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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of endoplasmic reticulum unfolded protein response
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Accession:GO:1900102 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
Synonyms:exact_synonym: down regulation of ER unfolded protein response;   down regulation of endoplasmic reticulum unfolded protein response;   down regulation of erUPR;   downregulation of ER unfolded protein response;   downregulation of endoplasmic reticulum unfolded protein response;   downregulation of erUPR;   inhibition of ER unfolded protein response;   inhibition of erUPR;   negative regulation of ER unfolded protein response;   negative regulation of erUPR
 narrow_synonym: inhibition of endoplasmic reticulum unfolded protein response
 related_synonym: down regulation of SREBP-mediated signalling pathway;   downregulation of SREBP-mediated signalling pathway;   inhibition of SREBP-mediated signalling pathway;   negative regulation of SREBP-mediated signalling pathway


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negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREBRF CREB3 regulatory factor involved_in IDA (PMID:18391022) UniProt PMID:18391022 NCBI chr 5:173,056,349...173,139,284
Ensembl chr 5:173,056,352...173,139,284
JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 5:181,236,897...181,243,906
Ensembl chr 5:181,236,897...181,248,096
JBrowse link
G XBP1 X-box binding protein 1 involved_in IDA (PMID:25239945) UniProt PMID:25239945 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6B activating transcription factor 6 beta involved_in IDA (PMID:9837962) UniProt PMID:9837962 NCBI chr 6:32,115,264...32,128,246
Ensembl chr 6:32,115,264...32,128,253
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein involved_in IDA (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 NCBI chr 4:6,260,368...6,303,265
Ensembl chr 4:6,269,849...6,303,265
JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BFAR bifunctional apoptosis regulator involved_in IMP (PMID:21068390) ParkinsonsUK-UCL PMID:21068390 NCBI chr16:14,632,831...14,669,236
Ensembl chr16:14,632,931...14,669,236
JBrowse link
G DDRGK1 DDRGK domain containing 1 involved_in IDA (PMID:28128204), (PMID:32160526) UniProt PMID:28128204 PMID:32160526 NCBI chr20:3,190,350...3,204,682
Ensembl chr20:3,190,350...3,204,685
JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS UniProt GO_REF:0000024 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 involved_in ISS UniProt GO_REF:0000024 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 involved_in ISO (MGI:5571560|PMID:24508390) WB PMID:24508390 MGI:5571560 NCBI chr 2:10,783,391...10,837,712
Ensembl chr 2:10,783,391...10,837,977
JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IDA (PMID:32160526) UniProt PMID:32160526 NCBI chr 6:96,521,806...96,555,276
Ensembl chr 6:96,521,595...96,555,276
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISS ARUK-UCL GO_REF:0000024 NCBI chr19:1,040,107...1,065,572
Ensembl chr19:1,039,997...1,065,572
JBrowse link
G NCK1 NCK adaptor protein 1 involved_in IDA
IBA
(PMID:14676213)
(PMID:21873635)
ParkinsonsUK-UCL
GO_Central
PMID:14676213 PMID:21873635 NCBI chr 3:136,862,208...136,951,606
Ensembl chr 3:136,862,208...136,951,606
JBrowse link
G NCK2 NCK adaptor protein 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:105,744,649...105,894,274
Ensembl chr 2:105,744,912...105,894,274
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,421...48,876,058
JBrowse link
G PPP1R15B protein phosphatase 1 regulatory subunit 15B involved_in TAS (PMID:22013210) ParkinsonsUK-UCL PMID:22013210 NCBI chr 1:204,398,684...204,412,454
Ensembl chr 1:204,403,381...204,411,817
JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 involved_in IDA (PMID:21216966) ParkinsonsUK-UCL PMID:21216966 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18537
    cellular process 17456
      signal transduction 6274
        negative regulation of signal transduction 1342
          negative regulation of endoplasmic reticulum unfolded protein response 17
            negative regulation of ATF6-mediated unfolded protein response 2
            negative regulation of IRE1-mediated unfolded protein response 6
            negative regulation of PERK-mediated unfolded protein response 6
Path 2
Term Annotations click to browse term
  biological_process 18537
    response to stimulus 9790
      cellular response to stimulus 8118
        cellular response to chemical stimulus 3681
          cellular response to organic substance 3000
            cellular response to topologically incorrect protein 125
              cellular response to unfolded protein 105
                endoplasmic reticulum unfolded protein response 81
                  regulation of endoplasmic reticulum unfolded protein response 32
                    negative regulation of endoplasmic reticulum unfolded protein response 17
                      negative regulation of ATF6-mediated unfolded protein response 2
                      negative regulation of IRE1-mediated unfolded protein response 6
                      negative regulation of PERK-mediated unfolded protein response 6
paths to the root