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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of leukocyte differentiation
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Accession:GO:1902106 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.
Synonyms:exact_synonym: down regulation of immune cell differentiation;   down regulation of leucocyte differentiation;   down regulation of leukocyte differentiation;   downregulation of immune cell differentiation;   downregulation of leucocyte differentiation;   downregulation of leukocyte differentiation;   negative regulation of immune cell differentiation;   negative regulation of leucocyte differentiation
 narrow_synonym: inhibition of immune cell differentiation;   inhibition of leucocyte differentiation;   inhibition of leukocyte differentiation


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negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI3 GLI family zinc finger 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr18:52,403,463...52,697,906
Ensembl chr18:52,404,072...52,697,900 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:121,083,750...121,090,548
Ensembl chr15:121,083,753...121,090,121 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1888832|PMID:10981962) Ensembl
MGI		 PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (MGI:3623701|PMID:16618805) MGI PMID:16618805 MGI:3623701 NCBI chr11:5,370,475...5,455,439
Ensembl chr11:5,370,496...5,455,358 		JBrowse link
G HMGB3 high mobility group box 3 acts_upstream_of_or_within ISO (MGI:2670545|PMID:12714519) MGI PMID:12714519 MGI:2670545 NCBI chr  X:122,591,413...122,599,496
Ensembl chr  X:122,592,936...122,599,493 		JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (MGI:3805135|PMID:18523151) MGI PMID:18523151 MGI:3805135 NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,763...127,503,257 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:27,684,320...27,750,856
Ensembl chr 6:27,684,030...27,750,852 		JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:22473704) UniProt PMID:22473704 NCBI chr11:7,195,556...7,321,071 JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,837...198,638,189 		JBrowse link
G RUNX3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,559...82,595,026 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (MGI:6840447|PMID:24515893) UniProt PMID:24515893 MGI:6840447 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,459...6,165,212 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,408...94,796,657 		JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100517285 leukocyte immunoglobulin-like receptor subfamily A member 6 involved_in ISO (PMID:16493035) ARUK-UCL PMID:16493035 NCBI chr 6:58,996,449...59,001,088 JBrowse link
negative regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLA-8 MHC class I antigen 8 involved_in ISO (PMID:20702625) BHF-UCL PMID:20702625 NCBI chr 7:23,622,352...23,625,818 JBrowse link
G TMEM176A transmembrane protein 176A involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 (PMID:21873635)
(MGI:4835631|PMID:20501748)		 GO_Central
Ensembl
MGI		 PMID:20501748 PMID:21873635 GO_REF:0000107 MGI:4835631 NCBI chr18:6,337,835...6,342,603
Ensembl chr18:6,337,837...6,342,555 		JBrowse link
G TMEM176B transmembrane protein 176B involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:4835631|PMID:20501748)		 GO_Central
GO_Central
MGI		 PMID:20501748 PMID:21873635 MGI:4835631 NCBI chr18:6,334,420...6,348,887
Ensembl chr18:6,342,611...6,348,867 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5320487|PMID:22615127) Ensembl
Ensembl
MGI		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr17:62,659,779...62,715,221
Ensembl chr17:62,659,786...62,709,235 		JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in ISS
IEA		 UniProt
UniProt
Ensembl
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:80,592,591...80,597,464
Ensembl chr 6:80,592,473...80,597,452 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (MGI:4837548|PMID:21029969) UniProt PMID:21029969 MGI:4837548 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3691926|PMID:12393421) Ensembl
Ensembl
MGI		 PMID:12393421 GO_REF:0000107 MGI:3691926 NCBI chr11:78,557,030...78,588,964
Ensembl chr11:78,557,013...78,589,193 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within ISO (MGI:1266928|PMID:9620849) MGI PMID:9620849 MGI:1266928 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644 		JBrowse link
G PRDM16 PR/SET domain 16 involved_in ISO (PMID:12816872) UniProt PMID:12816872 NCBI chr 6:64,704,181...65,012,580
Ensembl chr 6:64,704,920...65,012,570 		JBrowse link
G RARA retinoic acid receptor alpha involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,443...22,085,673 		JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) UniProt PMID:9199349 NCBI chr13:198,371,835...198,635,648
