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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cell cycle G1/S phase transition
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Accession:GO:1902807 term browser browse the term
Definition:Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
Synonyms:exact_synonym: down regulation of cell cycle G1/S phase transition;   downregulation of cell cycle G1/S phase transition
 narrow_synonym: inhibition of cell cycle G1/S phase transition

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negative regulation of cell cycle G1/S phase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1 amyloid beta precursor protein binding family B member 1 involved_in ISO PMID:12089154 UniProt PMID:12089154 RGD:127285400 NCBI chrNW_004936842:452,682...476,533
Ensembl chrNW_004936842:452,681...476,513 		JBrowse link
G Apc APC regulator of WNT signaling pathway involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:6,899,580...7,019,016
Ensembl chrNW_004936531:6,899,788...7,019,453 		JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B ISO RGD PMID:26526028 RGD:11252201 NCBI chrNW_004936652:3,576,975...3,582,790
Ensembl chrNW_004936652:3,538,986...3,581,159 		JBrowse link
G Cdkn2d cyclin dependent kinase inhibitor 2D acts_upstream_of_or_within ISO (PMID:7739547) MGI PMID:7739547 NCBI chrNW_004936659:840,602...843,078 JBrowse link
G Gpr15lg G protein-coupled receptor 15 ligand involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936767:790,152...798,265
Ensembl chrNW_004936767:790,676...798,265 		JBrowse link
G Men1 menin 1 ISO RGD PMID:15054094 RGD:1304318 NCBI chrNW_004936599:4,504,489...4,510,085
Ensembl chrNW_004936599:4,504,397...4,510,555 		JBrowse link
G Mettl13 methyltransferase 13, eEF1A N-terminus and K55 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:15,446,940...15,460,306
Ensembl chrNW_004936481:15,446,809...15,460,306 		JBrowse link
G Pten phosphatase and tensin homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
G Sox2 SRY-box transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936566:1,630,698...1,632,607
Ensembl chrNW_004936566:1,631,822...1,632,613 		JBrowse link
G Susd2 sushi domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:878,737...887,319
Ensembl chrNW_004936619:875,042...887,344 		JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:739,325...754,259
Ensembl chrNW_004936527:739,281...754,331 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936507:10,077,345...10,264,705
Ensembl chrNW_004936507:10,098,171...10,264,716 		JBrowse link
G E2f7 E2F transcription factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936568:5,206,135...5,245,324
Ensembl chrNW_004936568:5,206,135...5,244,450 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:21726810) UniProt PMID:21726810 NCBI chrNW_004936545:6,709,903...6,732,334 JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Pcbp4 poly(rC) binding protein 4 involved_in ISO (PMID:10891498) UniProt PMID:10891498 NCBI chrNW_004936529:3,304,171...3,308,422
Ensembl chrNW_004936529:3,300,712...3,308,288 		JBrowse link
G Pidd1 p53-induced death domain protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936888:565,889...571,273
Ensembl chrNW_004936888:565,912...571,247 		JBrowse link
G Pml PML nuclear body scaffold involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:33,135,186...33,173,218
Ensembl chrNW_004936471:33,135,164...33,177,666 		JBrowse link
G Ppp2r5c protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chrNW_004936835:54,478...192,486
Ensembl chrNW_004936835:96,930...192,756 		JBrowse link
G Prap1 proline rich acidic protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:19,477,278...19,480,387
Ensembl chrNW_004936486:19,477,453...19,480,297 		JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (PMID:17050675) UniProt PMID:17050675 NCBI chrNW_004936530:227,266...249,285 JBrowse link
G Rpl26 ribosomal protein L26 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:1,603,913...1,609,125
Ensembl chrNW_004936595:1,603,413...1,609,132 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16107883) Ensembl
MGI		 PMID:16107883 GO_REF:0000107 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
mitotic G1 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 involved_in IEA Ensembl GO_REF:0000107 Ensembl chrNW_004936599:973,838...983,316 JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISO (PMID:16286473) UniProt PMID:16286473 NCBI chrNW_004936562:2,690,907...2,733,455
Ensembl chrNW_004936562:2,690,858...2,733,620 		JBrowse link
G Fbxo31 F-box protein 31 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:1,801,539...1,831,988
Ensembl chrNW_004936641:1,801,548...1,830,440 		JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19744960) Ensembl
MGI		 PMID:19744960 GO_REF:0000107 NCBI chrNW_004936525:4,301,003...4,432,125
Ensembl chrNW_004936525:4,304,629...4,403,089 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936590:4,722,914...4,887,615
