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ONTOLOGY REPORT - ANNOTATIONS


Term:ATPase-coupled intramembrane lipid transporter activity
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Accession:GO:0140326 term browser browse the term
Definition:Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.
Synonyms:narrow_synonym: phospholipid flippase activity
 related_synonym: ATPase-coupled phospholipid transporter activity;   ATPase-dependent phospholipid transporter activity;   aminophospholipid-transporting ATPase;   phospholipid translocating ATPase activity;   phospholipid-transporting ATPase activity
 alt_id: GO:0004012;   GO:0008557
 xref: EC:7.6.2.1;   MetaCyc:3.6.3.1-RXN;   Reactome:R-HSA-939763 "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane";   Reactome:R-HSA-947591 "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane"



show annotations for term's descendants           Sort by:
ATPase-coupled intramembrane lipid transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca4 ATP binding cassette subfamily A member 4 enables ISO MGI:1857860 (PMID:10412977) RGD PMID:10412977 NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
JBrowse link
G Atp10a ATPase phospholipid transporting 10A (putative) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:109,556,760...109,730,440
Ensembl chr 1:109,556,782...109,730,437
JBrowse link
G Atp10b ATPase phospholipid transporting 10B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
JBrowse link
G Atp10d ATPase phospholipid transporting 10D (putative) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
JBrowse link
G Atp11a ATPase phospholipid transporting 11A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232
JBrowse link
G Atp11c ATPase phospholipid transporting 11C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:138,564,459...138,752,116
Ensembl chr  X:138,565,836...138,751,204
JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611
JBrowse link
G Atp8a2 ATPase phospholipid transporting 8A2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Atp8b2 ATPase phospholipid transporting 8B2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883
JBrowse link
G Atp8b3 ATPase phospholipid transporting 8B3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,175,544...9,195,449
Ensembl chr 7:9,175,391...9,195,442
JBrowse link
G Atp8b4 ATPase phospholipid transporting 8B4 (putative) enables IEA GO_REF:0000002
GO_REF:0000003
InterPro
UniProt
GO_REF:0000002 GO_REF:0000003 NCBI chr 3:113,554,979...113,757,635
Ensembl chr 3:113,556,192...113,757,225
JBrowse link
G Atp8b5 ATPase, class I, type 8B, member 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056
JBrowse link
G Atp9a ATPase phospholipid transporting 9A (putative) enables IEA
IBA
GO_REF:0000002
GO_REF:0000033
InterPro
GO_Central
GO_REF:0000002 GO_REF:0000033 NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818
JBrowse link
G Atp9b ATPase phospholipid transporting 9B (putative) enables IEA
IBA
GO_REF:0000003
GO_REF:0000033
GO_REF:0000002
UniProt
GO_Central
InterPro
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953
JBrowse link
aminophospholipid flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp8a2 ATPase phospholipid transporting 8A2 enables ISO (PMID:22912588) RGD PMID:22912588 NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 enables IEA
ISO
GO_REF:0000107
(PMID:20510206)
Ensembl
RGD
PMID:20510206 GO_REF:0000107 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Tmem30a transmembrane protein 30A enables ISO
IEA
(PMID:20510206)
GO_REF:0000107
RGD
Ensembl
PMID:20510206 GO_REF:0000107 NCBI chr 8:80,728,749...80,757,197
Ensembl chr 8:80,729,619...80,753,248
JBrowse link
G Tmem30b transmembrane protein 30B enables ISO (PMID:20510206) RGD PMID:20510206 NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:92,249,790...92,254,842
JBrowse link
ceramide floppase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 enables ISO
IEA
(PMID:24201375)
GO_REF:0000107
RGD
Ensembl
PMID:24201375 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A enables ISO (PMID:8898203) RGD PMID:8898203 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 NOT|enables ISO (PMID:8898203) RGD PMID:8898203 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca4 ATP binding cassette subfamily A member 4 enables ISO (PMID:24097981) RGD PMID:24097981 NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
JBrowse link
floppase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 enables ISO (PMID:16702602), (PMID:24097981) RGD PMID:16702602 PMID:24097981 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 enables ISO (PMID:24097981) RGD PMID:24097981 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A enables ISO (PMID:8898203) RGD PMID:8898203 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 enables ISO (PMID:16702602), (PMID:24576892) RGD PMID:16702602 PMID:24576892 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
glycosylceramide flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp10a ATPase phospholipid transporting 10A (putative) enables ISO (PMID:30530492) RGD PMID:30530492 NCBI chr 1:109,556,760...109,730,440
Ensembl chr 1:109,556,782...109,730,437
JBrowse link
G Atp10b ATPase phospholipid transporting 10B enables ISO (PMID:32172343) RGD PMID:32172343 NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
JBrowse link
G Atp10d ATPase phospholipid transporting 10D (putative) enables ISO (PMID:30530492) RGD PMID:30530492 NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
JBrowse link
