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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of leukocyte differentiation
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Accession:GO:1902106 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.
Synonyms:exact_synonym: down regulation of immune cell differentiation;   down regulation of leucocyte differentiation;   down regulation of leukocyte differentiation;   downregulation of immune cell differentiation;   downregulation of leucocyte differentiation;   downregulation of leukocyte differentiation;   negative regulation of immune cell differentiation;   negative regulation of leucocyte differentiation
 narrow_synonym: inhibition of immune cell differentiation;   inhibition of leucocyte differentiation;   inhibition of leukocyte differentiation


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negative regulation of alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GLI3 GLI family zinc finger 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,004,965...42,280,772
Ensembl chr 7:42,056,565...42,322,865 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,312,472...106,319,124
Ensembl chr2B:224,906,271...224,911,506 		JBrowse link
G SHH sonic hedgehog signaling molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1888832|PMID:10981962) MGI
Ensembl		 PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651 		JBrowse link
negative regulation of B cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT3 fms related receptor tyrosine kinase 3 acts_upstream_of_or_within ISO (MGI:3623701|PMID:16618805) MGI PMID:16618805 MGI:3623701 NCBI chr13:9,283,747...9,381,553
Ensembl chr13:27,627,178...27,723,940 		JBrowse link
G HMGB3 high mobility group box 3 acts_upstream_of_or_within ISO (MGI:2670545|PMID:12714519) MGI PMID:12714519 MGI:2670545 NCBI chr  X:140,632,163...140,639,774 JBrowse link
G ID2 inhibitor of DNA binding 2 acts_upstream_of_or_within ISO (MGI:3805135|PMID:18523151) MGI PMID:18523151 MGI:3805135 NCBI chr2A:8,681,592...8,684,014
Ensembl chr2A:8,847,776...8,850,720 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:18941195)
(MGI:3814493|PMID:18941195)		 UniProt PMID:18941195 MGI:3814493 NCBI chr 8:40,507,027...40,555,053 JBrowse link
negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr16:47,373,543...47,446,783 JBrowse link
G HMGB1 high mobility group box 1 involved_in ISO (PMID:22473704) UniProt PMID:22473704 NCBI chr13:11,737,942...11,894,923
Ensembl chr13:30,174,899...30,179,527 		JBrowse link
G RUNX3 RUNX family transcription factor 3 involved_in ISO (MGI:3772948|PMID:18258917) UniProt PMID:18258917 MGI:3772948 NCBI chr 1:24,097,321...24,164,065
Ensembl chr 1:25,073,134...25,137,335 		JBrowse link
negative regulation of CD8-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 involved_in ISO (MGI:6840447|PMID:24515893) UniProt PMID:24515893 MGI:6840447 NCBI chr 7:142,646,413...142,663,376
Ensembl chr 7:154,799,256...154,815,919 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 involved_in ISO (MGI:6140589|PMID:24880459) UniProt PMID:24880459 MGI:6140589 NCBI chr16:10,196,432...10,198,205 JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,350,798...130,366,690
Ensembl chr 1:133,959,847...133,975,729 		JBrowse link
negative regulation of cytotoxic T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LILRB4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:16493035) ARUK-UCL PMID:16493035 NCBI chr19:51,606,681...51,612,751 JBrowse link
negative regulation of dendritic cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100978774 patr class I histocompatibility antigen, alpha chain G involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,616,091...29,620,270
Ensembl chr 6:30,286,395...30,390,865 		JBrowse link
G TMEM176A transmembrane protein 176A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4835631|PMID:20501748) MGI
Ensembl		 PMID:20501748 GO_REF:0000107 MGI:4835631 NCBI chr 7:142,383,001...142,387,407
Ensembl chr 7:154,535,019...154,539,613 		JBrowse link
G TMEM176B transmembrane protein 176B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:4835631|PMID:20501748) MGI
Ensembl		 PMID:20501748 GO_REF:0000107 MGI:4835631 NCBI chr 7:142,373,598...142,383,646
