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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of amyloid-beta formation
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Accession:GO:1902003 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of amyloid-beta formation.


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regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein NOT ISO UniProtKB:Q7M6Y3 (PMID:26005850) RGD PMID:26005850 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Olfm1 olfactomedin 1 ISO (MGI:MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:MGI:5444053 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein NOT ISO UniProtKB:P05067:PRO_0000000092 (MGI:MGI:5637941|PMID:26005850) RGD PMID:26005850 MGI:MGI:5637941 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 ISO
ISS
(PMID:16641999)
GO_REF:0000024
RGD
UniProt
PMID:16641999 GO_REF:0000024 NCBI chr 6:109,169,739...109,205,004
Ensembl chr 6:109,169,741...109,205,004
JBrowse link
negative regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 ISS
ISO
GO_REF:0000024
(MGI:MGI:5487687|PMID:23467355), (MGI:MGI:5553242|PMID:18429932), (MGI:MGI:5774886|PMID:27030769)
Alzheimers_University_of_Toronto
RGD
PMID:18429932, PMID:23467355, PMID:27030769 GO_REF:0000024, MGI:MGI:5487687, MGI:MGI:5553242, MGI:MGI:5774886 NCBI chr 7:12,742,433...12,762,423
Ensembl chr 7:12,742,433...12,762,341
JBrowse link
G Apoe apolipoprotein E IEA
ISO
GO_REF:0000107
(PMID:24154541), (PMID:24259049)
Ensembl
RGD
PMID:24154541, PMID:24259049 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bin1 bridging integrator 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5811968|PMID:27179792)
(PMID:27179792)
Ensembl
RGD
PMID:27179792 GO_REF:0000107, MGI:MGI:5811968 NCBI chr18:25,163,575...25,222,139
Ensembl chr18:25,163,561...25,222,135
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO
IEA
UniProtKB:P05067 (PMID:20708605)
GO_REF:0000107
RGD
Ensembl
PMID:20708605 GO_REF:0000107 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clu clusterin IEA
ISO
ISS
GO_REF:0000107
(PMID:12047389), (PMID:17412999)
GO_REF:0000024
Ensembl
RGD
Alzheimers_University_of_Toronto
PMID:12047389, PMID:17412999 GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 ISO (PMID:17553422) RGD PMID:17553422 NCBI chr10:104,137,655...104,156,576
Ensembl chr10:104,137,655...104,156,576
JBrowse link
G Hap1 huntingtin-associated protein 1 IMP PMID:22731248 UniProt PMID:22731248 RGD:10047200 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Igf1 insulin-like growth factor 1 IEA
ISO
GO_REF:0000107
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
Ensembl
RGD
PMID:27277332 GO_REF:0000107 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 ISO
IEA
UniProtKB:P05067-4 (PMID:26094765)
GO_REF:0000107
RGD
Ensembl
PMID:26094765 GO_REF:0000107 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676
JBrowse link
G Olfm1 olfactomedin 1 ISO (MGI:MGI:5444053|PMID:22992957) RGD PMID:22992957 MGI:MGI:5444053 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO (PMID:25576397)
(MGI:MGI:3620333|PMID:16554819)
RGD PMID:16554819, PMID:25576397 MGI:MGI:3620333 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Prnp prion protein ISO UniProtKB:P12023 (MGI:MGI:3714552|PMID:17573534) RGD PMID:17573534 MGI:MGI:3714552 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 IEA
ISO
GO_REF:0000107
(PMID:24305806), (PMID:27853422)
Ensembl
RGD
PMID:24305806, PMID:27853422 GO_REF:0000107 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Sorl1 sortilin related receptor 1 ISO (PMID:16407538), (PMID:17855360), (PMID:21989385), (PMID:22621900), (PMID:24001769), (PMID:24523320)
(MGI:MGI:3801250|PMID:18362153), (MGI:MGI:3821635|PMID:19036982)
RGD PMID:16407538, PMID:17855360, PMID:18362153, PMID:19036982, PMID:21989385, PMID:22621900, PMID:24001769, PMID:24523320 MGI:MGI:3801250, MGI:MGI:3821635 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Spon1 spondin 1 ISO
IEA
(MGI:MGI:3607023|PMID:16227578)
GO_REF:0000107
RGD
Ensembl
PMID:16227578 GO_REF:0000107, MGI:MGI:3607023 NCBI chr 1:178,568,777...178,935,715
Ensembl chr 1:178,636,544...178,935,051
JBrowse link
positive regulation of amyloid-beta formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 ISO
IMP
IEA
(PMID:22086926)
GO_REF:0000107
RGD
Ensembl
PMID:22086926, PMID:22086926 GO_REF:0000107, RGD:14697726 NCBI chr 3:2,648,787...2,668,770
Ensembl chr 3:2,648,885...2,668,809
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 ISO (PMID:17293612) RGD PMID:17293612 NCBI chr20:9,743,269...9,842,735
