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ONTOLOGY REPORT - ANNOTATIONS


Term:secondary alcohol biosynthetic process
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Accession:GO:1902653 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of secondary alcohol.
Synonyms:exact_synonym: secondary alcohol anabolism;   secondary alcohol biosynthesis;   secondary alcohol formation;   secondary alcohol synthesis



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cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 acts_upstream_of_or_within ISO (MGI:2180727|PMID:8647961) MGI PMID:8647961 MGI:2180727 NCBI chr11:111,673,539...111,675,428
Ensembl chr11:115,606,136...115,608,122
JBrowse link
G CFTR CF transmembrane conductance regulator acts_upstream_of_or_within ISO (MGI:3709533|PMID:17085523) MGI PMID:17085523 MGI:3709533 NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864
JBrowse link
G DHCR24 24-dehydrocholesterol reductase acts_upstream_of_or_within ISO (MGI:2686848|PMID:14684813), (MGI:3624168|PMID:16321981), (MGI:3769949|PMID:16513830)
(PMID:11519011)
MGI PMID:11519011 PMID:14684813 PMID:16321981 PMID:16513830 MGI:2686848 MGI:3624168 MGI:3769949 NCBI chr 1:54,126,170...54,163,713
Ensembl chr 1:55,714,693...55,754,698
JBrowse link
G DHCR7 7-dehydrocholesterol reductase involved_in ISO (PMID:9465114) RGD
UniProt
PMID:9465114 PMID:9831636 PMID:10329655 RGD:2316918 RGD:632010 NCBI chr11:66,450,230...66,464,214
Ensembl chr11:69,721,741...69,735,715
JBrowse link
G EBP EBP cholestenol delta-isomerase involved_in ISO (PMID:9894009) RGD
UniProt
PMID:9894009 PMID:11171067 RGD:628445 NCBI chr  X:40,820,042...40,826,957 JBrowse link
G FDFT1 farnesyl-diphosphate farnesyltransferase 1 ISO RGD PMID:16440058 RGD:1626611 NCBI chr 8:7,363,250...7,399,863 JBrowse link
G G6PD glucose-6-phosphate dehydrogenase involved_in ISO (PMID:12027950) BHF-UCL PMID:12027950 NCBI chr  X:143,972,798...143,988,960
Ensembl chr  X:153,843,092...153,860,674
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase involved_in
acts_upstream_of_or_within
ISO (PMID:23063590)
(MGI:2180727|PMID:8647961), (MGI:3603484|PMID:15845870), (MGI:70238|PMID:7798939)
CACAO
MGI
PMID:7798939 PMID:8647961 PMID:15845870 PMID:23063590 MGI:2180727 MGI:3603484 MGI:70238 NCBI chr 5:39,936,630...39,961,519
Ensembl chr 5:40,548,919...40,573,785
JBrowse link
G HSD17B7 hydroxysteroid 17-beta dehydrogenase 7 involved_in ISO (PMID:12829805) UniProt PMID:12829805 NCBI chr 1:138,204,544...138,226,689 JBrowse link
G INSIG1 insulin induced gene 1 involved_in
acts_upstream_of_or_within
ISO (PMID:32322062)
(MGI:3689278|PMID:16955138)
UniProt
MGI
PMID:16955138 PMID:32322062 MGI:3689278 NCBI chr 7:146,893,730...146,906,329
Ensembl chr 7:158,619,531...158,632,012
JBrowse link
G INSIG2 insulin induced gene 2 involved_in
acts_upstream_of_or_within
ISO (PMID:32322062)
(MGI:3689278|PMID:16955138)
UniProt
MGI
PMID:16955138 PMID:32322062 MGI:3689278 NCBI chr2B:5,046,971...5,068,757
Ensembl chr2B:118,632,402...118,652,647
JBrowse link
G LBR lamin B receptor involved_in ISO (PMID:16784888)
(MGI:5308142|PMID:22140257)
(MGI:3822946|PMID:18785926)
(PMID:27336722)
UniProt PMID:16784888 PMID:18785926 PMID:22140257 PMID:27336722 MGI:3822946 MGI:5308142 NCBI chr 1:200,865,602...200,892,199
Ensembl chr 1:205,870,394...205,893,032
JBrowse link
G LOC100985156 3-keto-steroid reductase acts_upstream_of_or_within ISO (MGI:2673751|PMID:12829805) MGI PMID:12829805 MGI:2673751 NCBI chr10:38,424,713...38,447,193
Ensembl chr 1:142,001,162...142,022,865
JBrowse link
G LSS lanosterol synthase involved_in ISO PMID:7568116
(PMID:17186944)
RGD
UniProt
BHF-UCL
PMID:1429550 PMID:7568116 PMID:16440058 PMID:17186944 RGD:1626611 RGD:2316919 RGD:728996 NCBI chr21:32,535,564...32,571,379