Ensembl chr 7:154,525,878...154,535,862 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 Ensembl chr20:61,667,319...61,713,895 JBrowse link
negative regulation of granulocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,828,969...21,833,518
Ensembl chr 1:22,770,582...22,782,176 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 involved_in ISO (MGI:4837548|PMID:21029969) UniProt PMID:21029969 MGI:4837548 NCBI chr19:39,395,550...39,417,063
Ensembl chr19:47,989,430...48,008,739 		JBrowse link
G CUL4A cullin 4A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3691926|PMID:12393421) MGI
Ensembl		 PMID:12393421 GO_REF:0000107 MGI:3691926 NCBI chr13:94,350,484...94,409,183
Ensembl chr13:113,428,271...113,472,701 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1266928|PMID:9620849) MGI
Ensembl		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G PRDM16 PR/SET domain 16 involved_in ISO (PMID:12816872) UniProt PMID:12816872 NCBI chr 1:1,730,122...2,100,636
Ensembl chr 1:2,981,667...3,234,251 		JBrowse link
G RARA retinoic acid receptor alpha involved_in ISO (PMID:19917671) UniProt PMID:19917671 NCBI chr17:16,932,485...16,980,958 JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 Ensembl chr20:61,667,319...61,713,895 JBrowse link
negative regulation of immature T cell proliferation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (MGI:3615850|PMID:15964995) HGNC-UCL PMID:15964995 MGI:3615850 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CLEC4G C-type lectin domain family 4 member G acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5475030|PMID:23487419) MGI
Ensembl		 PMID:23487419 GO_REF:0000107 MGI:5475030 NCBI chr19:7,015,848...7,019,396
Ensembl chr19:7,870,730...7,873,631 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3695084|PMID:16230479) MGI
Ensembl		 PMID:16230479 GO_REF:0000107 MGI:3695084 NCBI chr17:17,560,337...17,600,808
Ensembl chr17:17,777,434...17,805,862 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,312,472...106,319,124
Ensembl chr2B:224,906,271...224,911,506 		JBrowse link
G TMEM131L transmembrane 131 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:145,808,457...145,978,954
Ensembl chr 4:157,630,958...157,802,132 		JBrowse link
negative regulation of lymphocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO7 F-box protein 7 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5317390|PMID:21652635) MGI
Ensembl		 PMID:21652635 GO_REF:0000107 MGI:5317390 NCBI chr22:13,481,255...13,505,301
Ensembl chr22:31,335,423...31,359,224 		JBrowse link
negative regulation of macrophage differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:183,876,051...183,889,723
Ensembl chr 3:192,341,320...192,354,885 		JBrowse link
G C1QC complement C1q C chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:21,828,969...21,833,518
Ensembl chr 1:22,770,582...22,782,176 		JBrowse link
G GATA2 GATA binding protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3769271|PMID:16254139) MGI
Ensembl		 PMID:16254139 GO_REF:0000107 MGI:3769271 NCBI chr 3:125,526,537...125,535,649
Ensembl chr 3:132,890,508...132,899,035 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570 		JBrowse link
G THOC5 THO complex subunit 5 acts_upstream_of_or_within ISO (MGI:1349551|PMID:10597251) MGI PMID:10597251 MGI:1349551 NCBI chr22:10,553,665...10,599,948
Ensembl chr22:28,357,644...28,404,346 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 Ensembl chr20:61,667,319...61,713,895 JBrowse link
negative regulation of mast cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZFPM1 zinc finger protein, FOG family member 1 involved_in ISO (MGI:3773481|PMID:18063754) BHF-UCL PMID:18063754 MGI:3773481 NCBI chr16:69,164,299...69,246,136 JBrowse link
negative regulation of memory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGL2 fibrinogen like 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6188369|PMID:29341118) MGI
Ensembl		 PMID:29341118 GO_REF:0000107 MGI:6188369 NCBI chr 7:69,114,082...69,120,575
Ensembl chr 7:82,926,266...82,932,550 		JBrowse link
G LOC100976419 interferon lambda-1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:36,394,462...36,397,363
Ensembl chr19:44,942,186...44,944,519 		JBrowse link
negative regulation of monocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APCS amyloid P component, serum involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:134,937,472...134,938,512
