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ONTOLOGY REPORT - ANNOTATIONS


Term:mitochondrial outer membrane permeabilization involved in programmed cell death
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Accession:GO:1902686 term browser browse the term
Definition:The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of a programmed cell death process.
Synonyms:exact_synonym: mitochondrial outer membrane permeabilization during programmed cell death;   mitochondrion outer membrane permeabilization involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in PCD;   positive regulation of mitochondrial membrane permeability involved in programmed cell death;   positive regulation of transport across mitochondrial membrane involved in PCD;   positive regulation of transport across mitochondrial membrane involved in programmed cell death
 narrow_synonym: MPT involved in PCD;   MPT involved in caspase-independent cell death;   MPT involved in non-apoptotic programmed cell death;   MPT involved in nonapoptotic programmed cell death;   MPT involved in programmed cell death;   mitochondrial membrane permeability transition involved in PCD;   mitochondrial membrane permeability transition involved in caspase-independent cell death;   mitochondrial membrane permeability transition involved in non-apoptotic programmed cell death;   mitochondrial membrane permeability transition involved in nonapoptotic programmed cell death;   mitochondrial membrane permeability transition involved in programmed cell death;   mitochondrial membrane permeabilization involved in PCD;   mitochondrial membrane permeabilization involved in caspase-independent cell death;   mitochondrial membrane permeabilization involved in non-apoptotic programmed cell death;   mitochondrial membrane permeabilization involved in nonapoptotic programmed cell death;   mitochondrial membrane permeabilization involved in programmed cell death;   mitochondrial permeability transition involved in PCD;   mitochondrial permeability transition involved in caspase-independent cell death;   mitochondrial permeability transition involved in non-apoptotic programmed cell death;   mitochondrial permeability transition involved in nonapoptotic programmed cell death;   mitochondrial permeability transition involved in programmed cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent cell death;   positive regulation of mitochondrial membrane permeability involved in non-apoptotic programmed cell death;   positive regulation of mitochondrial membrane permeability involved in nonapoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent cell death;   positive regulation of transport across mitochondrial membrane involved in non-apoptotic programmed cell death;   positive regulation of transport across mitochondrial membrane involved in nonapoptotic programmed cell death
 related_synonym: MPT involved in caspase-independent apoptosis;   MPT involved in regulated cell death;   mitochondrial membrane permeability transition involved in caspase-independent apoptosis;   mitochondrial membrane permeability transition involved in regulated cell death;   mitochondrial membrane permeabilization involved in caspase-independent apoptosis;   mitochondrial membrane permeabilization involved in regulated cell death;   mitochondrial permeability transition involved in caspase-independent apoptosis;   mitochondrial permeability transition involved in regulated cell death;   positive regulation of mitochondrial membrane permeability involved in caspase-independent apoptosis;   positive regulation of mitochondrial membrane permeability involved in regulated cell death;   positive regulation of transport across mitochondrial membrane involved in caspase-independent apoptosis;   positive regulation of transport across mitochondrial membrane involved in regulated cell death


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mitochondrial outer membrane permeabilization involved in programmed cell death term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppif peptidylprolyl isomerase F involved_in ISO (PMID:26387735) UniProt PMID:26387735 NCBI chrNW_004955437:13,295,766...13,301,918
Ensembl chrNW_004955437:13,295,663...13,302,175
JBrowse link
G Spg7 SPG7 matrix AAA peptidase subunit, paraplegin involved_in ISO PMID:26387735 UniProt PMID:26387735 RGD:13441202 NCBI chrNW_004955541:3,092,968...3,141,157
Ensembl chrNW_004955541:3,109,892...3,140,958
JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO (PMID:20436477) MGI PMID:20436477 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118
JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in ISO (PMID:18188704) UniProt PMID:18188704 NCBI chrNW_004955507:6,138,511...6,144,823
Ensembl chrNW_004955507:6,138,071...6,144,823
JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in ISO (PMID:18371312) UniProt PMID:18371312 NCBI chrNW_004955477:9,621,812...9,630,406
Ensembl chrNW_004955477:9,621,812...9,638,099
JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within ISO (PMID:11700312) MGI PMID:11700312 NCBI chrNW_004955445:10,368,869...10,520,246
Ensembl chrNW_004955445:10,369,514...10,603,953
JBrowse link
G Rhot1 ras homolog family member T1 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004955481:7,149,836...7,199,296
Ensembl chrNW_004955481:7,149,241...7,199,296
JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004955442:16,528,886...16,534,856 JBrowse link
G Vdac2 voltage dependent anion channel 2 involved_in ISO (PMID:31015432) UniProt PMID:31015432 NCBI chrNW_004955437:16,857,715...16,871,717
Ensembl chrNW_004955437:16,853,433...16,872,345
JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in ISO (PMID:18371312) UniProt PMID:18371312 NCBI chrNW_004955402:34,857,317...34,885,169
Ensembl chrNW_004955402:34,857,317...34,885,169
JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in ISO (PMID:15901672) ComplexPortal PMID:15901672 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997
JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO (PMID:15901672), (PMID:9393856) ComplexPortal PMID:9393856 PMID:15901672 NCBI chrNW_004955422:29,254,440...29,307,104
Ensembl chrNW_004955422:29,254,216...29,308,174
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) UniProt PMID:27098698 MGI:5796062 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428
JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539
JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within ISO (PMID:19096392) MGI PMID:19096392 NCBI chrNW_004955583:730,353...731,301
Ensembl chrNW_004955583:730,289...731,260
JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:269,382...313,056
Ensembl chrNW_004955442:238,597...283,328
JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in ISO (PMID:19154410) UniProt PMID:19154410 NCBI chrNW_004955534:497,518...500,309
Ensembl chrNW_004955534:496,933...510,934
JBrowse link
G Slc35f6 solute carrier family 35 member F6 involved_in ISO (PMID:19154410) UniProt PMID:19154410 NCBI chrNW_004955469:8,774,225...8,787,549
Ensembl chrNW_004955469:8,773,989...8,787,549
JBrowse link
G Tmem14a transmembrane protein 14A involved_in ISO (PMID:21723035) UniProt PMID:21723035 NCBI chrNW_004955411:5,372,713...5,380,033
Ensembl chrNW_004955411:5,373,251...5,379,767
JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO (PMID:22304920) UniProt PMID:22304920 NCBI chrNW_004955449:332,563...411,218
Ensembl chrNW_004955449:338,193...411,218
JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO (PMID:15967824) MGI PMID:15967824 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244
JBrowse link
G Bcl2l11 BCL2 like 11 acts_upstream_of_or_within ISO (PMID:15967824) MGI PMID:15967824 NCBI chrNW_004955470:2,740,682...2,780,225 JBrowse link
G Stpg1 sperm tail PG-rich repeat containing 1 involved_in ISO (PMID:23028632) UniProt PMID:23028632 NCBI chrNW_004955452:4,163,343...4,210,698
Ensembl chrNW_004955452:4,163,293...4,209,514
JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within ISO (PMID:19096392) MGI PMID:19096392 NCBI chrNW_004955452:7,372,917...7,375,072
Ensembl chrNW_004955452:7,373,001...7,375,856
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796067|PMID:26949185) UniProt PMID:26949185 MGI:5796067 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428
JBrowse link
G Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 involved_in ISO (PMID:26666268), (PMID:30092269) UniProt PMID:26666268 PMID:30092269 NCBI chrNW_004955455:8,472,833...8,474,745
Ensembl chrNW_004955455:8,472,833...8,479,129
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chrNW_004955555:668,641...676,351
Ensembl chrNW_004955555:667,973...676,351
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO (MGI:5514334|PMID:16543145) UniProt PMID:16543145 MGI:5514334 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (PMID:19255499) ParkinsonsUK-UCL PMID:19255499 NCBI chrNW_004955482:5,885,807...5,896,386
Ensembl chrNW_004955482:5,884,839...5,896,389
JBrowse link
G Siva1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012 NCBI chrNW_004955538:3,197,983...3,202,782 JBrowse link
G Znf205 zinc finger protein 205 involved_in ISO (PMID:22306510) BHF-UCL PMID:22306510 NCBI chrNW_004955442:14,242,239...14,249,276
Ensembl chrNW_004955442:14,242,423...14,249,309
JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:18591963) UniProt PMID:18591963 NCBI chrNW_004955452:1,059,168...1,066,096
Ensembl chrNW_004955452:1,058,930...1,066,096
JBrowse link
G Tmem102 transmembrane protein 102 involved_in ISO (PMID:17828305) UniProt PMID:17828305 NCBI chrNW_004955467:9,489,867...9,493,275
Ensembl chrNW_004955467:9,489,867...9,493,275
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12321
    cellular process 11505
      cell death 1733
        programmed cell death 1733
          mitochondrial outer membrane permeabilization involved in programmed cell death 32
            positive regulation of mitochondrial membrane permeability involved in apoptotic process + 30
Path 2
Term Annotations click to browse term
  biological_process 12321
    cellular process 11505
      cellular component organization or biogenesis 5341
        cellular component organization 5212
          organelle organization 2895
            mitochondrion organization 451
              mitochondrial membrane organization 96
                regulation of mitochondrial membrane permeability 52
                  positive regulation of mitochondrial membrane permeability 36
                    mitochondrial outer membrane permeabilization involved in programmed cell death 32
                      positive regulation of mitochondrial membrane permeability involved in apoptotic process + 30
paths to the root