lysophosphatidylcholine flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid enables ISO (PMID:26945070) RGD PMID:26945070 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
JBrowse link
N-retinylidene-phosphatidylethanolamine flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca4 ATP binding cassette subfamily A member 4 enables ISO MGI:1857860 (PMID:10412977), (PMID:10852960), (PMID:22735453) RGD PMID:10412977 PMID:10852960 PMID:22735453 NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
JBrowse link
phosphatidylcholine flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP binding cassette subfamily A member 3 enables ISO
ISS
(PMID:27177387), (PMID:31473345)
GO_REF:0000024
RGD
UniProt
PMID:27177387 PMID:31473345 GO_REF:0000024 NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
JBrowse link
G Atp10a ATPase phospholipid transporting 10A (putative) enables ISO (PMID:25947375), (PMID:29599178), (PMID:30530492) RGD PMID:25947375 PMID:29599178 PMID:30530492 NCBI chr 1:109,556,760...109,730,440
Ensembl chr 1:109,556,782...109,730,437
JBrowse link
G Atp10b ATPase phospholipid transporting 10B enables ISO (PMID:32172343) RGD PMID:32172343 NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 enables ISO
IEA
(PMID:25315773), (PMID:25947375)
GO_REF:0000107
RGD
Ensembl
PMID:25315773 PMID:25947375 GO_REF:0000107 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Atp8b2 ATPase phospholipid transporting 8B2 enables ISO (PMID:25315773) RGD PMID:25315773 NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883
JBrowse link
G Atp8b5 ATPase, class I, type 8B, member 5 enables ISO (PMID:19657017) RGD PMID:19657017 NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056
JBrowse link
phosphatidylcholine floppase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 enables ISO
IBA
(PMID:16702602), (PMID:24097981), (PMID:35974019)
GO_REF:0000033
RGD
GO_Central
PMID:16702602 PMID:24097981 PMID:35974019 GO_REF:0000033 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 enables ISO
IBA
IEA
(PMID:24097981)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:24097981 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A enables ISO (PMID:8898203) RGD PMID:8898203 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 enables ISS
IBA
IEA
ISO
GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:17523162), (PMID:24045840), (PMID:24806754), (PMID:31873305), (PMID:8898203)
UniProt
GO_Central
Ensembl
RGD
PMID:8898203 PMID:17523162 PMID:24045840 PMID:24806754 PMID:31873305 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 enables ISO (PMID:16702602) RGD PMID:16702602 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
phosphatidylethanolamine flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca4 ATP binding cassette subfamily A member 4 enables ISO (PMID:24097981) RGD PMID:24097981 NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A enables ISO (PMID:8898203) RGD PMID:8898203 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Atp11a ATPase phospholipid transporting 11A enables ISO (PMID:25315773), (PMID:25947375), (PMID:26567335), (PMID:36300302) RGD PMID:25315773 PMID:25947375 PMID:26567335 PMID:36300302 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
JBrowse link
G Atp11c ATPase phospholipid transporting 11C enables ISO (PMID:24904167), (PMID:25315773), (PMID:32493773) RGD PMID:24904167 PMID:25315773 PMID:32493773 NCBI chr  X:138,564,459...138,752,116
Ensembl chr  X:138,565,836...138,751,204
JBrowse link
G Atp8b5 ATPase, class I, type 8B, member 5 enables ISO (PMID:19657017) RGD PMID:19657017 NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056
JBrowse link
phosphatidylserine flippase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11a ATPase phospholipid transporting 11A enables ISO (PMID:25315773), (PMID:25947375), (PMID:26567335) RGD PMID:25315773 PMID:25947375 PMID:26567335 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
JBrowse link
G Atp11c ATPase phospholipid transporting 11C enables ISO (PMID:24904167), (PMID:25315773), (PMID:32493773) RGD PMID:24904167 PMID:25315773 PMID:32493773 NCBI chr  X:138,564,459...138,752,116
Ensembl chr  X:138,565,836...138,751,204
JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 enables ISO (PMID:31416931)
(PMID:20224745)
RGD PMID:20224745 PMID:31416931 NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 enables IMP PMID:19027009 UniProt PMID:19027009 RGD:39458026 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
phosphatidylserine floppase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 enables ISO
IBA
(PMID:24097981)
GO_REF:0000033
RGD
GO_Central
PMID:24097981 GO_REF:0000033 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 enables IEA
IBA
ISO
GO_REF:0000107
GO_REF:0000033
(PMID:24097981)
Ensembl
GO_Central
RGD
PMID:24097981 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
sphingolipid floppase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 enables ISO (PMID:24097981) RGD PMID:24097981 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20623
    ATP-dependent activity 629
      ATPase-coupled intramembrane lipid transporter activity 27
        flippase activity + 16
        floppase activity + 8
Path 2
Term Annotations click to browse term
  molecular_function 20623
    transporter activity 1252
      lipid transporter activity 173
        intramembrane lipid transporter activity 51
          ATPase-coupled intramembrane lipid transporter activity 27
            flippase activity + 16
            floppase activity + 8
paths to the root