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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of leukocyte differentiation
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Accession:GO:1902106 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.
Synonyms:exact_synonym: down regulation of immune cell differentiation;   down regulation of leucocyte differentiation;   down regulation of leukocyte differentiation;   downregulation of immune cell differentiation;   downregulation of leucocyte differentiation;   downregulation of leukocyte differentiation;   negative regulation of immune cell differentiation;   negative regulation of leucocyte differentiation
 narrow_synonym: inhibition of immune cell differentiation;   inhibition of leucocyte differentiation;   inhibition of leukocyte differentiation


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negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:7,800,817...8,071,531
Ensembl chr18:7,801,394...8,068,132 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,616,942...25,622,989 JBrowse link
G SHH sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:1888832|PMID:10981962) Ensembl
Ensembl
MGI		 PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (MGI:3623701|PMID:16618805) MGI PMID:16618805 MGI:3623701 NCBI chr25:11,551,372...11,670,891
Ensembl chr25:11,581,206...11,692,284 		JBrowse link
G HMGB3 high mobility group box 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2670545|PMID:12714519) MGI
Ensembl		 PMID:12714519 GO_REF:0000107 MGI:2670545 NCBI chr  X:119,152,166...119,159,803
Ensembl chr  X:119,155,786...119,159,814 		JBrowse link
G LOC102151783 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (MGI:3805135|PMID:18523151) MGI PMID:18523151 MGI:3805135 NCBI chr10:54,954,852...54,957,116 JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:24,262,451...24,306,162
Ensembl chr16:24,261,946...24,302,964 		JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr 5:82,253,496...82,313,765
Ensembl chr 5:82,255,617...82,313,168 		JBrowse link
G HMGB1 high mobility group box 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:9,431,223...9,558,167
Ensembl chr25:9,431,218...9,558,165 		JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839 		JBrowse link
G RUNX3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (MGI:6840447|PMID:24515893) UniProt PMID:24515893 MGI:6840447 NCBI chr16:15,111,078...15,126,618
Ensembl chr16:15,111,116...15,126,617 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in ISO (MGI:6140589|PMID:24880459) UniProt PMID:24880459 MGI:6140589 NCBI chr 6:31,511,003...31,511,995
Ensembl chr 6:31,509,268...31,511,557 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436 		JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC484306 leukocyte immunoglobulin-like receptor subfamily B member 3 involved_in ISO (PMID:16493035) ARUK-UCL PMID:16493035 NCBI chr 1:102,779,562...102,786,924 JBrowse link
negative regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TMEM176A transmembrane protein 176A involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:4835631|PMID:20501748)		 GO_Central
MGI		 PMID:20501748 PMID:21873635 MGI:4835631 NCBI chr16:14,927,031...14,931,350
Ensembl chr16:14,926,805...14,931,238 		JBrowse link
G TMEM176B transmembrane protein 176B acts_upstream_of_or_within
involved_in		 ISO
IBA		 (MGI:4835631|PMID:20501748)
(PMID:21873635)		 MGI
GO_Central		 PMID:20501748 PMID:21873635 MGI:4835631 NCBI chr16:14,918,491...14,926,673
Ensembl chr16:14,919,126...14,926,583 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS		 Ensembl
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,660,039...76,664,602
Ensembl chr 2:76,660,035...76,664,577 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (MGI:4837548|PMID:21029969) UniProt PMID:21029969 MGI:4837548 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830 		JBrowse link
G CUL4A cullin 4A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3691926|PMID:12393421) Ensembl
Ensembl
MGI		 PMID:12393421 GO_REF:0000107 MGI:3691926 NCBI chr22:60,624,215...60,667,844
