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ONTOLOGY REPORT - ANNOTATIONS

Term:constitutive heterochromatin formation
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Accession:GO:0140719 term browser browse the term
Definition:The compaction of chromatin into a conformation that is refactory to transcription.
Comment:Note that constitutive heterochromatin indicates that it usually cannot be reprogrammed to a transcriptionally-competent state, as opposed to facultative heterochromatin, which can be reprogrammed.
Synonyms:exact_synonym: constitutive heterochromatin assembly


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pericentric heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpv centromere protein V involved_in ISO
IBA		 (PMID:18772885)
GO_REF:0000033		 RGD
GO_Central		 PMID:18772885 GO_REF:0000033 NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761 		JBrowse link
G Dicer1 dicer 1 ribonuclease III acts_upstream_of_or_within ISO MGI:3589287 (PMID:15713842) RGD PMID:15713842 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965 		JBrowse link
G H3f3a H3.3 histone A acts_upstream_of_or_within ISO MGI:1101768 (PMID:26159997) RGD PMID:26159997 NCBI chr13:92,533,289...92,544,902
Ensembl chr13:92,533,298...92,544,908 		JBrowse link
G H3f3b H3.3 histone B acts_upstream_of_or_within ISO MGI:1097686 (PMID:26159997) RGD PMID:26159997 NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709 		JBrowse link
G Hells helicase, lymphoid specific involved_in ISO
IBA		 (MGI:3041983|PMID:14612388)
GO_REF:0000033		 RGD
GO_Central		 PMID:14612388 GO_REF:0000033 MGI:3041983 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:27043296) RGD PMID:27043296 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
subtelomeric heterochromatin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX, chromatin remodeler involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:4881400|PMID:20211137)
GO_REF:0000107
(PMID:26055325)		 UniProt
RGD
Ensembl		 PMID:20211137 PMID:26055325 GO_REF:0000024 GO_REF:0000107 MGI:4881400 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit involved_in ISO UniProtKB:P38827 (MGI:892875|PMID:9214638) RGD PMID:9214638 MGI:892875 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in ISO UniProtKB:P38827 (PMID:9214638) RGD PMID:9214638 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G H3f3a H3.3 histone A acts_upstream_of_or_within ISO MGI:1101768 (PMID:26159997) RGD PMID:26159997 NCBI chr13:92,533,289...92,544,902
Ensembl chr13:92,533,298...92,544,908 		JBrowse link
G H3f3b H3.3 histone B acts_upstream_of_or_within ISO MGI:1097686 (PMID:26159997) RGD PMID:26159997 NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709 		JBrowse link
G Hat1 histone acetyltransferase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517 		JBrowse link
G Rif1 replication timing regulatory factor 1 involved_in ISO (MGI:5584328|PMID:24735877) RGD PMID:24735877 MGI:5584328 NCBI chr 3:36,554,689...36,607,961
Ensembl chr 3:36,554,697...36,603,617 		JBrowse link
G Sirt6 sirtuin 6 involved_in ISO (PMID:21847107) RGD PMID:21847107 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      negative regulation of metabolic process 3098
        negative regulation of macromolecule metabolic process 2865
          negative regulation of macromolecule biosynthetic process 2478
            negative regulation of gene expression 1382
              negative regulation of gene expression, epigenetic 180
                heterochromatin formation 148
                  constitutive heterochromatin formation 11
                    pericentric heterochromatin formation + 6
                    silent mating-type cassette heterochromatin formation + 0
                    subtelomeric heterochromatin formation 8
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        regulation of metabolic process 6641
          regulation of biosynthetic process 5478
            regulation of cellular biosynthetic process 5386
              regulation of macromolecule biosynthetic process 5286
                regulation of gene expression 5170
                  negative regulation of gene expression 1382
                    negative regulation of gene expression, epigenetic 180
                      heterochromatin formation 148
                        constitutive heterochromatin formation 11
                          pericentric heterochromatin formation + 6
                          silent mating-type cassette heterochromatin formation + 0
                          subtelomeric heterochromatin formation 8
paths to the root