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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cell cycle checkpoint
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Accession:GO:1901976 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell cycle checkpoint.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
Synonyms:related_synonym: regulation of G1/S checkpoint;   regulation of G1/S transition checkpoint
 alt_id: GO:2001047


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO (PMID:18022368) RGD PMID:18022368 NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447 		JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24374861)		 UniProt
RGD		 PMID:24374861 GO_REF:0000024 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 involved_in ISO (PMID:23728299) RGD PMID:23728299 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Chek2 checkpoint kinase 2 IMP RGD PMID:20637979 RGD:10401658 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:44,820,693...44,837,935
Ensembl chr  X:44,820,820...44,837,934 		JBrowse link
G Ddx39b DExD-box helicase 39B involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22144908)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22144908 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,547,702...3,585,064
Ensembl chr20:3,572,056...3,584,996 		JBrowse link
G Thoc1 THO complex subunit 1 involved_in ISO (PMID:22144908) RGD PMID:22144908 NCBI chr18:983,824...1,019,123
Ensembl chr18:983,824...1,019,114 		JBrowse link
G Thoc5 THO complex subunit 5 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22144908)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22144908 GO_REF:0000024 GO_REF:0000107 NCBI chr14:79,758,805...79,792,718
Ensembl chr14:79,758,917...79,792,718 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 involved_in ISO UniProtKB:Q15554 (PMID:23426265) RGD PMID:23426265 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
positive regulation of cell cycle checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prox1 prospero homeobox 1 acts_upstream_of_or_within ISO (MGI:4946187|PMID:21040746) RGD PMID:21040746 MGI:4946187 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO (PMID:23352644) RGD PMID:23352644 NCBI chr15:45,212,797...45,228,001
Ensembl chr15:45,212,803...45,227,636 		JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:19229290)		 UniProt
Ensembl
RGD		 PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:22898774), (PMID:36322655) RGD PMID:22898774 PMID:36322655 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (MGI:4839685|PMID:20870947)
(PMID:20870947), (PMID:22898774), (PMID:8824189)		 RGD PMID:8824189 PMID:20870947 PMID:22898774 MGI:4839685 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) RGD PMID:25743205 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)		 RGD PMID:20870947 MGI:4839685 NCBI chr16:76,423,245...76,448,712
Ensembl chr16:76,423,245...76,448,712 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:18981471), (PMID:19273613)		 UniProt
Ensembl
RGD		 PMID:18981471 PMID:19273613 GO_REF:0000024 GO_REF:0000107 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:15342622) RGD PMID:15342622 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cry1 cryptochrome circadian regulator 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5567851|PMID:24489120)		 UniProt
RGD		 PMID:24489120 GO_REF:0000024 MGI:5567851 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO MGI:3851025 (MGI:3850765|PMID:19481525) RGD PMID:19481525 MGI:3850765 NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330 		JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in IBA
ISO		 PMID:21873635
(PMID:27723717), (PMID:27723720)		 RGD PMID:27723717 PMID:27723720 PMID:21873635 RGD:13792537 NCBI chr14:92,298,461...92,314,044
Ensembl chr14:92,299,553...92,314,104 		JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO MGI:5301830 (MGI:5299398|PMID:21911473) RGD PMID:21911473 MGI:5299398 NCBI chr 2:53,174,798...53,187,792
Ensembl chr 2:53,174,798...53,187,792 		JBrowse link
G Fem1b fem-1 homolog B involved_in ISS
ISO		 GO_REF:0000024
(PMID:19330022)		 UniProt
RGD		 PMID:19330022 GO_REF:0000024 NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577 		JBrowse link
G Nek1 NIMA-related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) RGD PMID:18843199 MGI:5619475 NCBI chr16:28,998,229...29,125,426
Ensembl chr16:28,998,231...29,117,723 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:21504906) RGD PMID:21504906 NCBI chr19:39,235,883...39,268,479
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Rnaseh2b ribonuclease H2, subunit B acts_upstream_of_or_within
involved_in		 ISO
IEA		 MGI:4432164 (MGI:5435090|PMID:22802351)
GO_REF:0000107		 RGD
Ensembl		 PMID:22802351 GO_REF:0000107 MGI:5435090 NCBI chr15:36,541,200...36,592,016
Ensembl chr15:36,541,218...36,584,118 		JBrowse link
G Rpa2 replication protein A2 involved_in ISO
ISS		 (PMID:21504906)
GO_REF:0000024		 RGD
UniProt		 PMID:21504906 GO_REF:0000024 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Wdr76 WD repeat domain 76 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:108,456,784...108,491,528
Ensembl chr 3:108,456,815...108,490,840 		JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in IBA
IEA
ISS
ISO		 PMID:21873635
GO_REF:0000107
GO_REF:0000002
GO_REF:0000024
(PMID:21926987)		 Ensembl
InterPro
UniProt
RGD		 PMID:21926987 PMID:21873635 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145 		JBrowse link
G Ccnb1 cyclin B1 involved_in ISO
IEA		 (PMID:18195732)
GO_REF:0000107		 RGD
Ensembl		 PMID:18195732 GO_REF:0000107 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
IBA
ISO
IEA		 GO_REF:0000024
PMID:21873635
(PMID:19282672)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19282672 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO
IEA		 (PMID:19893618)
GO_REF:0000107		 RGD
Ensembl		 PMID:19893618 GO_REF:0000107 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915 		JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17724024)
GO_REF:0000107		 RGD
Ensembl		 PMID:17724024 GO_REF:0000107 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) RGD PMID:21853124 MGI:5448515 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19527
    cellular process 18201
      signal transduction 6976
        intracellular signal transduction 2712
          cell cycle checkpoint signaling 180
            regulation of cell cycle checkpoint 37
              negative regulation of cell cycle checkpoint + 10
              positive regulation of cell cycle checkpoint + 11
              regulation of DNA damage checkpoint + 19
              regulation of spindle checkpoint + 17
Path 2
Term Annotations click to browse term
  biological_process 19527
    biological regulation 13192
      regulation of biological process 12837
        negative regulation of biological process 5661
          negative regulation of cellular process 5298
            negative regulation of cell cycle 385
              negative regulation of cell cycle process 311
                negative regulation of cell cycle phase transition 260
                  cell cycle checkpoint signaling 180
                    regulation of cell cycle checkpoint 37
                      negative regulation of cell cycle checkpoint + 10
                      positive regulation of cell cycle checkpoint + 11
                      regulation of DNA damage checkpoint + 19
                      regulation of spindle checkpoint + 17
paths to the root