Ensembl chr22:60,624,241...60,666,616 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1266928|PMID:9620849) MGI
Ensembl		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200 		JBrowse link
G PRDM16 PR/SET domain 16 involved_in ISO (PMID:12816872) UniProt PMID:12816872 NCBI chr 5:57,805,951...58,018,817
Ensembl chr 5:57,730,370...58,017,976 		JBrowse link
G RARA retinoic acid receptor alpha involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:22,254,803...22,298,614
Ensembl chr 9:22,254,806...22,289,459 		JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISO (PMID:9199349) UniProt PMID:9199349 NCBI chr31:30,170,859...30,420,344
Ensembl chr31:30,170,605...30,420,839 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) HGNC-UCL PMID:15964995 MGI:3615850 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
G CLEC4G C-type lectin domain family 4 member G acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5475030|PMID:23487419) MGI
Ensembl		 PMID:23487419 GO_REF:0000107 MGI:5475030 NCBI chr20:52,476,162...52,480,341
Ensembl chr20:52,476,200...52,479,930 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3695084|PMID:16230479) MGI
Ensembl		 PMID:16230479 GO_REF:0000107 MGI:3695084 NCBI chr 9:22,760,373...22,785,367
Ensembl chr 9:22,759,256...22,785,294 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,616,942...25,622,989 JBrowse link
G TMEM131L transmembrane 131 like involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:51,268,897...51,427,347
Ensembl chr15:51,268,855...51,427,212 		JBrowse link
negative regulation of lymphocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO7 F-box protein 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5317390|PMID:21652635) Ensembl
Ensembl
MGI		 PMID:21652635 GO_REF:0000107 MGI:5317390 NCBI chr10:30,928,059...30,948,858
Ensembl chr10:30,928,329...30,948,977 		JBrowse link
negative regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS		 Ensembl
UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr34:19,398,310...19,410,519
Ensembl chr34:19,354,825...19,409,844 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,660,039...76,664,602
Ensembl chr 2:76,660,035...76,664,577 		JBrowse link
G GATA2 GATA binding protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3769271|PMID:16254139) MGI
Ensembl		 PMID:16254139 GO_REF:0000107 MGI:3769271 NCBI chr20:2,472,251...2,488,380
Ensembl chr20:2,473,912...2,480,991 		JBrowse link
G MIR486 microRNA mir-486 involved_in ISO (PMID:25857263) BHF-UCL PMID:25857263 NCBI chr16:23,958,963...23,959,026
Ensembl chr16:23,958,963...23,959,026 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G THOC5 THO complex subunit 5 acts_upstream_of_or_within ISO (MGI:1349551|PMID:10597251) MGI PMID:10597251 MGI:1349551 NCBI chr26:22,748,857...22,785,288
Ensembl chr26:22,748,895...22,784,143 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
negative regulation of mast cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZFPM1 zinc finger protein, FOG family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:64,812,353...64,863,278 JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGL2 fibrinogen like 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:6188369|PMID:29341118) Ensembl
Ensembl
MGI		 PMID:29341118 GO_REF:0000107 MGI:6188369 NCBI chr18:17,328,794...17,335,429
Ensembl chr18:17,331,780...17,335,401 		JBrowse link
G IFNL1 interferon lambda 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:113,903,550...113,907,458 JBrowse link
G IL29L interleukin 29-like involved_in ISO (PMID:19346497) UniProt PMID:19346497 NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017 		JBrowse link
negative regulation of monocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK6 cyclin dependent kinase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869 		JBrowse link
G GPR68 G protein-coupled receptor 68 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3848292|PMID:19479052) MGI
Ensembl
Ensembl		 PMID:19479052 GO_REF:0000107 MGI:3848292 NCBI chr 8:62,090,050...62,108,922
Ensembl chr 8:62,092,135...62,093,217 		JBrowse link
G HOXA7 homeobox A7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr14:40,327,918...40,334,073
