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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cellular response to insulin stimulus
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Accession:GO:1900077 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus.
Synonyms:exact_synonym: down regulation of cellular response to insulin stimulus;   downregulation of cellular response to insulin stimulus
 narrow_synonym: inhibition of cellular response to insulin stimulus


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negative regulation of cellular response to insulin stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:4420367|PMID:19661063) RGD PMID:19661063 MGI:4420367 NCBI chr 7:20,135,248...20,184,757
Ensembl chr 7:20,135,375...20,184,754 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:23913704 RGD:13792716 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Lpl lipoprotein lipase IMP RGD PMID:25931001 RGD:13794384 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Mir15b microRNA 15b involved_in ISO (PMID:26179126) RGD PMID:26179126 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir195 microRNA 195 involved_in ISO (PMID:25240198) RGD PMID:25240198 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (MGI:5486574|PMID:11387233) RGD PMID:11387233 MGI:5486574 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO (MGI:6093414|PMID:28973536) RGD PMID:28973536 MGI:6093414 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237 		JBrowse link
negative regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein IDA RGD PMID:2766355 RGD:632173 NCBI chr11:78,117,903...78,145,956
Ensembl chr11:78,117,918...78,145,999 		JBrowse link
G Ankrd26 ankyrin repeat domain containing 26 acts_upstream_of_or_within ISO MGI:3774418 (MGI:5297321|PMID:21842266) RGD PMID:21842266 MGI:5297321 NCBI chr 4:151,670,604...151,740,032
Ensembl chr 4:151,672,037...151,739,968 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:17849011), (PMID:7830796) RGD PMID:7830796 PMID:17849011 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Gpr21 G protein-coupled receptor 21 acts_upstream_of_or_within ISO MGI:5314799 (MGI:5448902|PMID:22653059) RGD PMID:22653059 MGI:5448902 NCBI chr 3:21,275,007...21,279,008
Ensembl chr 3:21,275,007...21,277,930 		JBrowse link
G Grb10 growth factor receptor bound protein 10 involved_in IBA
ISO
IEA		 PMID:21873635
(MGI:3847873|PMID:15664450)
GO_REF:0000002
GO_REF:0000107		 RGD
InterPro
Ensembl		 PMID:15664450 PMID:21873635 GO_REF:0000002 GO_REF:0000107 MGI:3847873, RGD:13792537 NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Grb14 growth factor receptor bound protein 14 involved_in IDA
IBA
ISO
IEA
IMP		 PMID:21873635
(PMID:16246733)
GO_REF:0000107		 RGD
Ensembl		 PMID:16246733 PMID:9748281 PMID:21873635 PMID:18657188 GO_REF:0000107, RGD:61620, RGD:13792537, RGD:2307023 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889 		JBrowse link
G Grb7 growth factor receptor bound protein 7 NOT|involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (PMID:17569761) RGD PMID:17569761 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (MGI:3828398|PMID:16865359) RGD PMID:16865359 MGI:3828398 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F involved_in NAS PMID:26908121 ParkinsonsUK-UCL PMID:26908121 RGD:11059577 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K involved_in IBA
ISO		 PMID:21873635
(MGI:5294535|PMID:19250614)
(PMID:12556481)		 RGD PMID:12556481 PMID:19250614 PMID:21873635 MGI:5294535, RGD:13792537 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773 		JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:11692174 RGD:2312443 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500 		JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IMP PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 involved_in ISO (PMID:18458160) RGD PMID:18458160 NCBI chr 1:222,877,962...223,074,514
Ensembl chr 1:222,877,622...223,074,514 		JBrowse link
G Lep leptin involved_in ISO (PMID:14677856) RGD PMID:14677856 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lmbrd1 LMBR1 domain containing 1 acts_upstream_of_or_within ISO MGI:5559223 (MGI:5543853|PMID:24078630) RGD PMID:24078630 MGI:5543853 NCBI chr 9:27,096,387...27,178,095
Ensembl chr 9:27,096,297...27,178,090 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial acts_upstream_of_or_within ISO (MGI:5758857|PMID:9813005) RGD PMID:9813005 MGI:5758857 NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771 		JBrowse link
G Mir143 microRNA 143 acts_upstream_of_or_within ISO (MGI:5289772|PMID:21441927) RGD PMID:21441927 MGI:5289772 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir15b microRNA 15b involved_in ISO (PMID:26179126) RGD PMID:26179126 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir195 microRNA 195 involved_in ISO (PMID:25240198) RGD PMID:25240198 NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924 		JBrowse link
G Mstn myostatin involved_in ISO (MGI:3604221|PMID:16182246) RGD PMID:16182246 MGI:3604221 NCBI chr 9:48,453,982...48,458,809
