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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cell cycle checkpoint
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Accession:GO:1901976 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell cycle checkpoint.
Comment:Note that this term should not be used for direct manual annotation as it should always be possible to specify the type of checkpoint (i.e mitotic spindle or DNA damage etc).
Synonyms:related_synonym: regulation of G1/S checkpoint;   regulation of G1/S transition checkpoint
 alt_id: GO:2001047


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO (PMID:19010891) RGD PMID:19010891 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1bp MAD2L1 binding protein involved_in ISO
IEA 		(PMID:18022368)
GO_REF:0000107 		RGD
Ensembl		 PMID:18022368 GO_REF:0000107 NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447 		JBrowse link
G Prap1 proline-rich acidic protein 1 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:24374861)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:24374861 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:194,883,078...194,886,874
Ensembl chr 1:194,883,078...194,886,872 		JBrowse link
negative regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 involved_in ISO (PMID:23728299) RGD PMID:23728299 NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539 		JBrowse link
G Chek2 checkpoint kinase 2 IMP RGD PMID:20637979 RGD:10401658 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 involved_in ISO
IEA 		UniProtKB:Q15554 (PMID:23426265)
GO_REF:0000107 		RGD
Ensembl		 PMID:23426265 GO_REF:0000107 NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611 		JBrowse link
negative regulation of mitotic spindle assembly checkpoint signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ska1 spindle and kinetochore associated complex subunit 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:26981768) 		UniProt
Ensembl
RGD		 PMID:26981768 GO_REF:0000024 GO_REF:0000107 NCBI chr18:67,794,722...67,805,037
Ensembl chr18:67,794,725...67,805,037 		JBrowse link
G Ska3 spindle and kinetochore associated complex subunit 3 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:19646878) 		UniProt
Ensembl
RGD		 PMID:19646878 GO_REF:0000024 GO_REF:0000107 NCBI chr15:31,951,812...31,971,010
Ensembl chr15:31,951,825...31,971,010 		JBrowse link
positive regulation of cell cycle checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prox1 prospero homeobox 1 acts_upstream_of_or_within ISO
IEA 		(PMID:21040746)
GO_REF:0000107 		RGD
Ensembl		 PMID:21040746 GO_REF:0000107 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183 		JBrowse link
positive regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccar2 cell cycle and apoptosis regulator 2 involved_in ISO
IEA 		(PMID:23352644)
GO_REF:0000107 		RGD
Ensembl		 PMID:23352644 GO_REF:0000107 NCBI chr15:45,212,797...45,228,001
Ensembl chr15:45,212,803...45,227,636 		JBrowse link
G Tti1 TELO2 interacting protein 1 involved_in ISO
IEA 		(PMID:36724785)
GO_REF:0000107 		RGD
Ensembl		 PMID:36724785 GO_REF:0000107 NCBI chr 3:146,639,048...146,682,945
Ensembl chr 3:146,639,054...146,682,847 		JBrowse link
positive regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Knl1 kinetochore scaffold 1 involved_in ISO (PMID:35167144) RGD PMID:35167144 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915 		JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:19229290) 		UniProt
Ensembl
RGD		 PMID:19229290 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934 		JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease involved_in ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:33,947,599...33,978,461
Ensembl chr 6:33,948,206...33,978,401 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in ISO
IEA 		(PMID:22898774), (PMID:36322655)
GO_REF:0000107 		RGD
Ensembl		 PMID:22898774 PMID:36322655 GO_REF:0000107 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 involved_in ISO (PMID:22898774), (PMID:8824189) RGD PMID:8824189 PMID:22898774 NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470 		JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO
IEA 		(PMID:25743205)
GO_REF:0000107 		RGD
Ensembl		 PMID:25743205 GO_REF:0000107 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:18981471), (PMID:19273613) 		UniProt
Ensembl
RGD		 PMID:18981471 PMID:19273613 GO_REF:0000024 GO_REF:0000107 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 involved_in ISO
IEA 		(PMID:23108668)
GO_REF:0000107 		RGD
Ensembl		 PMID:23108668 GO_REF:0000107 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
positive regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO
IEA 		(PMID:15342622)
GO_REF:0000107 		RGD
Ensembl		 PMID:15342622 GO_REF:0000107 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
regulation of DNA damage checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cry1 cryptochrome circadian regulator 1 involved_in ISS
ISO 		GO_REF:0000024
(PMID:24489120) 		UniProt
RGD		 PMID:24489120 GO_REF:0000024 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091 		JBrowse link
G Cul4a cullin 4A acts_upstream_of_or_within ISO
IEA 		MGI:3851025 (PMID:19481525)
GO_REF:0000107 		RGD
