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ONTOLOGY REPORT - ANNOTATIONS


Term:secondary alcohol biosynthetic process
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Accession:GO:1902653 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of secondary alcohol.
Synonyms:exact_synonym: secondary alcohol anabolism;   secondary alcohol biosynthesis;   secondary alcohol formation;   secondary alcohol synthesis



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cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2180727|PMID:8647961)
GO_Central
MGI
PMID:8647961 PMID:21873635 MGI:2180727 NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943
JBrowse link
G APOA4 apolipoprotein A4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:16,751,588...16,754,215
Ensembl chr 5:16,751,799...16,754,837
JBrowse link
G CES1 carboxylesterase 1 involved_in ISO (PMID:11015575) BHF-UCL PMID:11015575 NCBI chr 2:60,276,723...60,305,970
Ensembl chr 2:60,236,150...60,321,178
JBrowse link
G CFTR CF transmembrane conductance regulator involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3709533|PMID:17085523) Ensembl
MGI
PMID:17085523 GO_REF:0000107 MGI:3709533 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
G CYB5R3 cytochrome b5 reductase 3 involved_in IEA UniProt GO_REF:0000043 NCBI chr10:22,829,898...22,848,284
Ensembl chr10:22,819,221...22,848,284
JBrowse link
G DHCR24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO (MGI:2686848|PMID:14684813), (MGI:3624168|PMID:16321981), (MGI:3769949|PMID:16513830)
(PMID:11519011)
MGI PMID:11519011 PMID:14684813 PMID:16321981 PMID:16513830 MGI:2686848 MGI:3624168 MGI:3769949 NCBI chr 5:54,294,055...54,324,389
Ensembl chr 5:54,294,046...54,321,921
JBrowse link
G DHCR7 7-dehydrocholesterol reductase involved_in IEA
ISO
IBA
(PMID:21873635) UniProt
RGD
GO_Central
PMID:9831636 PMID:10329655 PMID:21873635 GO_REF:0000041 RGD:2316918 RGD:632010 NCBI chr18:47,257,750...47,277,436
Ensembl chr18:47,261,730...47,274,236
JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:16440058 PMID:21873635 RGD:1626611 NCBI chr25:26,060,031...26,093,515
Ensembl chr25:26,060,386...26,093,582
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO (PMID:12027950) BHF-UCL PMID:12027950 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase acts_upstream_of_or_within
involved_in
ISO (MGI:2180727|PMID:8647961), (MGI:3603484|PMID:15845870), (MGI:70238|PMID:7798939)
(PMID:23063590)
MGI
CACAO
PMID:7798939 PMID:8647961 PMID:15845870 PMID:23063590 MGI:2180727 MGI:3603484 MGI:70238 NCBI chr 3:30,970,037...30,988,987
Ensembl chr 3:30,970,037...30,990,294
JBrowse link
G HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 4:66,633,706...66,654,005
Ensembl chr 4:66,633,572...66,652,196
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:2673751|PMID:12829805)
GO_Central
MGI
PMID:12829805 PMID:21873635 MGI:2673751 NCBI chr38:19,975,935...19,999,077
Ensembl chr38:19,977,086...19,999,010
JBrowse link
G INSIG1 insulin induced gene 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3689278|PMID:16955138)
GO_Central
MGI
PMID:16955138 PMID:21873635 MGI:3689278 NCBI chr16:18,260,456...18,271,855
Ensembl chr16:18,259,935...18,271,378
JBrowse link
G INSIG2 insulin induced gene 2 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3689278|PMID:16955138)
GO_Central
MGI
PMID:16955138 PMID:21873635 MGI:3689278 NCBI chr19:31,796,984...31,811,556
Ensembl chr19:31,791,710...31,811,386
JBrowse link
G LBR lamin B receptor involved_in ISO (PMID:27336722)
(PMID:16784888)
(MGI:5308142|PMID:22140257)
(MGI:3822946|PMID:18785926)
