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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cell cycle G2/M phase transition
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Accession:GO:1902750 term browser browse the term
Definition:Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the cell cycle.
Synonyms:exact_synonym: down regulation of cell cycle G2/M phase transition;   downregulation of cell cycle G2/M phase transition
 narrow_synonym: inhibition of cell cycle G2/M phase transition


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negative regulation of cell cycle G2/M phase transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf5 activating transcription factor 5 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:22528486)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22528486 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Macroh2a1 macroH2A.1 histone involved_in ISO (PMID:22194607) RGD PMID:22194607 NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072
JBrowse link
mitotic cytokinesis checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Chmp4c charged multivesicular body protein 4C involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:22422861), (PMID:24814515)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22422861 PMID:24814515 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668
JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A involved_in ISS
ISO
GO_REF:0000024
(PMID:24814515)
UniProt
RGD
PMID:24814515 GO_REF:0000024 NCBI chr19:34,934,999...34,948,267
Ensembl chr19:34,934,961...34,948,887
JBrowse link
G Zfyve19 zinc finger FYVE-type containing 19 involved_in ISO
IBA
(PMID:24814515)
PMID:21873635
RGD PMID:24814515 PMID:21873635 RGD:13792537 NCBI chr 3:106,195,779...106,203,969
Ensembl chr 3:106,195,899...106,203,969
JBrowse link
mitotic DNA replication checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Cdc6 cell division cycle 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011
JBrowse link
G Clspn claspin involved_in ISO
IBA
(PMID:16885022)
PMID:21873635
RGD PMID:16885022 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Hus1 HUS1 checkpoint clamp component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:83,688,702...83,703,466
Ensembl chr14:83,688,708...83,703,442
JBrowse link
G LOC103690165 checkpoint protein HUS1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Nae1 NEDD8 activating enzyme E1 subunit 1 involved_in ISO
IEA
(PMID:10722740)
GO_REF:0000107
RGD
Ensembl
PMID:10722740 GO_REF:0000107 NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
JBrowse link
G Orc1 origin recognition complex, subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:31,764,260...31,794,542
Ensembl chr 2:31,764,261...31,794,072
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Zfp830 zinc finger protein 830 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:4950701|PMID:21191184)
PMID:21873635
UniProt
RGD
PMID:21191184 PMID:21873635 GO_REF:0000024 MGI:4950701, RGD:13792537 NCBI chr10:67,701,340...67,702,804
Ensembl chr10:67,701,073...67,704,523
JBrowse link
mitotic G2 DNA damage checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Abraxas1 abraxas 1, BRCA1 A complex subunit involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622
JBrowse link
G Atm ATM serine/threonine kinase involved_in ISO (PMID:15149599) RGD PMID:15149599 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Babam1 BRISC and BRCA1 A complex member 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:19261746), (PMID:19261748), (PMID:19261749)
UniProt
RGD
PMID:19261746 PMID:19261748 PMID:19261749 GO_REF:0000024 NCBI chr16:18,068,830...18,074,938
Ensembl chr16:18,068,884...18,074,923
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19261748)
UniProt
RGD
PMID:19261748 GO_REF:0000024 NCBI chr 6:24,369,021...24,833,335
Ensembl chr 6:24,369,022...24,833,951
JBrowse link
G Blm BLM RecQ like helicase involved_in ISO (PMID:11309417) RGD PMID:11309417 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Brca1 BRCA1, DNA repair associated involved_in ISO
IEA
(PMID:17525340), (PMID:17643121), (PMID:19261748)
GO_REF:0000107
RGD
Ensembl
PMID:17525340 PMID:17643121 PMID:19261748 GO_REF:0000107 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brcc3 BRCA1/BRCA2-containing complex, subunit 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:17525341), (PMID:19261746), (PMID:19261748)
UniProt
RGD
PMID:17525341 PMID:19261746 PMID:19261748 GO_REF:0000024 NCBI chr 9:1,986,942...1,989,484
Ensembl chr 9:1,986,575...1,991,080
JBrowse link
G Brsk1 BR serine/threonine kinase 1 involved_in ISO (PMID:15150265) RGD PMID:15150265 NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365
