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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of amyloid-beta formation
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Accession:GO:1902430 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.
Synonyms:exact_synonym: down regulation of beta-amyloid formation;   downregulation of beta-amyloid formation
 narrow_synonym: inhibition of beta-amyloid formation


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negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5487687|PMID:23467355), (MGI:5553242|PMID:18429932), (MGI:5774886|PMID:27030769)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 PMID:23467355 PMID:27030769 GO_REF:0000024 MGI:5487687 MGI:5553242 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Apoe apolipoprotein E involved_in ISO
IEA
(PMID:24259049)
GO_REF:0000107
(PMID:24154541)
RGD
Ensembl
PMID:24154541 PMID:24259049 GO_REF:0000107 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Bin1 bridging integrator 1 involved_in ISO
IEA
(PMID:27179792)
(MGI:5811968|PMID:27179792)
GO_REF:0000107
RGD
Ensembl
PMID:27179792 GO_REF:0000107 MGI:5811968 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in ISO UniProtKB:P05067 (PMID:20708605) RGD PMID:20708605 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Clu clusterin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:12047389), (PMID:17412999)
Alzheimers_University_of_Toronto
Ensembl
RGD
PMID:12047389 PMID:17412999 GO_REF:0000024 GO_REF:0000107 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 involved_in ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:100,825,426...100,844,462
Ensembl chr10:100,825,426...100,844,462
JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:85,277,890...85,286,126
Ensembl chr10:85,277,890...85,286,126
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107
RGD
Ensembl
PMID:27277332 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P05067-4 (PMID:26094765)
Ensembl
RGD
PMID:26094765 GO_REF:0000107 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Olfm1 olfactomedin 1 acts_upstream_of_or_within ISO (MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:5444053 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 involved_in ISO (PMID:25576397)
(MGI:3620333|PMID:16554819)
RGD PMID:16554819 PMID:25576397 MGI:3620333 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Prnp prion protein involved_in ISO UniProtKB:P12023 (MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:3714552 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 involved_in ISO
IEA
(PMID:24305806), (PMID:27853422)
GO_REF:0000107
RGD
Ensembl
PMID:24305806 PMID:27853422 GO_REF:0000107 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rtn1 reticulon 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15286784)
UniProt
Ensembl
RGD
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436
JBrowse link
G Rtn2 reticulon 2 involved_in ISO
ISS
(PMID:15286784)
GO_REF:0000024
RGD
UniProt
PMID:15286784 GO_REF:0000024 NCBI chr 1:78,935,056...78,948,069
Ensembl chr 1:78,935,104...78,948,069
JBrowse link
G Rtn3 reticulon 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:15286784)
UniProt
RGD
PMID:15286784 GO_REF:0000024 NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275
JBrowse link
G Rtn4 reticulon 4 involved_in ISO
IEA
ISS
(PMID:15286784)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:15286784 GO_REF:0000024 GO_REF:0000107 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
(MGI:3801250|PMID:18362153), (MGI:3821635|PMID:19036982)
RGD PMID:16407538 PMID:17855360 PMID:18362153 PMID:19036982 PMID:21989385 More... MGI:3801250 MGI:3821635 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Spon1 spondin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3607023|PMID:16227578)
Ensembl
RGD
PMID:16227578 GO_REF:0000107 MGI:3607023 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    negative regulation of biological process 5613
      negative regulation of metabolic process 3180
        negative regulation of nitrogen compound metabolic process 2434
          negative regulation of cellular amide metabolic process 204
            negative regulation of amyloid-beta formation 19
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      organic substance metabolic process 11337
        macromolecule metabolic process 9793
          protein metabolic process 5891
            amyloid precursor protein metabolic process 73
              amyloid precursor protein catabolic process 59
                amyloid-beta formation 46
                  regulation of amyloid-beta formation 37
                    negative regulation of amyloid-beta formation 19
paths to the root