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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
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Accession:GO:1902235 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
Synonyms:exact_synonym: regulation of ER stress-induced apoptosis;   regulation of apoptosis in response to ER stress;   regulation of apoptosis triggered by ER stress;   regulation of endoplasmic reticulum stress-induced apoptosis;   regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;   regulation of intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress
 broad_synonym: regulation of apoptosis in response to endoplasmic reticulum stress


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regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (PMID:23000344) RGD PMID:23000344 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Erp29 endoplasmic reticulum protein 29 involved_in ISO (MGI:5613446|PMID:24370996) RGD PMID:24370996 MGI:5613446 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO (MGI:5613477|PMID:15147274) RGD PMID:15147274 MGI:5613477 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l1 Bcl2-like 1 involved_in ISO
ISS
(PMID:29507230)
GO_REF:0000024
RGD
UniProt
PMID:29507230 GO_REF:0000024 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Creb3 cAMP responsive element binding protein 3 involved_in ISO (PMID:16940180) RGD PMID:16940180 NCBI chr 5:59,063,532...59,068,196
Ensembl chr 5:59,063,531...59,068,188
JBrowse link
G Creb3l1 cAMP responsive element binding protein 3-like 1 involved_in IMP
ISO
PMID:15665855
(MGI:5616321|PMID:15665855)
RGD PMID:15665855, PMID:15665855 MGI:5616321, RGD:1558627 NCBI chr 3:80,892,433...80,933,283
Ensembl chr 3:80,892,435...80,933,283
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 acts_upstream_of_or_within ISO MGI:1341830|MGI:99682 (MGI:5525071|PMID:22240901) RGD PMID:22240901 MGI:5525071 NCBI chr 7:117,304,742...117,307,916
Ensembl chr 7:117,304,742...117,307,916
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 involved_in ISO
IMP
IBA
(PMID:15102845)
PMID:21873635
RGD PMID:15102845, PMID:15102845, PMID:21873635 RGD:1304324, RGD:13792537 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A involved_in ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907 PMID:20625543 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B involved_in ISO (PMID:12150907), (PMID:20625543) RGD PMID:12150907 PMID:20625543 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (MGI:5495588|PMID:23453807) RGD PMID:23453807 MGI:5495588 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:21857923) RGD PMID:21857923 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584
JBrowse link
G Ngf nerve growth factor involved_in NAS PMID:21266243 ParkinsonsUK-UCL PMID:21266243 RGD:10047230 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase involved_in ISS
ISO
GO_REF:0000024
(MGI:5495588|PMID:23453807)
UniProtKB:P58281 (PMID:23453807)
ParkinsonsUK-UCL
RGD
PMID:23453807 GO_REF:0000024 MGI:5495588 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Park7 Parkinsonism associated deglycase involved_in ISO
IEA
UniProtKB:Q99LX0 (PMID:14652021)
(MGI:5613479|PMID:14652021)
GO_REF:0000107
RGD
Ensembl
PMID:14652021 GO_REF:0000107 MGI:5613479 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 acts_upstream_of_or_within ISO MGI:2181360 (MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:4836774 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISS
ISO
GO_REF:0000024
(MGI:5433837|PMID:21113145)
(PMID:10973942), (PMID:11439185), (PMID:12150907), (PMID:21113145), (PMID:23453807)
ParkinsonsUK-UCL
RGD
PMID:10973942 PMID:11439185 PMID:12150907 PMID:21113145 PMID:23453807 GO_REF:0000024 MGI:5433837 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:5619464 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA
(PMID:17210132)
GO_REF:0000107
RGD
Ensembl
PMID:17210132 GO_REF:0000107 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Syvn1 synoviolin 1 involved_in
acts_upstream_of_or_within
ISO (PMID:12459480), (PMID:17059562)
MGI:2679656 (MGI:3575050|PMID:15611074)
RGD PMID:12459480 PMID:15611074 PMID:17059562 MGI:3575050 NCBI chr 1:221,409,281...221,416,229
