ONTOLOGY REPORT - ANNOTATIONS
Term: ATPase-coupled intramembrane lipid transporter activity
Accession: GO:0140326
browse the term
Definition: Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases.
Synonyms: narrow_synonym: phospholipid flippase activity
related_synonym: ATPase-coupled phospholipid transporter activity; ATPase-dependent phospholipid transporter activity; aminophospholipid-transporting ATPase; phospholipid translocating ATPase activity; phospholipid-transporting ATPase activity
alt_id: GO:0004012; GO:0008557
xref: EC:7.6.2.1; MetaCyc:3.6.3.1-RXN; Reactome:R-HSA-939763 "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane"; Reactome:R-HSA-947591 "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane"
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Abca4
ATP binding cassette subfamily A member 4
enables
ISO
MGI:1857860 (PMID:10412977)
RGD
PMID:10412977
NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
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Atp10a
ATPase phospholipid transporting 10A (putative)
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:109,556,760...109,730,440
Ensembl chr 1:109,556,782...109,730,437
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Atp10b
ATPase phospholipid transporting 10B
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
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Atp10d
ATPase phospholipid transporting 10D (putative)
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
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Atp11a
ATPase phospholipid transporting 11A
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
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Atp11b
ATPase phospholipid transporting 11B (putative)
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232
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Atp11c
ATPase phospholipid transporting 11C
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204
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Atp8a1
ATPase phospholipid transporting 8A1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611
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Atp8a2
ATPase phospholipid transporting 8A2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223
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Atp8b1
ATPase phospholipid transporting 8B1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Atp8b2
ATPase phospholipid transporting 8B2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883
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Atp8b3
ATPase phospholipid transporting 8B3
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:9,175,544...9,195,449
Ensembl chr 7:9,175,391...9,195,442
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Atp8b4
ATPase phospholipid transporting 8B4 (putative)
enables
IEA
GO_REF:0000002 GO_REF:0000003
InterPro UniProt
GO_REF:0000002 GO_REF:0000003
NCBI chr 3:113,554,979...113,757,635
Ensembl chr 3:113,556,192...113,757,225
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Atp8b5
ATPase, class I, type 8B, member 5
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056
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Atp9a
ATPase phospholipid transporting 9A (putative)
enables
IEA IBA
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818
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Atp9b
ATPase phospholipid transporting 9B (putative)
enables
IEA IBA
GO_REF:0000003 GO_REF:0000033 GO_REF:0000002
UniProt GO_Central InterPro
GO_REF:0000002 GO_REF:0000003 GO_REF:0000033
NCBI chr18:74,176,863...74,368,993
Ensembl chr18:74,176,863...74,368,953
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Atp8a2
ATPase phospholipid transporting 8A2
enables
ISO
(PMID:22912588)
RGD
PMID:22912588
NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223
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Atp8b1
ATPase phospholipid transporting 8B1
enables
IEA ISO
GO_REF:0000107 (PMID:20510206)
Ensembl RGD
PMID:20510206
GO_REF:0000107
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Tmem30a
transmembrane protein 30A
enables
ISO IEA
(PMID:20510206) GO_REF:0000107
RGD Ensembl
PMID:20510206
GO_REF:0000107
NCBI chr 8:80,728,749...80,757,197
Ensembl chr 8:80,729,619...80,753,248
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Tmem30b
transmembrane protein 30B
enables
ISO
(PMID:20510206)
RGD
PMID:20510206
NCBI chr 6:92,251,626...92,254,702
Ensembl chr 6:92,249,790...92,254,842
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Abca2
ATP binding cassette subfamily A member 2
enables
ISO IEA
(PMID:24201375) GO_REF:0000107
RGD Ensembl
PMID:24201375
GO_REF:0000107
NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
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Abcb1a
ATP binding cassette subfamily B member 1A
enables
ISO
(PMID:8898203)
RGD
PMID:8898203
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb4
ATP binding cassette subfamily B member 4
NOT|enables
ISO
(PMID:8898203)
RGD
PMID:8898203
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abca4
ATP binding cassette subfamily A member 4
enables
ISO
(PMID:24097981)
RGD
PMID:24097981
NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
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Abca1
ATP binding cassette subfamily A member 1
enables
ISO
(PMID:16702602), (PMID:24097981)
RGD
PMID:16702602 PMID:24097981
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abca7
ATP binding cassette subfamily A member 7
enables
ISO
(PMID:24097981)
RGD
PMID:24097981
NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
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Abcb1a
ATP binding cassette subfamily B member 1A
enables
ISO
(PMID:8898203)
RGD
PMID:8898203
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
enables
ISS
GO_REF:0000024
UniProt
GO_REF:0000024
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcg1
ATP binding cassette subfamily G member 1
enables
ISO
(PMID:16702602), (PMID:24576892)
RGD
PMID:16702602 PMID:24576892
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Atp10a
ATPase phospholipid transporting 10A (putative)
enables
ISO
(PMID:30530492)
RGD
PMID:30530492
NCBI chr 1:109,556,760...109,730,440
Ensembl chr 1:109,556,782...109,730,437
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Atp10b
ATPase phospholipid transporting 10B
enables
ISO
(PMID:32172343)
RGD
PMID:32172343
NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
