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ONTOLOGY REPORT - ANNOTATIONS

Term:molecular sensor activity
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Accession:GO:0140299 term browser browse the term
Definition:Binding to a molecule and eliciting a change in the protein's activity in response to the intracellular level of that molecule.
Synonyms:exact_synonym: small molecular sensor activity;   small molecule sensing activity
 narrow_synonym: small molecule sensor activity


show annotations for term's descendants           Sort by:
molecular sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 enables ISO (PMID:26972053) RGD PMID:26972053 NCBI chr14:79,086,136...79,090,549
Ensembl chr14:79,086,136...79,090,548 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 enables ISS
ISO		 GO_REF:0000024
(PMID:18403674)
(MGI:7388221|PMID:18403674)
(PMID:16407889), (PMID:18403674), (PMID:18604214)		 UniProt
RGD		 PMID:16407889 PMID:18403674 PMID:18604214 GO_REF:0000024 MGI:7388221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
amino acid sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sar1a secretion associated, Ras related GTPase 1A enables ISO (PMID:34290409) RGD PMID:34290409 NCBI chr20:29,623,529...29,635,935
Ensembl chr20:29,623,553...29,635,935 		JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B enables ISO (PMID:34290409) RGD PMID:34290409 NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066 		JBrowse link
ATP-dependent DNA damage sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmc1 DNA meiotic recombinase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:111,124,888...111,167,465
Ensembl chr 7:111,124,888...111,167,952 		JBrowse link
G Mlh1 mutL homolog 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617 		JBrowse link
G Mlh3 mutL homolog 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:104,881,483...104,917,686
Ensembl chr 6:104,881,483...104,917,728 		JBrowse link
G Msh2 mutS homolog 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh4 mutS homolog 4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:242,785,392...242,844,609
Ensembl chr 2:242,792,661...242,843,487 		JBrowse link
G Msh5 mutS homolog 5 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336 		JBrowse link
G Msh6 mutS homolog 6 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:48,229,403...48,340,237
Ensembl chr 9:48,253,410...48,340,237 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066 		JBrowse link
G Rad51 RAD51 recombinase enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rad51b RAD51 paralog B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:98,096,525...98,640,988
Ensembl chr 6:98,098,868...98,640,979 		JBrowse link
G Rad51c RAD51 paralog C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248 		JBrowse link
G Rad51d RAD51 paralog D enables ISO (PMID:16717288) RGD PMID:16717288 NCBI chr10:67,805,720...67,824,452
Ensembl chr10:67,740,712...67,824,434 		JBrowse link
G Xrcc2 X-ray repair cross complementing 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:9,423,873...9,502,980
Ensembl chr 4:9,423,898...9,442,482 		JBrowse link
G Xrcc3 X-ray repair cross complementing 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:130,863,405...130,873,765
Ensembl chr 6:130,863,959...130,872,444 		JBrowse link
calcium ion sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efcab9 EF-hand calcium binding domain 9 enables ISO
IBA		 (MGI:6316499|PMID:31056283)
(PMID:31056283)
GO_REF:0000033		 RGD
GO_Central		 PMID:31056283 GO_REF:0000033 MGI:6316499 NCBI chr10:17,107,123...17,112,282
Ensembl chr10:17,107,123...17,112,289 		JBrowse link
G Efhb EF hand domain family, member B enables ISO (PMID:30481768) RGD PMID:30481768 NCBI chr 9:6,372,191...6,441,678
Ensembl chr 9:6,372,194...6,441,919 		JBrowse link
G Efhd1 EF-hand domain family, member D1 enables ISO
IBA		 (PMID:26975899)
GO_REF:0000033		 RGD
GO_Central		 PMID:26975899 GO_REF:0000033 NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917 		JBrowse link
G Micu1 mitochondrial calcium uptake 1 enables ISO
IEA
ISS		 (PMID:27642082), (PMID:28615291), (PMID:32148862), (PMID:32494073), (PMID:32667285), (PMID:32762847), (PMID:32790952)
(PMID:27818145)
(PMID:24560927)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:24560927 PMID:27642082 PMID:27818145 PMID:28615291 PMID:32148862 More... GO_REF:0000024 GO_REF:0000107 NCBI chr20:27,668,681...27,816,322
Ensembl chr20:27,668,747...27,814,964 		JBrowse link
G Micu2 mitochondrial calcium uptake 2 enables ISO
IEA
ISS		 (PMID:28615291), (PMID:30699349), (PMID:31397067), (PMID:32148862), (PMID:32494073), (PMID:32667285), (PMID:32762847), (PMID:32790952)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28615291 PMID:30699349 PMID:31397067 PMID:32148862 PMID:32494073 More... GO_REF:0000024 GO_REF:0000107 NCBI chr15:32,064,872...32,146,874
Ensembl chr15:32,064,875...32,147,094 		JBrowse link
G Micu3 mitochondrial calcium uptake family, member 3 enables ISO
IDA		 (PMID:29725115), (PMID:30699349)
PMID:31862210		 RGD PMID:29725115 PMID:30699349 PMID:31862210 RGD:405650270 NCBI chr16:51,919,859...52,010,705
Ensembl chr16:51,925,225...52,010,613 		JBrowse link
G Syt1 synaptotagmin 1 enables ISO
EXP		 (PMID:21521611)
PMID:24001110		 RGD PMID:21521611 PMID:24001110 RGD:407429997 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803 		JBrowse link
DNA damage sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad23b RAD23 homolog B, nucleotide excision repair protein enables ISO (PMID:19941824) RGD PMID:19941824 NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319 		JBrowse link
