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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial outer membrane permeabilization involved in programmed cell death
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Accession:GO:1902686 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
Synonyms:exact_synonym: mitochondrial outer membrane permeabilization during programmed cell death;   mitochondrion outer membrane permeabilization involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in PCD;   positive regulation of mitochondrial membrane permeability involved in programmed cell death;   positive regulation of transport across mitochondrial membrane involved in PCD;   positive regulation of transport across mitochondrial membrane involved in programmed cell death
 narrow_synonym: MPT involved in PCD;   MPT involved in caspase-independent cell death;   MPT involved in non-apoptotic programmed cell death;   MPT involved in nonapoptotic programmed cell death;   MPT involved in programmed cell death;   mitochondrial membrane permeability transition involved in PCD;   mitochondrial membrane permeability transition involved in caspase-independent cell death;   mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death;   mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death;   mitochondrial membrane permeability transition involved in programmed cell death;   mitochondrial membrane permeabilization involved in PCD;   mitochondrial membrane permeabilization involved in caspase-independent cell death;   mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death;   mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death;   mitochondrial membrane permeabilization involved in programmed cell death;   mitochondrial permeability transition involved in PCD;   mitochondrial permeability transition involved in caspase-independent cell death;   mitochondrial permeability transition involved in non-apoptotic programmed cell death;   mitochondrial permeability transition involved in nonapoptotic programmed cell death;   mitochondrial permeability transition involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death;   positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death;   positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death;   positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death
 related_synonym: MPT involved in caspase-independent apoptosis;   MPT involved in regulated cell death;   mitochondrial membrane permeability transition involved in caspase-independent apoptosis;   mitochondrial membrane permeability transition involved in regulated cell death;   mitochondrial membrane permeabilization involved in caspase-independent apoptosis;   mitochondrial membrane permeabilization involved in regulated cell death;   mitochondrial permeability transition involved in caspase-independent apoptosis;   mitochondrial permeability transition involved in regulated cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis;   positive regulation of mitochondrial membrane permeability involved in regulated cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis;   positive regulation of transport across mitochondrial membrane involved in regulated cell death


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mitochondrial outer membrane permeabilization involved in programmed cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppif peptidylprolyl isomerase F involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:404,574...411,381 JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936641:451,762...484,229 JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:5566519|PMID:20436477) MGI
Ensembl
PMID:20436477 GO_REF:0000107 MGI:5566519 NCBI chrNW_004936807:708,340...750,127 JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in ISO (PMID:18188704) UniProt PMID:18188704 NCBI chrNW_004939661:2,128...6,384 JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:18,449,371...18,460,435 JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2158099|PMID:11700312) MGI
Ensembl
PMID:11700312 GO_REF:0000107 MGI:2158099 NCBI chrNW_004936514:6,223,745...6,401,985 JBrowse link
G Rhot1 ras homolog family member T1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:2,658,225...2,725,889 JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004936501:336,506...341,671 JBrowse link
G Rtl10 retrotransposon Gag like 10 involved_in ISO (PMID:23055042) UniProt PMID:23055042 NCBI chrNW_004936619:3,755,537...3,760,909 JBrowse link
G Vdac2 voltage dependent anion channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:4,122,447...4,136,228 JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,242,644...13,269,007 JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,347,608...25,354,772 JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO (PMID:9393856)
(PMID:15901672), (PMID:9393856)
ComplexPortal PMID:9393856 PMID:15901672 NCBI chrNW_004936485:18,654,046...18,707,324 JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936745:344,837...350,950 JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3047441|PMID:15288121) MGI
Ensembl
PMID:15288121 GO_REF:0000107 MGI:3047441 NCBI chrNW_004936476:7,371,270...7,418,756 JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (MGI:4437986|PMID:19096392) MGI PMID:19096392 MGI:4437986 NCBI chrNW_004936837:401,475...402,769 JBrowse link
G LOC101955831 heat shock 70 kDa protein 1 involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chrNW_004936727:1,718,952...1,721,691 JBrowse link
G LOC101956126 heat shock 70 kDa protein 1 involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:3,017,071...3,028,294 JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in ISO (PMID:19154410) UniProt PMID:19154410 NCBI chrNW_004936479:10,432,172...10,435,154 JBrowse link
G Slc35f6 solute carrier family 35 member F6 involved_in IEA UniProt
Ensembl
GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936493:5,731,106...5,747,270 JBrowse link
G Tmem14a transmembrane protein 14A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:8,179,949...8,198,204 JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:4,729,984...4,826,367 JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3581932|PMID:15967824) MGI
Ensembl
PMID:15967824 GO_REF:0000107 MGI:3581932 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2l11 BCL2 like 11 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3581932|PMID:15967824) Ensembl
MGI
PMID:15967824 GO_REF:0000107 MGI:3581932 NCBI chrNW_004936783:15,493...50,959 JBrowse link
G Stpg1 sperm tail PG-rich repeat containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:9,358,114...9,398,379 JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:4437986|PMID:19096392) MGI
Ensembl
PMID:19096392 GO_REF:0000107 MGI:4437986 NCBI chrNW_004936474:12,396,416...12,399,760 JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936745:344,837...350,950 JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:1,323,247...1,325,520 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:266,462...277,256 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chrNW_004936536:6,730,070...6,893,818 JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:1,778,862...1,804,071 JBrowse link
G Siva1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012 NCBI chrNW_004936621:641,456...650,067 JBrowse link
G Znf205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936694:1,072,633...1,084,923 JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 BCL2 binding component 3 involved_in
acts_upstream_of_or_within
ISO (PMID:17024184)
(MGI:3804133|PMID:16705087)
UniProt
MGI
PMID:16705087 PMID:17024184 MGI:3804133 NCBI chrNW_004936664:962,115...966,797 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO (MGI:2675761|PMID:12952892) MGI PMID:12952892 MGI:2675761 NCBI chrNW_004936497:4,985,995...4,986,720 JBrowse link
G Sh3glb1 SH3 domain containing GRB2 like, endophilin B1 acts_upstream_of_or_within ISO (MGI:3607027|PMID:16227588) MGI PMID:16227588 MGI:3607027 NCBI chrNW_004936732:2,066,848...2,097,947 JBrowse link
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:2675761|PMID:12952892) MGI
Ensembl
PMID:12952892 GO_REF:0000107 MGI:2675761 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bbc3 BCL2 binding component 3 acts_upstream_of ISO (MGI:3804133|PMID:16705087) MGI PMID:16705087 MGI:3804133 NCBI chrNW_004936664:962,115...966,797 JBrowse link
G Moap1 modulator of apoptosis 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936733:1,111,256...1,113,651 JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:6,479,640...6,486,080 JBrowse link
G Tmem102 transmembrane protein 102 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:718,513...720,553 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14983
    cellular process 13972
      cell death 1940
        programmed cell death 1761
          mitochondrial outer membrane permeabilization involved in programmed cell death 39
            positive regulation of mitochondrial membrane permeability involved in apoptotic process + 37
Path 2
Term Annotations click to browse term
  biological_process 14983
    cellular process 13972
      cellular component organization or biogenesis 5507
        cellular component organization 5370
          organelle organization 2991
            mitochondrion organization 496
              mitochondrial membrane organization 101
                regulation of mitochondrial membrane permeability 57
                  positive regulation of mitochondrial membrane permeability 43
                    mitochondrial outer membrane permeabilization involved in programmed cell death 39
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process + 37
paths to the root