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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial outer membrane permeabilization involved in programmed cell death
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Accession:GO:1902686 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
Synonyms:exact_synonym: mitochondrial outer membrane permeabilization during programmed cell death;   mitochondrion outer membrane permeabilization involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in PCD;   positive regulation of mitochondrial membrane permeability involved in programmed cell death;   positive regulation of transport across mitochondrial membrane involved in PCD;   positive regulation of transport across mitochondrial membrane involved in programmed cell death
 narrow_synonym: MPT involved in PCD;   MPT involved in caspase-independent cell death;   MPT involved in non-apoptotic programmed cell death;   MPT involved in nonapoptotic programmed cell death;   MPT involved in programmed cell death;   mitochondrial membrane permeability transition involved in PCD;   mitochondrial membrane permeability transition involved in caspase-independent cell death;   mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death;   mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death;   mitochondrial membrane permeability transition involved in programmed cell death;   mitochondrial membrane permeabilization involved in PCD;   mitochondrial membrane permeabilization involved in caspase-independent cell death;   mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death;   mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death;   mitochondrial membrane permeabilization involved in programmed cell death;   mitochondrial permeability transition involved in PCD;   mitochondrial permeability transition involved in caspase-independent cell death;   mitochondrial permeability transition involved in non-apoptotic programmed cell death;   mitochondrial permeability transition involved in nonapoptotic programmed cell death;   mitochondrial permeability transition involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death;   positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death;   positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death;   positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death
 related_synonym: MPT involved in caspase-independent apoptosis;   MPT involved in regulated cell death;   mitochondrial membrane permeability transition involved in caspase-independent apoptosis;   mitochondrial membrane permeability transition involved in regulated cell death;   mitochondrial membrane permeabilization involved in caspase-independent apoptosis;   mitochondrial membrane permeabilization involved in regulated cell death;   mitochondrial permeability transition involved in caspase-independent apoptosis;   mitochondrial permeability transition involved in regulated cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis;   positive regulation of mitochondrial membrane permeability involved in regulated cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis;   positive regulation of transport across mitochondrial membrane involved in regulated cell death



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mitochondrial outer membrane permeabilization involved in programmed cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppif peptidylprolyl isomerase F (cyclophilin F) involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892
JBrowse link
G Spg7 SPG7, paraplegin matrix AAA peptidase subunit involved_in ISO MGI GO_REF:0000096 MGI:4417868 MGI:4834177 NCBI chr 8:123,792,247...123,824,499
Ensembl chr 8:123,789,681...123,824,499
JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within IGI (MGI:5566519|PMID:20436477) MGI PMID:20436477 MGI:5566519 NCBI chr 6:120,870,080...120,894,074
Ensembl chr 6:120,868,891...120,893,814
JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex-1, subunit 2 involved_in ISO
ISS
(MGI:5514134|PMID:18188704) MGI
UniProt
PMID:18188704 GO_REF:0000096 MGI:4834177 MGI:5514134 NCBI chr19:44,127,685...44,134,909
Ensembl chr19:44,127,685...44,134,885
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within IDA (MGI:2158099|PMID:11700312) MGI PMID:11700312 MGI:2158099 NCBI chr 2:165,436,892...165,613,647
Ensembl chr 2:165,436,952...165,613,647
JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:80,099,844...80,158,733
Ensembl chr11:80,099,845...80,158,733
JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:26,057,431...26,063,499
Ensembl chr17:26,057,431...26,063,825
JBrowse link
G Vdac2 voltage-dependent anion channel 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr14:21,881,629...21,895,947
Ensembl chr14:21,875,306...21,895,947
JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr18:74,912,283...74,939,278
Ensembl chr18:74,912,268...74,939,279
JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bcl2l1 BCL2-like 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:152,600,652...152,675,723
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Bok BCL2-related ovarian killer involved_in IMP (MGI:5796062|PMID:27098698) UniProt PMID:27098698 MGI:5796062 NCBI chr 1:93,613,297...93,623,492
Ensembl chr 1:93,613,382...93,623,486
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within IGI (MGI:3047441|PMID:15288121) MGI PMID:15288121 MGI:3047441 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767
JBrowse link
G Hspa1a heat shock protein 1A involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
JBrowse link
G Hspa1b heat shock protein 1B involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within IDA (MGI:4437986|PMID:19096392) MGI PMID:19096392 MGI:4437986 NCBI chr17:36,132,605...36,133,803
Ensembl chr17:36,132,576...36,133,815
JBrowse link
G Mpv17l Mpv17 transgene, kidney disease mutant-like involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr16:13,721,025...13,767,483
Ensembl chr16:13,721,025...13,767,483
JBrowse link
G Slc25a31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 3:40,663,301...40,680,525
