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ONTOLOGY REPORT - ANNOTATIONS


Term:signaling receptor ligand precursor processing
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Accession:GO:0140448 term browser browse the term
Definition:The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.
Synonyms:narrow_synonym: ligand maturation
 related_synonym: signal maturation
 alt_id: GO:0035638


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signaling receptor ligand precursor processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in ISO
IEA
UniProtKB:P10749|UniProtKB:Q9NPP4 (PMID:15882992)
GO_REF:0000107
RGD
Ensembl
PMID:15882992 GO_REF:0000107 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO (PMID:12045255), (PMID:15746149) RGD PMID:12045255 PMID:15746149 NCBI chr  X:11,137,889...11,164,854
Ensembl chr  X:11,136,939...11,164,915
JBrowse link
G Ren renin involved_in IDA
IBA
ISO
PMID:21873635
(PMID:12045255)
MGI:2136642 (MGI:1351364|PMID:10617578)
RGD PMID:10617578 PMID:12045255, PMID:21321306, PMID:21873635, PMID:21873635 MGI:1351364, RGD:5132599, RGD:13792537, RGD:13792537 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
cytokine precursor processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in ISO UniProtKB:P10749|UniProtKB:Q9NPP4 (PMID:15882992) RGD PMID:15882992 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cma1 chymase 1 involved_in ISO (PMID:1919436) RGD PMID:1919436 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO (MGI:3795695|PMID:18519639) RGD PMID:18519639 MGI:3795695 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
JBrowse link
endothelin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 involved_in ISO (PMID:7805846) RGD PMID:7805846 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
enkephalin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E IDA RGD PMID:6326144 RGD:6483103 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Ctsl cathepsin L involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 ISO (MGI:3773775|PMID:8262946) RGD PMID:8262946 MGI:3773775 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
insulin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E involved_in IDA
IEA
ISO
GO_REF:0000107
MGI:1856395 (MGI:73445|PMID:7663508)
Ensembl
RGD
PMID:7663508, PMID:2822027 GO_REF:0000107 MGI:73445, RGD:1626225 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta ISO MGI:3864866 (MGI:4440670|PMID:20308425) RGD PMID:20308425 MGI:4440670 NCBI chr17:90,709,394...90,783,110
Ensembl chr17:90,710,555...90,756,048
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO (PMID:7626024) RGD PMID:7626024 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
islet amyloid polypeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk2 proprotein convertase subtilisin/kexin type 2 IMP PMID:15983213 BHF-UCL PMID:15983213 RGD:8554260 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
neuropeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mme membrane metallo-endopeptidase involved_in ISO UniProtKB:P05067 (PMID:24825898) RGD PMID:24825898 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
patched ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disp1 dispatched RND transporter family member 1 ISO MGI:2429759 (MGI:2389012|PMID:12421714) RGD PMID:12421714 MGI:2389012 NCBI chr13:101,451,932...101,597,570
Ensembl chr13:101,451,932...101,597,570
JBrowse link
peptide hormone processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:21518754)
(PMID:10880574)
(MGI:3530681|PMID:15637153), (MGI:5319447|PMID:22437503), (MGI:5319621|PMID:11884416)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:10880574 PMID:11884416 PMID:15637153 PMID:21518754 PMID:22437503 GO_REF:0000024 GO_REF:0000107 MGI:3530681 MGI:5319447 MGI:5319621 NCBI chr14:38,247,379...38,474,931
Ensembl chr14:38,247,791...38,473,648
JBrowse link
G Cpe carboxypeptidase E TAS RGD PMID:2784437 RGD:727682 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
JBrowse link
G Ece1 endothelin converting enzyme 1 involved_in ISO
IBA
(PMID:7864876)
PMID:21873635
RGD PMID:7864876, PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Ece2 endothelin-converting enzyme 2 involved_in TAS
ISO
(PMID:11718899) RGD PMID:11718899, PMID:15060002 RGD:1303943 NCBI chr11:83,948,896...83,985,429
Ensembl chr11:83,948,230...83,964,055
JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
IEA
IBA
(PMID:9242664)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:9242664, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182
JBrowse link
G LOC103690091 proSAAS ISO (MGI:1351397|PMID:10632593) RGD PMID:10632593 MGI:1351397 NCBI chr  X:15,324,261...15,328,617 JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in IMP
IBA
ISO
IDA
PMID:21873635
(MGI:3773775|PMID:8262946), (MGI:3807770|PMID:9242664)
pituitary adenylate cyclase-activating polypetide
RGD PMID:8262946 PMID:9242664, PMID:16497799, PMID:21873635, PMID:21873635, PMID:10087454 MGI:3773775 MGI:3807770, RGD:1601276, RGD:13792537, RGD:13792537, RGD:2308913 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in IMP
ISO
IBA
ISS
(PMID:28719828)
PMID:21873635
MGI:1857445 (MGI:2668770|PMID:12859669), (MGI:3807770|PMID:9242664)
GO_REF:0000024
RGD
UniProt
PMID:9242664 PMID:12859669 PMID:28719828, PMID:16497799, PMID:21873635, PMID:21873635 GO_REF:0000024 MGI:2668770 MGI:3807770, RGD:1601276, RGD:13792537, RGD:13792537 NCBI chr 3:137,618,891...137,923,385
Ensembl chr 3:137,618,898...137,925,605
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635, PMID:21873635 RGD:13792537, RGD:13792537 NCBI chr 7:12,247,498...12,255,721
Ensembl chr 7:12,247,498...12,255,719
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO
IBA
(PMID:8901832)
PMID:21873635
(MGI:3795695|PMID:18519639), (MGI:3807770|PMID:9242664), (MGI:74959|PMID:8468318)
RGD PMID:8468318 PMID:8901832 PMID:9242664 PMID:18519639, PMID:21873635, PMID:21873635 MGI:3795695 MGI:3807770 MGI:74959, RGD:13792537, RGD:13792537 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 involved_in IEP
ISO
IBA
(PMID:9242664)
PMID:21873635
RGD PMID:9242664, PMID:8070361, PMID:21873635, PMID:21873635 RGD:729476, RGD:13792537, RGD:13792537 NCBI chr 1:126,749,508...126,947,392
Ensembl chr 1:126,749,508...126,947,392
JBrowse link
G Scg5 secretogranin V involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:1332331|PMID:10089884)
Ensembl
UniProt
RGD
PMID:10089884 GO_REF:0000024 GO_REF:0000107 MGI:1332331 NCBI chr 3:105,235,065...105,279,475
Ensembl chr 3:105,235,050...105,279,462
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20078
    cellular process 18896
      signaling receptor ligand precursor processing 20
        cytokine precursor processing 3
        neuropeptide processing 1
        peptide hormone processing + 17
Path 2
Term Annotations click to browse term
  biological_process 20078
    metabolic process 12140
      organic substance metabolic process 11646
        organonitrogen compound metabolic process 7022
          protein metabolic process 6081
            proteolysis 1897
              protein processing 248
                signaling receptor ligand precursor processing 20
                  cytokine precursor processing 3
                  neuropeptide processing 1
                  peptide hormone processing + 17
paths to the root