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ONTOLOGY REPORT - ANNOTATIONS

Term:pore-forming activity
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Accession:GO:0140911 term browser browse the term
Definition:An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.
Synonyms:narrow_synonym: canonical holin activity;   holin activity;   pinholin activity
 alt_id: GO:0034290;   GO:0034291;   GO:0034292
 xref: TC:1.C


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pore-forming activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Defa24 defensin alpha 24 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,052,014...77,053,046
Ensembl chr16:77,052,014...77,053,046 		JBrowse link
G Defa3 defensin alpha 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,235,885...77,238,041
Ensembl chr16:77,235,885...77,238,041 		JBrowse link
G Defa31 defensin alpha 31 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,216,346...77,218,685
Ensembl chr16:77,216,346...77,217,475 		JBrowse link
G Defa5 defensin alpha 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,044,994...77,047,318
Ensembl chr16:77,044,994...77,047,318 		JBrowse link
G Defa6 defensin alpha 6 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,107,681...77,108,695
Ensembl chr16:77,107,681...77,108,695 		JBrowse link
G Defa8 defensin alpha 8 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,135,579...77,136,612
Ensembl chr16:77,135,579...77,136,612 		JBrowse link
G Defa9 defensin alpha 9 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,184,268...77,185,258
Ensembl chr16:77,184,231...77,185,267 		JBrowse link
G Defal1 defensin alpha-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,073,954...77,074,943
Ensembl chr16:77,073,954...77,074,943 		JBrowse link
G Mmd monocyte to macrophage differentiation-associated enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:75,570,366...75,598,610
Ensembl chr10:75,570,397...75,598,609 		JBrowse link
G Mmd2 monocyte to macrophage differentiation-associated 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:17,075,870...17,123,255
Ensembl chr12:17,076,260...17,123,904 		JBrowse link
G Mpeg1 macrophage expressed 1 enables ISO (PMID:26402460) RGD PMID:26402460 NCBI chr 1:218,876,848...218,881,364
Ensembl chr 1:218,876,069...218,908,715 		JBrowse link
G Np4 defensin NP-4 precursor enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,197,061...77,199,713
Ensembl chr16:77,121,639...77,122,502
Ensembl chr16:77,121,639...77,122,502 		JBrowse link
G Prf1 perforin 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:29,789,040...29,794,550
Ensembl chr20:29,788,972...29,795,124 		JBrowse link
G Ratnp-3b defensin rat NP-3 precursor enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:77,246,811...77,248,977
Ensembl chr16:77,216,342...77,248,966 		JBrowse link
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  molecular_function 19971
    pore-forming activity 14
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