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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of non-canonical NF-kappaB signal transduction
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Accession:GO:1901224 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of the non-canonical NF-kappaB cascade.
Synonyms:exact_synonym: positive regulation of NIK/NF-kappaB signaling
 narrow_synonym: activation of NIK/NF-kappaB cascade;   activation of p52-dependent NF-kappaB signaling;   positive regulation of NF-kappaB import into nucleus;   positive regulation of p52-dependent NF-kappaB signaling;   up regulation of p52-dependent NF-kappaB signaling;   upregulation of p52-dependent NF-kappaB signaling
 broad_synonym: activation of non-canonical NF-KB signaling;   activation of noncanonical NF-kappaB signaling;   activation of noncanonical nuclear factor kappaB (NF-kappaB) pathway;   positive regulation of non-canonical NF-KB signaling;   positive regulation of noncanonical NF-kappaB signaling;   positive regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway;   up regulation of non-canonical NF-KB signaling;   up regulation of noncanonical NF-kappaB signaling;   up regulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway;   upregulation of non-canonical NF-KB signaling;   upregulation of noncanonical NF-kappaB signaling;   upregulation of noncanonical nuclear factor kappaB (NF-kappaB) pathway
 related_synonym: positive regulation of NIK/NF-kappaB cascade;   up regulation of NIK/NF-kappaB cascade;   upregulation of NIK/NF-kappaB cascade
 alt_id: GO:0008588;   GO:0042346


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positive regulation of non-canonical NF-kappaB signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn4 actinin alpha 4 involved_in ISO (PMID:25411248) RGD PMID:25411248 NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:84,182,788...84,251,847 		JBrowse link
G Adissp adipose secreted signaling protein involved_in ISO (PMID:32024300) RGD PMID:32024300 NCBI chr 3:138,817,752...138,832,208
Ensembl chr 3:118,362,363...118,378,838 		JBrowse link
G Ager advanced glycosylation end product-specific receptor involved_in ISO
IEA		 UniProtKB:P05067 (PMID:15457210)
GO_REF:0000107		 RGD
Ensembl		 PMID:15457210 GO_REF:0000107 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Ago1 argonaute RISC component 1 involved_in ISO
IEA		 (PMID:26764146)
GO_REF:0000107		 RGD
Ensembl		 PMID:26764146 GO_REF:0000107 NCBI chr 5:144,006,618...144,064,740
Ensembl chr 5:138,722,111...138,773,546 		JBrowse link
G Ago3 argonaute RISC catalytic component 3 involved_in ISO
IEA		 (PMID:26764146)
GO_REF:0000107		 RGD
Ensembl		 PMID:26764146 GO_REF:0000107 NCBI chr 5:143,913,957...143,998,746
Ensembl chr 5:138,639,569...138,714,230 		JBrowse link
G Ank3 ankyrin 3 IMP RGD PMID:29079505 RGD:153344581 NCBI chr20:18,601,307...19,224,790
Ensembl chr20:18,602,786...19,086,300 		JBrowse link
G App amyloid beta precursor protein involved_in ISO
IEA		 UniProtKB:Q15109 (PMID:15457210), (PMID:29961672)
GO_REF:0000107
(PMID:22406537)		 RGD
Ensembl		 PMID:15457210 PMID:22406537 PMID:29961672 GO_REF:0000107 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G C1qtnf4 C1q and TNF related 4 involved_in ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:97,310,220...97,328,818
Ensembl chr 3:76,857,735...76,874,139 		JBrowse link
G Calr calreticulin acts_upstream_of_or_within ISO
IEA		 (PMID:24998604)
GO_REF:0000107		 RGD
Ensembl		 PMID:24998604 GO_REF:0000107 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15059845) RGD PMID:15059845 NCBI chr 5:61,759,220...61,761,164
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Cd74 CD74 molecule involved_in ISO (PMID:23736979) RGD PMID:23736979 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cd86 CD86 molecule involved_in ISO (PMID:23241883) RGD PMID:23241883 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Crebbp CREB binding protein IMP RGD PMID:20926146 RGD:10059423 NCBI chr10:11,842,307...11,968,266
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked involved_in ISO (PMID:30341167) RGD PMID:30341167 NCBI chr  X:12,152,346...12,165,983
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G Eda ectodysplasin-A acts_upstream_of_or_within ISO
IEA		 (PMID:12629675)
GO_REF:0000107		 RGD
Ensembl		 PMID:12629675 GO_REF:0000107 NCBI chr  X:69,118,577...69,520,274
Ensembl chr  X:65,078,673...65,480,172 		JBrowse link
G Edar ectodysplasin-A receptor acts_upstream_of_or_within ISO
IEA		 (PMID:12629675)
GO_REF:0000107		 RGD
Ensembl		 PMID:12629675 GO_REF:0000107 NCBI chr20:27,130,934...27,209,672
Ensembl chr20:26,587,839...26,666,494 		JBrowse link
G Edaradd EDAR associated via death domain IMP RGD PMID:22013926 RGD:14398762 NCBI chr17:92,850,791...92,894,808
Ensembl chr17:85,656,905...85,910,447 		JBrowse link
G Edn1 endothelin 1 involved_in IDA PMID:28484848 BHF-UCL PMID:28484848 RGD:13601996 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20038207)		 UniProt
