ONTOLOGY REPORT - ANNOTATIONS
Term: general transcription initiation factor activity
Accession: GO:0140223
browse the term
Definition: A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary.
Comment: Usage guidance: The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors are the constitutive machinery required for transcription initiation.
Synonyms: exact_synonym: GTF activity; basal transcription factor activity; general transcription factor activity
never_in_taxon: NCBITaxon:2 ! Bacteria
G
Dr1
down-regulator of transcription 1
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
G
Tbp
TATA box binding protein
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016
G
Tbpl1
TATA-box binding protein like 1
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122 Ensembl chr 1:22,778,459...22,803,122
G
Rrn3
RRN3 homolog, RNA polymerase I transcription factor
enables
IBA ISO
GO_REF:0000033 (PMID:11250903)
GO_Central RGD
PMID:11250903
GO_REF:0000033
NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663
G
Taf1
TATA-box binding protein associated factor 1
enables
ISO
(PMID:12498690)
RGD
PMID:12498690
NCBI chr X:66,640,915...66,716,543
Ensembl chr X:66,640,982...66,716,543
G
Taf1c
TATA-box binding protein associated factor, RNA polymerase 1 subunit C
enables
ISO
(PMID:12498690)
RGD
PMID:12498690
NCBI chr19:47,652,451...47,658,971
Ensembl chr19:47,652,452...47,658,971
G
Ubtf
upstream binding transcription factor
enables
ISO IBA
(PMID:12498690) GO_REF:0000033
RGD GO_Central
PMID:12498690
GO_REF:0000033
NCBI chr10:87,258,217...87,274,291
Ensembl chr10:87,258,217...87,272,969
G
Ccnh
cyclin H
contributes_to enables
ISO IEA
(PMID:7533895) GO_REF:0000107
RGD Ensembl
PMID:7533895
GO_REF:0000107
NCBI chr 2:15,835,064...15,855,648
Ensembl chr 2:15,834,833...15,855,819
G
Dr1
down-regulator of transcription 1
enables
ISO IBA
(PMID:8670811) GO_REF:0000033
RGD GO_Central
PMID:8670811
GO_REF:0000033
NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638
G
Drap1
Dr1 associated protein 1
enables
ISO IBA
(PMID:8670811) GO_REF:0000033
RGD GO_Central
PMID:8670811
GO_REF:0000033
NCBI chr 1:202,731,775...202,734,468
Ensembl chr 1:202,731,788...202,734,425
G
Gtf2a1
general transcription factor 2A subunit 1
enables
ISO
(PMID:27193682)
RGD
PMID:27193682
NCBI chr 6:110,488,891...110,521,502
Ensembl chr 6:110,488,931...110,521,511
G
Gtf2a2
general transcription factor 2A subunit 2
enables
ISO IBA
(PMID:27193682), (PMID:7958899) GO_REF:0000033
RGD GO_Central
PMID:7958899 PMID:27193682
GO_REF:0000033
NCBI chr 8:70,662,447...70,675,576
Ensembl chr 8:70,662,428...70,675,569
G
Gtf2b
general transcription factor IIB
enables
IEA IBA ISO
GO_REF:0000107 GO_REF:0000033 (PMID:27193682)
Ensembl GO_Central RGD
PMID:27193682
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:231,767,317...231,785,626
Ensembl chr 2:231,767,238...231,785,651
G
Gtf2e1
general transcription factor IIE subunit 1
enables
ISO
(PMID:27193682)
RGD
PMID:27193682
NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942
G
Gtf2e2
general transcription factor IIE subunit 2
enables
ISO
(PMID:27193682)
RGD
PMID:27193682
NCBI chr16:58,399,307...58,449,467
Ensembl chr16:58,399,107...58,449,371
G
Gtf2f1
general transcription factor IIF subunit 1
enables
ISO IBA
(PMID:27193682), (PMID:7929273) GO_REF:0000033
RGD GO_Central
PMID:7929273 PMID:27193682
GO_REF:0000033
NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
G
Gtf2f2
general transcription factor IIF subunit 2
enables
IDA
PMID:7929273
RGD ARUK-UCL
PMID:1429731 PMID:7929273
RGD:632949 , RGD:9681417
