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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of purine nucleotide metabolic process
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Accession:GO:1900542 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of purine nucleotide metabolic process.
Synonyms:exact_synonym: regulation of purine nucleotide metabolism
 narrow_synonym: regulation of purine metabolic process;   regulation of purine metabolism


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regulation of purine nucleotide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LACC1 laccase domain containing 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:43,879,178...43,893,932
Ensembl chr13:43,879,284...43,893,932 		JBrowse link
negative regulation of ATP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 ISO RGD PMID:21325440 RGD:9685453 NCBI chr10:95,694,186...95,877,266
Ensembl chr10:95,711,779...95,877,266 		JBrowse link
G FLCN folliculin involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:17,212,212...17,237,330
Ensembl chr17:17,212,212...17,237,188 		JBrowse link
G H19 H19 imprinted maternally expressed transcript acts_upstream_of IMP (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr11:1,995,176...2,001,466
Ensembl chr11:1,995,166...2,001,470 		JBrowse link
G MIR675 microRNA 675 acts_upstream_of IMP (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr11:1,996,759...1,996,831
Ensembl chr11:1,996,759...1,996,831 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in IMP (PMID:24289924) ParkinsonsUK-UCL PMID:24289924 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 involved_in IMP (PMID:20165904) BHF-UCL PMID:20165904 NCBI chr 2:229,023,973...229,271,287
Ensembl chr 2:228,850,526...229,271,287 		JBrowse link
negative regulation of ATP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FIS1 fission, mitochondrial 1 involved_in IMP (PMID:32521232) ARUK-UCL PMID:32521232 NCBI chr 7:101,239,472...101,245,081
Ensembl chr 7:101,239,458...101,252,316 		JBrowse link
G TSPO translocator protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:43,151,559...43,163,242
Ensembl chr22:43,151,547...43,163,242 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPCA hippocalcin involved_in ISO
IEA		 RGD
Ensembl		 PMID:15336960 GO_REF:0000107 RGD:9686438 NCBI chr 1:32,885,996...32,894,646
Ensembl chr 1:32,885,994...32,898,441 		JBrowse link
G RD3 RD3 regulator of GUCY2D involved_in IMP
IEA		 (PMID:21928830), (PMID:30559291) UniProt
Ensembl		 PMID:21928830 PMID:30559291 GO_REF:0000107 NCBI chr 1:211,476,522...211,492,162
Ensembl chr 1:211,476,522...211,492,162 		JBrowse link
negative regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TP53 tumor protein p53 involved_in IMP (PMID:21336310) CACAO PMID:21336310 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
positive regulation of ATP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chr 1:167,809,386...167,914,134
Ensembl chr 1:167,809,386...167,914,215 		JBrowse link
G BCL2L1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G ENO1 enolase 1 involved_in IDA
IGI		 (PMID:15459207) CAFA PMID:15459207 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190 		JBrowse link
G HNF1A HNF1 homeobox A involved_in ISO
IEA		 RGD
Ensembl		 PMID:20841353 GO_REF:0000107 RGD:150540305 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
G IL4 interleukin 4 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 involved_in ISO PMID:15459207 CAFA PMID:15459207 RGD:12793039 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II involved_in IEA Ensembl GO_REF:0000107 NCBI chr MT:7,586...8,269
Ensembl chr MT:7,586...8,269 		JBrowse link
G MTCO2P12 MT-CO2 pseudogene 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:632,757...633,438
Ensembl chr 1:632,757...633,438 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor ISO RGD PMID:22629444 RGD:7240532 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 involved_in ISO
IEA		 RGD
Ensembl		 PMID:26888427 GO_REF:0000107 RGD:11040458 NCBI chr11:78,068,297...78,079,862
Ensembl chr11:78,068,297...78,079,862 		JBrowse link
G PID1 phosphotyrosine interaction domain containing 1 involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:229,023,973...229,271,287
Ensembl chr 2:228,850,526...229,271,287 		JBrowse link
G PINK1 PTEN induced kinase 1 involved_in TAS (PMID:20871098) ParkinsonsUK-UCL PMID:20871098 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha acts_upstream_of IMP (PMID:31574452) ARUK-UCL PMID:31574452 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24096089 RGD:10413842 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (PMID:24747689) AgBase PMID:24747689 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 involved_in ISO
IEA		 RGD
Ensembl		 PMID:19764902 GO_REF:0000107 RGD:13628741 NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO RGD PMID:23590160 RGD:8694322 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,540 		JBrowse link
G TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase involved_in ISO
