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ONTOLOGY REPORT - ANNOTATIONS

Term:cAMP/PKA signal transduction
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Accession:GO:0141156 term browser browse the term
Definition:An intracellular signaling cassette that starts with production of cyclic AMP (cAMP) by adenylate cyclase (either transmembrane or soluble), which activates protein kinase A, and ends with activation of downstream effectors such as the transcription factor CREB that further transmit the signal within the cell.
Synonyms:exact_synonym: cAMP/PKA signaling cassette
 broad_synonym: PKA signaling;   cAMP signaling;   protein kinase A signaling


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cAMP/PKA signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy8 adenylate cyclase 8 IDA RGD PMID:8163524 RGD:69741 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I IDA RGD PMID:8396727 RGD:631732 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Akap7 A-kinase anchoring protein 7 IMP RGD PMID:17901878 RGD:2312630 NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797 		JBrowse link
G Atf1 activating transcription factor 1 involved_in ISO
IEA		 (PMID:25644539)
GO_REF:0000107		 RGD
Ensembl		 PMID:25644539 GO_REF:0000107 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 involved_in ISO (PMID:25644539) RGD PMID:25644539 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Edn1 endothelin 1 involved_in ISO (PMID:30990108) RGD PMID:30990108 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A involved_in IEA
ISO		 GO_REF:0000107
(PMID:30990108)		 Ensembl
RGD		 PMID:30990108 GO_REF:0000107 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase IMP RGD PMID:28258188 RGD:13792662 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Ghrhr growth hormone releasing hormone receptor IDA RGD PMID:10465288 RGD:1624951 NCBI chr 4:84,498,159...84,532,851
Ensembl chr 4:84,500,212...84,532,776 		JBrowse link
G Glp1r glucagon-like peptide 1 receptor IMP RGD PMID:10446905 RGD:1598448 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in ISO MGI:2451168 (PMID:10518565) RGD PMID:10518565 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha involved_in ISO (PMID:21812984) RGD PMID:21812984 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ptger3 prostaglandin E receptor 3 IMP RGD PMID:11278900 RGD:10003101 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11278900 RGD:10003101 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IEA
ISO		 GO_REF:0000107
MGI:5608917 (PMID:31534133)		 Ensembl
RGD		 PMID:31534133 GO_REF:0000107 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044 		JBrowse link
G Sfn stratifin involved_in ISO (PMID:18606808) RGD PMID:18606808 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
negative regulation of cAMP/PKA signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpar1 lysophosphatidic acid receptor 1 IMP RGD PMID:12139919 RGD:727395 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 IMP RGD PMID:11408607 RGD:633494 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Nucb2 nucleobindin 2 IDA RGD PMID:22486620 RGD:9831186 NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 IMP RGD PMID:16019191 RGD:9835005 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Pde11a phosphodiesterase 11A IDA RGD PMID:11502204 RGD:633590 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde11a_v1 phosphodiesterase 11A, variant 1 IDA RGD PMID:11502204 RGD:633590
G Pde11a_v2 phosphodiesterase 11A, variant 2 IDA RGD PMID:11502204 RGD:633590
G Pde11a_v3 phosphodiesterase 11A, variant 3 IDA RGD PMID:11502204 RGD:633590
G Pde2a phosphodiesterase 2A IDA RGD PMID:12107056 RGD:625635 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde3a phosphodiesterase 3A IMP RGD PMID:9884079 RGD:2312525 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B IMP RGD PMID:9884079 RGD:2312525 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pkia cAMP-dependent protein kinase inhibitor alpha involved_in ISO (PMID:21812984) RGD PMID:21812984 NCBI chr 2:94,398,869...94,473,638
Ensembl chr 2:94,398,869...94,414,282 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha involved_in ISO
IEA		 (PMID:21812984)
GO_REF:0000107		 RGD
Ensembl		 PMID:21812984 GO_REF:0000107 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta involved_in ISO (PMID:21812984) RGD PMID:21812984 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942 		JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha involved_in ISO
IEA		 (PMID:21812984)
GO_REF:0000107		 RGD
Ensembl		 PMID:21812984 GO_REF:0000107 NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta involved_in ISO (PMID:21812984) RGD PMID:21812984 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933 		JBrowse link
positive regulation of cAMP/PKA signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 IDA RGD PMID:17901570 RGD:2325275 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773 		JBrowse link
G Adcyap1r1 ADCYAP receptor type I IDA hop2 splice variant RGD PMID:16905223 RGD:2315974 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Adgrv1 adhesion G protein-coupled receptor V1 acts_upstream_of_or_within ISO (PMID:24191038) RGD PMID:24191038 NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO		 GO_REF:0000024
(PMID:10982546)		 UniProt
RGD		 PMID:10982546 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Adora2b adenosine A2B receptor IMP RGD PMID:8012696 PMID:11882603 RGD:2316150, RGD:631750 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Adrb2 adrenoceptor beta 2 involved_in IEA
