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ONTOLOGY REPORT - ANNOTATIONS
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Term:
FAD-dependent H3K4me/H3K4me3 demethylase activity
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Accession:
GO:0140682
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Definition:
Catalysis of the removal of a methyl group from a di- or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a flavin adenine dinucleotide (FAD)-dependent amine oxidation reaction.
Synonyms:
exact_synonym:
histone H3-di/monomethyl-lysine-4 FAD-dependent demethylase activity
broad_synonym:
histone H3K4me2 demethylase activity
related_synonym:
histone H3K4me demethylase activity
xref:
EC:1.14.99.66; RHEA:60244
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Genes (2)
FAD-dependent H3K4me/H3K4me3 demethylase activity
Symbol
Object Name
Qualifiers
Evidence
Notes
Source
PubMed Reference(s)
RGD Reference(s)
Position
G
Kdm1a
lysine demethylase 1A
enables
IEA
UniProt
GO_REF:0000117
NCBI chrNW_004624764:7,664,550...7,742,494
G
Kdm1b
lysine demethylase 1B
enables
IEA
UniProt
GO_REF:0000117
NCBI chrNW_004624756:8,447,780...8,506,870
Ensembl chrNW_004624756:8,449,585...8,506,858
Term paths to the root
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Path 1
Term
Annotations
molecular_function
18439
catalytic activity
5599
oxidoreductase activity
699
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
180
FAD-dependent H3K4me/H3K4me3 demethylase activity
2
Path 2
Term
Annotations
molecular_function
18439
catalytic activity
5599
demethylase activity
37
protein demethylase activity
28
histone demethylase activity
28
histone H3 demethylase activity
26
histone H3K4 demethylase activity
7
FAD-dependent H3K4me/H3K4me3 demethylase activity
2