Ensembl chr 1:138,734,046...138,735,093 		JBrowse link
G CDK6 cyclin dependent kinase 6 involved_in ISO (PMID:26542173) UniProt PMID:26542173 NCBI chr 7:84,603,419...84,835,082 JBrowse link
G GPR68 G protein-coupled receptor 68 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3848292|PMID:19479052) MGI
Ensembl		 PMID:19479052 GO_REF:0000107 MGI:3848292 NCBI chr14:71,859,025...71,891,126
Ensembl chr14:91,207,679...91,208,806 		JBrowse link
G HOXA7 homeobox A7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:27,799,317...27,802,492
Ensembl chr 7:27,396,898...27,402,142 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1266928|PMID:9620849) MGI
Ensembl		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:124,387,561...124,393,551
Ensembl chr 8:127,131,512...127,136,863 		JBrowse link
G ZBTB46 zinc finger and BTB domain containing 46 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5320487|PMID:22615127) MGI
Ensembl		 PMID:22615127 GO_REF:0000107 MGI:5320487 Ensembl chr20:61,667,319...61,713,895 JBrowse link
negative regulation of myeloid leukocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LYN LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:52,318,497...52,455,741
Ensembl chr 8:49,755,708...49,825,287 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO RGD PMID:7737424 RGD:2299083 NCBI chr17:45,243,588...45,252,135
Ensembl chr17:50,113,622...50,131,636 		JBrowse link
negative regulation of natural killer cell differentiation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PGLYRP1 peptidoglycan recognition protein 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5297102|PMID:20709292) MGI
Ensembl		 PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr19:43,033,080...43,037,726
Ensembl chr19:51,569,275...51,573,764 		JBrowse link
G PGLYRP2 peptidoglycan recognition protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5297102|PMID:20709292) MGI
Ensembl		 PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr19:14,999,893...15,012,376
Ensembl chr19:15,986,090...15,997,726 		JBrowse link
G PGLYRP3 peptidoglycan recognition protein 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5297102|PMID:20709292) MGI
Ensembl		 PMID:20709292 GO_REF:0000107 MGI:5297102 NCBI chr 1:128,642,034...128,656,082
Ensembl chr 1:132,270,957...132,283,860 		JBrowse link
G PGLYRP4 peptidoglycan recognition protein 4 acts_upstream_of_or_within ISO (MGI:5297102|PMID:20709292) MGI PMID:20709292 MGI:5297102 NCBI chr 1:128,681,726...128,700,275
Ensembl chr 1:132,310,256...132,329,013 		JBrowse link
negative regulation of neutrophil differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1266928|PMID:9620849) MGI
Ensembl		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G TRIB1 tribbles pseudokinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:122,115,194...122,123,319
Ensembl chr 8:124,867,359...124,872,924 		JBrowse link
negative regulation of osteoclast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN18 claudin 18 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5489769|PMID:22437732) MGI
Ensembl		 PMID:22437732 GO_REF:0000107 MGI:5489769 NCBI chr 3:135,037,555...135,061,105
Ensembl chr 3:142,478,031...142,512,548 		JBrowse link
G FBN1 fibrillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111 		JBrowse link
G FBXW7 F-box and WD repeat domain containing 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:144,660,676...144,874,404
Ensembl chr 4:156,312,274...156,402,351 		JBrowse link
G TJP2 tight junction protein 2 acts_upstream_of_or_within ISO (MGI:5489769|PMID:22437732) MGI PMID:22437732 MGI:5489769 NCBI chr 9:55,536,627...55,690,472
Ensembl chr 9:67,886,421...68,021,189 		JBrowse link
negative regulation of osteoclast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCA calcitonin related polypeptide alpha involved_in ISO (PMID:10822112) UniProt PMID:10822112 NCBI chr11:15,055,897...15,061,539
Ensembl chr11:14,745,588...14,751,267 		JBrowse link
G CEACAM1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:5691608|PMID:25490771) MGI PMID:25490771 MGI:5691608 NCBI chr19:39,395,550...39,417,063
Ensembl chr19:47,989,430...48,008,739 		JBrowse link
G CTNNB1 catenin beta 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3578468|PMID:15866165) MGI
