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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cellular response to insulin stimulus
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Accession:GO:1900077 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to insulin stimulus.
Synonyms:exact_synonym: down regulation of cellular response to insulin stimulus;   downregulation of cellular response to insulin stimulus
 narrow_synonym: inhibition of cellular response to insulin stimulus


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negative regulation of cellular response to insulin stimulus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 involved_in ISO (MGI:4420367|PMID:19661063) RGD PMID:19661063 MGI:4420367 NCBI chr 7:26,256,179...26,306,128
Ensembl chr 7:26,256,459...26,306,126
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:23913704 RGD:13792716 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Lpl lipoprotein lipase IMP RGD PMID:25931001 RGD:13794384 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (MGI:5486574|PMID:11387233) RGD PMID:11387233 MGI:5486574 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO (MGI:6093414|PMID:28973536) RGD PMID:28973536 MGI:6093414 NCBI chr10:53,595,854...53,608,437
Ensembl chr10:53,595,854...53,608,435
JBrowse link
negative regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein IDA RGD PMID:2766355 RGD:632173 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Ankrd26 ankyrin repeat domain 26 acts_upstream_of_or_within ISO MGI:3774418 (MGI:5297321|PMID:21842266) RGD PMID:21842266 MGI:5297321 NCBI chr 4:150,548,656...150,616,928
Ensembl chr 4:150,547,467...150,616,895
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO
IEA
(PMID:17849011), (PMID:7830796)
GO_REF:0000107
RGD
Ensembl
PMID:7830796 PMID:17849011 GO_REF:0000107 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Gpr21 G protein-coupled receptor 21 acts_upstream_of_or_within ISO MGI:5314799 (MGI:5448902|PMID:22653059) RGD PMID:22653059 MGI:5448902 NCBI chr 3:21,764,377...21,767,300
Ensembl chr 3:21,764,377...21,767,300
JBrowse link
G Grb10 growth factor receptor bound protein 10 involved_in IBA
ISO
IEA
PMID:21873635
(MGI:3847873|PMID:15664450)
GO_REF:0000002
GO_REF:0000107
RGD
InterPro
Ensembl
PMID:15664450, PMID:21873635 GO_REF:0000002 GO_REF:0000107 MGI:3847873, RGD:13792537 NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
JBrowse link
G Grb14 growth factor receptor bound protein 14 involved_in IDA
IBA
ISO
IEA
IMP
PMID:21873635
(PMID:16246733)
GO_REF:0000107
RGD
Ensembl
PMID:16246733, PMID:9748281, PMID:21873635, PMID:18657188 GO_REF:0000107, RGD:61620, RGD:13792537, RGD:2307023 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grb7 growth factor receptor bound protein 7 NOT|involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (PMID:17569761) RGD PMID:17569761 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
(MGI:3828398|PMID:16865359)
Ensembl
RGD
PMID:16865359 GO_REF:0000107 MGI:3828398 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F involved_in NAS PMID:26908121 ParkinsonsUK-UCL PMID:26908121 RGD:11059577 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K involved_in IBA
ISO
PMID:21873635
(MGI:5294535|PMID:19250614)
(PMID:12556481)
RGD PMID:12556481 PMID:19250614, PMID:21873635 MGI:5294535, RGD:13792537 NCBI chr10:63,775,639...63,796,879
Ensembl chr10:63,776,378...63,795,899
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:11692174 RGD:2312443 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IMP PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 involved_in ISO (PMID:18458160) RGD PMID:18458160 NCBI chr 1:243,201,073...243,398,531
Ensembl chr 1:243,276,403...243,398,536
JBrowse link
G Lmbrd1 LMBR1 domain containing 1 acts_upstream_of_or_within ISO MGI:5559223 (MGI:5543853|PMID:24078630) RGD PMID:24078630 MGI:5543853 NCBI chr 9:30,939,555...31,038,381
Ensembl chr 9:30,939,555...31,038,379
JBrowse link
G Mir143 microRNA 143 acts_upstream_of_or_within ISO (MGI:5289772|PMID:21441927) RGD PMID:21441927 MGI:5289772 NCBI chr18:56,971,273...56,971,377
Ensembl chr18:56,971,273...56,971,377
JBrowse link
G Mstn myostatin involved_in ISO (MGI:3604221|PMID:16182246) RGD PMID:16182246 MGI:3604221 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:21707536) RGD PMID:21707536 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Ncoa5 nuclear receptor coactivator 5 acts_upstream_of_or_within ISO MGI:5581698 (MGI:5559256|PMID:24332041) RGD PMID:24332041 MGI:5559256 NCBI chr 3:161,465,733...161,498,951
Ensembl chr 3:161,465,743...161,498,951