JBrowse link
G Brsk2 BR serine/threonine kinase 2 involved_in ISS PMID:15150265 UniProt PMID:15150265 RGD:8554801 NCBI chr 1:197,035,522...197,088,624
Ensembl chr 1:197,035,633...197,088,092
JBrowse link
G Ccng1 cyclin G1 IMP RGD PMID:9464250 RGD:2316029 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdc14b cell division cycle 14B involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr17:844,731...934,787
Ensembl chr17:844,685...933,235
JBrowse link
G Cdk1 cyclin-dependent kinase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:2679752|PMID:12937170)
RGD PMID:12937170 PMID:21873635 MGI:2679752, RGD:13792537 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
IEA
ISS
(PMID:15790566)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15790566 GO_REF:0000024 GO_REF:0000107 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A involved_in ISO (PMID:23213251) RGD PMID:23213251 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO (PMID:20932473) RGD PMID:20932473 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Clspn claspin involved_in ISO
IBA
(PMID:18662541)
PMID:21873635
RGD PMID:18662541 PMID:21873635 RGD:13792537 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Donson DNA replication fork stabilization factor DONSON involved_in ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:30,911,616...30,933,150
Ensembl chr11:30,923,239...30,932,889
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog involved_in ISO (PMID:17085480) RGD PMID:17085480 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Foxn3 forkhead box N3 involved_in ISO UniProtKB:P38111 (PMID:9154802) RGD PMID:9154802 NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401
JBrowse link
G Foxo4 forkhead box O4 acts_upstream_of_or_within ISO (MGI:2183145|PMID:12048180) RGD PMID:12048180 MGI:2183145 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 involved_in ISO (PMID:18662541) RGD PMID:18662541 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952
JBrowse link
G Hmga2 high mobility group AT-hook 2 involved_in ISO
ISS
(PMID:16061642)
GO_REF:0000024
RGD
UniProt
PMID:16061642 GO_REF:0000024 NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO MGI:3773690 (MGI:5432078|PMID:20467439) RGD PMID:20467439 MGI:5432078 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G LOC100302465 hypothetical LOC100302465 involved_in ISO (MGI:4455105|PMID:20154723) RGD PMID:20154723 MGI:4455105 NCBI chr 1:189,059,744...189,293,353
Ensembl chr 1:189,059,746...189,293,435
JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase acts_upstream_of_or_within ISO MGI:2684310 (MGI:2682526|PMID:14614141) RGD PMID:14614141 MGI:2682526 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:3027036 (MGI:2683367|PMID:14690604)
PMID:21873635
Ensembl
RGD
PMID:14690604 PMID:21873635 GO_REF:0000107 MGI:2683367, RGD:13792537 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Mrnip MRN complex interacting protein involved_in ISO (PMID:27568553) RGD PMID:27568553 NCBI chr10:34,501,359...34,525,474
Ensembl chr10:34,501,384...34,525,469
JBrowse link
G Nbn nibrin involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
ISS
PMID:21873635
MGI:2183796 (MGI:3805397|PMID:18614044)
GO_REF:0000107
GO_REF:0000024
(PMID:11438675)
RGD
Ensembl
UniProt
PMID:11438675 PMID:18614044 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:3805397, RGD:13792537 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:21741933) RGD PMID:21741933 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902
JBrowse link
G Plk1 polo-like kinase 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:18662541)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18662541 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Rint1 RAD50 interactor 1 involved_in ISO (PMID:11096100) RGD PMID:11096100 NCBI chr 4:11,319,416...11,355,773
Ensembl chr 4:11,320,955...11,355,736
JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor acts_upstream_of_or_within ISO MGI:3904866 (MGI:5435138|PMID:22448250) RGD PMID:22448250 MGI:5435138 NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414
JBrowse link
G Taok1 TAO kinase 1 involved_in ISO
IEA
ISS
(PMID:17396146)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,373,076...62,465,295
Ensembl chr10:62,381,404...62,465,766
JBrowse link
G Taok2 TAO kinase 2 involved_in ISO
IEA
ISS
(PMID:17396146)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
JBrowse link
G Taok3 TAO kinase 3 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17396146)
Ensembl
UniProt
RGD
PMID:17396146 GO_REF:0000024 GO_REF:0000107 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:133,597,618...133,639,513
Ensembl chr 1:133,597,716...133,639,523
