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ONTOLOGY REPORT - ANNOTATIONS

Term:signaling receptor ligand precursor processing
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Accession:GO:0140448 term browser browse the term
Definition:The cleavage of a peptide bond in a precursor form of a signaling receptor ligand, resulting in the mature (active) form of the ligand.
Synonyms:narrow_synonym: ligand maturation
 related_synonym: signal maturation
 alt_id: GO:0035638


show annotations for term's descendants           Sort by:
signaling receptor ligand precursor processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 involved_in ISO (PMID:14993236), (PMID:31838721) RGD PMID:14993236 PMID:31838721 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in ISO MGI:1857753|MGI:4354847 (PMID:14993236), (PMID:17169360), (PMID:28751722) RGD PMID:14993236 PMID:17169360 PMID:28751722 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Bace1 beta-secretase 1 involved_in ISO MGI:2389228 (PMID:17099708) RGD PMID:17099708 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bace2 beta-secretase 2 involved_in ISO MGI:109548 (PMID:31838721) RGD PMID:31838721 NCBI chr11:36,707,447...36,789,550
Ensembl chr11:36,707,458...36,789,546 		JBrowse link
G Casp1 caspase 1 involved_in ISO UniProtKB:P10749|UniProtKB:Q9NPP4 (PMID:15882992) RGD PMID:15882992 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cstl1 cystatin-like 1 involved_in ISO
IBA		 (PMID:12869695)
GO_REF:0000033		 RGD
GO_Central		 PMID:12869695 GO_REF:0000033 NCBI chr 3:136,199,914...136,204,912
Ensembl chr 3:136,199,914...136,204,912 		JBrowse link
G Mep1a meprin A subunit alpha involved_in ISO (PMID:22923609) RGD PMID:22923609 NCBI chr 9:17,474,634...17,504,147
Ensembl chr 9:17,474,619...17,504,147 		JBrowse link
angiotensin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:11303049), (PMID:14757757), (PMID:18158355), (PMID:27649628)
(PMID:11432860), (PMID:1320019), (PMID:4322742), (PMID:6270633)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:1320019 PMID:4322742 PMID:6270633 PMID:11303049 PMID:11432860 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 involved_in ISO UniProtKB:Q9BYF1 (PMID:18263657), (PMID:20357030), (PMID:23462816) RGD PMID:18263657 PMID:20357030 PMID:23462816 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Anpep alanyl aminopeptidase, membrane involved_in ISO (PMID:8876246) RGD PMID:8876246 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789 		JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
IEA		 (PMID:12045255), (PMID:15746149)
GO_REF:0000107		 RGD
Ensembl		 PMID:12045255 PMID:15746149 GO_REF:0000107 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Cpa3 carboxypeptidase A3 involved_in ISO (PMID:15173164) RGD PMID:15173164 NCBI chr 2:102,712,483...102,744,219
Ensembl chr 2:102,712,589...102,744,203 		JBrowse link
G Enpep glutamyl aminopeptidase involved_in ISO MGI:2182774 (PMID:16889841), (PMID:19228697) RGD PMID:16889841 PMID:19228697 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947 		JBrowse link
G Mme membrane metallo-endopeptidase involved_in ISO MGI:1917258|MGI:2137696 (PMID:27649628), (PMID:28559246) RGD PMID:27649628 PMID:28559246 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Prcp prolylcarboxypeptidase involved_in ISO (PMID:27649628) RGD PMID:27649628 NCBI chr 1:146,931,487...146,983,891
Ensembl chr 1:146,930,561...146,984,530 		JBrowse link
G Prep prolyl endopeptidase involved_in ISO (PMID:27649628) RGD PMID:27649628 NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466 		JBrowse link
G Ren renin involved_in
acts_upstream_of_or_within		 IDA
ISO
IBA		 (PMID:27649628), (PMID:6337154)
MGI:2136642 (PMID:10617578)
GO_REF:0000033
(PMID:12045255)		 RGD
GO_Central		 PMID:6337154 PMID:10617578 PMID:12045255 PMID:27649628 PMID:21321306 GO_REF:0000033, RGD:5132599 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
cytokine precursor processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 involved_in ISO UniProtKB:P10749|UniProtKB:Q9NPP4 (PMID:15882992) RGD PMID:15882992 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Cma1 chymase 1 involved_in ISO (PMID:1919436) RGD PMID:1919436 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
ISS
IEA		 (PMID:7737999)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:7737999 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18519639)		 Ensembl
RGD		 PMID:18519639 GO_REF:0000107 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
endothelin maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ece1 endothelin converting enzyme 1 involved_in ISO
IEA		 (PMID:7805846)
GO_REF:0000107		 RGD
Ensembl		 PMID:7805846 GO_REF:0000107 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
enkephalin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E IDA RGD PMID:6326144 RGD:6483103 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Ctsl cathepsin L involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO (PMID:8262946) RGD PMID:8262946 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127 		JBrowse link
epidermal growth factor receptor ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 involved_in IEA
ISO		 GO_REF:0000107
(PMID:14993236), (PMID:17079736)		 Ensembl
RGD		 PMID:14993236 PMID:17079736 GO_REF:0000107 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Mep1a meprin A subunit alpha involved_in ISO (PMID:22923609) RGD PMID:22923609 NCBI chr 9:17,474,634...17,504,147
Ensembl chr 9:17,474,619...17,504,147 		JBrowse link
insulin processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cpe carboxypeptidase E involved_in
acts_upstream_of_or_within		 IDA
IMP
ISO
IEA		 MGI:1856395 (PMID:9348219)
MGI:1856395 (PMID:7663508)
GO_REF:0000107		 RGD