RGD		 PMID:20038207 GO_REF:0000024 NCBI chr 6:21,941,147...21,977,115
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Glrx glutaredoxin IMP RGD PMID:19938943 RGD:9686063 NCBI chr 2:7,073,737...7,083,548
Ensembl chr 2:5,341,885...5,351,680 		JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist acts_upstream_of_or_within ISO (PMID:18505784) RGD PMID:18505784 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:100,512,313...100,524,082 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in ISO (PMID:18006747) RGD PMID:18006747 NCBI chr10:31,383,801...31,415,334
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645)
(PMID:16267105)		 RGD PMID:14660645 PMID:16267105 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Ifi35 interferon-induced protein 35 involved_in ISO
IEA		 (PMID:29038465)
GO_REF:0000107		 RGD
Ensembl		 PMID:29038465 GO_REF:0000107 NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,381,010...86,389,952 		JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO		 GO_REF:0000107
(PMID:10227969)		 Ensembl
RGD		 PMID:10227969 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il18r1 interleukin 18 receptor 1 involved_in ISO
IEA		 MGI:2136765 (PMID:10227969)
GO_REF:0000107		 RGD
Ensembl		 PMID:10227969 GO_REF:0000107 NCBI chr 9:50,223,274...50,257,370
Ensembl chr 9:42,727,869...42,760,715 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:18390750) RGD PMID:18390750 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (PMID:22733818) RGD PMID:22733818 NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807 		JBrowse link
G Lgals9 galectin 9 involved_in ISO (PMID:25754930) RGD PMID:25754930 NCBI chr10:64,405,044...64,428,249
Ensembl chr10:63,907,018...63,930,045 		JBrowse link
G Lrrc19 leucine rich repeat containing 19 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:19679103)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:19679103 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:114,610,625...114,623,682
Ensembl chr 5:109,497,121...109,507,938 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in ISO
IEA		 (PMID:10094049)
GO_REF:0000107		 RGD
Ensembl		 PMID:10094049 GO_REF:0000107 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mir182 microRNA 182 involved_in ISO (PMID:28855441) RGD PMID:28855441 NCBI chr 4:59,752,246...59,752,307
Ensembl chr 4:58,784,818...58,784,879 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 involved_in ISO (PMID:12019269) RGD PMID:12019269 NCBI chr 1:74,848,020...74,885,945
Ensembl chr 1:65,932,595...65,960,934 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO UniProtKB:Q9ULZ3 (PMID:15817483) RGD PMID:15817483 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nmi N-myc (and STAT) interactor involved_in ISO (PMID:29038465) RGD PMID:29038465 NCBI chr 3:56,824,778...56,848,891
Ensembl chr 3:36,415,607...36,439,498 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 involved_in ISO
IEA		 (PMID:25093298)
GO_REF:0000107		 RGD
Ensembl		 PMID:25093298 GO_REF:0000107 NCBI chr 4:85,391,142...85,442,281
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in ISO
IEA		 (PMID:25093298)
MGI:3529594 (PMID:22033934)
GO_REF:0000107		 RGD
Ensembl		 PMID:22033934 PMID:25093298 GO_REF:0000107 NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 involved_in ISO (PMID:30769772) RGD PMID:30769772 NCBI chr19:47,619,853...47,964,089
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISO
IEA		 (PMID:19946272)
GO_REF:0000107		 RGD
Ensembl		 PMID:19946272 GO_REF:0000107 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Phb1 prohibitin 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:23241883)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23241883 GO_REF:0000024 GO_REF:0000107 NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Phb2 prohibitin 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:23241883)		 UniProt
Ensembl
RGD		 PMID:23241883 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:159,203,948...159,208,561
Ensembl chr 4:157,517,577...157,522,272 		JBrowse link
G Ptp4a3 protein tyrosine phosphatase 4A3 involved_in ISO
IEA		 (PMID:23178297)
GO_REF:0000107		 RGD
Ensembl		 PMID:23178297 GO_REF:0000107 NCBI chr 7:107,518,220...107,549,949
Ensembl chr 7:105,628,029...105,660,919 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO
IEA		 UniProtKB:Q96P20 (PMID:15817483)
GO_REF:0000107		 RGD
Ensembl		 PMID:15817483 GO_REF:0000107 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19136968)		 Ensembl
RGD		 PMID:19136968 GO_REF:0000107 NCBI chr 3:161,249,389...161,266,321
Ensembl chr 3:140,789,080...140,806,005 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 acts_upstream_of_or_within ISO
IEA		 (PMID:23583643)
GO_REF:0000107		 RGD
Ensembl		 PMID:23583643 GO_REF:0000107 NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839 		JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 acts_upstream_of_or_within ISO (PMID:23583643) RGD PMID:23583643 NCBI chr 3:41,531,319...41,596,496
