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ONTOLOGY REPORT - ANNOTATIONS


Term:signaling receptor ligand precursor processing
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Accession:GO:0140448 term browser browse the term
Definition:The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.
Synonyms:narrow_synonym: ligand maturation
 related_synonym: signal maturation
 alt_id: GO:0035638



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signaling receptor ligand precursor processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in ISO UniProtKB:P10749|UniProtKB:Q9NPP4 (PMID:15882992) RGD PMID:15882992 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO (PMID:12045255), (PMID:15746149) RGD PMID:12045255 PMID:15746149 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Ren renin acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
MGI:2136642 (MGI:1351364|PMID:10617578)
PMID:21873635
(PMID:12045255)
RGD PMID:10617578 PMID:12045255 PMID:21321306 PMID:21873635 MGI:1351364, RGD:5132599, RGD:13792537 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
cytokine precursor processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in ISO
IEA
UniProtKB:P10749|UniProtKB:Q9NPP4 (PMID:15882992)
GO_REF:0000107
RGD
Ensembl
PMID:15882992 GO_REF:0000107 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cma1 chymase 1 involved_in ISO (PMID:1919436) RGD PMID:1919436 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO (MGI:3795695|PMID:18519639) RGD PMID:18519639 MGI:3795695 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600
JBrowse link
endothelin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 involved_in ISO
IEA
(PMID:7805846)
GO_REF:0000107
RGD
Ensembl
PMID:7805846 GO_REF:0000107 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
enkephalin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E IDA RGD PMID:6326144 RGD:6483103 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Ctsl cathepsin L involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO (MGI:3773775|PMID:8262946) RGD PMID:8262946 MGI:3773775 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
insulin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E acts_upstream_of_or_within
involved_in
IDA
ISO
IEA
MGI:1856395 (MGI:73445|PMID:7663508)
GO_REF:0000107
RGD
Ensembl
PMID:7663508 PMID:2822027 GO_REF:0000107 MGI:73445, RGD:1626225 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta acts_upstream_of_or_within ISO MGI:3864866 (MGI:4440670|PMID:20308425) RGD PMID:20308425 MGI:4440670 NCBI chr17:85,861,086...86,003,244
Ensembl chr17:85,929,618...86,003,398
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO (PMID:7626024) RGD PMID:7626024 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Yipf5 Yip1 domain family, member 5 involved_in ISO (PMID:33164986) RGD PMID:33164986 NCBI chr18:32,123,814...32,159,752
Ensembl chr18:32,123,842...32,157,642
JBrowse link
islet amyloid polypeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in IMP PMID:15983213 BHF-UCL PMID:15983213 RGD:8554260 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
neuropeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mme membrane metallo-endopeptidase involved_in ISO UniProtKB:P05067 (PMID:24825898) RGD PMID:24825898 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
patched ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disp1 dispatched RND transporter family member 1 acts_upstream_of_or_within ISO MGI:2429759 (MGI:2389012|PMID:12421714) RGD PMID:12421714 MGI:2389012 NCBI chr13:94,720,928...94,866,702
Ensembl chr13:94,720,928...94,866,702
JBrowse link
peptide hormone processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase involved_in ISO
ISS
IEA
(PMID:10880574)
(MGI:3530681|PMID:15637153), (MGI:5319447|PMID:22437503), (MGI:5319621|PMID:11884416)
GO_REF:0000024
GO_REF:0000107
(PMID:21518754)
RGD
UniProt
Ensembl
PMID:10880574 PMID:11884416 PMID:15637153 PMID:21518754 PMID:22437503 GO_REF:0000024 GO_REF:0000107 MGI:3530681 MGI:5319447 MGI:5319621 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
JBrowse link
G Cpe carboxypeptidase E TAS RGD PMID:2784437 RGD:727682 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233
JBrowse link
G Ece1 endothelin converting enzyme 1 involved_in ISO
IBA
(PMID:7864876)
PMID:21873635
RGD PMID:7864876 PMID:21873635 RGD:13792537 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Ece2 endothelin-converting enzyme 2 involved_in TAS
ISO
(PMID:11718899) RGD PMID:11718899 PMID:15060002 RGD:1303943 NCBI chr11:80,259,130...80,299,685
Ensembl chr11:80,263,162...80,278,428
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
IEA
IBA
(PMID:9242664)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:9242664 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in IMP
ISO
IBA
IDA
(MGI:3773775|PMID:8262946), (MGI:3807770|PMID:9242664)
PMID:21873635
pituitary adenylate cyclase-activating polypetide
RGD PMID:8262946 PMID:9242664 PMID:16497799 PMID:21873635 PMID:10087454 MGI:3773775 MGI:3807770, RGD:1601276, RGD:13792537, RGD:2308913 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:1351397|PMID:10632593)
GO_REF:0000107
RGD
Ensembl
PMID:10632593 GO_REF:0000107 MGI:1351397 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in
acts_upstream_of_or_within
IMP
ISO
ISS
IBA
(MGI:3807770|PMID:9242664)
MGI:1857445 (MGI:2668770|PMID:12859669)
GO_REF:0000024
(PMID:28719828)
PMID:21873635
RGD
UniProt
PMID:9242664 PMID:12859669 PMID:28719828 PMID:16497799 PMID:21873635 GO_REF:0000024 MGI:2668770 MGI:3807770, RGD:1601276, RGD:13792537 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in IBA
ISO
PMID:21873635
(MGI:3795695|PMID:18519639), (MGI:3807770|PMID:9242664), (MGI:74959|PMID:8468318)
(PMID:8901832)
RGD PMID:8468318 PMID:8901832 PMID:9242664 PMID:18519639 PMID:21873635 MGI:3795695 MGI:3807770 MGI:74959, RGD:13792537 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 involved_in IEP
IEA
ISO
IBA
GO_REF:0000107
(PMID:9242664)
PMID:21873635
Ensembl
RGD
PMID:9242664 PMID:8070361 PMID:21873635 GO_REF:0000107, RGD:729476, RGD:13792537 NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
JBrowse link
G Scg5 secretogranin V involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:1332331|PMID:10089884)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:10089884 GO_REF:0000024 GO_REF:0000107 MGI:1332331 NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      primary metabolic process 10535
        protein metabolic process 5935
          proteolysis 1907
            protein processing 256
              signaling receptor ligand precursor processing 21
                cytokine precursor processing 3
                neuropeptide processing 1
                peptide hormone processing + 18
Path 2
Term Annotations click to browse term
  biological_process 19497
    metabolic process 11824
      organic substance metabolic process 11355
        macromolecule metabolic process 9812
          protein metabolic process 5935
            proteolysis 1907
              protein processing 256
                signaling receptor ligand precursor processing 21
                  cytokine precursor processing 3
                  neuropeptide processing 1
                  peptide hormone processing + 18
paths to the root