Ensembl chr20:9,743,269...9,840,489
JBrowse link
G Apoe apolipoprotein E ISO (PMID:24154541), (PMID:24259049) RGD PMID:24154541, PMID:24259049 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G App amyloid beta precursor protein ISO UniProtKB:P49768 (PMID:23640054) RGD PMID:23640054 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Casp3 caspase 3 ISO
IDA
(PMID:17553422) RGD PMID:17553422, PMID:17553422 RGD:13825190 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEA
ISO
GO_REF:0000107
UniProtKB:P05067 (MGI:MGI:4437154|PMID:20164328)
Ensembl
RGD
PMID:20164328 GO_REF:0000107, MGI:MGI:4437154 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Clu clusterin ISO
ISS
IEA
(MGI:MGI:2384259|PMID:12145324)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:12145324 GO_REF:0000024, GO_REF:0000107, MGI:MGI:2384259 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Csnk1e casein kinase 1, epsilon IDA RGD PMID:17360493 RGD:10395238 NCBI chr 7:120,651,976...120,675,559
Ensembl chr 7:120,651,881...120,672,359
JBrowse link
G Efna1 ephrin A1 ISO (PMID:24217950) RGD PMID:24217950 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Epha4 Eph receptor A4 ISO UniProtKB:P20827 (PMID:24217950) RGD PMID:24217950 NCBI chr 9:83,111,222...83,253,486
Ensembl chr 9:83,111,222...83,253,458
JBrowse link
G Gsap gamma-secretase activating protein ISO
IBA
(PMID:20811458)
PMID:21873635
(MGI:MGI:4830390|PMID:20811458)
RGD PMID:20811458, PMID:21873635 MGI:MGI:4830390, RGD:13792537 NCBI chr 4:10,423,090...10,517,887
Ensembl chr 4:10,423,139...10,517,848
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO UniProtKB:P49841 (PMID:12761548) RGD PMID:12761548 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Ifng interferon gamma ISO UniProtKB:P05067|UniProtKB:P10636|UniProtKB:P49768 (PMID:19808651)
UniProtKB:P05067|UniProtKB:P15261 (MGI:MGI:3697769|PMID:17255335)
RGD PMID:17255335, PMID:19808651 MGI:MGI:3697769 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 ISO UniProtKB:P01579|UniProtKB:P05067 (MGI:MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:MGI:3697769 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Lrrtm3 leucine rich repeat transmembrane neuronal 3 ISO (PMID:17098871)
(MGI:MGI:3695648|PMID:17098871)
RGD PMID:17098871 MGI:MGI:3695648 NCBI chr20:25,990,304...26,163,656
Ensembl chr20:25,990,304...26,163,656
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO
ISS
IEA
(PMID:24577224)
(MGI:MGI:5432454|PMID:22539346), (MGI:MGI:5560380|PMID:24577224)
GO_REF:0000024
GO_REF:0000107
RGD
Alzheimers_University_of_Toronto
Ensembl
PMID:22539346, PMID:24577224 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5432454, MGI:MGI:5560380 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO (MGI:MGI:6414694|PMID:21329555) RGD PMID:21329555 MGI:MGI:6414694 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 IEA
ISO
GO_REF:0000107
(MGI:MGI:6114922|PMID:24305806)
(PMID:24305806)
Ensembl
RGD
PMID:24305806 GO_REF:0000107, MGI:MGI:6114922 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Slc2a13 solute carrier family 2 member 13 ISO UniProtKB:P05067-4 (PMID:26094765) RGD PMID:26094765 NCBI chr 7:132,430,852...132,757,558
Ensembl chr 7:132,430,853...132,757,558
JBrowse link
G Sp1 Sp1 transcription factor ISO (PMID:14701757) RGD PMID:14701757 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Tnf tumor necrosis factor ISO (MGI:MGI:3697769|PMID:17255335) RGD PMID:17255335 MGI:MGI:3697769 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    regulation of biological process 13075
      regulation of metabolic process 6996
        regulation of nitrogen compound metabolic process 5851
          regulation of cellular amide metabolic process 436
            regulation of amyloid-beta formation 34
              negative regulation of amyloid-beta formation 15
              positive regulation of amyloid-beta formation 21
Path 2
Term Annotations click to browse term
  biological_process 20028
    metabolic process 12271
      organic substance metabolic process 11651
        macromolecule metabolic process 10086
          protein metabolic process 6228
            amyloid precursor protein metabolic process 66
              amyloid precursor protein catabolic process 51
                regulation of amyloid precursor protein catabolic process 41
                  regulation of amyloid-beta formation 34
                    negative regulation of amyloid-beta formation 15
                    positive regulation of amyloid-beta formation 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.