Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:integrated stress response signaling
go back to main search page
Accession:GO:0140467 term browser browse the term
Definition:The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery.
Synonyms:related_synonym: ISR
 xref: Wikipedia:Integrated_stress_response



show annotations for term's descendants           Sort by:
 
integrated stress response signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:3798818|PMID:12667446)
(PMID:32132707)
UniProt
RGD
PMID:12667446 PMID:32132707 GO_REF:0000024 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Dele1 DAP3 binding cell death enhancer 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:32132706), (PMID:32132707)
UniProt
RGD
PMID:32132706 PMID:32132707 GO_REF:0000024 NCBI chr18:30,085,093...30,098,105
Ensembl chr18:30,085,126...30,098,756
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:32132707)
UniProt
RGD
PMID:32132707 GO_REF:0000024 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISS
ISO
GO_REF:0000024
(PMID:32132706), (PMID:32132707)
UniProt
RGD
PMID:32132706 PMID:32132707 GO_REF:0000024 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359
JBrowse link
GCN2-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO
ISS
(PMID:26102367)
(MGI:2149467|PMID:10655230), (MGI:3582244|PMID:11106749), (MGI:3589053|PMID:16121183), (MGI:3770235|PMID:16054071), (MGI:5700278|PMID:26102367)
GO_REF:0000024
RGD
UniProt
PMID:10655230 PMID:11106749 PMID:16054071 PMID:16121183 PMID:26102367 GO_REF:0000024 MGI:2149467 MGI:3582244 MGI:3589053 MGI:3770235 MGI:5700278 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630
JBrowse link
G Impact impact RWD domain protein involved_in ISS
ISO
GO_REF:0000024
(MGI:5494763|PMID:23447528)
UniProt
RGD
PMID:23447528 GO_REF:0000024 MGI:5494763 NCBI chr18:4,108,872...4,147,571
Ensembl chr18:4,108,853...4,147,569
JBrowse link
HRI-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISO
ISS
(PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132707 GO_REF:0000024 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Dele1 DAP3 binding cell death enhancer 1 involved_in ISO
ISS
(PMID:32132706), (PMID:32132707)
GO_REF:0000024
RGD
UniProt
PMID:32132706 PMID:32132707 GO_REF:0000024 NCBI chr18:30,085,093...30,098,105
Ensembl chr18:30,085,126...30,098,756
JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:32132707)
UniProt
Ensembl
RGD
PMID:32132707 GO_REF:0000024 GO_REF:0000107 NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573
JBrowse link
G Oma1 OMA1 zinc metallopeptidase involved_in ISS
ISO
GO_REF:0000024
(PMID:32132706), (PMID:32132707)
UniProt
RGD
PMID:32132706 PMID:32132707 GO_REF:0000024 NCBI chr 5:118,083,728...118,136,980
Ensembl chr 5:118,083,728...118,136,980
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5774886|PMID:27030769) RGD PMID:27030769 MGI:5774886 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO
IBA
(PMID:14676213)
PMID:21873635
UniProtKB:O55033 (MGI:5613478|PMID:14676213)
RGD PMID:14676213 PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO
IBA
UniProtKB:Q99M51 (MGI:5613478|PMID:14676213)
PMID:21873635
RGD PMID:14676213 PMID:21873635 MGI:5613478, RGD:13792537 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IBA
(PMID:21216966)
PMID:21873635
(MGI:5619464|PMID:21216966)
RGD PMID:21216966 PMID:21873635 MGI:5619464, RGD:13792537 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:3722921|PMID:14729979), (MGI:3798818|PMID:12667446)
UniProt
RGD
PMID:12667446 PMID:14729979 GO_REF:0000024 MGI:3722921 MGI:3798818 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 involved_in ISO (MGI:3722921|PMID:14729979), (MGI:6467680|PMID:17707796) RGD PMID:14729979 PMID:17707796 MGI:3722921 MGI:6467680 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISO
ISS
(PMID:33384352)
GO_REF:0000024
RGD
UniProt
PMID:33384352 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 involved_in ISO (MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:2677605 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Qrich1 glutamine-rich 1 involved_in ISO (PMID:33384352) RGD PMID:33384352 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 acts_upstream_of_or_within ISO MGI:4456438 (MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:5914333 NCBI chr12:32,052,542...32,061,596
Ensembl chr12:32,052,543...32,071,903
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member involved_in ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371
JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISS
ISO
GO_REF:0000024
(MGI:5648772|PMID:26015568)
UniProt
RGD
PMID:26015568 GO_REF:0000024 MGI:5648772 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:5619464 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Tmem33 transmembrane protein 33 involved_in ISO
ISS
(PMID:26268696)
GO_REF:0000024
RGD
UniProt
PMID:26268696 GO_REF:0000024 NCBI chr14:40,888,485...40,910,715
Ensembl chr14:40,885,712...40,910,715
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    response to stimulus 10209
      response to stress 4154
        cellular response to stress 2090
          integrated stress response signaling 19
            GCN2-mediated signaling 2
            HRI-mediated signaling 4
            PERK-mediated unfolded protein response + 14
            PKR-mediated signaling 0
paths to the root