315
    biological regulation 11855
      regulation of biological process 11474
        regulation of cellular process 11118
          regulation of metabolic process 6552
            regulation of primary metabolic process 5127
              regulation of protein metabolic process 1796
                regulation of amyloid precursor protein catabolic process 45
                  negative regulation of amyloid precursor protein catabolic process + 20
                  positive regulation of amyloid precursor protein catabolic process + 26
                  regulation of amyloid-beta formation + 37
paths to the root