Ensembl chr14:40,329,127...40,330,842 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1266928|PMID:9620849) MGI
Ensembl		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200 		JBrowse link
G MIR125B-1 microRNA mir-125b-1 involved_in ISO (PMID:28389358) ARUK-UCL PMID:28389358 NCBI chr 5:12,097,672...12,097,732
Ensembl chr 5:12,097,658...12,097,745 		JBrowse link
G MIR125B-2 microRNA mir-125b-2 involved_in ISO (PMID:28389358) ARUK-UCL PMID:28389358 NCBI chr31:13,304,980...13,305,040
Ensembl chr31:13,304,964...13,305,052 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in ISS
IEA		 UniProt
Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 NCBI chr24:47,290,696...47,329,342
Ensembl chr24:47,292,684...47,329,570 		JBrowse link
negative regulation of myeloid leukocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr29:7,367,617...7,448,862
Ensembl chr29:7,332,684...7,448,507 		JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in ISO RGD PMID:7737424 RGD:2299083 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955 		JBrowse link
G NME2 non-metastatic cells 2, protein (NM23B) expressed in ISO RGD PMID:7737424 RGD:2299083 NCBI chr 9:27,002,114...27,005,740
Ensembl chr 9:27,001,733...27,015,934 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGLYRP1 peptidoglycan recognition protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5297102|PMID:20709292) MGI
Ensembl		 PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr 1:109,614,404...109,618,242
Ensembl chr 1:109,614,437...109,618,242 		JBrowse link
G PGLYRP2 peptidoglycan recognition protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5297102|PMID:20709292) MGI
Ensembl		 PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr20:46,724,906...46,730,227
Ensembl chr20:46,726,224...46,730,321 		JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1266928|PMID:9620849) MGI
Ensembl		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200 		JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in ISO (MGI:5488531|PMID:23515163) CACAO PMID:23515163 MGI:5488531 NCBI chr13:23,337,788...23,346,304
Ensembl chr13:23,337,788...23,346,304 		JBrowse link
negative regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN18 claudin 18 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5489769|PMID:22437732) MGI
Ensembl
Ensembl		 PMID:22437732 GO_REF:0000107 MGI:5489769 NCBI chr23:34,229,115...34,257,431
Ensembl chr23:34,228,992...34,255,650 		JBrowse link
G FBN1 fibrillin 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr30:14,640,973...14,864,151
Ensembl chr30:14,640,973...14,864,151 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:50,187,579...50,417,188
Ensembl chr15:50,189,240...50,417,195 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (MGI:5489769|PMID:22437732) MGI PMID:22437732 MGI:5489769 NCBI chr 1:88,126,134...88,251,018
Ensembl chr 1:88,126,136...88,230,654 		JBrowse link
negative regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL3 chemokine (C-C motif) ligand 3 involved_in ISS UniProt
UniProt		 GO_REF:0000024 NCBI chr 9:37,693,711...37,695,137
Ensembl chr 9:37,686,480...37,695,573 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:5691608|PMID:25490771) MGI PMID:25490771 MGI:5691608 NCBI chr 1:111,902,429...111,919,191
Ensembl chr 1:111,745,413...111,917,830 		JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 involved_in ISO (PMID:10822112) UniProt PMID:10822112 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645 		JBrowse link
G CTNNB1 catenin beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3578468|PMID:15866165) MGI
Ensembl		 PMID:15866165 GO_REF:0000107 MGI:3578468 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927 		JBrowse link
G FBN1 fibrillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:14,640,973...14,864,151
Ensembl chr30:14,640,973...14,864,151 		JBrowse link
G FSTL3 follistatin like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:57,878,623...57,884,240
Ensembl chr20:57,879,722...57,884,172 		JBrowse link
G GPR137 G protein-coupled receptor 137 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:52,776,857...52,781,050