Ensembl		 PMID:7663508 PMID:9348219 PMID:2822027 PMID:12829804 GO_REF:0000107, RGD:1626225, RGD:405650689 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Ero1b endoplasmic reticulum oxidoreductase 1 beta acts_upstream_of_or_within
involved_in		 ISO MGI:3864866 (PMID:20308425) RGD PMID:20308425 NCBI chr17:85,861,086...86,003,244
Ensembl chr17:85,929,618...86,003,398 		JBrowse link
G Ins2 insulin 2 involved_in IEA
ISO		 GO_REF:0000107
MGI:2442682 (PMID:20424817)		 Ensembl
RGD		 PMID:20424817 GO_REF:0000107 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta involved_in ISO MGI:5504624 (PMID:31184304) RGD PMID:31184304 NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in ISO MGI:2384741 (PMID:12136131) RGD PMID:12136131 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in ISO (PMID:7626024)
MGI:1857445 (PMID:9452465)		 RGD PMID:7626024 PMID:9452465 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127 		JBrowse link
G Slc30a8 solute carrier family 30 member 8 involved_in ISO MGI:4362061 (PMID:19542200), (PMID:19706465) RGD PMID:19542200 PMID:19706465 NCBI chr 7:83,591,993...83,627,786
Ensembl chr 7:83,591,993...83,626,305 		JBrowse link
G Yipf5 Yip1 domain family, member 5 involved_in ISO
ISS		 (PMID:33164986)
GO_REF:0000024		 RGD
UniProt		 PMID:33164986 GO_REF:0000024 NCBI chr18:32,123,814...32,136,947
Ensembl chr18:32,123,842...32,157,642 		JBrowse link
islet amyloid polypeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in IMP PMID:15983213 BHF-UCL PMID:15983213 RGD:8554260 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127 		JBrowse link
neuropeptide processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mme membrane metallo-endopeptidase involved_in ISO
IEA		 UniProtKB:P05067 (PMID:24825898)
GO_REF:0000107		 RGD
Ensembl		 PMID:24825898 GO_REF:0000107 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
patched ligand maturation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Disp1 dispatched RND transporter family member 1 acts_upstream_of_or_within ISO MGI:2429759 (PMID:12421714) RGD PMID:12421714 NCBI chr13:94,720,928...94,866,695
Ensembl chr13:94,720,928...94,866,702 		JBrowse link
peptide hormone processing term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase involved_in ISO
IEA
ISS		 (PMID:10880574)
(PMID:11884416), (PMID:15637153), (PMID:22437503)
GO_REF:0000002
(PMID:21518754)
GO_REF:0000024
GO_REF:0000107		 RGD
InterPro
UniProt
Ensembl		 PMID:10880574 PMID:11884416 PMID:15637153 PMID:21518754 PMID:22437503 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503 		JBrowse link
G Cpe carboxypeptidase E TAS RGD PMID:2784437 RGD:727682 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Ece1 endothelin converting enzyme 1 involved_in ISO
IBA		 (PMID:7864876)
GO_REF:0000033		 RGD
GO_Central		 PMID:7864876 GO_REF:0000033 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Ece2 endothelin-converting enzyme 2 involved_in TAS
ISO		 (PMID:11718899) RGD PMID:11718899 PMID:15060002 RGD:1303943 NCBI chr11:80,259,130...80,278,446
Ensembl chr11:80,263,162...80,278,428 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) involved_in ISO
IBA
IEA		 (PMID:9242664)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:9242664 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 involved_in IMP
ISO
IBA
IDA		 (PMID:8262946), (PMID:9242664)
GO_REF:0000033
pituitary adenylate cyclase-activating polypetide		 RGD
GO_Central		 PMID:8262946 PMID:9242664 PMID:16497799 PMID:10087454 GO_REF:0000033, RGD:1601276, RGD:2308913 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10632593)		 Ensembl
RGD		 PMID:10632593 GO_REF:0000107 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566 		JBrowse link
G Pcsk2 proprotein convertase subtilisin/kexin type 2 involved_in
acts_upstream_of_or_within		 IMP
ISO
IBA
ISS		 (PMID:9242664)
MGI:1857445 (PMID:12859669)
GO_REF:0000033
GO_REF:0000024
(PMID:28719828)		 RGD
GO_Central
UniProt		 PMID:9242664 PMID:12859669 PMID:28719828 PMID:16497799 GO_REF:0000024 GO_REF:0000033, RGD:1601276 NCBI chr 3:130,880,422...131,183,127
Ensembl chr 3:130,880,422...131,183,127 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 involved_in ISO
IBA
IEA		 (PMID:8901832)
(PMID:18519639), (PMID:8468318), (PMID:9242664)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:8468318 PMID:8901832 PMID:9242664 PMID:18519639 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 involved_in IEP
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:9242664)		 GO_Central
Ensembl
RGD		 PMID:9242664 PMID:8070361 GO_REF:0000033 GO_REF:0000107, RGD:729476 NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596 		JBrowse link
G Scg5 secretogranin V involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:10089884)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:10089884 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        macromolecule metabolic process 9812
          protein metabolic process 5297
            protein maturation 643
              protein processing 269
                signaling receptor ligand precursor processing 37
                  cytokine precursor processing 4
                  neuropeptide processing 1
                  peptide hormone processing + 31
Path 2
Term Annotations click to browse term
  biological_process 20076
    cellular process 19155
      metabolic process 11953
        biosynthetic process 8474
          macromolecule biosynthetic process 7498
            gene expression 7054
              protein maturation 643
                protein processing 269
                  signaling receptor ligand precursor processing 37
                    cytokine precursor processing 4
                    neuropeptide processing 1
                    peptide hormone processing + 31
paths to the root