Ensembl chrNW_004936590:4,722,873...4,890,156 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:23,544,974...23,586,716
Ensembl chrNW_004936475:23,544,953...23,586,740 		JBrowse link
G Rpa2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:12,127,026...12,147,120
Ensembl chrNW_004936474:12,126,245...12,147,130 		JBrowse link
G Rps27l ribosomal protein S27 like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:23,738,896...23,742,355
Ensembl chrNW_004936471:23,738,823...23,745,382 		JBrowse link
G Sde2 SDE2 telomere maintenance homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936526:2,763,243...2,779,506
Ensembl chrNW_004936526:2,760,639...2,779,657 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16107883) Ensembl
MGI		 PMID:16107883 GO_REF:0000107 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Trex1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23993650)
(PMID:18045533)		 Ensembl
MGI		 PMID:18045533 PMID:23993650 GO_REF:0000107 NCBI chrNW_004936529:264,535...266,451
Ensembl chrNW_004936529:264,468...266,422 		JBrowse link
G Wac WW domain containing adaptor with coiled-coil involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936613:2,793,706...2,862,984
Ensembl chrNW_004936613:2,794,732...2,865,913 		JBrowse link
mitotic G1/S transition checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo like kinase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936474:26,026,878...26,032,098
Ensembl chrNW_004936474:26,026,842...26,032,218 		JBrowse link
G Plk5 polo like kinase 5 (inactive) involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936588:826,473...838,818 JBrowse link
negative regulation of G1/S transition of mitotic cell cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936469:20,743,195...20,811,567
Ensembl chrNW_004936469:20,743,213...20,811,569 		JBrowse link
G Apc APC regulator of WNT signaling pathway involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936531:6,899,580...7,019,016
Ensembl chrNW_004936531:6,899,788...7,019,453 		JBrowse link
G Bcl2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12855558), (PMID:14660795)
(PMID:14660795)		 Ensembl
MGI		 PMID:12855558 PMID:14660795 GO_REF:0000107 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
G Brd7 bromodomain containing 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:3,394,423...3,432,998
Ensembl chrNW_004936475:3,393,373...3,433,103 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 ISO RGD PMID:28587927 RGD:13515054 NCBI chrNW_004936469:25,494,820...25,745,783
Ensembl chrNW_004936469:25,494,883...25,740,223 		JBrowse link
G Cdc73 cell division cycle 73 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936638:1,365,457...1,482,497
Ensembl chrNW_004936638:1,365,648...1,483,277 		JBrowse link
G Cdk2ap2 cyclin dependent kinase 2 associated protein 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936599:2,257,731...2,259,883
Ensembl chrNW_004936599:2,257,671...2,259,886 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21628527) MGI
Ensembl		 PMID:21628527 GO_REF:0000107 NCBI chrNW_004936476:22,717,308...22,725,127
Ensembl chrNW_004936476:22,717,260...22,725,182 		JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B acts_upstream_of_or_within ISO (PMID:23154982) MGI PMID:23154982 NCBI chrNW_004936652:3,576,975...3,582,790
Ensembl chrNW_004936652:3,538,986...3,581,159 		JBrowse link
G Crlf3 cytokine receptor like factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:2,877,564...2,916,952
Ensembl chrNW_004936538:2,877,564...2,916,925 		JBrowse link
G Ctdsp1 CTD small phosphatase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22210897) Ensembl
MGI		 PMID:22210897 GO_REF:0000107 NCBI chrNW_004936569:901,357...905,149
Ensembl chrNW_004936569:900,439...903,622 		JBrowse link
G Ctdsp2 CTD small phosphatase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22210897) Ensembl
MGI		 PMID:22210897 GO_REF:0000107 NCBI chrNW_004936646:1,952,123...1,977,279
Ensembl chrNW_004936646:1,952,123...1,977,337 		JBrowse link
G Ctdspl CTD small phosphatase like involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22210897) Ensembl
MGI		 PMID:22210897 GO_REF:0000107 NCBI chrNW_004936473:27,228,512...27,340,483
Ensembl chrNW_004936473:27,228,036...27,340,483 		JBrowse link
G Dact1 dishevelled binding antagonist of beta catenin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:3,017,029...3,026,759
Ensembl chrNW_004936495:3,017,150...3,025,684 		JBrowse link
G Dcun1d3 defective in cullin neddylation 1 domain containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:6,134,221...6,168,641
Ensembl chrNW_004936501:6,131,401...6,168,667 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936833:551,989...843,064
Ensembl chrNW_004936833:551,799...844,121 		JBrowse link
G E2f7 E2F transcription factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936568:5,206,135...5,245,324
Ensembl chrNW_004936568:5,206,135...5,244,450 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19303854) Ensembl
MGI		 PMID:19303854 GO_REF:0000107 NCBI chrNW_004936527:5,024,077...5,069,152