Ensembl chr13:198,371,837...198,638,189 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5320487|PMID:22615127) Ensembl
Ensembl
MGI		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr17:62,659,779...62,715,221
Ensembl chr17:62,659,786...62,709,235 		JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) HGNC-UCL PMID:15964995 MGI:3615850 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G CLEC4G C-type lectin domain family 4 member G acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5475030|PMID:23487419) MGI
Ensembl		 PMID:23487419 GO_REF:0000107 MGI:5475030 NCBI chr 2:71,433,406...71,436,570
Ensembl chr 2:71,433,421...71,436,567 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3695084|PMID:16230479) Ensembl
Ensembl
MGI		 PMID:16230479 GO_REF:0000107 MGI:3695084 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:121,083,750...121,090,548
Ensembl chr15:121,083,753...121,090,121 		JBrowse link
G TMEM131L transmembrane 131 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:75,466,134...75,644,869
Ensembl chr 8:75,466,140...75,644,826 		JBrowse link
negative regulation of lymphocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO7 F-box protein 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5317390|PMID:21652635) Ensembl
Ensembl
MGI		 PMID:21652635 GO_REF:0000107 MGI:5317390 NCBI chr 5:12,505,646...12,526,206
Ensembl chr 5:12,505,654...12,526,232 		JBrowse link
negative regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in ISS
IEA		 UniProt
UniProt
Ensembl
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:80,592,591...80,597,464
Ensembl chr 6:80,592,473...80,597,452 		JBrowse link
G GATA2 GATA binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3769271|PMID:16254139) Ensembl
Ensembl
MGI		 PMID:16254139 GO_REF:0000107 MGI:3769271 NCBI chr13:71,981,139...71,997,626
Ensembl chr13:71,984,067...71,997,619 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5320487|PMID:22615127) Ensembl
Ensembl
MGI		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr17:62,659,779...62,715,221
Ensembl chr17:62,659,786...62,709,235 		JBrowse link
negative regulation of mast cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZFPM1 zinc finger protein, FOG family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:1,091,158...1,153,972
Ensembl chr 6:1,091,259...1,107,096 		JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGL2 fibrinogen like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:6188369|PMID:29341118) Ensembl
Ensembl
MGI		 PMID:29341118 GO_REF:0000107 MGI:6188369 NCBI chr 9:102,869,044...102,875,564
Ensembl chr 9:102,868,802...102,875,576 		JBrowse link
G IL29 interleukin 29 (interferon, lambda 1) involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:51,484,658...51,485,233
Ensembl chr17:51,484,658...51,485,233 		JBrowse link
negative regulation of monocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APCS amyloid P component, serum involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:90,900,585...90,901,854
Ensembl chr 4:90,898,689...90,901,874 		JBrowse link
G CDK6 cyclin dependent kinase 6 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:72,510,858...72,765,631
Ensembl chr 9:72,518,101...72,764,129 		JBrowse link
G GPR68 G protein-coupled receptor 68 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3848292|PMID:19479052) Ensembl
Ensembl
MGI		 PMID:19479052 GO_REF:0000107 MGI:3848292 NCBI chr 7:112,885,160...112,904,214
Ensembl chr 7:112,885,163...112,904,246 		JBrowse link
G HOXA7 homeobox A7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr18:45,417,137...45,419,113
Ensembl chr18:45,417,203...45,419,101 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1266928|PMID:9620849) Ensembl
MGI		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644 		JBrowse link
G MIR125B-1 microRNA mir-125b-1 involved_in ISO (PMID:28389358) ARUK-UCL PMID:28389358 NCBI chr 9:49,109,435...49,109,514
Ensembl chr 9:49,109,435...49,109,514 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in ISS
IEA		 UniProt
Ensembl
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5320487|PMID:22615127) Ensembl
Ensembl
MGI		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr17:62,659,779...62,715,221
Ensembl chr17:62,659,786...62,709,235 		JBrowse link
negative regulation of myeloid leukocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:75,793,273...75,903,710
Ensembl chr 4:75,793,492...75,903,496 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO RGD PMID:7737424 RGD:2299083 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 ISO RGD PMID:7737424 RGD:2299083 NCBI chr12:27,439,529...27,445,025
Ensembl chr12:27,439,260...27,445,027 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGLYRP1 peptidoglycan recognition protein 1 acts_upstream_of_or_within ISO (MGI:5297102|PMID:20709292) MGI PMID:20709292 MGI:5297102 NCBI chr 6:52,318,544...52,322,504