Ensembl chr18:52,776,858...52,779,783 		JBrowse link
G GPR137B G protein-coupled receptor 137B involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:3,819,338...3,864,690
Ensembl chr 4:3,825,602...3,864,780 		JBrowse link
G GPR55 G protein-coupled receptor 55 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:42,864,869...42,931,786
Ensembl chr25:42,866,416...42,908,332 		JBrowse link
G IAPP islet amyloid polypeptide acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3037515|PMID:14970190) MGI
Ensembl		 PMID:14970190 GO_REF:0000107 MGI:3037515 NCBI chr27:26,295,481...26,299,967
Ensembl chr27:26,295,481...26,299,967 		JBrowse link
G IFNB1 interferon beta 1 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) MGI PMID:17442941 MGI:3836131 NCBI chr11:40,668,295...40,668,855
Ensembl chr11:40,668,295...40,668,855 		JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) MGI PMID:17442941 MGI:3836131 NCBI chr10:10,406,866...10,411,698
Ensembl chr10:10,406,867...10,411,698 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 ISS
ISO		 (MGI:2675763|PMID:12941478), (MGI:3836131|PMID:17442941) UniProt
UniProt
MGI		 PMID:12941478 PMID:17442941 GO_REF:0000024 MGI:2675763 MGI:3836131 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO (MGI:5295788|PMID:21982707) MGI PMID:21982707 MGI:5295788 NCBI chr19:826,711...1,192,340
Ensembl chr19:850,784...1,186,498 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2386137|PMID:12161749) MGI
Ensembl		 PMID:12161749 GO_REF:0000107 MGI:2386137 NCBI chr25:44,612,146...44,731,347
Ensembl chr25:44,611,523...44,730,200 		JBrowse link
G LOC484306 leukocyte immunoglobulin-like receptor subfamily B member 3 involved_in ISO (PMID:18802077) UniProt PMID:18802077 NCBI chr 1:102,779,562...102,786,924 JBrowse link
G LOC611446 leukocyte immunoglobulin-like receptor subfamily A member 6 involved_in ISO (PMID:18802077) UniProt PMID:18802077 NCBI chr 1:102,955,916...102,978,669 JBrowse link
G LRRC17 leucine rich repeat containing 17 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr18:17,103,834...17,132,653
Ensembl chr18:17,104,184...17,118,012 		JBrowse link
G MAFB MAF bZIP transcription factor B involved_in ISO (MGI:3849531|PMID:19440205) UniProt PMID:19440205 MGI:3849531 NCBI chr24:28,769,904...28,772,519
Ensembl chr24:28,770,944...28,774,948 		JBrowse link
G MAFB MAF bZIP transcription factor B involved_in IEA Ensembl GO_REF:0000107
G NF1 neurofibromin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3689489|PMID:17053831) MGI
Ensembl		 PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382 		JBrowse link
G PIAS3 protein inhibitor of activated STAT 3 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) MGI PMID:17442941 MGI:3836131 NCBI chr17:58,650,791...58,660,755
Ensembl chr17:58,571,694...58,660,663 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3689489|PMID:17053831) Ensembl
Ensembl
MGI		 PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:3040721|PMID:14976225) RGD
Ensembl
MGI		 PMID:14976225 PMID:17540629 GO_REF:0000107 MGI:3040721 RGD:4107086 NCBI chr16:24,262,451...24,306,162
Ensembl chr16:24,261,946...24,302,964 		JBrowse link
G TCTA T cell leukemia translocation altered involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr20:39,820,845...39,824,526
Ensembl chr20:39,822,211...39,824,200 		JBrowse link
G TMEM178A transmembrane protein 178A involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr17:31,633,547...31,684,126
Ensembl chr17:31,633,467...31,683,786 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:52,607,598...52,623,799
Ensembl chr19:52,607,713...52,623,811 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr13:18,155,765...18,183,263
Ensembl chr13:18,156,367...18,183,444 		JBrowse link
G TOB2 transducer of ERBB2, 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3785228|PMID:18358842) MGI
Ensembl
Ensembl		 PMID:18358842 GO_REF:0000107 MGI:3785228 NCBI chr10:23,817,778...23,830,330
Ensembl chr10:23,826,437...23,827,447 		JBrowse link
G UBASH3B ubiquitin associated and SH3 domain containing B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5619442|PMID:23149425) MGI