Ensembl chr 3:21,110,679...21,179,933 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO
IEA		 (PMID:23178297)
GO_REF:0000107		 RGD
Ensembl		 PMID:23178297 GO_REF:0000107 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 IMP RGD PMID:32308116 RGD:156420143 NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:20041225) RGD PMID:20041225 NCBI chr 1:163,190,476...163,195,885
Ensembl chr 1:153,777,472...153,783,680 		JBrowse link
G Rtkn2 rhotekin 2 involved_in ISO
IEA		 (PMID:26124677)
GO_REF:0000107		 RGD
Ensembl		 PMID:26124677 GO_REF:0000107 NCBI chr20:20,535,553...20,608,863
Ensembl chr20:20,525,256...20,609,951 		JBrowse link
G Sash1 SAM and SH3 domain containing 1 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:23776175)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:23776175 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:4,940,207...5,238,777
Ensembl chr 1:3,121,332...3,439,870 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 IMP RGD PMID:14720208 RGD:10042970 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:20577214)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:20577214 GO_REF:0000024 GO_REF:0000107 NCBI chr10:102,257,413...102,263,086
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Tcim transcriptional and immune response regulator involved_in ISO (PMID:19684084) RGD PMID:19684084 NCBI chr16:74,298,344...74,299,637
Ensembl chr16:67,593,410...67,597,581 		JBrowse link
G Terf2ip TERF2 interacting protein involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr19:56,886,211...56,893,300
Ensembl chr19:39,976,906...39,984,064 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr7 toll-like receptor 7 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr  X:30,644,324...30,670,796
Ensembl chr  X:27,027,425...27,054,754 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:31124343)
(PMID:21689636)
(PMID:10383454), (PMID:17922812), (PMID:20041225)
GO_REF:0000107		 RGD
Ensembl		 PMID:10383454 PMID:17922812 PMID:20041225 PMID:21689636 PMID:31124343 GO_REF:0000107 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11a TNF receptor superfamily member 11A involved_in ISO (PMID:9367155) RGD PMID:9367155 NCBI chr13:22,442,930...22,501,257
Ensembl chr13:21,928,408...21,986,695 		JBrowse link
G Tnfsf11 TNF superfamily member 11 involved_in ISO (PMID:9367155) RGD PMID:9367155 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tnfsf14 TNF superfamily member 14 involved_in ISO
IEA		 (PMID:12393901)
GO_REF:0000107		 RGD
Ensembl		 PMID:12393901 GO_REF:0000107 NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,069,104...2,073,216 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:28592261) RGD PMID:28592261 NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Trim26 tripartite motif-containing 26 involved_in IEA
ISO		 GO_REF:0000107
(PMID:34017102)		 Ensembl
RGD		 PMID:34017102 GO_REF:0000107 NCBI chr20:1,711,564...1,736,389
Ensembl chr20:1,709,788...1,731,120 		JBrowse link
G Trim44 tripartite motif-containing 44 involved_in ISO (PMID:23460740) RGD PMID:23460740 NCBI chr 3:109,048,643...109,183,821
Ensembl chr 3:88,592,719...88,729,188 		JBrowse link
G Trim55 tripartite motif-containing 55 involved_in IEA
ISO		 GO_REF:0000107
(PMID:37816088)		 Ensembl
RGD		 PMID:37816088 GO_REF:0000107 NCBI chr 2:102,100,229...102,142,173
Ensembl chr 2:102,088,443...102,142,168 		JBrowse link
G Trim56 tripartite motif containing 56 involved_in ISO (PMID:35952808) RGD PMID:35952808 NCBI chr12:25,193,224...25,204,032
Ensembl chr12:19,551,521...19,567,462 		JBrowse link
G Trip6 thyroid hormone receptor interactor 6 involved_in ISO
IBA
IEA		 (PMID:15657077)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:15657077 GO_REF:0000033 GO_REF:0000107 NCBI chr12:25,022,959...25,027,366
Ensembl chr12:19,386,014...19,390,618 		JBrowse link
G Vcp valosin-containing protein involved_in ISO
IEA		 (PMID:37816088)
GO_REF:0000107		 RGD
Ensembl		 PMID:37816088 GO_REF:0000107 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:57,210,168...57,229,571 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    positive regulation of biological process 6766
      positive regulation of signaling 2097
        positive regulation of signal transduction 1768
          positive regulation of intracellular signal transduction 1254
            positive regulation of non-canonical NF-kappaB signal transduction 70
Path 2
Term Annotations click to browse term
  biological_process 20558
    biological regulation 13833
      regulation of biological process 13394
        signaling 7862
          signal transduction 7301
            intracellular signal transduction 3189
              intracellular signaling cassette 2051
                non-canonical NF-kappaB signal transduction 137
                  regulation of non-canonical NF-kappaB signal transduction 115
                    positive regulation of non-canonical NF-kappaB signal transduction 70
paths to the root