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ONTOLOGY REPORT - ANNOTATIONS

Term:very long-chain fatty acid beta-oxidation
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Accession:GO:0140493 term browser browse the term
Definition:A fatty acid beta-oxidation pathway acting on a very long-chain fatty acid. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. The partway stars with the conversion of an acyl-CoA to a trans-2-enoyl-CoA, catalyzed by acyl-CoA oxidase; the electrons removed by oxidation pass directly to oxygen and produce hydrogen peroxide, which is cleaved by peroxisomal catalases. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and ends when only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
Comment:While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).


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very long-chain fatty acid beta-oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-Coenzyme A oxidase 1, palmitoyl involved_in ISO
ISS		 MGI
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000119 MGI:4834177 NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28762
    cellular process 18488
      metabolic process 11920
        catabolic process 2895
          lipid catabolic process 359
            fatty acid catabolic process 109
              very long-chain fatty acid catabolic process 7
                very long-chain fatty acid beta-oxidation 1
Path 2
Term Annotations click to browse term
  biological_process 28762
    cellular process 18488
      metabolic process 11920
        small molecule metabolic process 1936
          organic acid metabolic process 1055
            oxoacid metabolic process 1048
              carboxylic acid metabolic process 1026
                monocarboxylic acid metabolic process 757
                  fatty acid metabolic process 496
                    fatty acid catabolic process 109
                      fatty acid beta-oxidation 79
                        fatty acid beta-oxidation using acyl-CoA oxidase 6
                          very long-chain fatty acid beta-oxidation 1
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