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ONTOLOGY REPORT - ANNOTATIONS

Term:very long-chain fatty acid beta-oxidation
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Accession:GO:0140493 term browser browse the term
Definition:A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
Comment:While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).


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very long-chain fatty acid beta-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:32169171)		 Ensembl
RGD		 PMID:32169171 GO_REF:0000107 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      cellular metabolic process 10293
        cellular lipid metabolic process 1068
          fatty acid metabolic process 454
            fatty acid catabolic process 115
              very long-chain fatty acid catabolic process 7
                very long-chain fatty acid beta-oxidation 1
Path 2
Term Annotations click to browse term
  biological_process 20115
    metabolic process 12289
      cellular metabolic process 10293
        organic acid metabolic process 1033
          oxoacid metabolic process 1022
            carboxylic acid metabolic process 1007
              monocarboxylic acid metabolic process 730
                fatty acid metabolic process 454
                  fatty acid catabolic process 115
                    fatty acid beta-oxidation 81
                      fatty acid beta-oxidation using acyl-CoA oxidase 7
                        very long-chain fatty acid beta-oxidation 1
paths to the root