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Trim39 tripartite motif-containing 39 involved_in ISO
ISS
(PMID:23213251)
GO_REF:0000024
RGD
UniProt
PMID:23213251 GO_REF:0000024 NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117
JBrowse link
G Uimc1 ubiquitin interaction motif containing 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:17525340), (PMID:17525341), (PMID:17525342), (PMID:17643121), (PMID:19261748)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17525340 PMID:17525341 PMID:17525342 PMID:17643121 PMID:19261748 GO_REF:0000024 GO_REF:0000107 NCBI chr17:9,523,793...9,592,810
Ensembl chr17:9,527,794...9,592,799
JBrowse link
mitotic G2/M transition checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated acts_upstream_of_or_within ISO (MGI:3052267|PMID:15254237) RGD PMID:15254237 MGI:3052267 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 involved_in ISO
ISS
(PMID:19223857)
GO_REF:0000024
RGD
UniProt
PMID:19223857 GO_REF:0000024 NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
JBrowse link
G Chek1 checkpoint kinase 1 involved_in ISO
ISS
(PMID:33108758)
GO_REF:0000024
RGD
UniProt
PMID:33108758 GO_REF:0000024 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chfr checkpoint with forkhead and ring finger domains involved_in ISS
ISO
GO_REF:0000024
(PMID:18172500), (PMID:19182791)
UniProt
RGD
PMID:18172500 PMID:19182791 GO_REF:0000024 NCBI chr12:46,504,497...46,538,104
Ensembl chr12:46,504,497...46,538,014
JBrowse link
G Ints3 integrator complex subunit 3 involved_in ISO (PMID:19683501) RGD PMID:19683501 NCBI chr 2:175,859,421...175,911,683
Ensembl chr 2:175,859,440...175,911,709
JBrowse link
G Nabp1 nucleic acid binding protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:19683501)
UniProt
RGD
PMID:19683501 GO_REF:0000024 NCBI chr 9:50,098,552...50,133,982
Ensembl chr 9:50,126,726...50,134,107
JBrowse link
G Nabp2 nucleic acid binding protein 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:19683501)
UniProt
RGD
PMID:19683501 GO_REF:0000024 NCBI chr 7:830,949...836,551
Ensembl chr 7:830,949...838,027
JBrowse link
G Pabir1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 involved_in ISO
ISS
(PMID:33108758)
GO_REF:0000024
RGD
UniProt
PMID:33108758 GO_REF:0000024 NCBI chr 1:222,114,988...222,116,294
Ensembl chr 1:222,112,591...222,116,396
JBrowse link
negative regulation of G2/M transition of mitotic cell cycle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aven apoptosis and caspase activation inhibitor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634
JBrowse link
G Chek1 checkpoint kinase 1 IMP RGD PMID:11278490 RGD:2316109 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:21702045) RGD PMID:21702045 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Gpr132 G protein-coupled receptor 132 involved_in IBA
ISO
PMID:21873635
(MGI:1890145|PMID:9770487)
RGD PMID:9770487 PMID:21873635 MGI:1890145, RGD:13792537 NCBI chr 6:131,924,061...131,943,327
Ensembl chr 6:131,924,160...131,942,168
JBrowse link
G Miip migration and invasion inhibitory protein involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:158,292,510...158,299,531
Ensembl chr 5:158,292,511...158,299,694
JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 involved_in ISO (PMID:11701125) RGD PMID:11701125 NCBI chr15:38,098,027...38,157,143
Ensembl chr15:38,097,886...38,157,140
JBrowse link
G Rad21 RAD21 cohesin complex component involved_in ISO (MGI:1340883|PMID:10375619) RGD PMID:10375619 MGI:1340883 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Usp47 ubiquitin specific peptidase 47 involved_in ISO (PMID:19966869) RGD PMID:19966869 NCBI chr 1:166,152,104...166,235,312
Ensembl chr 1:166,152,199...166,235,312
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      cell cycle process 1175
        negative regulation of cell cycle process 280
          negative regulation of cell cycle phase transition 236
            negative regulation of cell cycle G2/M phase transition 65
              negative regulation of G2/M transition of mitotic cell cycle + 63
              negative regulation of G2/MI transition of meiotic cell cycle + 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        negative regulation of biological process 5613
          negative regulation of cellular process 5061
            negative regulation of cell cycle 364
              negative regulation of cell cycle process 280
                negative regulation of cell cycle phase transition 236
                  negative regulation of cell cycle G2/M phase transition 65
                    negative regulation of G2/M transition of mitotic cell cycle + 63
                    negative regulation of G2/MI transition of meiotic cell cycle + 0
paths to the root