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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac endothelial to mesenchymal transition
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Accession:GO:0140074 term browser browse the term
Definition:A transition where a cardiac endothelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. Endocardial cells (specialized endothelial cells that line the heart) undergo EndMT, and give rise to mesenchymal cells necessary for proper heart development. EndMT, specifically generates valve progenitor cells that give rise to the mitral and tricuspid valves. EndMT also contributes to endocardial cushion formation, as well as to generation of cardiac fibroblasts and smooth muscle cells, but not cardiac myocytes.
Synonyms:exact_synonym: EndMT;   EndoMT



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cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C involved_in IDA (MGI:5693177|PMID:26053665) BHF-UCL PMID:26053665 MGI:5693177 NCBI chr 5:17,779,814...17,935,266
Ensembl chr 5:17,779,279...17,935,266
JBrowse link
positive regulation of cardiac endothelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gata5 GATA binding protein 5 involved_in IMP (MGI:5286818|PMID:21633169) BHF-UCL PMID:21633169 MGI:5286818 NCBI chr 2:179,966,881...179,977,296
Ensembl chr 2:179,966,926...179,976,492
JBrowse link
G Mir342 microRNA 342 involved_in ISO (PMID:26857067) BHF-UCL PMID:26857067 NCBI chr12:108,624,879...108,624,977
Ensembl chr12:108,624,879...108,624,977
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28746
    cellular process 17701
      cellular developmental process 4867
        cell differentiation 4843
          mesenchymal cell differentiation 259
            cardiac endothelial to mesenchymal transition 3
              negative regulation of cardiac endothelial to mesenchymal transition 0
              positive regulation of cardiac endothelial to mesenchymal transition 2
              regulation of cardiac endothelial to mesenchymal transition + 2
Path 2
Term Annotations click to browse term
  biological_process 28746
    developmental process 7254
      anatomical structure development 6680
        tissue development 2266
          mesenchyme development 319
            mesenchymal cell differentiation 259
              cardiac endothelial to mesenchymal transition 3
                negative regulation of cardiac endothelial to mesenchymal transition 0
                positive regulation of cardiac endothelial to mesenchymal transition 2
                regulation of cardiac endothelial to mesenchymal transition + 2
paths to the root