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ONTOLOGY REPORT - ANNOTATIONS

Term:chromosomal 5-methylcytosine DNA demethylation pathway
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Accession:GO:0141166 term browser browse the term
Definition:A process that chemically modifies 5-methylcytosine (5meC) to make it a substrate for the base excision repair pathway, which then restores the unmodified cytosine.
Comment:Note that this term describes the biochemical pathways of chromosomal cytosine demethylation but is agnostic to the effect on gene expression. If the data supports it, consider co-annotating to 'positive regulation of gene expression, epigenetic ; GO:0044029' or a child.
Synonyms:related_synonym: epigenetic 5-methylcytosine DNA demethylation;   epigenetic 5-methylcytosine DNA demethylation pathway;   epigenetic DNA demethylation


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chromosomal 5-methylcytosine DNA demethylation pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tet1 tet methylcytosine dioxygenase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052 		JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193 		JBrowse link
chromosomal 5-methylcytosine DNA demethylation, oxidation pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tet2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO MGI:5301343 (PMID:21803851) RGD PMID:21803851 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    cellular process 19326
      metabolic process 12309
        macromolecule metabolic process 10164
          nucleic acid metabolic process 5153
            DNA metabolic process 961
              chromosomal 5-methylcytosine DNA demethylation pathway 3
                chromosomal 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway + 0
                chromosomal 5-methylcytosine DNA demethylation, oxidation pathway 1
                chromosomal 5-methylcytosine DNA demethylation, oxidative deamination pathway 0
Path 2
Term Annotations click to browse term
  biological_process 20134
    cellular process 19326
      metabolic process 12309
        primary metabolic process 10935
          nucleobase-containing compound metabolic process 5746
            nucleic acid metabolic process 5153
              DNA metabolic process 961
                chromosomal 5-methylcytosine DNA demethylation pathway 3
                  chromosomal 5-methylcytosine DNA demethylation, direct 5-methylcytosine excision pathway + 0
                  chromosomal 5-methylcytosine DNA demethylation, oxidation pathway 1
                  chromosomal 5-methylcytosine DNA demethylation, oxidative deamination pathway 0
paths to the root