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:21707536) RGD PMID:21707536 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Ncl nucleolin acts_upstream_of_or_within ISO (MGI:5758857|PMID:9813005) RGD PMID:9813005 MGI:5758857 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Ncoa5 nuclear receptor coactivator 5 acts_upstream_of_or_within ISO MGI:5581698 (MGI:5559256|PMID:24332041) RGD PMID:24332041 MGI:5559256 NCBI chr 3:153,736,420...153,769,838
Ensembl chr 3:153,736,420...153,769,553 		JBrowse link
G Nucb2 nucleobindin 2 IDA RGD PMID:22486620 RGD:9831186 NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 involved_in ISO (PMID:19079291) RGD PMID:19079291 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:31091439)		 UniProt
Ensembl
RGD		 PMID:31091439 GO_REF:0000024 GO_REF:0000107 NCBI chr17:81,496,669...81,668,180
Ensembl chr17:81,496,670...81,668,029 		JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta involved_in ISO
ISS		 (PMID:31091439)
GO_REF:0000024		 RGD
UniProt		 PMID:31091439 GO_REF:0000024 NCBI chr10:82,706,016...82,734,938
Ensembl chr10:82,701,098...82,734,938 		JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma involved_in ISS
ISO		 GO_REF:0000024
(PMID:31091439)		 UniProt
RGD		 PMID:31091439 GO_REF:0000024 NCBI chr 7:63,020,004...63,035,086
Ensembl chr 7:63,020,000...63,035,078 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IMP RGD PMID:20501641 RGD:6484547 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:2679305 (MGI:2677557|PMID:11923480) RGD PMID:11923480 MGI:2677557 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta involved_in IDA PMID:11714718 UniProt PMID:11714718 RGD:8553365 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta involved_in ISO (MGI:3836105|PMID:18285345) RGD PMID:18285345 MGI:3836105 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcq protein kinase C, theta involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:15364919)		 UniProt
Ensembl
RGD		 PMID:15364919 GO_REF:0000024 GO_REF:0000107 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Prkcz protein kinase C, zeta involved_in ISO (PMID:15069075) RGD PMID:15069075 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:4941441|PMID:20484139), (MGI:5488890|PMID:12612081)		 UniProt
RGD		 PMID:12612081 PMID:20484139 GO_REF:0000024 MGI:4941441 MGI:5488890 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E involved_in IDA
ISO		 PMID:15738637
(MGI:3772995|PMID:18006633)		 RGD PMID:18006633 PMID:15738637 MGI:3772995, RGD:8553759 NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (MGI:6379079|PMID:26063811) RGD PMID:26063811 MGI:6379079 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IMP RGD PMID:18073321 RGD:2298860 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in ISO
IMP		 (PMID:18952604) RGD PMID:18952604 PMID:18952604 RGD:8554230 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc27a4 solute carrier family 27 member 4 involved_in ISO (PMID:25603556) RGD PMID:25603556 NCBI chr 3:13,075,022...13,087,943
Ensembl chr 3:13,075,022...13,087,943 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3045683|PMID:15169905)		 Ensembl
RGD		 PMID:15169905 GO_REF:0000107 MGI:3045683 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(MGI:3045683|PMID:15169905)		 Ensembl
RGD		 PMID:15169905 GO_REF:0000107 MGI:3045683 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Tns2 tensin 2 involved_in ISO (PMID:23401856) RGD PMID:23401856 NCBI chr 7:133,229,746...133,247,889
Ensembl chr 7:133,206,364...133,247,888 		JBrowse link
G Trim72 tripartite motif containing 72 acts_upstream_of_or_within ISO (MGI:5602876|PMID:23965929) RGD PMID:23965929 MGI:5602876 NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606 		JBrowse link
G Tsc2 TSC complex subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Ybx1 Y box binding protein 1 IMP RGD PMID:12554649 RGD:727501 NCBI chr 5:132,882,137...132,899,108
Ensembl chr 5:132,882,145...132,898,862 		JBrowse link
G Zfp592 zinc finger protein 592 acts_upstream_of_or_within ISO (MGI:5758857|PMID:9813005) RGD PMID:9813005 MGI:5758857 NCBI chr 1:134,951,286...135,002,443
Ensembl chr 1:134,967,783...135,002,443 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    negative regulation of biological process 5785
      negative regulation of response to stimulus 1771
        negative regulation of cellular response to insulin stimulus 56
          negative regulation of insulin receptor signaling pathway + 51
Path 2
Term Annotations click to browse term
  biological_process 18877
    response to stimulus 10238
      response to chemical 6178
        response to organic substance 3915
          response to organonitrogen compound 1522
            response to peptide 735
              response to peptide hormone 633
                response to insulin 375
                  cellular response to insulin stimulus 274
                    regulation of cellular response to insulin stimulus 88
                      negative regulation of cellular response to insulin stimulus 56
                        negative regulation of insulin receptor signaling pathway + 51
paths to the root