JBrowse link
G Nucb2 nucleobindin 2 IDA RGD PMID:22486620 RGD:9831186 NCBI chr 1:185,106,773...185,143,278
Ensembl chr 1:185,104,656...185,143,272
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 involved_in ISO (PMID:19079291) RGD PMID:19079291 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in ISS
ISO
GO_REF:0000024
(PMID:31091439)
UniProt
RGD
PMID:31091439 GO_REF:0000024 NCBI chr17:85,533,056...85,748,843 JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta involved_in ISO
ISS
(PMID:31091439)
GO_REF:0000024
RGD
UniProt
PMID:31091439 GO_REF:0000024 NCBI chr10:85,655,223...85,684,138
Ensembl chr10:85,658,324...85,684,138
JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:31091439)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:31091439 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:70,483,948...70,498,995
Ensembl chr 7:70,483,942...70,498,995
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IMP RGD PMID:20501641 RGD:6484547 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:2679305 (MGI:2677557|PMID:11923480) RGD PMID:11923480 MGI:2677557 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta involved_in IDA PMID:11714718 UniProt PMID:11714718 RGD:8553365 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta involved_in IEA
ISO
GO_REF:0000107
(MGI:3836105|PMID:18285345)
Ensembl
RGD
PMID:18285345 GO_REF:0000107 MGI:3836105 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcq protein kinase C, theta involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15364919)
UniProt
Ensembl
RGD
PMID:15364919 GO_REF:0000024 GO_REF:0000107 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Prkcz protein kinase C, zeta involved_in ISO (PMID:15069075) RGD PMID:15069075 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:4941441|PMID:20484139), (MGI:5488890|PMID:12612081)
UniProt
RGD
PMID:12612081 PMID:20484139 GO_REF:0000024 MGI:4941441 MGI:5488890 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E involved_in IDA
ISO
PMID:15738637
(MGI:3772995|PMID:18006633)
RGD PMID:18006633, PMID:15738637 MGI:3772995, RGD:8553759 NCBI chr 1:207,820,719...207,987,123
Ensembl chr 1:207,887,209...207,987,136
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (MGI:6379079|PMID:26063811) RGD PMID:26063811 MGI:6379079 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IMP RGD PMID:18073321 RGD:2298860 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in ISO
IMP
(PMID:18952604) RGD PMID:18952604, PMID:18952604 RGD:8554230 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Slc27a4 solute carrier family 27 member 4 involved_in ISO (PMID:25603556) RGD PMID:25603556 NCBI chr 3:8,363,937...8,376,858
Ensembl chr 3:8,363,937...8,376,858
JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3045683|PMID:15169905)
Ensembl
RGD
PMID:15169905 GO_REF:0000107 MGI:3045683 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs3 suppressor of cytokine signaling 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3045683|PMID:15169905)
Ensembl
RGD
PMID:15169905 GO_REF:0000107 MGI:3045683 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Tns2 tensin 2 involved_in ISO (PMID:23401856) RGD PMID:23401856 NCBI chr 7:143,702,623...143,720,995
Ensembl chr 7:143,707,237...143,720,595
JBrowse link
G Trim72 tripartite motif containing 72 acts_upstream_of_or_within ISO (MGI:5602876|PMID:23965929) RGD PMID:23965929 MGI:5602876 NCBI chr 1:199,450,042...199,457,902
Ensembl chr 1:199,449,973...199,457,895
JBrowse link
G Tsc2 TSC complex subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Ybx1 Y box binding protein 1 IMP RGD PMID:12554649 RGD:727501 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19611
    negative regulation of biological process 5615
      negative regulation of response to stimulus 1672
        negative regulation of cellular response to insulin stimulus 50
          negative regulation of insulin receptor signaling pathway + 45
Path 2
Term Annotations click to browse term
  biological_process 19611
    response to stimulus 10435
      response to chemical 6230
        response to organic substance 3878
          response to organonitrogen compound 1463
            response to peptide 695
              response to peptide hormone 599
                response to insulin 356
                  cellular response to insulin stimulus 268
                    regulation of cellular response to insulin stimulus 83
                      negative regulation of cellular response to insulin stimulus 50
                        negative regulation of insulin receptor signaling pathway + 45
paths to the root