Ensembl chr21:45,787,252...45,822,181
JBrowse link
G MVK mevalonate kinase involved_in ISO (PMID:1377680) UniProt PMID:1377680 NCBI chr12:107,150,477...107,173,978
Ensembl chr12:110,544,991...110,568,524
JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 involved_in ISO (PMID:17140581) HGNC-UCL PMID:17140581 NCBI chr 7:45,227,289...45,256,094
Ensembl chr 7:45,297,271...45,324,692
JBrowse link
G PMVK phosphomevalonate kinase involved_in ISO (PMID:8663599) UniProt PMID:8663599 NCBI chr 1:130,273,246...130,286,614
Ensembl chr 1:133,882,840...133,894,818
JBrowse link
G TM7SF2 transmembrane 7 superfamily member 2 involved_in ISO (PMID:16784888)
(MGI:3822946|PMID:18785926)
UniProt PMID:16784888 PMID:18785926 MGI:3822946 RGD:13825441 NCBI chr11:60,473,934...60,478,579
Ensembl chr11:63,812,769...63,816,812
JBrowse link
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 ISO RGD PMID:7581240 RGD:2316902 NCBI chr 7:84,110,130...84,132,870
Ensembl chr 7:97,708,806...97,729,824
JBrowse link
cholesterol biosynthetic process via desmosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHCR24 24-dehydrocholesterol reductase involved_in ISO (PMID:11519011) UniProt PMID:11519011 NCBI chr 1:54,126,170...54,163,713
Ensembl chr 1:55,714,693...55,754,698
JBrowse link
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SC5D sterol-C5-desaturase ISO RGD PMID:7961720 RGD:2316911 NCBI chr11:116,139,979...116,160,745
Ensembl chr11:120,063,743...120,078,386
JBrowse link
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E involved_in ISO (PMID:1917954) RGD
BHF-UCL
PMID:1917954 PMID:9225228 RGD:10059686 NCBI chr19:41,853,669...41,857,252
Ensembl chr19:50,459,906...50,463,490
JBrowse link
G ERLIN1 ER lipid raft associated 1 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr10:96,756,261...96,791,925
Ensembl chr10:100,238,320...100,273,942
JBrowse link
G ERLIN2 ER lipid raft associated 2 involved_in ISO (PMID:24217618) UniProt PMID:24217618 NCBI chr 8:37,034,391...37,057,164
Ensembl chr 8:34,212,704...34,233,583
JBrowse link
G IDI2 isopentenyl-diphosphate delta isomerase 2 acts_upstream_of_or_within ISO (MGI:5490819|PMID:17202134) MGI PMID:17202134 MGI:5490819 NCBI chr10:1,056,280...1,062,070
Ensembl chr10:1,102,655...1,108,246
JBrowse link
G SOD1 superoxide dismutase 1 involved_in ISO (PMID:15473258) UniProt PMID:15473258 NCBI chr21:18,029,831...18,037,526 JBrowse link
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3768186|PMID:17916878) BHF-UCL PMID:17916878 MGI:3768186 NCBI chr21:28,534,697...28,619,590
Ensembl chr21:41,839,115...41,933,050
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO PMID:23536474 BHF-UCL PMID:23536474 RGD:13792517 NCBI chr 8:54,942,509...54,952,500
Ensembl chr 8:56,593,799...56,604,037
JBrowse link
G FDPS farnesyl diphosphate synthase ISO RGD PMID:18637708 RGD:2316295 NCBI chr 1:130,653,316...130,665,196
Ensembl chr 1:134,258,968...134,270,237
JBrowse link
G FGF1 fibroblast growth factor 1 involved_in ISO (PMID:19229075) BHF-UCL PMID:19229075 NCBI chr 5:137,949,100...138,054,553
Ensembl chr 5:144,056,387...144,078,001
JBrowse link
G LOC100990437 NADPH--cytochrome P450 reductase ISO RGD PMID:19264869 RGD:2316785 NCBI chr 7:68,035,021...68,105,934
Ensembl chr 7:82,364,418...82,437,530
JBrowse link
G SCAP SREBF chaperone involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chr 3:47,314,535...47,379,455
Ensembl chr 3:48,414,012...48,479,845
JBrowse link
G SCP2 sterol carrier protein 2 ISO RGD PMID:2554812 RGD:9850260 NCBI chr 1:52,195,491...52,324,227
Ensembl chr 1:53,797,254...53,924,939
JBrowse link
G SEC14L2 SEC14 like lipid binding 2 ISO RGD PMID:11226224 RGD:727312 NCBI chr22:11,432,608...11,460,973
Ensembl chr22:29,234,162...29,261,937
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 involved_in