Ensembl chr 6:52,318,531...52,322,638 		JBrowse link
G PGLYRP2 peptidoglycan recognition protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5297102|PMID:20709292) Ensembl
Ensembl
MGI		 PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr 2:62,135,578...62,140,180
Ensembl chr 2:62,134,533...62,140,184 		JBrowse link
G PGLYRP3 peptidoglycan recognition protein 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5297102|PMID:20709292) MGI
Ensembl		 PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr 4:96,261,753...96,277,521
Ensembl chr 4:96,261,775...96,277,521 		JBrowse link
G PGLYRP4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO (MGI:5297102|PMID:20709292) MGI PMID:20709292 MGI:5297102 NCBI chr 4:96,243,174...96,247,517
Ensembl chr 4:96,243,118...96,261,495 		JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:21873635)
(MGI:1266928|PMID:9620849)		 Ensembl
GO_Central
MGI		 PMID:9620849 PMID:21873635 GO_REF:0000107 MGI:1266928 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644 		JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 4:14,289,739...14,298,119
Ensembl chr 4:14,289,751...14,297,663 		JBrowse link
negative regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN18 claudin 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5489769|PMID:22437732) Ensembl
Ensembl
MGI		 PMID:22437732 GO_REF:0000107 MGI:5489769 NCBI chr13:78,794,573...78,823,761
Ensembl chr13:78,794,580...78,822,796 		JBrowse link
G FBN1 fibrillin 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:123,102,011...123,359,649
Ensembl chr 1:123,102,009...123,359,649 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:76,482,027...76,699,354
Ensembl chr 8:76,482,844...76,699,348 		JBrowse link
G LTF lactotransferrin involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr13:29,413,886...29,445,751
Ensembl chr13:29,413,886...29,445,739 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (MGI:5489769|PMID:22437732) MGI PMID:22437732 MGI:5489769 NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983 		JBrowse link
negative regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCB calcitonin-related polypeptide beta involved_in ISO (PMID:10822112) UniProt PMID:10822112 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G CCL3L1 chemokine (C-C motif) ligand 3-like 1 involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr12:39,491,999...39,493,345
Ensembl chr12:39,491,914...39,493,774 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:5691608|PMID:25490771) MGI PMID:25490771 MGI:5691608 NCBI chr 6:49,437,308...49,460,614 JBrowse link
G CTNNB1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3578468|PMID:15866165) Ensembl
MGI		 PMID:15866165 GO_REF:0000107 MGI:3578468 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G FBN1 fibrillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:123,102,011...123,359,649
Ensembl chr 1:123,102,009...123,359,649 		JBrowse link
G FSTL3 follistatin like 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:77,656,655...77,662,608
Ensembl chr 2:77,656,663...77,662,613 		JBrowse link
G GPR137 G protein-coupled receptor 137 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 2:7,826,454...7,831,010
Ensembl chr 2:7,826,456...7,830,969 		JBrowse link
G GPR137B G protein-coupled receptor 137B involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr14:55,125,405...55,181,688
Ensembl chr14:55,125,409...55,181,670 		JBrowse link
G GPR55 G protein-coupled receptor 55 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:131,655,655...131,674,816
Ensembl chr15:131,655,663...131,673,693 		JBrowse link
G IAPP islet amyloid polypeptide acts_upstream_of_or_within ISO (MGI:3037515|PMID:14970190) MGI PMID:14970190 MGI:3037515 NCBI chr 5:52,046,570...52,051,475
Ensembl chr 5:52,046,573...52,050,446 		JBrowse link
G IFNB1 interferon beta 1 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) MGI PMID:17442941 MGI:3836131 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) MGI PMID:17442941 MGI:3836131 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (MGI:2675763|PMID:12941478), (MGI:3836131|PMID:17442941) MGI PMID:12941478 PMID:17442941 MGI:2675763 MGI:3836131 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO (MGI:5295788|PMID:21982707) MGI PMID:21982707 MGI:5295788 NCBI chr 8:84,812,041...85,555,200
Ensembl chr 8:85,084,133...85,514,516 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2386137|PMID:12161749) Ensembl
MGI		 PMID:12161749 GO_REF:0000107 MGI:2386137 NCBI chr15:133,501,067...133,626,647
Ensembl chr15:133,501,092...133,626,644 		JBrowse link
G LOC100517285 leukocyte immunoglobulin-like receptor subfamily A member 6 involved_in ISO (PMID:18802077) UniProt PMID:18802077 NCBI chr 6:58,996,449...59,001,088 JBrowse link
G LRRC17 leucine rich repeat containing 17 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:103,062,653...103,099,886