Ensembl		 PMID:19481525 GO_REF:0000107 NCBI chr16:83,086,688...83,124,503
Ensembl chr16:76,384,546...76,422,330 		JBrowse link
G ENSRNOG00000069571 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr  X:34,530,495...34,531,833 JBrowse link
G Etaa1 ETAA1 activator of ATR kinase involved_in ISO
IBA 		(PMID:27723717), (PMID:27723720)
GO_REF:0000033 		RGD
GO_Central		 PMID:27723717 PMID:27723720 GO_REF:0000033 NCBI chr14:92,298,461...92,314,044
Ensembl chr14:92,299,553...92,314,104 		JBrowse link
G Fbxo4 F-box protein 4 acts_upstream_of_or_within ISO
IEA 		MGI:5301830 (PMID:21911473)
GO_REF:0000107 		RGD
Ensembl		 PMID:21911473 GO_REF:0000107 NCBI chr 2:54,902,394...54,915,388
Ensembl chr 2:53,174,798...53,187,792 		JBrowse link
G Fem1b fem-1 homolog B involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:19330022) 		UniProt
Ensembl
RGD		 PMID:19330022 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:63,265,301...63,278,577
Ensembl chr 8:63,265,301...63,278,577 		JBrowse link
G LOC134486336 ewing's tumor-associated antigen 1 homolog involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Nek1 NIMA-related kinase 1 involved_in ISO (PMID:18843199) RGD PMID:18843199 NCBI chr16:28,998,229...29,125,426
Ensembl chr16:28,998,231...29,117,723 		JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 involved_in ISO (PMID:21504906) RGD PMID:21504906 NCBI chr19:56,145,221...56,177,871
Ensembl chr19:39,236,787...39,268,479 		JBrowse link
G Rnaseh2b ribonuclease H2, subunit B acts_upstream_of_or_within ISO
IEA 		MGI:4432164 (PMID:22802351)
GO_REF:0000107 		RGD
Ensembl		 PMID:22802351 GO_REF:0000107 NCBI chr15:36,541,200...36,592,016
Ensembl chr15:36,541,218...36,584,118 		JBrowse link
G Rpa2 replication protein A2 involved_in ISO
ISS 		(PMID:21504906)
GO_REF:0000024 		RGD
UniProt		 PMID:21504906 GO_REF:0000024 NCBI chr 5:150,260,668...150,271,329
Ensembl chr 5:144,976,748...144,987,350 		JBrowse link
G Wdr76 WD repeat domain 76 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:108,456,784...108,491,528
Ensembl chr 3:108,456,815...108,490,840 		JBrowse link
regulation of meiosis I spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zwint ZW10 interacting kinetochore protein involved_in ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:26486467) 		UniProt
Ensembl
RGD		 PMID:26486467 GO_REF:0000024 GO_REF:0000107 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957 		JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 involved_in ISO
IEA
IBA
ISS 		(PMID:21926987)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000002
GO_REF:0000024 		RGD
Ensembl
GO_Central
InterPro
UniProt		 PMID:21926987 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:156,238,640...156,266,005
Ensembl chr 1:156,262,841...156,268,145 		JBrowse link
G Ccnb1 cyclin B1 involved_in ISO
IEA 		(PMID:18195732)
GO_REF:0000107 		RGD
Ensembl		 PMID:18195732 GO_REF:0000107 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 involved_in ISS
IBA
ISO
IEA 		GO_REF:0000024
GO_REF:0000033
(PMID:19282672)
GO_REF:0000107 		UniProt
GO_Central
RGD
Ensembl		 PMID:19282672 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782 		JBrowse link
G Dusp1 dual specificity phosphatase 1 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO
IEA 		(PMID:19893618)
GO_REF:0000107 		RGD
Ensembl		 PMID:19893618 GO_REF:0000107 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915 		JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 acts_upstream_of_or_within
involved_in 		ISO
IEA
IBA 		(PMID:17724024)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:17724024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112 		JBrowse link
G Prpf4b pre-mRNA processing factor 4B involved_in ISS
ISO 		GO_REF:0000024
(PMID:17998396) 		UniProt
RGD		 PMID:17998396 GO_REF:0000024 NCBI chr17:29,985,343...30,020,285
Ensembl chr17:29,985,343...30,019,625 		JBrowse link
G Usp44 ubiquitin specific peptidase 44 involved_in ISO
IEA 		(PMID:21853124)
GO_REF:0000107 		RGD
Ensembl		 PMID:21853124 GO_REF:0000107 NCBI chr 7:28,364,169...28,412,039
Ensembl chr 7:28,364,033...28,410,053 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      signal transduction 7313
        intracellular signal transduction 3197
          cell cycle checkpoint signaling 177
            regulation of cell cycle checkpoint 39
              negative regulation of cell cycle checkpoint + 8
              positive regulation of cell cycle checkpoint + 12
              regulation of DNA damage checkpoint + 18
              regulation of spindle checkpoint + 20
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        negative regulation of biological process 5844
          negative regulation of cellular process 5621
            negative regulation of cell cycle 391
              negative regulation of cell cycle process 310
                negative regulation of cell cycle phase transition 259
                  cell cycle checkpoint signaling 177
                    regulation of cell cycle checkpoint 39
                      negative regulation of cell cycle checkpoint + 8
                      positive regulation of cell cycle checkpoint + 12
                      regulation of DNA damage checkpoint + 18
                      regulation of spindle checkpoint + 20
paths to the root