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ONTOLOGY REPORT - ANNOTATIONS

Term:neurofibrillary tangle assembly
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Accession:GO:1902988 term browser browse the term
Definition:The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle.
Comment:Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
Synonyms:exact_synonym: neurofibrillary tangle formation
 narrow_synonym: flame-shaped neurofibrillary tangle assembly;   flame-shaped neurofibrillary tangle formation;   star-shaped neurofibrillary tangle assembly;   star-shaped neurofibrillary tangle formation


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negative regulation of neurofibrillary tangle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing involved_in IMP (MGI:5569468|PMID:22986780) Alzheimers_University_of_Toronto PMID:22986780 MGI:5569468 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593 		JBrowse link
positive regulation of neurofibrillary tangle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Clu clusterin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28573
    cellular process 17545
      cellular component organization or biogenesis 6954
        cellular component biogenesis 3427
          cellular component assembly 3135
            inclusion body assembly 31
              neurofibrillary tangle assembly 3
                negative regulation of neurofibrillary tangle assembly 1
                positive regulation of neurofibrillary tangle assembly 2
                regulation of neurofibrillary tangle assembly + 3
paths to the root