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Atp10d
ATPase phospholipid transporting 10D (putative)
enables
ISO
(PMID:30530492)
RGD
PMID:30530492
NCBI chr14:35,911,728...36,012,549
Ensembl chr14:35,912,141...36,012,564
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Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
enables
ISO
(PMID:26945070)
RGD
PMID:26945070
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
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Abca4
ATP binding cassette subfamily A member 4
enables
ISO
MGI:1857860 (PMID:10412977), (PMID:10852960), (PMID:22735453)
RGD
PMID:10412977 PMID:10852960 PMID:22735453
NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
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Abca3
ATP binding cassette subfamily A member 3
enables
ISO ISS
(PMID:27177387), (PMID:31473345) GO_REF:0000024
RGD UniProt
PMID:27177387 PMID:31473345
GO_REF:0000024
NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
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Atp10a
ATPase phospholipid transporting 10A (putative)
enables
ISO
(PMID:25947375), (PMID:29599178), (PMID:30530492)
RGD
PMID:25947375 PMID:29599178 PMID:30530492
NCBI chr 1:109,556,760...109,730,440
Ensembl chr 1:109,556,782...109,730,437
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Atp10b
ATPase phospholipid transporting 10B
enables
ISO
(PMID:32172343)
RGD
PMID:32172343
NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637
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Atp8b1
ATPase phospholipid transporting 8B1
enables
ISO IEA
(PMID:25315773), (PMID:25947375) GO_REF:0000107
RGD Ensembl
PMID:25315773 PMID:25947375
GO_REF:0000107
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Atp8b2
ATPase phospholipid transporting 8B2
enables
ISO
(PMID:25315773)
RGD
PMID:25315773
NCBI chr 2:175,378,514...175,402,265
Ensembl chr 2:175,378,517...175,401,883
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Atp8b5
ATPase, class I, type 8B, member 5
enables
ISO
(PMID:19657017)
RGD
PMID:19657017
NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056
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Abca1
ATP binding cassette subfamily A member 1
enables
ISO IBA
(PMID:16702602), (PMID:24097981), (PMID:35974019) GO_REF:0000033
RGD GO_Central
PMID:16702602 PMID:24097981 PMID:35974019
GO_REF:0000033
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abca7
ATP binding cassette subfamily A member 7
enables
ISO IBA IEA
(PMID:24097981) GO_REF:0000033 GO_REF:0000107
RGD GO_Central Ensembl
PMID:24097981
GO_REF:0000033 GO_REF:0000107
NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
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Abcb1a
ATP binding cassette subfamily B member 1A
enables
ISO
(PMID:8898203)
RGD
PMID:8898203
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcb4
ATP binding cassette subfamily B member 4
enables
ISS IBA IEA ISO
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 (PMID:17523162), (PMID:24045840), (PMID:24806754), (PMID:31873305), (PMID:8898203)
UniProt GO_Central Ensembl RGD
PMID:8898203 PMID:17523162 PMID:24045840 PMID:24806754 PMID:31873305
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcg1
ATP binding cassette subfamily G member 1
enables
ISO
(PMID:16702602)
RGD
PMID:16702602
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Atp8b1
ATPase phospholipid transporting 8B1
enables
IEA
GO_REF:0000116
RHEA
GO_REF:0000116
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Abca4
ATP binding cassette subfamily A member 4
enables
ISO
(PMID:24097981)
RGD
PMID:24097981
NCBI chr 2:210,164,813...210,302,069
Ensembl chr 2:210,164,813...210,302,069
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Abcb1a
ATP binding cassette subfamily B member 1A
enables
ISO
(PMID:8898203)
RGD
PMID:8898203
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Atp11a
ATPase phospholipid transporting 11A
enables
ISO
(PMID:25315773), (PMID:25947375), (PMID:26567335), (PMID:36300302)
RGD
PMID:25315773 PMID:25947375 PMID:26567335 PMID:36300302
NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
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Atp11c
ATPase phospholipid transporting 11C
enables
ISO
(PMID:24904167), (PMID:25315773), (PMID:32493773)
RGD
PMID:24904167 PMID:25315773 PMID:32493773
NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204
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Atp8b5
ATPase, class I, type 8B, member 5
enables
ISO
(PMID:19657017)
RGD
PMID:19657017
NCBI chr 5:57,505,897...57,620,065
Ensembl chr 5:57,506,466...57,620,056
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Atp11a
ATPase phospholipid transporting 11A
enables
ISO
(PMID:25315773), (PMID:25947375), (PMID:26567335)
RGD
PMID:25315773 PMID:25947375 PMID:26567335
NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
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Atp11c
ATPase phospholipid transporting 11C
enables
ISO
(PMID:24904167), (PMID:25315773), (PMID:32493773)
RGD
PMID:24904167 PMID:25315773 PMID:32493773
NCBI chr X:138,564,459...138,752,116
Ensembl chr X:138,565,836...138,751,204
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Atp8a1
ATPase phospholipid transporting 8A1
enables
ISO
(PMID:31416931) (PMID:20224745)
RGD
PMID:20224745 PMID:31416931
NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611
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Atp8b1
ATPase phospholipid transporting 8B1
enables
IMP
PMID:19027009
UniProt
PMID:19027009
RGD:39458026
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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Abca1
ATP binding cassette subfamily A member 1
enables
ISO IBA
(PMID:24097981) GO_REF:0000033
RGD GO_Central
PMID:24097981
GO_REF:0000033
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abca7
ATP binding cassette subfamily A member 7
enables
IEA IBA ISO
GO_REF:0000107 GO_REF:0000033 (PMID:24097981)
Ensembl GO_Central RGD
PMID:24097981
GO_REF:0000033 GO_REF:0000107
NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
G
Atp8b1
ATPase phospholipid transporting 8B1
enables
IEA
GO_REF:0000116
RHEA
GO_REF:0000116
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
G
Abca1
ATP binding cassette subfamily A member 1
enables
ISO
(PMID:24097981)
RGD
PMID:24097981
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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