UniProt PMID:16784888 PMID:18785926 PMID:22140257 PMID:27336722 MGI:3822946 MGI:5308142 NCBI chr 7:39,289,517...39,309,026
Ensembl chr 7:39,288,147...39,307,606
JBrowse link
G LSS lanosterol synthase involved_in IBA
ISO
(PMID:21873635) GO_Central
RGD
PMID:1429550 PMID:16440058 PMID:21873635 RGD:1626611 RGD:2316919 NCBI chr31:39,479,255...39,502,439
Ensembl chr31:39,480,581...39,503,042
JBrowse link
G MVD mevalonate diphosphate decarboxylase involved_in IEA UniProt GO_REF:0000041 NCBI chr 5:64,683,146...64,691,576
Ensembl chr 5:64,682,276...64,691,073
JBrowse link
G MVK mevalonate kinase involved_in ISO (PMID:1377680) UniProt PMID:1377680 NCBI chr26:17,497,516...17,519,015
Ensembl chr26:17,497,513...17,519,385
JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO (PMID:17140581) HGNC-UCL PMID:17140581
G PMVK phosphomevalonate kinase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:42,532,968...42,563,618
Ensembl chr 7:42,533,217...42,540,625
JBrowse link
G PORCN porcupine O-acyltransferase involved_in ISO (PMID:9894009) UniProt
RGD
PMID:9894009 PMID:11171067 RGD:628445 NCBI chr  X:41,774,857...41,779,474
Ensembl chr  X:41,762,692...41,779,476
JBrowse link
G TM7SF2 transmembrane 7 superfamily member 2 involved_in IEA UniProt GO_REF:0000041 NCBI chr18:52,079,367...52,083,762
Ensembl chr18:52,079,425...52,085,390
JBrowse link
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 ISO RGD PMID:7581240 RGD:2316902 NCBI chr14:17,746,654...17,767,019
Ensembl chr14:17,746,656...17,766,658
JBrowse link
cholesterol biosynthetic process via desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHCR24 24-dehydrocholesterol reductase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:54,294,055...54,324,389
Ensembl chr 5:54,294,046...54,321,921
JBrowse link
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SC5D sterol-C5-desaturase ISO RGD PMID:7961720 RGD:2316911 NCBI chr 5:12,760,591...12,774,484
Ensembl chr 5:12,763,286...12,775,393
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:1917954) RGD
BHF-UCL
PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr 1:110,525,717...110,528,534
Ensembl chr 1:110,525,722...110,528,440
JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr28:12,924,942...12,962,016
Ensembl chr28:12,927,018...12,961,983
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:27,622,549...27,639,807
Ensembl chr16:27,625,417...27,639,202
JBrowse link
G SOD1 superoxide dismutase 1 involved_in ISO (PMID:15473258) UniProt PMID:15473258 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3768186|PMID:17916878) BHF-UCL PMID:17916878 MGI:3768186 NCBI chr31:36,574,406...36,627,598
Ensembl chr31:36,553,380...36,620,043
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr29:9,285,315...9,295,895
Ensembl chr29:9,286,181...9,332,310
JBrowse link
G FDPS farnesyl diphosphate synthase ISO RGD PMID:18637708 RGD:2316295 NCBI chr 7:42,241,086...42,250,373
Ensembl chr 7:42,241,107...42,250,225
JBrowse link
G FGF1 fibroblast growth factor 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:37,467,431...37,554,770
Ensembl chr 2:37,470,985...37,554,619
JBrowse link
G LOC477539 SEC14-like protein 2 ISO RGD PMID:11226224 RGD:727312 NCBI chr26:23,542,555...23,563,579 JBrowse link
G POR cytochrome p450 oxidoreductase ISO RGD PMID:19264869 RGD:2316785 NCBI chr 6:7,247,780...7,316,282
Ensembl chr 6:7,263,574...7,316,297
JBrowse link
G SCAP SREBF chaperone involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chr20:41,418,507...41,485,681
Ensembl chr20:41,418,536...41,487,024
JBrowse link
G SCP2 sterol carrier protein 2 ISO RGD PMID:2554812 RGD:9850260 NCBI chr 5:55,860,053...55,971,657
Ensembl chr 5:55,860,549...55,964,014
