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ONTOLOGY REPORT - ANNOTATIONS


Term:neurofibrillary tangle assembly
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Accession:GO:1902988 term browser browse the term
Definition:The aggregation, arrangement and bonding together of a set of components to form a neurofibrillary tangle.
Comment:Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
Synonyms:exact_synonym: neurofibrillary tangle formation
 narrow_synonym: flame-shaped neurofibrillary tangle assembly;   flame-shaped neurofibrillary tangle formation;   star-shaped neurofibrillary tangle assembly;   star-shaped neurofibrillary tangle formation



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negative regulation of neurofibrillary tangle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sorl1 sortilin related receptor 1 involved_in ISO (MGI:5569468|PMID:22986780) RGD PMID:22986780 MGI:5569468 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
positive regulation of neurofibrillary tangle assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:24154541) RGD PMID:24154541 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Clu clusterin involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:15897157)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:15897157 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link

Term paths to the root
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  biological_process 19497
    cellular process 18359
      cellular component organization or biogenesis 6620
        cellular component biogenesis 3380
          cellular component assembly 3088
            inclusion body assembly 27
              neurofibrillary tangle assembly 3
                negative regulation of neurofibrillary tangle assembly 1
                positive regulation of neurofibrillary tangle assembly 2
                regulation of neurofibrillary tangle assembly + 3
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