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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of endoplasmic reticulum unfolded protein response
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Accession:GO:1900101 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
Synonyms:exact_synonym: regulation of ER unfolded protein response;   regulation of erUPR
 related_synonym: regulation of SREBP-mediated signalling pathway

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negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955437:582,083...592,026
Ensembl chrNW_004955437:582,431...591,810 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein involved_in ISO (PMID:20160352) ParkinsonsUK-UCL PMID:20160352 RGD:10047363 NCBI chrNW_004955514:3,902,508...3,924,281
Ensembl chrNW_004955514:3,902,454...3,924,610 		JBrowse link
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crebrf CREB3 regulatory factor involved_in ISO (PMID:18391022) UniProt PMID:18391022 NCBI chrNW_004955408:25,718,523...25,769,551
Ensembl chrNW_004955408:25,719,187...25,774,555 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:25239945) UniProt PMID:25239945 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bfar bifunctional apoptosis regulator involved_in ISO (PMID:21068390) ParkinsonsUK-UCL PMID:21068390 NCBI chrNW_004955442:4,229,236...4,255,623
Ensembl chrNW_004955442:4,226,756...4,255,623 		JBrowse link
G Ddrgk1 DDRGK domain containing 1 involved_in ISO (PMID:28128204), (PMID:32160526)
(MGI:5912977|PMID:28128204)		 UniProt PMID:28128204 PMID:32160526 MGI:5912977 NCBI chrNW_004955415:14,085,404...14,098,220
Ensembl chrNW_004955415:14,085,404...14,098,856 		JBrowse link
G Pdia6 protein disulfide isomerase family A member 6 involved_in ISO (PMID:24508390) WB PMID:24508390 NCBI chrNW_004955487:5,735,698...5,744,601
Ensembl chrNW_004955487:5,735,698...5,748,015 		JBrowse link
G Ufl1 UFM1 specific ligase 1 involved_in ISO (PMID:32160526) UniProt PMID:32160526 NCBI chrNW_004955411:22,548,139...22,577,287
Ensembl chrNW_004955411:22,548,219...22,580,903 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) ARUK-UCL PMID:27030769 MGI:5774886 NCBI chrNW_004955495:6,818,002...6,838,177
Ensembl chrNW_004955495:6,815,562...6,836,772 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:14676213)
(MGI:5613478|PMID:14676213)		 ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chrNW_004955501:1,867,956...1,963,091 JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO (MGI:5613478|PMID:14676213) ParkinsonsUK-UCL PMID:14676213 MGI:5613478 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 involved_in ISO (PMID:21216966)
(MGI:5619464|PMID:21216966)		 ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chrNW_004955445:7,754,313...7,819,229
Ensembl chrNW_004955445:7,754,319...7,819,275 		JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 involved_in ISO (PMID:9837962) UniProt PMID:9837962 NCBI chrNW_004955462:14,352,956...14,553,299
Ensembl chrNW_004955462:14,357,945...14,548,543 		JBrowse link
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2 antagonist/killer 1 involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chrNW_004955437:2,036,415...2,041,997
Ensembl chrNW_004955437:2,036,415...2,041,997 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 involved_in ISO (PMID:16645094), (PMID:28128204) UniProt PMID:16645094 PMID:28128204 NCBI chrNW_004955478:7,720,664...7,803,662
Ensembl chrNW_004955478:7,751,830...7,799,460 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (PMID:20348923) UniProt PMID:20348923 NCBI chrNW_004955446:1,020,707...1,098,327
Ensembl chrNW_004955446:1,020,043...1,098,820 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:16645094) UniProt PMID:16645094 NCBI chrNW_004955455:3,037,885...3,041,827 JBrowse link
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) UniProt PMID:23220234 NCBI chrNW_004955410:19,984,768...19,995,446
Ensembl chrNW_004955410:19,984,768...19,995,733 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO (PMID:26268696) UniProt PMID:26268696 NCBI chrNW_004955443:5,747,681...5,773,759
Ensembl chrNW_004955443:5,747,699...5,773,773 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) UniProt PMID:23220234 NCBI chrNW_004955410:19,984,768...19,995,446
Ensembl chrNW_004955410:19,984,768...19,995,733 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5648772|PMID:26015568) UniProt PMID:26015568 MGI:5648772 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO (PMID:26268696) UniProt PMID:26268696 NCBI chrNW_004955443:5,747,681...5,773,759
Ensembl chrNW_004955443:5,747,699...5,773,773 		JBrowse link
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:15234121) ParkinsonsUK-UCL PMID:15234121 NCBI chrNW_004955444:12,217,337...12,233,570
Ensembl chrNW_004955444:12,217,337...12,234,193 		JBrowse link
G Ficd FIC domain protein adenylyltransferase involved_in ISO (PMID:25601083) UniProt PMID:25601083 NCBI chrNW_004955455:9,794,919...9,799,006
Ensembl chrNW_004955455:9,795,116...9,799,006 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12321
    regulation of biological process 8603
      regulation of signaling 3102
        regulation of signal transduction 2620
          regulation of endoplasmic reticulum unfolded protein response 23
            negative regulation of endoplasmic reticulum unfolded protein response + 12
            positive regulation of endoplasmic reticulum unfolded protein response + 10
            regulation of ATF6-mediated unfolded protein response + 3
            regulation of IRE1-mediated unfolded protein response + 8
            regulation of PERK-mediated unfolded protein response + 8
Path 2
Term Annotations click to browse term
  biological_process 12321
    response to stimulus 6667
      response to chemical 3560
        response to organic substance 2859
          response to topologically incorrect protein 92
            response to unfolded protein 78
              cellular response to unfolded protein 70
                endoplasmic reticulum unfolded protein response 59
                  regulation of endoplasmic reticulum unfolded protein response 23
                    negative regulation of endoplasmic reticulum unfolded protein response + 12
                    positive regulation of endoplasmic reticulum unfolded protein response + 10
                    regulation of ATF6-mediated unfolded protein response + 3
                    regulation of IRE1-mediated unfolded protein response + 8
                    regulation of PERK-mediated unfolded protein response + 8
paths to the root