Ensembl		 PMID:15866165 GO_REF:0000107 MGI:3578468 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030 		JBrowse link
G FBN1 fibrillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:27,358,780...27,593,539
Ensembl chr15:45,682,450...45,918,111 		JBrowse link
G GPR137B G protein-coupled receptor 137B involved_in ISO (MGI:6362357|PMID:31173907) UniProt PMID:31173907 MGI:6362357 NCBI chr 1:211,709,507...211,775,846
Ensembl chr 1:216,696,105...216,778,370 		JBrowse link
G GPR55 G protein-coupled receptor 55 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:118,159,511...118,163,334
Ensembl chr2B:236,958,210...236,959,169 		JBrowse link
G IAPP islet amyloid polypeptide acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3037515|PMID:14970190) MGI
Ensembl		 PMID:14970190 GO_REF:0000107 MGI:3037515 NCBI chr12:64,918,000...64,925,191
Ensembl chr12:67,520,986...67,528,103 		JBrowse link
G IFNB1 interferon beta 1 acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) MGI PMID:17442941 MGI:3836131 NCBI chr 9:20,884,742...20,886,317 JBrowse link
G IFNG interferon gamma acts_upstream_of_or_within ISO (MGI:3836131|PMID:17442941) MGI PMID:17442941 MGI:3836131 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (MGI:2675763|PMID:12941478), (MGI:3836131|PMID:17442941) MGI PMID:12941478 PMID:17442941 MGI:2675763 MGI:3836131 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B acts_upstream_of_or_within ISO (MGI:5295788|PMID:21982707) MGI PMID:21982707 MGI:5295788 NCBI chr 4:134,405,934...135,213,851
Ensembl chr 4:145,706,307...146,141,029 		JBrowse link
G INPP5D inositol polyphosphate-5-phosphatase D acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2386137|PMID:12161749) MGI
Ensembl		 PMID:12161749 GO_REF:0000107 MGI:2386137 NCBI chr2B:120,287,606...120,436,526
Ensembl chr2B:239,201,762...239,350,190 		JBrowse link
G LILRB4 leukocyte immunoglobulin like receptor B4 involved_in ISO (PMID:18802077) UniProt PMID:18802077 NCBI chr19:51,606,681...51,612,751 JBrowse link
G LOC100971914 wiskott-Aldrich syndrome protein homolog involved_in ISO (MGI:5706679|PMID:26644563) UniProt PMID:26644563 MGI:5706679 NCBI chr2A:39,474,444...39,702,230 JBrowse link
G LOC100991256 leukocyte immunoglobulin-like receptor subfamily B member 3 involved_in ISO (PMID:18802077) UniProt PMID:18802077 NCBI chr19:51,148,567...51,154,764 JBrowse link
G LRRC17 leucine rich repeat containing 17 involved_in ISO (MGI:3850892|PMID:19336404) UniProt PMID:19336404 MGI:3850892 NCBI chr 7:94,884,624...94,917,576
Ensembl chr 7:107,756,505...107,767,445 		JBrowse link
G MAFB MAF bZIP transcription factor B involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:37,023,988...37,027,446
Ensembl chr20:38,127,722...38,128,693 		JBrowse link
G NF1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3689489|PMID:17053831) Ensembl
MGI		 PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295 		JBrowse link
G PIAS3 protein inhibitor of activated STAT 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3836131|PMID:17442941) MGI
Ensembl		 PMID:17442941 GO_REF:0000107 MGI:3836131 NCBI chr 1:121,900,224...121,911,513
Ensembl chr 1:113,758,691...113,768,714 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3689489|PMID:17053831) MGI
Ensembl		 PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G SFRP1 secreted frizzled related protein 1 acts_upstream_of_or_within ISO (MGI:3040721|PMID:14976225) RGD
MGI		 PMID:14976225 PMID:17540629 MGI:3040721 RGD:4107086 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G TCTA T cell leukemia translocation altered involved_in ISO (PMID:19560569) UniProt PMID:19560569 NCBI chr 3:49,340,010...49,344,288 JBrowse link
G TNFAIP6 TNF alpha induced protein 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:38,669,652...38,692,037
Ensembl chr2B:155,933,842...155,956,382 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:115,614,778...115,643,387
Ensembl chr 8:118,134,305...118,162,422 		JBrowse link
G TOB2 transducer of ERBB2, 2 acts_upstream_of_or_within ISO (MGI:3785228|PMID:18358842) MGI PMID:18358842 MGI:3785228 NCBI chr22:22,329,783...22,344,795 JBrowse link
G UBASH3B ubiquitin associated and SH3 domain containing B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5619442|PMID:23149425) MGI