NCBI chr15:51,206,027...51,327,166
Ensembl chr15:51,206,031...51,327,253
G
Gtf2h2
general transcription factor IIH subunit 2
enables
ISO
(PMID:10924514), (PMID:27193682)
RGD
PMID:10924514 PMID:27193682
NCBI chr 2:31,623,752...31,652,697
Ensembl chr 2:31,624,678...31,652,592
G
Gtf2h3
general transcription factor IIH subunit 3
enables
ISO IEA
(PMID:27193682) GO_REF:0000107
RGD Ensembl
PMID:27193682
GO_REF:0000107
NCBI chr12:32,009,010...32,025,484
Ensembl chr12:32,009,014...32,025,497
G
Gtf2h4
general transcription factor 2H subunit 4
enables
ISO
(PMID:27193682)
RGD
PMID:27193682
NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984
G
Prrx1
paired related homeobox 1
enables
ISO
(PMID:32188878)
RGD
PMID:32188878
NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866
G
Prrx2
paired related homeobox 2
enables
ISO
(PMID:32188878)
RGD
PMID:32188878
NCBI chr 3:14,132,574...14,168,533
Ensembl chr 3:14,094,004...14,168,535
G
Snapc2
small nuclear RNA activating complex, polypeptide 2
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr12:2,605,794...2,608,997
Ensembl chr12:2,605,810...2,608,999
G
Snapc4
small nuclear RNA activating complex, polypeptide 4
enables
ISO
(PMID:9418884)
RGD
PMID:9418884
NCBI chr 3:9,182,061...9,200,819
Ensembl chr 3:9,182,067...9,199,518
G
Snapc5
small nuclear RNA activating complex, polypeptide 5
enables
ISO
(PMID:9732265)
RGD
PMID:9732265
NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964
G
Taf1
TATA-box binding protein associated factor 1
enables
ISO
UniProtKB:Q15545 (PMID:17996705), (PMID:25412659)
RGD
PMID:17996705 PMID:25412659
NCBI chr X:66,640,915...66,716,543
Ensembl chr X:66,640,982...66,716,543
G
Taf10
TATA-box binding protein associated factor 10
contributes_to enables
ISO IBA
(PMID:9603525) GO_REF:0000033 (PMID:11564863)
RGD GO_Central
PMID:9603525 PMID:11564863
GO_REF:0000033
NCBI chr 1:160,095,108...160,096,401
Ensembl chr 1:160,095,108...160,096,376
G
Taf11
TATA-box binding protein associated factor 11
contributes_to
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr20:5,955,774...5,963,593
Ensembl chr20:5,955,777...5,961,905
G
Taf12
TATA-box binding protein associated factor 12
contributes_to
ISO
(PMID:9603525)
RGD
PMID:9603525
NCBI chr 5:144,472,816...144,490,299
Ensembl chr 5:144,472,841...144,488,849
G
Taf2
TATA-box binding protein associated factor 2
contributes_to
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:86,422,613...86,479,616
Ensembl chr 7:86,422,613...86,479,616
G
Taf4
TATA-box binding protein associated factor 4
contributes_to
ISO IBA
(PMID:9603525) GO_REF:0000033
RGD GO_Central
PMID:9603525
GO_REF:0000033
NCBI chr 3:167,017,992...167,083,413
Ensembl chr 3:167,017,993...167,083,356
G
Taf4b
TATA-box binding protein associated factor 4b
contributes_to
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr18:5,952,737...6,086,408
Ensembl chr18:5,952,769...6,068,307
G
Taf5
TATA-box binding protein associated factor 5
contributes_to enables
ISO IBA
(PMID:9603525) GO_REF:0000033 (PMID:9045704)
RGD GO_Central
PMID:9045704 PMID:9603525
GO_REF:0000033
NCBI chr 1:245,958,428...245,973,914
Ensembl chr 1:245,958,428...245,973,914
G
Taf6
TATA-box binding protein associated factor 6
contributes_to enables
ISO IBA IEA
(PMID:9603525) GO_REF:0000033 GO_REF:0000107 (PMID:15328371)
RGD GO_Central Ensembl
PMID:9603525 PMID:15328371
GO_REF:0000033 GO_REF:0000107
NCBI chr12:17,055,864...17,064,244
Ensembl chr12:17,055,873...17,064,247
G
Taf6l
TATA-box binding protein associated factor 6 like
enables
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 1:205,672,147...205,684,721