ISO		 GO_REF:0000107
ComplexPortal:CPX-1070|UniProtKB:P18762 (PMID:20395454)
ComplexPortal:CPX-1070|UniProtKB:P07550 (PMID:20395454)		 Ensembl
RGD		 PMID:20395454 GO_REF:0000107 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:22500019) RGD PMID:22500019 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Calcr calcitonin receptor involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:O60896|UniProtKB:P10997-PRO_0000004106 (PMID:22500019)		 Ensembl
RGD		 PMID:22500019 GO_REF:0000107 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392 		JBrowse link
G Chga chromogranin A IDA RGD PMID:22459152 RGD:6906968 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398 		JBrowse link
G Crh corticotropin releasing hormone IDA RGD PMID:7477349 RGD:70047 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IMP RGD PMID:20682782 RGD:5491010 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP
IDA		 RGD PMID:16005543 PMID:21277852 PMID:20682782 RGD:5131269, RGD:5491003, RGD:5491010 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Ece1 endothelin converting enzyme 1 IMP RGD PMID:22881710 RGD:7243859 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Ghrh growth hormone releasing hormone IDA RGD PMID:10579333 RGD:1624957 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889 		JBrowse link
G Gip gastric inhibitory polypeptide IMP RGD PMID:8958204 RGD:2312537 NCBI chr10:80,968,360...80,976,506
Ensembl chr10:80,968,352...80,976,503 		JBrowse link
G Gpr3 G protein-coupled receptor 3 IDA RGD PMID:12220620 RGD:632931 NCBI chr 5:145,411,500...145,414,621
Ensembl chr 5:145,411,510...145,414,590 		JBrowse link
G Iapp islet amyloid polypeptide involved_in ISO UniProtKB:O60896|UniProtKB:P30988 (PMID:22500019)
ComplexPortal:CPX-3187|UniProtKB:O60896|UniProtKB:P30988 (PMID:22500019)		 RGD PMID:22500019 NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920 		JBrowse link
G Insl3 insulin-like 3 IDA RGD PMID:12114498 RGD:633070 NCBI chr16:18,398,682...18,400,566
Ensembl chr16:18,384,829...18,400,560 		JBrowse link
G Mc1r melanocortin 1 receptor involved_in IEA
ISO		 GO_REF:0000107
(PMID:18292087)		 Ensembl
RGD		 PMID:18292087 GO_REF:0000107 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:17045821) RGD PMID:17045821 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 IMP RGD PMID:14654844 RGD:2302817 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Ramp3 receptor activity modifying protein 3 involved_in ISO UniProtKB:P10997|UniProtKB:P30988 (PMID:22500019) RGD PMID:22500019 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902 		JBrowse link
G Sct secretin IDA RGD PMID:12403838 RGD:9590237 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Spatc1l spermatogenesis and centriole associated 1-like acts_upstream_of_or_within ISO PR:Q9DBC7 (PMID:30026308) RGD PMID:30026308 NCBI chr20:12,074,040...12,083,873
Ensembl chr20:12,074,047...12,083,301 		JBrowse link
G Taar1 trace-amine-associated receptor 1 IDA RGD PMID:26372541 RGD:11531774 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
G Ucn urocortin IDA RGD PMID:7477349 RGD:70047 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950 		JBrowse link
regulation of cAMP/PKA signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap6 A-kinase anchoring protein 6 involved_in IDA PMID:12709444 BHF-UCL PMID:12709444 RGD:8554839 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B acts_upstream_of_or_within ISO (PMID:24336715) RGD PMID:24336715 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:24464040)		 ParkinsonsUK-UCL
RGD		 PMID:24464040 GO_REF:0000024 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Pde10a phosphodiesterase 10A acts_upstream_of_or_within ISO (PMID:18923023) RGD PMID:18923023 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde4a phosphodiesterase 4A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18923023)
GO_REF:0000107		 RGD
Ensembl		 PMID:18923023 GO_REF:0000107 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4d phosphodiesterase 4D IMP RGD PMID:18073242 RGD:2312596 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Sctr secretin receptor IMP RGD PMID:12403838 RGD:9590237 NCBI chr13:31,127,781...31,190,162
Ensembl chr13:31,127,858...31,180,189 		JBrowse link
G Sesn2 sestrin 2 acts_upstream_of_or_within ISO MGI:3587950 (PMID:22958918) RGD PMID:22958918 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20075
    cellular process 19154
      signal transduction 7183
        intracellular signal transduction 3075
          intracellular signaling cassette 2003
            cAMP/PKA signal transduction 64
              negative regulation of cAMP/PKA signal transduction 16
              positive regulation of cAMP/PKA signal transduction 26
              regulation of cAMP/PKA signal transduction + 50
Path 2
Term Annotations click to browse term
  biological_process 20075
    biological regulation 13559
      regulation of biological process 13136
        signaling 7744
          signal transduction 7183
            intracellular signal transduction 3075
              intracellular signaling cassette 2003
                cAMP/PKA signal transduction 64
                  negative regulation of cAMP/PKA signal transduction 16
                  positive regulation of cAMP/PKA signal transduction 26
                  regulation of cAMP/PKA signal transduction + 50
paths to the root