Ensembl		 PMID:23149425 GO_REF:0000107 MGI:5619442 NCBI chr11:117,489,411...117,647,719
Ensembl chr11:121,410,545...121,563,133 		JBrowse link
negative regulation of plasma cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3051167|PMID:15240705) MGI
Ensembl		 PMID:15240705 GO_REF:0000107 MGI:3051167 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) acts_upstream_of ISO (PMID:22962438) ARUK-UCL PMID:22962438 NCBI chr 1:183,094,601...183,246,957 JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:1,440,837...1,538,501
Ensembl chr18:16,562,052...16,659,570 		JBrowse link
negative regulation of regulatory T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD44 CD44 molecule (Indian blood group) involved_in ISO (MGI:5688819|PMID:25065622) UniProt PMID:25065622 MGI:5688819 NCBI chr11:35,110,732...35,258,238
Ensembl chr11:34,985,634...35,079,009 		JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:91,054,917...91,106,234
Ensembl chr2B:209,239,417...209,244,498 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 ISO RGD PMID:30287503 RGD:38549580 NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984 		JBrowse link
G IRF1 interferon regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:127,903,887...127,913,843
Ensembl chr 5:134,067,441...134,075,035 		JBrowse link
G LAG3 lymphocyte activating 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:6,903,770...6,909,778
Ensembl chr12:6,817,507...6,823,047 		JBrowse link
G MDK midkine involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:46,339,365...46,342,388
Ensembl chr11:46,891,540...46,893,254 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:3806904|PMID:18713990) BHF-UCL PMID:18713990 MGI:3806904 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
negative regulation of T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD74 CD74 molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:52620|PMID:7679955) MGI
Ensembl		 PMID:7679955 GO_REF:0000107 MGI:52620 NCBI chr 5:145,825,635...145,836,916
Ensembl chr 5:151,830,311...151,841,334 		JBrowse link
G CYLD CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (MGI:5449492|PMID:23066153) MGI PMID:23066153 MGI:5449492 NCBI chr16:31,004,393...31,064,546
Ensembl chr16:49,882,751...49,942,629 		JBrowse link
G DTX1 deltex E3 ubiquitin ligase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2663321|PMID:12794108) MGI
Ensembl		 PMID:12794108 GO_REF:0000107 MGI:2663321 NCBI chr12:110,661,247...110,702,780
Ensembl chr12:114,046,700...114,085,372 		JBrowse link
G IFNB1 interferon beta 1 involved_in ISO (PMID:20554961) UniProt PMID:20554961 NCBI chr 9:20,884,742...20,886,317 JBrowse link
G LOC100972354 interferon alpha-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:21,245,017...21,246,210
Ensembl chr 9:21,863,062...21,863,736 		JBrowse link
G LOC100976419 interferon lambda-1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:36,394,462...36,397,363
Ensembl chr19:44,942,186...44,944,519 		JBrowse link
G NRARP NOTCH regulated ankyrin repeat protein acts_upstream_of_or_within ISO (MGI:2663321|PMID:12794108) MGI PMID:12794108 MGI:2663321 NCBI chr 9:108,358,959...108,361,586 JBrowse link
G PRDX2 peroxiredoxin 2 acts_upstream_of_or_within ISO (MGI:3796974|PMID:16290204) MGI PMID:16290204 MGI:3796974 NCBI chr19:12,359,084...12,363,552
Ensembl chr19:13,103,422...13,107,369 		JBrowse link
negative regulation of T cell differentiation in thymus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:34,542,132...34,549,286
Ensembl chr14:52,821,872...52,828,752 		JBrowse link
G FOXJ1 forkhead box J1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:70,084,920...70,089,865
Ensembl chr17:75,638,634...75,641,666 		JBrowse link
G IHH Indian hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:106,312,472...106,319,124
Ensembl chr2B:224,906,271...224,911,506 		JBrowse link
G NFKBID NFKB inhibitor delta acts_upstream_of_or_within ISO (MGI:2177878|PMID:11931770) MGI PMID:11931770 MGI:2177878 NCBI chr19:32,805,772...32,817,778
Ensembl chr19:41,553,727...41,568,555 		JBrowse link
G RAG2 recombination activating 2 ISO RGD PMID:30206106 RGD:38508903 NCBI chr11:36,558,419...36,564,997
Ensembl chr11:36,431,703...36,433,286 		JBrowse link
G SHH sonic hedgehog signaling molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:1888832|PMID:10981962) MGI