Ensembl chr 1:205,672,149...205,684,655
G
Taf7
TATA-box binding protein associated factor 7
contributes_to enables
ISO IBA
(PMID:9603525) GO_REF:0000033 (PMID:25412659), (PMID:7824954)
RGD GO_Central
PMID:7824954 PMID:9603525 PMID:25412659
GO_REF:0000033
NCBI chr18:29,459,937...29,462,086
Ensembl chr18:29,452,943...29,462,134
G
Taf7l
TATA-box binding protein associated factor 7-like
contributes_to
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr X:97,660,222...97,675,241
Ensembl chr X:97,660,222...97,675,023
G
Taf7l-ps1
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, pseudogene 1
contributes_to
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:51,763,259...51,764,401
Ensembl chr 7:51,763,259...51,764,401
G
Taf9
TATA-box binding protein associated factor 9
contributes_to
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769
G
Taf9b
TATA-box binding protein associated factor 9b
contributes_to
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604
G
Tbp
TATA box binding protein
contributes_to enables
IDA ISO
(PMID:27193682), (PMID:9841876)
RGD
PMID:9841876 PMID:27193682 PMID:7980586
RGD:2306552
NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016
G
Tbpl1
TATA-box binding protein like 1
enables
ISO
(PMID:10220372), (PMID:15767669)
RGD
PMID:10220372 PMID:15767669
NCBI chr 1:22,777,892...22,803,305
Ensembl chr 1:22,778,459...22,803,122 Ensembl chr 1:22,778,459...22,803,122
G
Tbpl2
TATA box binding protein-like 2
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:6,771,825...6,793,281
Ensembl chr 3:6,772,419...6,793,231
G
Brf1
BRF1, RNA polymerase III transcription initiation factor subunit
enables
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 6:132,034,378...132,081,313
Ensembl chr 6:132,037,272...132,081,278
G
Gtf3a
general transcription factor III A
IDA
RGD
PMID:11814676
RGD:632850
NCBI chr12:8,136,746...8,144,690
Ensembl chr12:8,136,747...8,144,690
G
Gtf3c1
general transcription factor IIIC subunit 1
enables
ISO IEA
(PMID:17409385) GO_REF:0000107
RGD Ensembl
PMID:17409385
GO_REF:0000107
NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201
G
Gtf3c2
general transcription factor IIIC subunit 2
enables
ISO
(PMID:17409385)
RGD
PMID:17409385
NCBI chr 6:25,196,439...25,221,338
Ensembl chr 6:25,197,268...25,220,490
G
Gtf3c3
general transcription factor IIIC subunit 3
enables
ISO
(PMID:17409385)
RGD
PMID:17409385
NCBI chr 9:55,882,252...55,943,037
Ensembl chr 9:55,883,721...55,942,967
G
Gtf3c4
general transcription factor IIIC subunit 4
enables
ISO
(PMID:17409385)
RGD
PMID:17409385
NCBI chr 3:12,154,803...12,172,795
Ensembl chr 3:12,154,805...12,172,725
G
Gtf3c5
general transcription factor IIIC subunit 5
enables
ISO
(PMID:17409385)
RGD
PMID:17409385
NCBI chr 3:11,893,867...11,914,187
Ensembl chr 3:11,893,875...11,914,180
G
Gtf3c6
general transcription factor 3C subunit 6
enables
ISO
(PMID:17409385)
RGD
PMID:17409385
NCBI chr20:43,656,400...43,668,382
Ensembl chr20:43,655,875...43,667,873
G
Snapc4
small nuclear RNA activating complex, polypeptide 4
enables
ISO
(PMID:9418884)
RGD
PMID:9418884
NCBI chr 3:9,182,061...9,200,819
Ensembl chr 3:9,182,067...9,199,518
G
Snapc5
small nuclear RNA activating complex, polypeptide 5
enables
ISO
(PMID:9732265)
RGD
PMID:9732265
NCBI chr 8:64,677,204...64,680,769
Ensembl chr 8:64,677,205...64,681,964
G
Tbp
TATA box binding protein
enables
ISO
(PMID:26638071)
RGD
PMID:26638071
NCBI chr 1:56,463,330...56,480,430
Ensembl chr 1:56,463,618...56,510,016
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all