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ONTOLOGY REPORT - ANNOTATIONS

Term:protein-containing complex destabilizing activity
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Accession:GO:0140776 term browser browse the term
Definition:A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex.
Synonyms:broad_synonym: protein unfoldase activity


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ATP-dependent protein disaggregase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clpb ClpB family mitochondrial disaggregase enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:32573439), (PMID:34115842)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:32573439 PMID:34115842 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788 		JBrowse link
G Haus8l2 HAUS augmin-like complex, subunit 8 like 2 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr11:5,628,432...5,630,535
Ensembl chr11:5,628,427...5,630,533 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A enables ISO (PMID:23921388) RGD PMID:23921388 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B enables ISO (PMID:23921388) RGD PMID:23921388 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 enables ISO
IEA		 (PMID:23921388)
GO_REF:0000107		 RGD
Ensembl		 PMID:23921388 GO_REF:0000107 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase enables ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386 		JBrowse link
microtubule severing ATPase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fign fidgetin, microtubule severing factor enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:48,637,510...48,760,772
Ensembl chr 3:48,642,496...48,760,787 		JBrowse link
G Fignl1 fidgetin-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455 		JBrowse link
G Katna1 katanin catalytic subunit A1 enables IEA
ISO		 GO_REF:0000003
GO_REF:0000107
(PMID:10751153)		 UniProt
Ensembl
RGD		 PMID:10751153 GO_REF:0000003 GO_REF:0000107 NCBI chr 1:2,202,501...2,244,132
Ensembl chr 1:2,202,490...2,244,131 		JBrowse link
G Katnal1 katanin catalytic subunit A1 like 1 enables ISO
ISS		 (PMID:26929214)
(PMID:22654668)
GO_REF:0000024		 RGD
UniProt		 PMID:22654668 PMID:26929214 GO_REF:0000024 NCBI chr12:6,094,663...6,156,114
Ensembl chr12:6,102,836...6,157,553 		JBrowse link
G Katnal2 katanin catalytic subunit A1 like 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr18:70,531,759...70,607,886
Ensembl chr18:70,531,754...70,608,082 		JBrowse link
G Spast spastin enables IEA
ISO
ISS		 GO_REF:0000003
GO_REF:0000104
(PMID:15716377), (PMID:16219033), (PMID:17389232), (PMID:23745751), (PMID:26875866)
GO_REF:0000024		 UniProt
RGD		 PMID:15716377 PMID:16219033 PMID:17389232 PMID:23745751 PMID:26875866 GO_REF:0000003 GO_REF:0000024 GO_REF:0000104 NCBI chr 6:21,055,349...21,106,586
Ensembl chr 6:21,055,349...21,107,954 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    protein-containing complex destabilizing activity 12
      ATP-dependent protein disaggregase activity 6
      actin filament debranching activity 0
      actin filament severing activity 0
      microtubule severing ATPase activity 6
paths to the root