Ensembl chr 1:221,409,271...221,417,886
JBrowse link
G Tmbim6 transmembrane BAX inhibitor motif containing 6 involved_in
acts_upstream_of_or_within
ISO (PMID:21075086)
MGI:1913418 (MGI:5525071|PMID:22240901)
RGD PMID:21075086 PMID:22240901 MGI:5525071 NCBI chr 7:141,039,433...141,070,269
Ensembl chr 7:141,034,982...141,069,989
JBrowse link
G Txndc12 thioredoxin domain containing 12 acts_upstream_of_or_within ISO (PMID:18628206) RGD PMID:18628206 NCBI chr 5:128,450,830...128,475,858
Ensembl chr 5:128,450,680...128,475,864
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (MGI:3629256|PMID:16571599) RGD PMID:16571599 MGI:3629256 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Xbp1 X-box binding protein 1 involved_in IEA
IMP
ISO
GO_REF:0000107
PMID:20625543
(PMID:19135031)
Ensembl
RGD
PMID:19135031, PMID:20625543 GO_REF:0000107, RGD:10047191 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyou1 hypoxia up-regulated 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:3697528|PMID:17116640)
Ensembl
RGD
PMID:17116640 GO_REF:0000107 MGI:3697528 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO UniProtKB:O15354 (MGI:3697528|PMID:17116640), (MGI:5495588|PMID:23453807) RGD PMID:17116640 PMID:23453807 MGI:3697528 MGI:5495588 NCBI chr 1:48,880,015...50,069,998 JBrowse link
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
GO_REF:0000024
(MGI:5648772|PMID:26015568), (MGI:5796067|PMID:26949185)
UniProt
RGD
PMID:26015568 PMID:26949185 GO_REF:0000024 MGI:5648772 MGI:5796067 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO MGI:1913418 (MGI:5525071|PMID:22240901) RGD PMID:22240901 MGI:5525071 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:14676213)
UniProtKB:O55033 (MGI:5613475|PMID:16835242)
RGD PMID:14676213 PMID:16835242 MGI:5613475 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO UniProtKB:Q99M51 (MGI:5613475|PMID:16835242) RGD PMID:16835242 MGI:5613475 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:5619464 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Rnf183 ring finger protein 183 involved_in ISO (PMID:29507230) RGD PMID:29507230 NCBI chr 5:78,283,722...78,292,729
Ensembl chr 5:78,284,879...78,285,451
JBrowse link
G Serinc3 serine incorporator 3 acts_upstream_of_or_within ISO (MGI:2671011|PMID:12486168) RGD PMID:12486168 MGI:2671011 NCBI chr 3:160,018,643...160,038,078
Ensembl chr 3:160,018,646...160,038,078
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:5607229|PMID:20955178) RGD PMID:20955178 MGI:5607229 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Spop speckle type BTB/POZ protein acts_upstream_of_or_within ISO MGI:102851 (MGI:4836774|PMID:20811152) RGD PMID:20811152 MGI:4836774 NCBI chr10:83,231,187...83,311,987
Ensembl chr10:83,231,238...83,311,592
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    cellular process 18463
      regulation of cellular process 12352
        regulation of cellular response to stress 681
          regulation of response to endoplasmic reticulum stress 82
            regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 32
              negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 22
              positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 9
              regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway + 2
Path 2
Term Annotations click to browse term
  biological_process 19610
    biological regulation 13577
      regulation of biological process 12853
        regulation of cellular process 12352
          regulation of cell death 1761
            regulation of programmed cell death 1587
              regulation of apoptotic process 1551
                regulation of apoptotic signaling pathway 408
                  regulation of intrinsic apoptotic signaling pathway 183
                    regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 32
                      negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway + 22
                      positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 9
                      regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway + 2
paths to the root