Ensembl chr 9:103,062,667...103,094,350 		JBrowse link
G MAFB MAF bZIP transcription factor B involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,408,390...43,411,782
Ensembl chr17:43,404,927...43,411,739 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (MGI:3689489|PMID:17053831) MGI PMID:17053831 MGI:3689489 NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969 		JBrowse link
G PIAS3 protein inhibitor of activated STAT 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3836131|PMID:17442941) Ensembl
Ensembl
MGI		 PMID:17442941 GO_REF:0000107 MGI:3836131 NCBI chr 4:99,463,418...99,475,141
Ensembl chr 4:99,465,690...99,475,140 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3689489|PMID:17053831) Ensembl
Ensembl
MGI		 PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:3040721|PMID:14976225) RGD
Ensembl
Ensembl
MGI		 PMID:14976225 PMID:17540629 GO_REF:0000107 MGI:3040721 RGD:4107086 NCBI chr17:10,436,414...10,489,773
Ensembl chr17:10,436,426...10,489,748 		JBrowse link
G TCTA T cell leukemia translocation altered involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:31,991,408...31,995,274
Ensembl chr13:31,991,610...31,998,129 		JBrowse link
G TMEM178A transmembrane protein 178A involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr 3:100,613,878...100,887,023
Ensembl chr 3:100,613,881...100,669,651 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in ISO (MGI:6810809|PMID:9168977) ComplexPortal PMID:9168977 MGI:6810809 NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125 		JBrowse link
G TOB2 transducer of ERBB2, 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3785228|PMID:18358842) Ensembl
Ensembl
MGI		 PMID:18358842 GO_REF:0000107 MGI:3785228 NCBI chr 5:7,086,397...7,098,643
Ensembl chr 5:7,086,651...7,098,637 		JBrowse link
G UBASH3B ubiquitin associated and SH3 domain containing B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5619442|PMID:23149425) Ensembl
Ensembl
MGI		 PMID:23149425 GO_REF:0000107 MGI:5619442 NCBI chr 9:49,630,678...49,772,348
Ensembl chr 9:49,630,793...49,770,897 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3051167|PMID:15240705) MGI
Ensembl		 PMID:15240705 GO_REF:0000107 MGI:3051167 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,250...125,393,330 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 9:68,025,673...68,132,162 JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:96,769,862...96,847,136
Ensembl chr 6:96,770,253...96,847,125 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD44 CD44 molecule involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,703...25,884,153 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr15:107,283,081...107,288,041
Ensembl chr15:107,282,927...107,289,103 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO RGD PMID:30287503 RGD:38549580 NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,949...10,039,704 		JBrowse link
G IRF1 interferon regulatory factor 1 involved_in IEA
ISS		 Ensembl
Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:134,776,122...134,783,646
Ensembl chr 2:134,776,129...134,783,801 		JBrowse link
G LAG3 lymphocyte activating 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 5:63,929,669...63,935,054
Ensembl chr 5:63,929,625...63,935,410 		JBrowse link
G MDK midkine involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,788...16,133,510 		JBrowse link
G MIR21 microRNA mir-21 involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358 		JBrowse link
G MIR30B microRNA mir-30b involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chr 4:6,952,794...6,952,869
Ensembl chr 4:6,952,794...6,952,869 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) BHF-UCL PMID:18713990 MGI:3806904 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,569...115,659,263 		JBrowse link
negative regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD74 CD74 molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:52620|PMID:7679955) MGI
Ensembl		 PMID:7679955 GO_REF:0000107 MGI:52620 NCBI chr 2:151,402,210...151,409,924
Ensembl chr 2:151,402,211...151,409,833 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (MGI:5449492|PMID:23066153) MGI PMID:23066153 MGI:5449492 NCBI chr 6:34,058,091...34,121,939
Ensembl chr 6:34,059,081...34,121,264 		JBrowse link
G DTX1 deltex E3 ubiquitin ligase 1 acts_upstream_of_or_within ISO (MGI:2663321|PMID:12794108) MGI PMID:12794108 MGI:2663321 NCBI chr14:38,559,705...38,599,790
Ensembl chr14:38,560,924...38,599,787 		JBrowse link
G IFNB1 interferon beta 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IL29 interleukin 29 (interferon, lambda 1) involved_in ISO (PMID:19346497) UniProt PMID:19346497 NCBI chr17:51,484,658...51,485,233
Ensembl chr17:51,484,658...51,485,233 		JBrowse link