acts_upstream_of_or_within
ISO (PMID:32322062)
(MGI:1098057|PMID:9329978)
(MGI:3623165|PMID:9062341), (MGI:83216|PMID:8833906)
(MGI:3603730|PMID:16046411)
UniProt
MGI
PMID:8833906 PMID:9062341 PMID:9329978 PMID:16046411 PMID:32322062 MGI:1098057 MGI:3603730 MGI:3623165 MGI:83216 NCBI chr17:33,458,196...33,484,643
Ensembl chr17:38,405,794...38,432,045
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 involved_in ISO (PMID:32322062) UniProt PMID:32322062 NCBI chr22:22,725,790...22,799,749
Ensembl chr22:40,811,459...40,884,947
JBrowse link
regulation of cholesterol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 NOT|involved_in ISO (PMID:21810484) ARUK-UCL PMID:21810484 NCBI chr 9:108,067,633...108,089,742
Ensembl chr 9:137,036,696...137,057,776
JBrowse link
G APOB apolipoprotein B acts_upstream_of_or_within ISO (MGI:3652707|PMID:16455790) MGI PMID:16455790 MGI:3652707 NCBI chr2A:20,986,464...21,029,004
Ensembl chr2A:21,100,356...21,145,129
JBrowse link
G DHCR7 7-dehydrocholesterol reductase ISO RGD PMID:10329655 RGD:632010 NCBI chr11:66,450,230...66,464,214
Ensembl chr11:69,721,741...69,735,715
JBrowse link
G LPCAT3 lysophosphatidylcholine acyltransferase 3 involved_in ISO (MGI:6278041|PMID:29395055) UniProt PMID:29395055 MGI:6278041 NCBI chr12:7,107,925...7,149,982
Ensembl chr12:7,024,015...7,065,945
JBrowse link
G PEX2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (MGI:3027293|PMID:14673138) MGI PMID:14673138 MGI:3027293 NCBI chr 8:73,508,349...73,526,560
Ensembl chr 8:75,146,255...75,147,172
JBrowse link
G SCAP SREBF chaperone acts_upstream_of_or_within ISO (MGI:3770209|PMID:16054043) MGI PMID:16054043 MGI:3770209 NCBI chr 3:47,314,535...47,379,455
Ensembl chr 3:48,414,012...48,479,845
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12659
    metabolic process 7935
      small molecule metabolic process 1289
        alcohol metabolic process 264
          secondary alcohol metabolic process 113
            secondary alcohol biosynthetic process 39
              (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process 0
              1,3-dichloro-2-propanol biosynthetic process 0
              2-hydroxy-but-3-enyl glucosinolate biosynthetic process 0
              acetoin biosynthetic process 0
              asperfuranone biosynthetic process + 0
              butanediol biosynthetic process 0
              cholesterol biosynthetic process + 39
              ecdysone biosynthetic process 0
              ergosterol biosynthetic process + 0
              menthol biosynthetic process 0
              propan-2-ol biosynthetic process 0
              vitamin D3 biosynthetic process 0
              zymosterol biosynthetic process 0
Path 2
Term Annotations click to browse term
  biological_process 12659
    metabolic process 7935
      biosynthetic process 4044
        organic substance biosynthetic process 3958
          organic hydroxy compound biosynthetic process 181
            alcohol biosynthetic process 102
              secondary alcohol biosynthetic process 39
                (17Z)-protosta-17(20),24-dien-3beta-ol biosynthetic process 0
                1,3-dichloro-2-propanol biosynthetic process 0
                2-hydroxy-but-3-enyl glucosinolate biosynthetic process 0
                acetoin biosynthetic process 0
                asperfuranone biosynthetic process + 0
                butanediol biosynthetic process 0
                cholesterol biosynthetic process + 39
                ecdysone biosynthetic process 0
                ergosterol biosynthetic process + 0
                menthol biosynthetic process 0
                propan-2-ol biosynthetic process 0
                vitamin D3 biosynthetic process 0
                zymosterol biosynthetic process 0
paths to the root