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 acts_upstream_of_or_within
involved_in
ISO (MGI:1098057|PMID:9329978)
(PMID:32322062)
(MGI:3623165|PMID:9062341), (MGI:83216|PMID:8833906)
(MGI:3603730|PMID:16046411)
MGI
UniProt
PMID:8833906 PMID:9062341 PMID:9329978 PMID:16046411 PMID:32322062 MGI:1098057 MGI:3603730 MGI:3623165 MGI:83216 NCBI chr 5:41,663,809...41,686,764
Ensembl chr 5:41,663,773...41,686,776
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chr10:23,451,923...23,532,765
Ensembl chr10:23,452,561...23,518,689
Ensembl chr10:23,452,561...23,518,689
JBrowse link
regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:48,610,906...48,630,932
Ensembl chr 9:48,613,996...48,629,857
JBrowse link
G APOB apolipoprotein B acts_upstream_of_or_within ISO (MGI:3652707|PMID:16455790) MGI PMID:16455790 MGI:3652707 NCBI chr17:15,877,937...15,916,032
Ensembl chr17:15,878,244...15,915,135
JBrowse link
G DHCR7 7-dehydrocholesterol reductase ISO RGD PMID:10329655 RGD:632010 NCBI chr18:47,257,750...47,277,436
Ensembl chr18:47,261,730...47,274,236
JBrowse link
G LPCAT3 lysophosphatidylcholine acyltransferase 3 involved_in ISO (MGI:6278041|PMID:29395055) UniProt PMID:29395055 MGI:6278041 NCBI chr27:38,028,438...38,068,854
Ensembl chr27:38,028,120...38,068,502
JBrowse link
G PEX2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (MGI:3027293|PMID:14673138) MGI PMID:14673138 MGI:3027293 NCBI chr29:24,943,563...24,960,834 JBrowse link
G SCAP SREBF chaperone acts_upstream_of_or_within ISO (MGI:3770209|PMID:16054043) MGI PMID:16054043 MGI:3770209 NCBI chr20:41,418,507...41,485,681
Ensembl chr20:41,418,536...41,487,024
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13880
    metabolic process 8980
      small molecule metabolic process 1417
        alcohol metabolic process 288
          secondary alcohol metabolic process 121
            secondary alcohol biosynthetic process 42
              (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process 0
              1,3-dichloro-2-propanol biosynthetic process 0
              2-hydroxy-but-3-enyl glucosinolate biosynthetic process 0
              acetoin biosynthetic process 0
              asperfuranone biosynthetic process + 0
              butanediol biosynthetic process 0
              cholesterol biosynthetic process + 42
              ecdysone biosynthetic process 0
              ergosterol biosynthetic process + 0
              menthol biosynthetic process 0
              propan-2-ol biosynthetic process 0
              vitamin D3 biosynthetic process 0
              zymosterol biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 13880
    metabolic process 8980
      biosynthetic process 4553
        organic substance biosynthetic process 4459
          organic hydroxy compound biosynthetic process 198
            alcohol biosynthetic process 114
              secondary alcohol biosynthetic process 42
                (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process 0
                1,3-dichloro-2-propanol biosynthetic process 0
                2-hydroxy-but-3-enyl glucosinolate biosynthetic process 0
                acetoin biosynthetic process 0
                asperfuranone biosynthetic process + 0
                butanediol biosynthetic process 0
                cholesterol biosynthetic process + 42
                ecdysone biosynthetic process 0
                ergosterol biosynthetic process + 0
                menthol biosynthetic process 0
                propan-2-ol biosynthetic process 0
                vitamin D3 biosynthetic process 0
                zymosterol biosynthetic process 0
paths to the root