G NRARP NOTCH regulated ankyrin repeat protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2663321|PMID:12794108) Ensembl
Ensembl
MGI		 PMID:12794108 GO_REF:0000107 MGI:2663321
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3796974|PMID:16290204) Ensembl
MGI		 PMID:16290204 GO_REF:0000107 MGI:3796974 NCBI chr 2:66,207,829...66,211,474
Ensembl chr 2:66,207,828...66,212,009 		JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637 		JBrowse link
G FOXJ1 forkhead box J1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:5,307,370...5,312,117
Ensembl chr12:5,307,374...5,312,106 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:121,083,750...121,090,548
Ensembl chr15:121,083,753...121,090,121 		JBrowse link
G NFKBID NFKB inhibitor delta acts_upstream_of_or_within ISO (MGI:2177878|PMID:11931770) MGI PMID:11931770 MGI:2177878 NCBI chr 6:45,298,289...45,307,471
Ensembl chr 6:45,298,288...45,306,316 		JBrowse link
G RAG2 recombination activating 2 ISO RGD PMID:30206106 RGD:38508903 NCBI chr 2:24,547,605...24,553,944
Ensembl chr 2:24,547,644...24,558,403 		JBrowse link
G SHH sonic hedgehog signaling molecule acts_upstream_of_or_within ISO (MGI:1888832|PMID:10981962) MGI PMID:10981962 MGI:1888832 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
G ZC3H8 zinc finger CCCH-type containing 8 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:44,161,299...44,195,413
Ensembl chr 3:44,161,310...44,184,683 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chr 2:59,905,901...59,926,504
Ensembl chr 2:59,905,919...59,926,495 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chr 9:115,535,185...115,857,457
Ensembl chr 9:115,550,569...115,659,263 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr  X:43,303,777...43,328,164
Ensembl chr  X:43,303,785...43,322,968 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:3817792|PMID:18792410)		 GO_Central
GO_Central
MGI		 PMID:18792410 PMID:21873635 MGI:3817792 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,208,799...116,292,381 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:263,769,403...263,822,101
Ensembl chr 1:263,772,173...263,822,104 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5450776|PMID:23034280) Ensembl
Ensembl
MGI		 PMID:23034280 GO_REF:0000107 MGI:5450776 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,408...94,796,657 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:93,541,334...93,551,200
Ensembl chr 6:93,541,334...93,551,193 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:68,498,114...68,516,829
Ensembl chr 3:68,498,189...68,517,445 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 9:115,447,438...115,460,649
Ensembl chr 9:115,448,973...115,460,950 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in ISS
IEA
IBA		 (PMID:21873635) UniProt
Ensembl
GO_Central
UniProt
GO_Central		 PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2450484|PMID:12594267) Ensembl
Ensembl
MGI		 PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chr13:125,377,247...125,401,328
Ensembl chr13:125,377,250...125,393,330 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3761239|PMID:16424184) Ensembl
Ensembl
MGI		 PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr10:10,263,441...10,269,882
Ensembl chr10:10,264,244...10,269,879 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 3:93,777,402...93,925,859
Ensembl chr 3:93,783,964...93,925,863 		JBrowse link
G ZNF397 zinc finger protein 397 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 6:119,076,683...119,144,643
Ensembl chr 6:119,076,714...119,086,759 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3580753|PMID:15917799) MGI
Ensembl		 PMID:15917799 GO_REF:0000107 MGI:3580753 NCBI chr 9:116,204,807...116,292,455
Ensembl chr 9:116,208,799...116,292,381 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17636
    negative regulation of biological process 5746
      negative regulation of immune system process 515
        negative regulation of hemopoiesis 120
          negative regulation of leukocyte differentiation 114
            negative regulation of dendritic cell differentiation 4
            negative regulation of lymphocyte differentiation + 65
            negative regulation of myeloid leukocyte differentiation + 52
Path 2
Term Annotations click to browse term
  biological_process 17636
    cellular process 16423
      cellular developmental process 4451
        cell differentiation 4426
          cell development 3138
            hemopoiesis 1019
              leukocyte differentiation 659
                regulation of leukocyte differentiation 326
                  negative regulation of leukocyte differentiation 114
                    negative regulation of dendritic cell differentiation 4
                    negative regulation of lymphocyte differentiation + 65
                    negative regulation of myeloid leukocyte differentiation + 52
paths to the root