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Term:pore-forming activity
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Accession:GO:0140911 term browser browse the term
Definition:An activity in which a protein is inserted into the membrane of another cell where it forms transmembrane pores. Pores disrupts the integrity of the cell membrane, resulting in deregulated ion homeostasis, cellular dysfunction, and can result in cell death.
Synonyms:narrow_synonym: canonical holin activity;   holin activity;   pinholin activity
 alt_id: GO:0034290;   GO:0034291;   GO:0034292
 xref: TC:1.C

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pore-forming activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmd monocyte to macrophage differentiation-associated enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:75,073,278...75,101,528
Ensembl chr10:75,073,365...75,101,528
JBrowse link
G Mmd2 monocyte to macrophage differentiation-associated 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:11,962,733...12,009,776
Ensembl chr12:11,962,757...12,009,773
JBrowse link
G Prf1 perforin 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:29,246,202...29,251,712
Ensembl chr20:29,246,202...29,251,701
JBrowse link

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  molecular_function 20538
    pore-forming activity 3
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