Ensembl		 PMID:23149425 GO_REF:0000107 MGI:5619442 NCBI chr 5:11,496,254...11,614,769
Ensembl chr 5:11,500,669...11,614,675 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3051167|PMID:15240705) MGI
Ensembl		 PMID:15240705 GO_REF:0000107 MGI:3051167 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G LOC490269 complement receptor type 2 acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 7:6,456,238...6,480,672 JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD44 CD44 molecule involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl
GO_Central		 PMID:21873635 GO_REF:0000107 NCBI chr37:12,647,712...12,653,874
Ensembl chr37:12,634,563...12,653,874 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO RGD PMID:30287503 RGD:38549580 NCBI chr 6:7,487,164...7,488,576
Ensembl chr 6:7,487,250...7,488,576 		JBrowse link
G IRF1 interferon regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:20,773,801...20,781,106
Ensembl chr11:20,760,120...20,781,608 		JBrowse link
G LAG3 lymphocyte activating 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:38,260,673...38,266,771
Ensembl chr27:38,260,674...38,265,819 		JBrowse link
G MDK midkine involved_in ISO (PMID:22323540) UniProt PMID:22323540
G MIR21 microRNA mir-21 involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624 		JBrowse link
G MIR30B microRNA mir-30b involved_in ISO (PMID:22387553) BHF-UCL PMID:22387553 NCBI chr13:30,906,038...30,906,097
Ensembl chr13:30,906,038...30,906,097 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) BHF-UCL PMID:18713990 MGI:3806904 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892 		JBrowse link
negative regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD74 CD74 molecule acts_upstream_of_or_within ISO (MGI:52620|PMID:7679955) MGI PMID:7679955 MGI:52620 NCBI chr 4:58,689,745...58,698,421
Ensembl chr 4:58,689,752...58,698,151 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (MGI:5449492|PMID:23066153) MGI PMID:23066153 MGI:5449492 NCBI chr 2:64,561,684...64,628,829
Ensembl chr 2:64,562,503...64,628,175 		JBrowse link
G DTX1 deltex E3 ubiquitin ligase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2663321|PMID:12794108) MGI
Ensembl		 PMID:12794108 GO_REF:0000107 MGI:2663321 NCBI chr26:10,469,850...10,502,682 JBrowse link
G IFNB1 interferon beta 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr11:40,668,295...40,668,855
Ensembl chr11:40,668,295...40,668,855 		JBrowse link
G IFNL1 interferon lambda 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:113,903,550...113,907,458 JBrowse link
G IL29L interleukin 29-like involved_in ISO (PMID:19346497) UniProt PMID:19346497 NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017 		JBrowse link
G NRARP NOTCH regulated ankyrin repeat protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:2663321|PMID:12794108) Ensembl
Ensembl
MGI		 PMID:12794108 GO_REF:0000107 MGI:2663321 NCBI chr 9:48,394,568...48,396,849
Ensembl chr 9:48,394,754...48,395,098 		JBrowse link
G PRDX2 peroxiredoxin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3796974|PMID:16290204) Ensembl
Ensembl
MGI		 PMID:16290204 GO_REF:0000107 MGI:3796974 NCBI chr20:49,352,271...49,356,755
Ensembl chr20:49,352,266...49,356,682 		JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:29,997,563...30,254,307
Ensembl chr 8:29,997,569...30,004,557 		JBrowse link
G FOXJ1 forkhead box J1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:4,512,898...4,517,764
Ensembl chr 9:4,513,628...4,517,756 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:25,616,942...25,622,989 JBrowse link
G NFKBID NFKB inhibitor delta acts_upstream_of_or_within ISO (MGI:2177878|PMID:11931770) MGI PMID:11931770 MGI:2177878 NCBI chr 1:116,763,371...116,770,683
Ensembl chr 1:116,757,289...116,772,325 		JBrowse link
G RAG2 recombination activating 2 ISO RGD PMID:30206106 RGD:38508903 NCBI chr18:31,614,143...31,621,489
Ensembl chr18:31,618,481...31,620,064 		JBrowse link
G SHH sonic hedgehog signaling molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1888832|PMID:10981962) MGI