G Sirt6 sirtuin 6 enables ISO (PMID:31995034), (PMID:32538779) RGD PMID:31995034 PMID:32538779 NCBI chr 7:8,082,312...8,087,776
Ensembl chr 7:8,082,364...8,098,914 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor enables ISO (PMID:10873465), (PMID:19941824) RGD PMID:10873465 PMID:19941824 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
glucose sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gck glucokinase enables IDA PMID:17470517 BHF-UCL PMID:17470517 RGD:8554539 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Gckr glucokinase regulator enables IDA
ISO		 PMID:19807849
PMID:14627435
(PMID:14627435)		 RGD PMID:14627435 PMID:19807849 PMID:14627435 RGD:8554135, RGD:1598592 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654 		JBrowse link
membrane curvature sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arfip2 ADP-ribosylation factor interacting protein 2 enables ISO (PMID:29768204) RGD PMID:29768204 NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336 		JBrowse link
G Ica1 islet cell autoantigen 1 enables ISO
IEA		 (PMID:29768204)
GO_REF:0000107		 RGD
Ensembl		 PMID:29768204 GO_REF:0000107 NCBI chr 4:36,656,475...36,804,705
Ensembl chr 4:36,656,475...36,804,298 		JBrowse link
G Pick1 protein interacting with PRKCA 1 enables ISO (PMID:29768204) RGD PMID:29768204 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
osmolarity-sensing monoatomic cation channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn7a sodium voltage-gated channel alpha subunit 7 enables IDA
ISO		 PMID:21084682
(MGI:3628881|PMID:11992118)		 RGD PMID:11992118 PMID:21084682 MGI:3628881, RGD:401966867 NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256 		JBrowse link
G Tmem63a transmembrane protein 63a enables ISO (MGI:6378787|PMID:27045885)
(PMID:27045885)		 RGD PMID:27045885 MGI:6378787 NCBI chr13:92,662,872...92,696,186
Ensembl chr13:92,663,968...92,696,183 		JBrowse link
G Tmem63b transmembrane protein 63B enables ISO (MGI:6378298|PMID:31243992), (MGI:6378787|PMID:27045885), (MGI:6514514|PMID:32375046) RGD PMID:27045885 PMID:31243992 PMID:32375046 MGI:6378298 MGI:6378787 MGI:6514514 NCBI chr 9:15,313,867...15,340,722
Ensembl chr 9:15,320,432...15,340,720 		JBrowse link
G Tmem63c transmembrane protein 63c enables ISS
ISO		 GO_REF:0000024
(MGI:6378787|PMID:27045885)
(PMID:27045885)		 UniProt
RGD		 PMID:27045885 GO_REF:0000024 MGI:6378787 NCBI chr 6:106,667,389...106,738,778
Ensembl chr 6:106,672,934...106,736,990 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IDA RGD PMID:18279313 RGD:10047048 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
osmosensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 enables ISO MGI:2667379 (PMID:11025659), (PMID:12777254) RGD PMID:11025659 PMID:12777254 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
oxygen sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egln2 egl-9 family hypoxia-inducible factor 2 enables ISO (PMID:11595184) RGD PMID:11595184 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 enables ISO
IMP		 (PMID:30922174)
(MGI:6208149|PMID:29887397), (MGI:6220487|PMID:26437605), (MGI:6442705|PMID:30922174)		 RGD PMID:26437605 PMID:29887397 PMID:30922174 PMID:30922174 MGI:6208149 MGI:6220487 MGI:6442705, RGD:42722001 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Park7 Parkinsonism associated deglycase enables ISO (MGI:3723371|PMID:17766438) RGD PMID:17766438 MGI:3723371 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
stalled ribosome sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcn1 GCN1 activator of EIF2AK4 enables ISO (PMID:36638793), (PMID:37651229), (PMID:37951215), (PMID:37951216) RGD PMID:36638793 PMID:37651229 PMID:37951215 PMID:37951216 NCBI chr12:40,991,512...41,052,661
Ensembl chr12:40,991,512...41,052,555 		JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 enables ISO (PMID:32610081)
(PMID:32289254), (PMID:35857590)		 RGD PMID:32289254 PMID:32610081 PMID:35857590 NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626 		JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor enables ISO (PMID:27863242) RGD PMID:27863242 NCBI chr 2:46,797,853...46,799,621
Ensembl chr 2:46,797,853...46,799,746 		JBrowse link
G Zfp598 zinc finger protein 598 enables ISO (PMID:30293783) RGD PMID:30293783 NCBI chr10:13,694,224...13,706,235
Ensembl chr10:13,694,286...13,706,233 		JBrowse link
sterol sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc38a9 solute carrier family 38, member 9 enables ISS
ISO		 GO_REF:0000024
(PMID:28336668)		 UniProt
RGD		 PMID:28336668 GO_REF:0000024 NCBI chr 2:44,291,637...44,374,897
Ensembl chr 2:44,291,989...44,368,955 		JBrowse link
zinc ion sensor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc39a4 solute carrier family 39 member 4 enables IEA
ISO
ISS		 GO_REF:0000107
(PMID:32348750)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:32348750 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:108,333,368...108,337,553
Ensembl chr 7:108,333,381...108,337,553 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20736
    molecular function regulator activity 2183
      molecular sensor activity 49
        DNA damage sensor activity + 18
        amino acid sensor activity + 2
        carbon monoxide sensor activity 0
        glucose sensor activity 2
        inositol pyrophosphate sensor activity 0
        lipid sensor activity + 1
        membrane curvature sensor activity 3
        metal ion sensor activity + 8
        nitric oxide sensor activity 0
        osmosensor activity + 6
        oxygen sensor activity 3
        peroxide sensor activity 0
        phosphorelay sensor kinase activity 0
        stalled ribosome sensor activity 4
paths to the root