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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of endoplasmic reticulum unfolded protein response
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Accession:GO:1900102 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
Synonyms:exact_synonym: down regulation of ER unfolded protein response;   down regulation of endoplasmic reticulum unfolded protein response;   down regulation of erUPR;   downregulation of ER unfolded protein response;   downregulation of endoplasmic reticulum unfolded protein response;   downregulation of erUPR;   inhibition of ER unfolded protein response;   inhibition of erUPR;   negative regulation of ER unfolded protein response;   negative regulation of erUPR
 narrow_synonym: inhibition of endoplasmic reticulum unfolded protein response
 related_synonym: down regulation of SREBP-mediated signalling pathway;   downregulation of SREBP-mediated signalling pathway;   inhibition of SREBP-mediated signalling pathway;   negative regulation of SREBP-mediated signalling pathway


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negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO (PMID:18391022) RGD PMID:18391022 NCBI chr10:16,399,170...16,479,650 JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945) RGD PMID:25239945 NCBI chr14:80,390,629...80,395,713 JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,090,921...4,098,920 JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in IGI
ISO
PMID:20160352
(PMID:20160352)
RGD PMID:20160352, PMID:20160352 RGD:10047363 NCBI chr14:73,810,478...73,834,993 JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) RGD PMID:21068390 NCBI chr10:1,552,019...1,585,040 JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:28128204), (PMID:32160526)
(MGI:5912977|PMID:28128204)
RGD PMID:28128204 PMID:32160526 MGI:5912977 NCBI chr 3:117,861,916...117,882,680 JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 6:61,270,385...61,276,795 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 3:18,055,507...18,059,969 JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 involved_in ISO (MGI:5571560|PMID:24508390) RGD PMID:24508390 MGI:5571560 NCBI chr 6:40,062,980...40,080,223 JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISO
ISS
(PMID:32160526)
GO_REF:0000024
RGD
UniProt
PMID:32160526 GO_REF:0000024 NCBI chr 5:38,962,721...38,995,134 JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:9,691,452...9,711,466 JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA
(PMID:14676213)
UniProtKB:O55033 (MGI:5613478|PMID:14676213)
PMID:21873635
RGD PMID:14676213, PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 8:101,018,610...101,079,237 JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA
UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
PMID:21873635
RGD PMID:14676213, PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 9:45,713,979...45,840,330 JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO (PMID:21216966)
(MGI:5619464|PMID:21216966)
RGD PMID:21216966 MGI:5619464 NCBI chr 3:156,638,811...156,687,503 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18342
      signal transduction 6880
        negative regulation of signal transduction 1264
          negative regulation of endoplasmic reticulum unfolded protein response 14
            negative regulation of ATF6-mediated unfolded protein response 2
            negative regulation of IRE1-mediated unfolded protein response 6
            negative regulation of PERK-mediated unfolded protein response 4
Path 2
Term Annotations click to browse term
  biological_process 19492
    response to stimulus 10355
      cellular response to stimulus 8741
        cellular response to chemical stimulus 3542
          cellular response to organic substance 2868
            cellular response to topologically incorrect protein 119
              cellular response to unfolded protein 99
                endoplasmic reticulum unfolded protein response 71
                  regulation of endoplasmic reticulum unfolded protein response 26
                    negative regulation of endoplasmic reticulum unfolded protein response 14
                      negative regulation of ATF6-mediated unfolded protein response 2
                      negative regulation of IRE1-mediated unfolded protein response 6
                      negative regulation of PERK-mediated unfolded protein response 4
paths to the root