Ensembl		 PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr16:18,650,553...18,663,571
Ensembl chr16:18,484,809...18,662,903 		JBrowse link
G ZC3H8 zinc finger CCCH-type containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:36,584,828...36,621,194
Ensembl chr17:36,597,916...36,613,722 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 NCBI chr 6:19,254,183...19,280,973
Ensembl chr 6:19,254,487...19,389,291 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chr20:45,051,135...45,068,445
Ensembl chr20:45,050,526...45,072,805 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chr 7:25,883,297...25,909,608
Ensembl chr 7:25,883,251...25,906,892 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr  X:42,331,229...42,362,841
Ensembl chr  X:42,344,108...42,350,758 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr19:17,750,780...17,756,394
Ensembl chr19:17,750,780...17,756,394 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:21873635)
(MGI:3817792|PMID:18792410)		 GO_Central
GO_Central
MGI		 PMID:18792410 PMID:21873635 MGI:3817792 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,265,836...25,312,417
Ensembl chr 7:25,233,235...25,305,174 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:59,881,889...59,943,271
Ensembl chr 9:59,881,966...59,929,341 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:5450776|PMID:23034280) Ensembl
Ensembl
MGI		 PMID:23034280 GO_REF:0000107 MGI:5450776 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr15:4,972,369...4,984,218
Ensembl chr15:4,972,956...4,980,371 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:48,590,996...48,610,264
Ensembl chr17:48,591,768...48,610,392 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:24,077,752...24,086,560
Ensembl chr 9:24,077,761...24,086,261 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 7:25,983,064...25,994,605
Ensembl chr 7:25,963,719...25,992,801 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IBA
IEA		 (PMID:21873635) GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2450484|PMID:12594267) MGI
Ensembl		 PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chr34:20,112,302...20,135,705
Ensembl chr34:20,113,322...20,124,704 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3761239|PMID:16424184) MGI
Ensembl		 PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr38:15,538,744...15,543,686
Ensembl chr38:15,539,029...15,542,152 		JBrowse link
G LOC111089966 zinc finger protein 271 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 7:54,714,912...54,727,638 JBrowse link
G RTP2 receptor transporter protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:20,087,395...20,091,248
Ensembl chr34:20,087,226...20,115,428 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr10:48,916,446...48,977,183
Ensembl chr10:48,972,842...48,974,452 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3580753|PMID:15917799) MGI
Ensembl		 PMID:15917799 GO_REF:0000107 MGI:3580753 NCBI chr 7:25,265,836...25,312,417
Ensembl chr 7:25,233,235...25,305,174 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17428
    negative regulation of biological process 5812
      negative regulation of immune system process 525
        negative regulation of hemopoiesis 124
          negative regulation of leukocyte differentiation 116
            negative regulation of dendritic cell differentiation 3
            negative regulation of lymphocyte differentiation + 65
            negative regulation of myeloid leukocyte differentiation + 55
Path 2
Term Annotations click to browse term
  biological_process 17428
    cellular process 16176
      cellular developmental process 4466
        cell differentiation 4441
          cell development 3157
            hemopoiesis 1035
              leukocyte differentiation 657
                regulation of leukocyte differentiation 337
                  negative regulation of leukocyte differentiation 116
                    negative regulation of dendritic cell differentiation 3
                    negative regulation of lymphocyte differentiation + 65
                    negative regulation of myeloid leukocyte differentiation + 55
paths to the root