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ONTOLOGY REPORT - ANNOTATIONS

Term:integrated stress response signaling
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Accession:GO:0140467 term browser browse the term
Definition:The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
Synonyms:related_synonym: ISR
 xref: Wikipedia:Integrated_stress_response


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integrated stress response signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3798818|PMID:12667446)
(PMID:32132707)		 UniProt
RGD		 PMID:12667446 PMID:32132707 GO_REF:0000024 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in ISO (PMID:30639358) RGD PMID:30639358 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dele1 DAP3 binding cell death enhancer 1 involved_in ISO
ISS		 (PMID:32132706), (PMID:32132707)
GO_REF:0000024		 RGD
UniProt		 PMID:32132706 PMID:32132707 GO_REF:0000024 NCBI chr18:30,085,093...30,098,105
Ensembl chr18:30,085,126...30,098,756 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:32132707)		 UniProt
RGD		 PMID:32132707 GO_REF:0000024 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISS
ISO		 GO_REF:0000024
(PMID:32132706), (PMID:32132707)		 UniProt
RGD		 PMID:32132706 PMID:32132707 GO_REF:0000024 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
GCN2-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:2149467|PMID:10655230), (MGI:3582244|PMID:11106749), (MGI:3589053|PMID:16121183), (MGI:3770235|PMID:16054071), (MGI:5576818|PMID:24333428), (MGI:5700278|PMID:26102367)
(PMID:25329545), (PMID:26102367)		 UniProt
Ensembl
RGD		 PMID:10655230 PMID:11106749 PMID:16054071 PMID:16121183 PMID:24333428 More... GO_REF:0000024 GO_REF:0000107 MGI:2149467 MGI:3582244 MGI:3589053 MGI:3770235 MGI:5576818 MGI:5700278 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Gcn1 GCN1 activator of EIF2AK4 involved_in ISO (MGI:5576818|PMID:24333428) RGD PMID:24333428 MGI:5576818 NCBI chr12:40,991,512...41,052,661
Ensembl chr12:40,991,512...41,052,555 		JBrowse link
G Impact impact RWD domain protein involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(MGI:5494763|PMID:23447528)		 UniProt
GO_Central
RGD		 PMID:23447528 GO_REF:0000024 GO_REF:0000033 MGI:5494763 NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 acts_upstream_of ISS
ISO		 GO_REF:0000024
(PMID:32610081)		 UniProt
RGD		 PMID:32610081 GO_REF:0000024 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
HRI-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad3a ATPase family, AAA domain containing 3A acts_upstream_of ISO
ISS		 (PMID:37832546)
GO_REF:0000024		 RGD
UniProt		 PMID:37832546 GO_REF:0000024 NCBI chr 5:166,350,302...166,370,492
Ensembl chr 5:166,350,304...166,370,482 		JBrowse link
G Atf4 activating transcription factor 4 involved_in ISO
ISS		 (PMID:32132707)
GO_REF:0000024		 RGD
UniProt		 PMID:32132707 GO_REF:0000024 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Dele1 DAP3 binding cell death enhancer 1 involved_in ISO
ISS		 (PMID:32132706), (PMID:32132707)
(PMID:37550454), (PMID:37832546)
(PMID:38340717)
(PMID:37327776)
GO_REF:0000024		 RGD
UniProt		 PMID:32132706 PMID:32132707 PMID:37327776 PMID:37550454 PMID:37832546 More... GO_REF:0000024 NCBI chr18:30,085,093...30,098,105
Ensembl chr18:30,085,126...30,098,756 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:32132706), (PMID:32132707), (PMID:37550454), (PMID:38340717)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:32132706 PMID:32132707 PMID:37550454 PMID:38340717 GO_REF:0000024 GO_REF:0000107 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS		 (PMID:38340717)
GO_REF:0000024		 RGD
UniProt		 PMID:38340717 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISS
ISO		 GO_REF:0000024
(PMID:32132706), (PMID:32132707)		 UniProt
RGD		 PMID:32132706 PMID:32132707 GO_REF:0000024 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980 		JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA		 (PMID:14676213)
GO_REF:0000033
UniProtKB:O55033 (MGI:5613478|PMID:14676213)		 RGD
GO_Central		 PMID:14676213 GO_REF:0000033 MGI:5613478 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA		 UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
GO_REF:0000033		 RGD
GO_Central		 PMID:14676213 GO_REF:0000033 MGI:5613478 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IBA
IEA		 (PMID:21216966)
(MGI:5619464|PMID:21216966)
GO_REF:0000033
GO_REF:0000118		 RGD
GO_Central
TreeGrafter		 PMID:21216966 GO_REF:0000033 GO_REF:0000118 MGI:5619464 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3722921|PMID:14729979), (MGI:3798818|PMID:12667446)		 UniProt
RGD		 PMID:12667446 PMID:14729979 GO_REF:0000024 MGI:3722921 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) RGD PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS		 (PMID:33384352)
GO_REF:0000024		 RGD
UniProt		 PMID:33384352 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359 		JBrowse link
G Rpap2 RNA polymerase II associated protein 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:30118681)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:30118681 GO_REF:0000024 GO_REF:0000107 NCBI chr14:2,109,044...2,187,343
Ensembl chr14:2,109,053...2,187,350 		JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4456438 (PMID:28797121)		 Ensembl
RGD		 PMID:28797121 GO_REF:0000107 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903 		JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO		 GO_REF:0000024
(MGI:5648772|PMID:26015568)		 UniProt
RGD		 PMID:26015568 GO_REF:0000024 MGI:5648772 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA		 (MGI:5619464|PMID:21216966)
GO_REF:0000107		 RGD
Ensembl		 PMID:21216966 GO_REF:0000107 MGI:5619464 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS		 (PMID:26268696)
GO_REF:0000024		 RGD
UniProt		 PMID:26268696 GO_REF:0000024 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cellular response to stimulus 9075
        cellular response to stress 2061
          integrated stress response signaling 24
            GCN2-mediated signaling 4
            HRI-mediated signaling 6
            PERK-mediated unfolded protein response + 15
            PKR/eIFalpha signaling 0
Path 2
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of biological process 13322
        regulation of cellular process 12748
          signal transduction 7209
            intracellular signal transduction 2864
              intracellular signaling cassette 1991
                integrated stress response signaling 24
                  GCN2-mediated signaling 4
                  HRI-mediated signaling 6
                  PERK-mediated unfolded protein response + 15
                  PKR/eIFalpha signaling 0
paths to the root