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ONTOLOGY REPORT - ANNOTATIONS


Term:amyloid-beta clearance by transcytosis
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Accession:GO:0150093 term browser browse the term
Definition:The process in which amyloid-beta is removed from extracellular brain regions by cell surface receptor-mediated endocytosis, followed by transcytosis across the blood-brain barrier.



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amyloid-beta clearance by transcytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cltc clathrin heavy chain involved_in ISO GO_Central GO_REF:0000119 NCBI chr11:86,585,178...86,648,637
Ensembl chr11:86,585,177...86,648,391
JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 involved_in ISO
IEA
IDA
IBA
(PMID:20630619) GO_Central
Ensembl
ARUK-UCL
PMID:20630619 GO_REF:0000033 GO_REF:0000107 GO_REF:0000119 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017
JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110
JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein involved_in ISO
IMP
IGI
(PMID:26005850) GO_Central
ARUK-UCL
PMID:26005850 GO_REF:0000119 NCBI chr 7:89,778,711...89,858,655
Ensembl chr 7:89,779,421...89,862,673
JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr 9:64,622,582...64,645,038
Ensembl chr 9:64,622,581...64,645,040
JBrowse link
G Rab11b RAB11B, member RAS oncogene family involved_in ISO
IEA
GO_Central
Ensembl
GO_REF:0000107 GO_REF:0000119 NCBI chr17:33,961,458...33,979,460
Ensembl chr17:33,961,458...33,979,504
JBrowse link
G Rab5a RAB5A, member RAS oncogene family involved_in IEA
ISO
Ensembl
GO_Central
GO_REF:0000107 GO_REF:0000119 NCBI chr17:53,786,262...53,814,706
Ensembl chr17:53,786,262...53,814,708
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28636
    multicellular organismal process 9060
      transcytosis 26
        amyloid-beta clearance by transcytosis 7
Path 2
Term Annotations click to browse term
  biological_process 28636
    localization 5643
      establishment of localization 4992
        transport 4668
          vesicle-mediated transport 1655
            transcytosis 26
              amyloid-beta clearance by transcytosis 7
paths to the root