Ensembl chrNW_004936527:5,024,068...5,063,939 		JBrowse link
G Fam107a family with sequence similarity 107 member A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:2,438,995...2,483,746
Ensembl chrNW_004936473:2,438,626...2,484,071 		JBrowse link
G Fbxo7 F-box protein 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21652635) Ensembl
MGI		 PMID:21652635 GO_REF:0000107 NCBI chrNW_004936492:7,261,442...7,276,779
Ensembl chrNW_004936492:7,261,009...7,276,943 		JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:21702045) UniProt PMID:21702045 NCBI chrNW_004936513:11,025,753...11,064,312
Ensembl chrNW_004936513:11,025,715...11,064,312 		JBrowse link
G Gjc2 gap junction protein gamma 2 ISO RGD PMID:28278052 RGD:13208599 NCBI chrNW_004936864:67,608...71,543
Ensembl chrNW_004936864:69,445...70,752 		JBrowse link
G Gpnmb glycoprotein nmb involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:397,200...425,663
Ensembl chrNW_004936478:397,145...424,801 		JBrowse link
G Haspin histone H3 associated protein kinase acts_upstream_of_or_within ISO (PMID:10358056) MGI PMID:10358056 NCBI chrNW_004936677:401,198...404,472
Ensembl chrNW_004936677:401,395...403,713 		JBrowse link
G Inhba inhibin subunit beta A involved_in ISO (PMID:9884026) HGNC-UCL PMID:9884026 NCBI chrNW_004936478:16,878,725...16,884,065 JBrowse link
G Jade1 jade family PHD finger 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23001567) MGI
Ensembl		 PMID:23001567 GO_REF:0000107 NCBI chrNW_004936642:2,154,662...2,207,186
Ensembl chrNW_004936642:2,157,543...2,207,146 		JBrowse link
G Kank2 KN motif and ankyrin repeat domains 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936659:1,320,169...1,340,137
Ensembl chrNW_004936659:1,321,980...1,337,746 		JBrowse link
G Klf4 KLF transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936559:5,105,456...5,109,970
Ensembl chrNW_004936559:5,105,463...5,109,970 		JBrowse link
G LOC101960905 butyrophilin subfamily 2 member A2-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936671:2,149,443...2,157,518
Ensembl chrNW_004936671:2,149,361...2,157,536 		JBrowse link
G LOC101961779 zinc finger protein 655 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936750:1,833,141...1,853,192
Ensembl chrNW_004936750:1,833,153...1,853,640 		JBrowse link
G LOC101977127 cyclin-dependent kinase inhibitor 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936652:3,539,004...3,545,321 JBrowse link
G LOC101978198 protein Jade-1-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:12,066,761...12,069,438 JBrowse link
G Myo16 myosin XVI involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936472:3,157,508...3,548,164
Ensembl chrNW_004936472:3,212,773...3,574,114 		JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel acts_upstream_of ISO (PMID:16311606) BHF-UCL PMID:16311606 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Ppp2r3b protein phosphatase 2 regulatory subunit B''beta acts_upstream_of_or_within ISO (PMID:9927208) MGI PMID:9927208 NCBI chrNW_004936644:4,187,961...4,207,779 JBrowse link
G Prmt2 protein arginine methyltransferase 2 involved_in ISO (MGI:3653799|PMID:16616919) UniProt PMID:16616919 MGI:3653799 NCBI chrNW_004936778:12,988...31,217
Ensembl chrNW_004936778:12,967...29,077 		JBrowse link
G Pten phosphatase and tensin homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7958874) Ensembl
MGI
TreeGrafter		 PMID:7958874 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936565:1,596,227...1,746,706
Ensembl chrNW_004936565:1,597,593...1,746,846 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936561:4,108,393...4,157,993
Ensembl chrNW_004936561:4,107,861...4,157,647 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936475:6,087,055...6,140,012
Ensembl chrNW_004936475:6,086,584...6,144,067 		JBrowse link
G Zc3h12d zinc finger CCCH-type containing 12D involved_in ISO (PMID:19531561) UniProt PMID:19531561 NCBI chrNW_004936489:2,454,889...2,472,392
Ensembl chrNW_004936489:2,455,728...2,472,328 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15871
    cellular process 15001
      cell cycle process 1233
        negative regulation of cell cycle process 282
          negative regulation of cell cycle phase transition 234
            negative regulation of cell cycle G1/S phase transition 73
              negative regulation of G1/S transition of mitotic cell cycle + 66
Path 2
Term Annotations click to browse term
  biological_process 15871
    biological regulation 11036
      regulation of biological process 10703
        negative regulation of biological process 5108
          negative regulation of cellular process 4787
            negative regulation of cell cycle 349
              negative regulation of cell cycle process 282
                negative regulation of cell cycle phase transition 234
                  negative regulation of cell cycle G1/S phase transition 73
                    negative regulation of G1/S transition of mitotic cell cycle + 66
paths to the root