Ensembl		 PMID:10981962 GO_REF:0000107 MGI:1888832 NCBI chr 7:147,400,112...147,414,036
Ensembl chr 7:159,114,666...159,126,651 		JBrowse link
G ZC3H8 zinc finger CCCH-type containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:89,750,479...89,800,330
Ensembl chr2A:113,342,973...113,387,110 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4R interleukin 4 receptor acts_upstream_of_or_within ISO (MGI:3761239|PMID:16424184) MGI PMID:16424184 MGI:3761239 Ensembl chr16:27,642,702...27,737,445 JBrowse link
G JAK3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISO (MGI:4942267|PMID:9670042) BHF-UCL PMID:9670042 MGI:4942267 NCBI chr 1:148,684,689...148,989,775
Ensembl chr 1:152,391,450...152,415,845 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:41,550,462...41,567,492
Ensembl chr  X:49,402,652...49,417,029 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:114,637,328...114,642,586
Ensembl chr 4:125,782,563...125,787,984 		JBrowse link
G IL4 interleukin 4 acts_upstream_of_or_within ISO (MGI:3817792|PMID:18792410) MGI PMID:18792410 MGI:3817792 NCBI chr 5:128,091,342...128,099,886
Ensembl chr 5:134,253,039...134,261,581 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:149,454,748...149,539,566
Ensembl chr 1:153,160,661...153,213,402 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:93,975,164...94,031,516
Ensembl chr 9:122,313,791...122,365,102 		JBrowse link
G SMAD7 SMAD family member 7 involved_in ISO (MGI:5634593|PMID:25642768) BHF-UCL PMID:25642768 MGI:5634593 NCBI chr18:42,306,324...42,337,214 JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:5450776|PMID:23034280) MGI
Ensembl		 PMID:23034280 GO_REF:0000107 MGI:5450776 NCBI chr 1:130,350,798...130,366,690
Ensembl chr 1:133,959,847...133,975,729 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:36,743,341...36,753,261
Ensembl chr 1:38,093,917...38,103,556 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:74,598,870...74,622,502
Ensembl chr2A:76,105,957...76,128,495 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:9,791,008...9,803,894
Ensembl chr17:9,973,920...9,985,660 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 1:148,528,535...148,662,839
Ensembl chr 1:152,251,683...152,262,668 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:51,647,404...51,665,990
Ensembl chr 9:71,929,728...71,948,779 		JBrowse link
G BCL6 BCL6 transcription repressor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2450484|PMID:12594267) MGI
Ensembl		 PMID:12594267 GO_REF:0000107 MGI:2450484 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124 		JBrowse link
G HLX H2.0 like homeobox acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3761239|PMID:16424184) MGI
Ensembl		 PMID:16424184 GO_REF:0000107 MGI:3761239 NCBI chr 1:196,465,704...196,471,803
Ensembl chr 1:201,500,470...201,506,222 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) UniProt PMID:12242343 MGI:3687909 NCBI chr2A:46,813,589...46,878,102
Ensembl chr2A:47,804,431...47,806,041 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3580753|PMID:15917799) MGI
Ensembl		 PMID:15917799 GO_REF:0000107 MGI:3580753 NCBI chr 1:149,454,748...149,539,566
Ensembl chr 1:153,160,661...153,213,402 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15372
    negative regulation of biological process 5275
      negative regulation of immune system process 480
        negative regulation of hemopoiesis 112
          negative regulation of leukocyte differentiation 107
            negative regulation of dendritic cell differentiation 4
            negative regulation of lymphocyte differentiation + 62
            negative regulation of myeloid leukocyte differentiation + 47
Path 2
Term Annotations click to browse term
  biological_process 15372
    cellular process 14077
      cellular developmental process 4055
        cell differentiation 4031
          cell development 2907
            hemopoiesis 952
              leukocyte differentiation 607
                regulation of leukocyte differentiation 320
                  negative regulation of leukocyte differentiation 107
                    negative regulation of dendritic cell differentiation 4
                    negative regulation of lymphocyte differentiation + 62
                    negative regulation of myeloid leukocyte differentiation + 47
paths to the root