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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cell cycle checkpoint
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Accession:GO:1901976 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell cycle checkpoint.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
Synonyms:related_synonym: regulation of G1/S checkpoint;   regulation of G1/S transition checkpoint
 alt_id: GO:2001047


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:16,410,083...16,721,232
Ensembl chr12:16,410,083...16,719,824
JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO (PMID:18022368) RGD PMID:18022368 NCBI chr 9:17,217,141...17,221,465
Ensembl chr 9:17,216,495...17,221,434
JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:24374861)
UniProt
RGD
PMID:24374861 GO_REF:0000024 NCBI chr 1:212,558,257...212,562,053
Ensembl chr 1:212,558,257...212,562,051
JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 involved_in ISO (PMID:23728299) RGD PMID:23728299 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Chek2 checkpoint kinase 2 IMP RGD PMID:20637979 RGD:10401658 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Da2-19 uncharacterized LOC302729 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:48,196,789...48,213,506
Ensembl chr  X:48,196,916...48,213,505
JBrowse link
G Ddx39b DExD-box helicase 39B involved_in ISS
ISO
GO_REF:0000024
(PMID:22144908)
UniProt
RGD
PMID:22144908 GO_REF:0000024 NCBI chr20:4,806,103...4,818,600
Ensembl chr20:4,806,108...4,818,568
JBrowse link
G Thoc1 THO complex 1 involved_in ISO (PMID:22144908) RGD PMID:22144908 NCBI chr18:1,142,540...1,177,084
Ensembl chr18:1,142,782...1,176,974
JBrowse link
G Thoc5 THO complex 5 involved_in ISS
ISO
GO_REF:0000024
(PMID:22144908)
UniProt
RGD
PMID:22144908 GO_REF:0000024 NCBI chr14:85,138,219...85,171,729
Ensembl chr14:85,142,279...85,171,726
JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:Q15554 (PMID:23426265)
Ensembl
RGD
PMID:23426265 GO_REF:0000107 NCBI chr20:3,329,677...3,344,286
Ensembl chr20:3,329,677...3,344,286
JBrowse link
positive regulation of cell cycle checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prox1 prospero homeobox 1 acts_upstream_of_or_within ISO (MGI:4946187|PMID:21040746) RGD PMID:21040746 MGI:4946187 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO (PMID:23352644) RGD PMID:23352644 NCBI chr15:51,818,887...51,834,443
Ensembl chr15:51,818,897...51,834,030
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19229290)
UniProt
Ensembl
RGD
PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:122,743,274...122,776,801
Ensembl chr 8:122,743,189...122,776,806
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:36,910,064...36,940,868
Ensembl chr 6:36,910,675...36,940,868
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (PMID:20870947), (PMID:8824189)
(MGI:4839685|PMID:20870947)
RGD PMID:8824189 PMID:20870947 MGI:4839685 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:25743205) RGD PMID:25743205 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Pcid2 PCI domain containing 2 involved_in ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
RGD PMID:20870947 MGI:4839685 NCBI chr16:81,757,582...81,783,047
Ensembl chr16:81,756,971...81,783,047
JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
ISO
GO_REF:0000024
(PMID:18981471), (PMID:19273613)
UniProt
RGD
PMID:18981471 PMID:19273613 GO_REF:0000024 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO (PMID:15342622) RGD PMID:15342622 NCBI chr 3:58,965,025...59,120,507
Ensembl chr 3:58,965,552...59,067,369
JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cry1 cryptochrome circadian regulator 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5567851|PMID:24489120)
UniProt
RGD
PMID:24489120 GO_REF:0000024 MGI:5567851 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO MGI:3851025 (MGI:3850765|PMID:19481525) RGD PMID:19481525 MGI:3850765 NCBI chr16:81,718,784...81,756,653
Ensembl chr16:81,719,028...81,756,654
JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in ISO
IBA
(PMID:27723717), (PMID:27723720)
PMID:21873635
RGD PMID:27723717 PMID:27723720, PMID:21873635 RGD:13792537 NCBI chr14:102,290,655...102,293,674
Ensembl chr14:102,290,418...102,293,677
JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO MGI:5301830 (MGI:5299398|PMID:21911473) RGD PMID:21911473 MGI:5299398 NCBI chr 2:53,797,954...53,811,134
Ensembl chr 2:53,797,954...53,811,134
JBrowse link
G Fem1b fem-1 homolog B involved_in ISS
ISO
GO_REF:0000024
(PMID:19330022)
UniProt
RGD
PMID:19330022 GO_REF:0000024 NCBI chr 8:67,695,041...67,708,313
Ensembl chr 8:67,694,904...67,708,304
JBrowse link
G Nek1 NIMA-related kinase 1 involved_in ISO (MGI:5619475|PMID:18843199) RGD PMID:18843199 MGI:5619475 NCBI chr16:32,321,010...32,439,421
Ensembl chr16:32,321,010...32,439,421
JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:21504906) RGD PMID:21504906 NCBI chr19:43,477,121...43,499,068
Ensembl chr19:42,964,586...42,972,101
JBrowse link
G Rnaseh2b ribonuclease H2, subunit B acts_upstream_of_or_within ISO MGI:4432164 (MGI:5435090|PMID:22802351) RGD PMID:22802351 MGI:5435090 NCBI chr15:45,422,010...45,472,792
Ensembl chr15:45,422,010...45,464,892
JBrowse link
G Rpa2 replication protein A2 involved_in ISO
ISS
(PMID:21504906)
GO_REF:0000024
RGD
UniProt
PMID:21504906 GO_REF:0000024 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Wdr76 WD repeat domain 76 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:113,445,498...113,479,483
Ensembl chr 3:113,448,877...113,478,215
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:21926987)
UniProt
RGD
PMID:21926987, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:166,981,738...166,985,363
Ensembl chr 1:166,983,175...166,985,054
JBrowse link
G Ccnb1 cyclin B1 involved_in ISO (PMID:18195732) RGD PMID:18195732 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:19282672)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19282672 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:86,387,238...86,554,108
Ensembl chr 5:86,387,078...86,554,102
JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:17724024)
GO_REF:0000107
RGD
Ensembl
PMID:17724024 GO_REF:0000107 NCBI chr 1:193,335,629...193,391,620
Ensembl chr 1:193,335,645...193,391,638
JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO (MGI:5448515|PMID:21853124) RGD PMID:21853124 MGI:5448515 NCBI chr 7:34,714,293...34,759,352
Ensembl chr 7:34,744,483...34,759,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      signal transduction 6881
        intracellular signal transduction 2607
          cell cycle checkpoint signaling 173
            regulation of cell cycle checkpoint 37
              negative regulation of cell cycle checkpoint + 11
              positive regulation of cell cycle checkpoint + 10
              regulation of DNA damage checkpoint + 19
              regulation of spindle checkpoint + 17
Path 2
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of biological process 12773
        negative regulation of biological process 5621
          negative regulation of cellular process 5117
            negative regulation of cell cycle 364
              negative regulation of cell cycle process 280
                negative regulation of cell cycle phase transition 236
                  cell cycle checkpoint signaling 173
                    regulation of cell cycle checkpoint 37
                      negative regulation of cell cycle checkpoint + 11
                      positive regulation of cell cycle checkpoint + 10
                      regulation of DNA damage checkpoint + 19
                      regulation of spindle checkpoint + 17
paths to the root