IEA		 RGD
Ensembl		 PMID:20348225 GO_REF:0000107 RGD:13432160 NCBI chr  X:154,411,539...154,421,726
Ensembl chr  X:154,411,524...154,421,726 		JBrowse link
G TMSB4X thymosin beta 4 X-linked involved_in IDA (PMID:21106936) CAFA PMID:21106936 NCBI chr  X:12,975,110...12,977,223
Ensembl chr  X:12,975,110...12,977,227 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISS
IEA		 ARUK-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:41,158,508...41,163,116
Ensembl chr 6:41,158,506...41,163,186 		JBrowse link
G VCP valosin containing protein involved_in IMP (PMID:23498975) ParkinsonsUK-UCL PMID:23498975 NCBI chr 9:35,056,064...35,072,625
Ensembl chr 9:35,053,928...35,072,668 		JBrowse link
positive regulation of ATP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BEND3 BEN domain containing 3 involved_in IDA (PMID:28977671) UniProt PMID:28977671 NCBI chr 6:107,065,182...107,115,515
Ensembl chr 6:107,065,182...107,115,515 		JBrowse link
positive regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3794903|PMID:18340377) MGI
Ensembl		 PMID:18340377 GO_REF:0000107 MGI:3794903 NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746 		JBrowse link
G GUCA1A guanylate cyclase activator 1A involved_in ISO
IBA
IEA
ISS		 (PMID:21873635) RGD
GO_Central
Ensembl
UniProt		 PMID:12545196 PMID:21873635 GO_REF:0000024 GO_REF:0000107 RGD:1599357 NCBI chr 6:42,173,364...42,180,056
Ensembl chr 6:42,173,364...42,181,338 		JBrowse link
G GUCA1ANB-GUCA1A GUCA1ANB-GUCA1A readthrough involved_in IEA
IBA
ISS		 (PMID:21873635) Ensembl
GO_Central
UniProt		 PMID:21873635 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:42,155,406...42,180,056
Ensembl chr 6:42,155,406...42,181,338 		JBrowse link
G NOS1 nitric oxide synthase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170 		JBrowse link
G NOS2 nitric oxide synthase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 involved_in ISS
IBA
IMP		 (PMID:21873635)
(PMID:17502619)		 BHF-UCL
GO_Central		 PMID:17502619 PMID:21873635 GO_REF:0000024 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
positive regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLST8 MTOR associated protein, LST8 homolog involved_in NAS (PMID:20670887) ComplexPortal PMID:20670887 NCBI chr16:2,205,454...2,209,453
Ensembl chr16:2,204,248...2,209,453 		JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in NAS (PMID:20670887) ComplexPortal PMID:20670887 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 involved_in NAS (PMID:20670887) ComplexPortal PMID:20670887 NCBI chr17:80,544,838...80,966,368
Ensembl chr17:80,544,819...80,966,371 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in ISO (MGI:5574521|PMID:24872551) UniProt PMID:24872551 MGI:5574521 NCBI chr12:4,321,213...4,360,028
Ensembl chr12:4,307,763...4,360,028 		JBrowse link
regulation of 'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase involved_in TAS (PMID:12140278), (PMID:19843166) ParkinsonsUK-UCL PMID:12140278 PMID:19843166 NCBI chr 2:134,838,616...134,902,034
Ensembl chr 2:134,838,616...134,902,034 		JBrowse link
regulation of acetyl-CoA biosynthetic process from pyruvate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDK1 pyruvate dehydrogenase kinase 1 involved_in TAS
IEA		 Reactome
Ensembl		 GO_REF:0000107 Reactome:R-HSA-204174 NCBI chr 2:172,555,373...172,724,312
Ensembl chr 2:172,555,373...172,608,669 		JBrowse link
G PDK2 pyruvate dehydrogenase kinase 2 involved_in IEA
ISS
TAS		 Ensembl
UniProt
Reactome		 GO_REF:0000024 GO_REF:0000107 Reactome:R-HSA-204174 NCBI chr17:50,094,737...50,112,152
Ensembl chr17:50,094,737...50,112,152 		JBrowse link
G PDK3 pyruvate dehydrogenase kinase 3 involved_in TAS
IMP		 (PMID:22865452) Reactome
UniProt		 PMID:22865452 Reactome:R-HSA-204174 NCBI chr  X:24,465,286...24,550,466
Ensembl chr  X:24,465,244...24,550,466 		JBrowse link
G PDK4 pyruvate dehydrogenase kinase 4 involved_in TAS
IMP
IEA		 (PMID:21852536) Reactome
UniProt
Ensembl		 PMID:21852536 GO_REF:0000107 Reactome:R-HSA-204174 NCBI chr 7:95,583,499...95,596,516
Ensembl chr 7:95,583,499...95,596,516 		JBrowse link
regulation of acyl-CoA biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNCA synuclein alpha acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3628986|PMID:16636270)
(MGI:3629421|PMID:16734431)		 MGI
Ensembl		 PMID:16636270 PMID:16734431 GO_REF:0000107 MGI:3628986 MGI:3629421 NCBI chr 4:89,724,099...89,838,304
Ensembl chr 4:89,700,345...89,838,315 		JBrowse link
regulation of ATP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SPHK2 sphingosine kinase 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr19:48,619,506...48,630,405
Ensembl chr19:48,619,291...48,630,717 		JBrowse link
regulation of ATP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IMP (PMID:24005319) ParkinsonsUK-UCL PMID:24005319 NCBI chr 1:28,236,124...28,238,100
Ensembl chr 1:28,236,109...28,246,906 		JBrowse link
G DNM1L dynamin 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650 		JBrowse link
regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCA1A guanylate cyclase activator 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (MGI:3052899|PMID:15336959) Ensembl
MGI		 PMID:15336959 GO_REF:0000107 MGI:3052899 NCBI chr 6:42,173,364...42,180,056
Ensembl chr 6:42,173,364...42,181,338 		JBrowse link
G GUCA1ANB-GUCA1A GUCA1ANB-GUCA1A readthrough involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,155,406...42,180,056
Ensembl chr 6:42,155,406...42,181,338 		JBrowse link
G GUCA1B guanylate cyclase activator 1B acts_upstream_of_or_within
involved_in		 ISO
IBA		 (MGI:3052899|PMID:15336959)
(PMID:21873635)		 MGI
GO_Central		 PMID:15336959 PMID:21873635 MGI:3052899 NCBI chr 6:42,183,284...42,194,956
Ensembl chr 6:42,183,284...42,194,956 		JBrowse link
regulation of mitochondrial ATP synthesis coupled proton transport term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANTKMT adenine nucleotide translocase lysine methyltransferase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:721,146...722,590
Ensembl chr16:720,581...722,590 		JBrowse link
G ATPSCKMT ATP synthase c subunit lysine N-methyltransferase involved_in IMP
IEA
IBA		 (PMID:30530489)
(PMID:21873635)		 UniProt
Ensembl
GO_Central		 PMID:21873635 PMID:30530489 GO_REF:0000107 NCBI chr 5:10,225,507...10,249,888
Ensembl chr 5:10,225,507...10,249,897 		JBrowse link
G DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:73,680,918...73,683,453
Ensembl chr 7:73,680,918...73,683,453 		JBrowse link
regulation of NAD metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MACROH2A1 macroH2A.1 histone involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:135,334,381...135,399,887
Ensembl chr 5:135,334,381...135,399,914 		JBrowse link
regulation of NADP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNF1A HNF1 homeobox A involved_in ISO
IEA		 RGD
Ensembl		 PMID:20841353 GO_REF:0000107 RGD:150540305 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
G ME1 malic enzyme 1 involved_in IMP (PMID:23334421) CACAO PMID:23334421 NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051 		JBrowse link
G ME2 malic enzyme 2 involved_in IMP (PMID:23334421) CACAO PMID:23334421 NCBI chr18:50,879,118...50,954,257
Ensembl chr18:50,879,080...50,954,257 		JBrowse link
regulation of pentose-phosphate shunt term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:16234247 RGD:1625062 NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949 		JBrowse link
G PGAM1 phosphoglycerate mutase 1 involved_in IDA (PMID:12189148) UniProt PMID:12189148 NCBI chr10:97,426,191...97,433,444
Ensembl chr10:97,426,191...97,433,444 		JBrowse link
G TIGAR TP53 induced glycolysis regulatory phosphatase involved_in IMP
IBA		 (PMID:25928429)
(PMID:21873635)		 UniProt
GO_Central		 PMID:21873635 PMID:25928429 NCBI chr12:4,321,213...4,360,028
Ensembl chr12:4,307,763...4,360,028 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19532
    metabolic process 12880
      small molecule metabolic process 2015
        regulation of small molecule metabolic process 415
          regulation of nucleotide metabolic process 63
            regulation of purine nucleotide metabolic process 62
              negative regulation of purine nucleotide metabolic process + 11
              positive regulation of purine nucleotide metabolic process + 33
              regulation of ATP metabolic process + 36
              regulation of NAD metabolic process + 2
              regulation of NADP metabolic process + 10
              regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway + 0
              regulation of purine nucleotide biosynthetic process + 46
              regulation of purine nucleotide catabolic process + 0
              regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA + 0
Path 2
Term Annotations click to browse term
  biological_process 19532
    cellular process 16835
      cellular metabolic process 7965
        heterocycle metabolic process 3789
          nucleobase-containing compound metabolic process 3589
            nucleobase-containing small molecule metabolic process 663
              nucleoside phosphate metabolic process 585
                nucleotide metabolic process 578
                  purine nucleotide metabolic process 514
                    regulation of purine nucleotide metabolic process 62
                      negative regulation of purine nucleotide metabolic process + 11
                      positive regulation of purine nucleotide metabolic process + 33
                      regulation of ATP metabolic process + 36
                      regulation of NAD metabolic process + 2
                      regulation of NADP metabolic process + 10
                      regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway + 0
                      regulation of purine nucleotide biosynthetic process + 46
                      regulation of purine nucleotide catabolic process + 0
                      regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA + 0
paths to the root