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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cellular response to vascular endothelial growth factor stimulus
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Accession:GO:1902548 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to vascular endothelial growth factor stimulus.
Comment:ADAMTS12 (UniProt ID P58397) in human in PMID:17895370 inhibits the formation of VEGF-induced tubular structures in BAE-1 cells (endothelial cell line).
Synonyms:exact_synonym: down regulation of cellular response to VEGF;   down regulation of cellular response to vascular endothelial growth factor;   down regulation of cellular response to vascular endothelial growth factor stimulus;   downregulation of cellular response to VEGF;   downregulation of cellular response to vascular endothelial growth factor;   downregulation of cellular response to vascular endothelial growth factor stimulus;   negative regulation of cellular response to VEGF;   negative regulation of cellular response to vascular endothelial growth factor
 narrow_synonym: down regulation of cellular response to VEGFA;   down regulation of cellular response to VEGFB;   downregulation of cellular response to VEGFA;   downregulation of cellular response to VEGFB;   inhibition of cellular response to VEGF;   inhibition of cellular response to VEGFA;   inhibition of cellular response to VEGFB;   inhibition of cellular response to vascular endothelial growth factor;   inhibition of cellular response to vascular endothelial growth factor stimulus;   negative regulation of cellular response to VEGFA;   negative regulation of cellular response to VEGFB



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negative regulation of cellular response to vascular endothelial growth factor stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 involved_in ISO (PMID:17895370) RGD PMID:17895370 NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
JBrowse link
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:25147342) RGD PMID:25147342 NCBI chr13:45,156,137...45,255,292
Ensembl chr13:45,156,146...45,255,246
JBrowse link
negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir16 microRNA 16 involved_in ISO (PMID:21885851) RGD PMID:21885851 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mir322 microRNA 322 involved_in ISO (PMID:21885851) RGD PMID:21885851 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688
JBrowse link
negative regulation of vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgra2 adhesion G protein-coupled receptor A2 acts_upstream_of_or_within ISO MGI:4949903 (MGI:4949015|PMID:21421844) RGD PMID:21421844 MGI:4949015 NCBI chr16:64,932,964...64,971,433
Ensembl chr16:64,933,315...64,971,483
JBrowse link
G Cadm4 cell adhesion molecule 4 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6271409|PMID:25893857)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:25893857 GO_REF:0000024 GO_REF:0000107 MGI:6271409 NCBI chr 1:80,075,232...80,096,511
Ensembl chr 1:80,075,202...80,097,423
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
GO_REF:0000024
(MGI:3831615|PMID:19033661)
UniProt
RGD
PMID:19033661 GO_REF:0000024 MGI:3831615 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO (PMID:23798385) RGD PMID:23798385 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Hrg histidine-rich glycoprotein involved_in ISO
ISS
(PMID:16489009)
GO_REF:0000024
RGD
UniProt
PMID:16489009 GO_REF:0000024 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
JBrowse link
G Il12a interleukin 12A acts_upstream_of ISO UniProtKB:P29460 (PMID:30106099) RGD PMID:30106099 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B acts_upstream_of ISO UniProtKB:P29459 (PMID:30106099) RGD PMID:30106099 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G LOC681544 similar to histidine-rich glycoprotein involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr11:78,039,371...78,049,353
Ensembl chr11:78,039,376...78,049,353
JBrowse link
G Mir16 microRNA 16 acts_upstream_of
involved_in
ISO (PMID:23083510)
(PMID:21885851)
RGD PMID:21885851 PMID:23083510 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mir199a2 microRNA 199a-2 acts_upstream_of ISO (PMID:28358369) RGD PMID:28358369 NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063
JBrowse link
G Mir322 microRNA 322 involved_in ISO (PMID:21885851) RGD PMID:21885851 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688
JBrowse link
G Mir342 microRNA 342 involved_in ISO (PMID:26857067) RGD PMID:26857067 NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in ISO UniProtKB:P15692 (PMID:30496354) RGD PMID:30496354 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Sema6a semaphorin 6A involved_in ISO (PMID:21536891) RGD PMID:21536891 NCBI chr18:40,050,623...40,171,954
Ensembl chr18:40,050,624...40,171,954
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (PMID:21536891) RGD PMID:21536891 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Xdh xanthine dehydrogenase involved_in IEA
ISO
GO_REF:0000107
(PMID:18386220)
Ensembl
RGD
PMID:18386220 GO_REF:0000107 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    response to stimulus 10575
      negative regulation of response to stimulus 1788
        negative regulation of cellular response to growth factor stimulus 126
          negative regulation of cellular response to vascular endothelial growth factor stimulus 18
            negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor 2
            negative regulation of vascular endothelial growth factor signaling pathway 16
Path 2
Term Annotations click to browse term
  biological_process 20091
    response to stimulus 10575
      response to endogenous stimulus 2234
        cellular response to endogenous stimulus 1809
          cellular response to growth factor stimulus 846
            regulation of cellular response to growth factor stimulus 338
              regulation of cellular response to vascular endothelial growth factor stimulus 31
                negative regulation of cellular response to vascular endothelial growth factor stimulus 18
                  negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor 2
                  negative regulation of vascular endothelial growth factor signaling pathway 16
paths to the root