Ensembl chr 3:40,663,285...40,680,527
JBrowse link
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 involved_in IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321
JBrowse link
G Slc25a5 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 involved_in ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr  X:36,059,250...36,062,461
Ensembl chr  X:36,059,304...36,062,460
JBrowse link
G Slc35f6 solute carrier family 35, member F6 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:30,805,272...30,817,073
Ensembl chr 5:30,805,277...30,817,073
JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 1:21,236,609...21,300,391
Ensembl chr 1:21,288,799...21,300,391
JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983
JBrowse link
G Bax BCL2-associated X protein acts_upstream_of_or_within IGI (MGI:3581932|PMID:15967824) MGI PMID:15967824 MGI:3581932 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bcl2l11 BCL2-like 11 (apoptosis facilitator) acts_upstream_of_or_within IGI (MGI:3581932|PMID:15967824) MGI PMID:15967824 MGI:3581932 NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467
JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:20041405) BHF-UCL PMID:20041405 NCBI chr 6:31,039,595...31,039,682
Ensembl chr 6:31,039,595...31,039,682
JBrowse link
G Mir29b-1 microRNA 29b-1 involved_in ISO (PMID:20041405) BHF-UCL PMID:20041405 NCBI chr 6:31,039,958...31,040,028
Ensembl chr 6:31,039,958...31,040,028
JBrowse link
G Mir29b-2 microRNA 29b-2 involved_in ISO (PMID:20041405) BHF-UCL PMID:20041405 NCBI chr 1:194,719,348...194,719,428
Ensembl chr 1:194,719,348...194,719,428
JBrowse link
G Mir29c microRNA 29c involved_in ISO (PMID:20041405) BHF-UCL PMID:20041405 NCBI chr 1:194,719,855...194,719,942
Ensembl chr 1:194,719,855...194,719,942
JBrowse link
G Stpg1 sperm tail PG rich repeat containing 1 involved_in IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096 MGI:4834177 MGI:6201960 NCBI chr 4:135,221,982...135,265,114
Ensembl chr 4:135,222,101...135,265,114
JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atpif1 ATPase inhibitory factor 1 acts_upstream_of_or_within IMP (MGI:4437986|PMID:19096392) MGI PMID:19096392 MGI:4437986 NCBI chr 4:132,257,866...132,262,784
Ensembl chr 4:132,257,866...132,260,970
JBrowse link
G Bak1 BCL2-antagonist/killer 1 involved_in IC (MGI:6225541|PMID:27488021) ComplexPortal PMID:27488021 MGI:6225541 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983
JBrowse link
G Bok BCL2-related ovarian killer involved_in IDA (MGI:5796067|PMID:26949185) UniProt PMID:26949185 MGI:5796067 NCBI chr 1:93,613,297...93,623,492
Ensembl chr 1:93,613,382...93,623,486
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr10:75,768,964...75,773,584
Ensembl chr10:75,768,964...75,773,581
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IDA (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in IDA (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 5:124,111,665...124,141,278
Ensembl chr 5:124,111,691...124,143,621
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr12:112,611,262...112,615,586
Ensembl chr12:112,611,113...112,615,583
JBrowse link
G Zfp13 zinc finger protein 13 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr17:23,788,820...23,818,729
Ensembl chr17:23,794,818...23,818,461
JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 BCL2 binding component 3 involved_in
acts_upstream_of_or_within
ISO
IMP
IBA
(MGI:3804133|PMID:16705087)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:16705087 PMID:21873635 GO_REF:0000096 MGI:3804133 MGI:4834177 MGI:6201960 NCBI chr 7:16,042,307...16,052,259
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within IMP (MGI:2675761|PMID:12952892) MGI PMID:12952892 MGI:2675761 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636
JBrowse link
G Sh3glb1 SH3-domain GRB2-like B1 (endophilin) acts_upstream_of_or_within IMP (MGI:3607027|PMID:16227588) MGI PMID:16227588 MGI:3607027 NCBI chr 3:144,389,426...144,426,186
Ensembl chr 3:144,389,439...144,426,096
JBrowse link
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein acts_upstream_of_or_within IMP (MGI:2675761|PMID:12952892) MGI PMID:12952892 MGI:2675761 NCBI chr 7:45,111,119...45,116,344
Ensembl chr 7:45,111,121...45,116,322
JBrowse link
G Bbc3 BCL2 binding component 3 acts_upstream_of IMP (MGI:3804133|PMID:16705087) MGI PMID:16705087 MGI:3804133 NCBI chr 7:16,042,307...16,052,259
Ensembl chr 7:16,042,318...16,052,130
JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr12:102,706,089...102,709,920
Ensembl chr12:102,708,489...102,709,920
JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp6 caspase 6 involved_in IC (MGI:6874517|PMID:22018804) ComplexPortal PMID:22018804 MGI:6874517 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752
JBrowse link
G Mul1 mitochondrial ubiquitin ligase activator of NFKB 1 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr 4:138,160,239...138,169,576
Ensembl chr 4:138,161,982...138,169,576
JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO MGI GO_REF:0000096 MGI:4834177 NCBI chr11:69,694,421...69,696,450
Ensembl chr11:69,694,429...69,696,450
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28739
    cellular process 17696
      cell death 2346
        programmed cell death 2148
          mitochondrial outer membrane permeabilization involved in programmed cell death 46
            positive regulation of mitochondrial membrane permeability involved in apoptotic process + 44
Path 2
Term Annotations click to browse term
  biological_process 28739
    cellular process 17696
      cellular component organization or biogenesis 6689
        cellular component organization 6489
          organelle organization 3541
            mitochondrion organization 590
              mitochondrial membrane organization 120
                regulation of mitochondrial membrane permeability 68
                  positive regulation of mitochondrial membrane permeability 49
                    mitochondrial outer membrane permeabilization involved in programmed cell death 46
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process + 44
paths to the root